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Journal of Chinese Integrative Medicine ›› 2010, Vol. 8 ›› Issue (2): 116-120.doi: 10.3736/jcim20100204

• Original Clinical Research • Previous Articles     Next Articles

Survival time of advanced gastric cancer patients treated with integrated traditional Chinese and Western medicine therapy

Ni-da Cao,Ai-guang Zhao, Jin-kun Yang   

  1. The First Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
  • Received:2009-09-02 Accepted:2009-12-08 Online:2010-02-20 Published:2010-02-15
  • Contact: Ni-da CAO E-mail:amandatsao_tsao@yahoo.com.cn

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Background

Advanced gastric cancer has a low survival rate while traditional Chinese medicine (TCM) therapy has effects in inhibiting tumor growth, lengthening survival time and improving the quality of life.
Objective

To analyze the effects of integrated traditional Chinese and Western medicine therapy on the survival time and quality of life of advanced gastric cancer patients.
Design, setting, participants and interventions

A total of 95 advanced gastric cancer patients were enrolled and divided into comprehensive group (48 cases) and control group (47 cases). The patients in the comprehensive group from the First Department of Oncology, Longhua Hospital, were treated with TCM therapy and chemotherapy based on the gastric cancer treatment guidelines made by the First Department of Oncology of Longhua Hospital, and the patients in the control group from Renji Hospital and Ruijin Hospital in Shanghai were treated with chemotherapy only.
Main outcome measures

The survival time in the two groups were observed and compared. The Karnofsky score, body weight, the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) score, response rate and chemotherapy-related adverse events in the comprehensive group were observed.
Results

The estimated median survival time in the comprehensive group was 16.12 months, longer than 9.64 months in the control group (P<0.05). The scores of function and symptom of EORTC QLQ-C30 in the comprehensive group decreased, while the overall health status increased, and the results indicated that the quality of life of the patients in the comprehensive group was improved. In the comprehensive group, the body weight after treatment was higher than that before treatment (P=0.037), while there was no difference in Karnofsky scores between that before and after treatment (P=0.061). All the patients in the comprehensive group were assessable. The complete response rate was 0, 3 cases had a partial response, 34 cases had stable disease, and 11 cases had disease progression. The overall response rate was 6.25% (3/48), and the disease control rate was 77.08% (37/48). No patient withdrew because of severe adverse events and there was no chemotherapy-related death.
Conclusion

Integrated traditional Chinese and Western medicine can prolong the survival time and improve the quality of life of advanced gastric cancer patients, and enhance the comprehensive effects.

Key words: Gastric cancer, Integrated traditional Chinese and Western medicine therapy, Survival time, Quality of life, Controlled clinical trial

Table 1

General data of the included patients"

General information Control group Comprehensive group
Gender (Male/Female) 33/14 26/22
Median age (Years) 52 52
Pathology
Poorly differentiated
adenocarcinoma		 22 21
Signet-ring cell carcinoma 13 10
Mucinous adenocarcinoma 0 1
Moderately differentiated
adenocarcinoma		 2 4
Others 10 12
Metastasis
Liver 19 13
Pancreas 2 2
Abdominal or pelvic cavity 19 29
Celiac lymph nodes 9 13
Lung 4 0
Gallbladder 1 0
Umbilicus 0 1
Treatment
Initial treatment 47 24
Retreatment 0 24

Table 2

EORTC QLQ-C30 scores in comprehensive group before and after the treatment"

Item Comprehensive group
Before treatment After treatment P
Functional subscale 8.53±2.27 7.97±2.01* 0.000
Physical function 1.49±0.33 1.54±0.30 0.154
Role function 2.04±0.88 1.85±0.82* 0.023
Emotional function 1.70±0.64 1.54±0.54* 0.000
Cognitive function 1.24±0.39 1.14±0.32* 0.024
Social function 2.04±0.98 1.91±0.89* 0.022
Global quality of life subscale 4.22±1.24 4.54±1.17* 0.012
Symptom subscale 5.65±1.86 4.88±1.37* 0.013
Fatigue 2.38±0.69 2.21±0.62* 0.030
Nausea and vomiting 1.33±0.74 1.21±0.51 0.241
Pain 1.94±0.87 1.52±0.65* 0.000
Dyspnea 1.17±0.48 1.13±0.44 0.569
Sleep disturbance 1.54±0.82 1.48±0.68 0.444
Poor appetite 2.29±1.03 1.88±0.91* 0.001
Constipation 1.16±0.82 1.13±0.39* 0.006
Diarrhea 1.17±0.52 1.19±0.49 0.785
Financial difficulty 1.96±0.82 2.31±0.80* 0.000
[1] Van Cutsem E . The treatment of advanced gastric cancer: new findings on the activity of the taxanes[J]. Oncologist, 2004,9(Suppl 2):9-15