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Journal of Chinese Integrative Medicine ›› 2010, Vol. 8 ›› Issue (2): 101-105.doi: 10.3736/jcim20100201

• Editorial •     Next Articles

Possibility and necessity of constructing new nanoformula systems of traditional Chinese medicine

 Chang-quan Ling, Yong-hua Su   

  1. Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Received:2009-09-09 Accepted:2010-01-12 Online:2010-02-20 Published:2010-02-15
  • Contact: Chang-quan Ling E-mail:lingchangquan@hotmail.com

The past decade has witnessed the remarkable progress on nanotechnology and nanoherb. With the globally rapid development of nanotechnology, we are considering to construct new nanoformula systems of traditional Chinese medicine (TCM) by using porous materials, multilayered core-shell particles or nanoparticles containing various multifunctional parts. With the compatibility of sovereign, minister, assistant and courier in a formula, new nanoformula systems of TCM will have various advantages, such as containing multiple active species, controlled release, targeting function, and labeling and tracing capabilities. Using the latest breakthroughs of nanotechnology for the modern research of TCM will greatly help enhance the ability to investigate the principles of TCM, and to design, screen and utilize new nanoformula systems of TCM.

Key words: Nanotechnology, Formula, Traditional Chinese herbal drug

[1] Hochella MF . There's plenty of room at the bottom: nanoscience in geochemistry[J]. Geochim Et Cosmochim Acta, 2002,66(5):735-743
doi: 10.1016/S0016-7037(01)00868-7
[2] Xu HB, Yang XL, Xie CS, Yang YJ . Application of nanotechnology on the study of traditional Chinese herbal medicine[J]. Zhongguo Yao Ke Da Xue Xue Bao, 2001,32(3):161-165
徐辉碧, 杨祥良, 谢长生, 杨亚江 . 纳米技术在中药研究中的应用[J]. 中国药科大学学报, 2001,32(3):161-165
[3] Yang XL, Xu HB, Wu JZ, Xie CS . Application of nano-technology in the research of traditional Chinese medicine[J]. Hua Zhong Li Gong Da Xue Xue Bao, 2000,28(12):104-105
杨祥良, 徐辉碧, 吴继洲, 谢长生 . 基于纳米技术的中药基础问题研究[J]. 华中理工大学学报, 2000,28(12):104-105
[4] Xiao PG . Chinese herbal medicine must accelerate modernization for entering the WTO[J]. Zhong Yao Yan Jiu Yu Xin Xi, 2000,2(1):8
肖培根 . 面对入世中药必须加快现代化[J]. 中药研究与信息, 2000,2(1):8
[5] Hu ZB . Look into the future based upon the tradition[J]. Shanghai Zhong Yi Yao Za Zhi, 2000,34(2):4-6
胡之璧 .立足传统, 展望未来 , 传统中药研究开发浅见[J]. 上海中医药杂志, 2000,34(2):4-6
[6] Lan XL, Jia XB, Chen Y, Sun E, Jin XY, Li LD . Application of several nanometer drug delivery systems to improving ADME/Tox of Chinese materia medica[J]. Zhong Cao Yao, 2008,39(11):1746-1748
兰雪莲, 贾晓斌, 陈彦, 孙娥, 金晓勇, 李连达 . 几种纳米给药系统在改善中药ADME/Tox性质方面的应用[J]. 中草药, 2008,39(11):1746-1748
[7] Liu LF, Zhang YD . Modernization of TCM in the research of nanometer traditional Chinese medicine[J]. Zhongguo Xian Dai Yi Xue Za Zhi, 2009,19(8):1186-1191
刘丽芳, 张阳德 . 纳米中药研究与中药现代化[J]. 中国现代医学杂志, 2009,19(8):1186-1191
[8] Yan DM, Wang L, Zhu LL, Miao Z, Liang LC, Yang JY . Influences of nanometer Sijunzi Decoction on antioxidative ability and immunity in aging mice induced by D-galactose[J]. Zhongguo Lao Nian Xue Za Zhi, 2007,27(12):1134-1136
闫冬梅, 王琳, 祝立玲, 苗智, 梁立春, 杨景云 . 纳米四君子汤对半乳糖致衰老小鼠抗氧化及免疫功能的影响[J]. 中国老年学杂志, 2007,27(12):1134-1136
[9] Fan L, Cui GL, Wang XJ, Wu QT, Hou X . Promoting effect of nanometer Xinjiguben powder on cardiomyocyte proliferation[J]. Mudanjiang Yi Xue Yuan Xue Bao, 2007,28(4):27-29
范蕾, 崔国利, 王学军, 吴庆田, 侯霞 . 纳米中药心肌固本散在促进心肌细胞增殖方面的研究[J]. 牡丹江医学院学报, 2007,28(4):27-29
[10] Lai CY, Trewyn BG, Jeftinija DM, Jefttinija K, Xu S, Jeftinija S, Lin VS . A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules[J]. J Am Chem Soc, 2003,125(15):4451-4459
doi: 10.1021/ja028650l
[11] Lu J, Liong M, Zink JI, Tamanoi F . Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs[J]. Small, 2007,8(3):1341-1346
[12] Slowing I, Trewyn BG, Lin VS . Effect of surface functionalization of MCM-41-type mesoporous silica nano-particles on the endocytosis by human cancer cells[J]. J Am Chem Soc, 2006,128(46):14792-14793
doi: 10.1021/ja0645943
[13] Zhao Y, Trewyn BG, Slowing II, Lin VS . Mesoporous silica nanoparticle-based double drug delivery system for glucose-responsive controlled release of insulin and cyclic AMP[J]. J Am Chem Soc, 2009,131(24):8398-8400
doi: 10.1021/ja901831u
[14] Yang XY, Li Y, Tendeloo GV, Xiao FS, Su BL . One-pot synjournal of catalytically stable and active nanoreactors: encapsulation of size-controlled nanoparticles within a hierarchically macroporous core@ordered mesoporous shell system[J]. Adv Mater, 2009,21(13):1368-1372
doi: 10.1002/adma.v21:13
[15] Deng Y, Deng C, Qi D, Liu C, Liu J, Zhang X, Zhao D . Synjournal of core/shell colloidal magnetic zeolite microspheres for the immobilization of trypsin[J]. Adv Mater, 2009,21(13):1377-1382
doi: 10.1002/adma.v21:13
[16] Kilian KA , Böcking T, Gaus K, Gooding JJ.Introducing distinctly different chemical functionalities onto the internal and external surfaces of mesoporous materials[J]. Angew Chem Int Ed, 2008,47(14):2697-2699
doi: 10.1002/(ISSN)1521-3773
[17] Kim J, Lee JE, Lee SH, Yu JH, Lee JH, Park TG, Hyeon T . Designed fabrication of a multifunctional polymer nanomedical platform for simultaneous cancer-targeted imaging and magnetically guided drug delivery[J]. Adv Mater, 2008,20(3):478-483
doi: 10.1002/(ISSN)1521-4095
[18] Stoeva SI, Huo F, Lee JS, Mirkin CA . Three-layer composite magnetic nanoparticle probes for DNA[J]. J Am Chem Soc, 2005,127(44):15362-15363
doi: 10.1021/ja055056d
[19] Zhao DQ, Yang F . “Top-down” and “bottom-up”[J]. Cai Liao Dao Bao, 2001,15(11):1-3
赵大庆, 杨锋 . “top-down”和“bottom-up”——评我国纳米科技发展的导向问题[J]. 材料导报, 2001,15(11):1-3
[20] Li ZX, Wu XH, He FY, Liu WL, Liu W . Study on pharmacokinetics of tetramethylpyrazine in Buyanghuanwu Decoction[J]. Zhongguo Yao Ye, 2007,16(18):23-24
李再新, 吴小红, 贺福元, 刘文龙, 刘伟 . 补阳还五汤中川芎嗪的药代动力学研究[J]. 中国药业, 2007,16(18):23-24
[21] Zou JM, Meng J, Yan ZH, Long ZX, Shi XJ . Pharmacokinetic studies of icariin in Chinese formulated medicine[J]. Zhong Cao Yao, 2002,33(1):55-58
邹节明, 孟杰, 颜正华, 龙致贤, 施雪筠 . 中药复方有效成分淫羊藿苷的药代动力学研究[J]. 中草药, 2002,33(1):55-58
[22] Wang YX, He MS . The usage of acute death rates in animals for the assay of pharmacokinetic parameters of four traditional Chinese herbal medicines[J]. Zhong Cheng Yao, 1991,13(5):24-25
王尧先, 赫梅生 . 用动物急性死亡率法估测四种中成药的药动学参数[J]. 中成药, 1991,13(5):24-25
[23] Fu HY, Zhou AX, He YZ, Guo SY, Shen H . Pharmacodynamic research on Mahuang Decoction, Guizhi Decoction, Yinqiao Powder and Sangju Yin by inhibiting the hyperfunction of intestinal peristalsis[J]. Zhong Cheng Yao, 1993,15(1):35-36
富杭育, 周爱香, 贺玉琢, 郭淑英, 沈鸿 . 以抑制肠蠕动亢进作用再探麻黄汤、桂枝汤、银翘散、桑菊饮的药效动力学[J]. 中成药, 1993,15(1):35-36
[24] Wang XF, Qin J . Bacterioassay of pharmacokinetic parameters of methyl hydroquinone in rabbits[J]. Xi Bei Yao Xue Za Zhi, 1997,12(2):70-71
王西发, 秦骏 . 微生物法测定家兔体内鹿蹄草素药动学参数[J]. 西北药学杂志, 1997,12(2):70-71
[25] Chan WC, Nie S . Quantum dot bioconjugates for ultrasensitive nonisotopic detection[J]. Science, 1998,281(5385):2016-2018
doi: 10.1126/science.281.5385.2016
[26] Delehanty JB, Boeneman K, Bradburne CE, Robertson K, Medintz IL . Quantum dots: a powerful tool for understanding the intricacies of nanoparticle-mediated drug delivery[J]. Expert Opin Drug Deliv, 2009,6(10):1091-1112
doi: 10.1517/17425240903167934
[27] Zhang CY, Ma H, Ding Y, Jin L, Chen DY, Miao Q, Nie SM . Studies on quantum dots-labeled trichosanthin[J]. Gao Deng Xue Xiao Hua Xue Xue Bao, 2001,22(1):34-37
张春阳, 马辉, 丁尧, 金雷, 陈瓞延, 苗琦, 聂书明 . 量子点标记天花粉蛋白的研究[J]. 高等学校化学学报, 2001,22(1):34-37
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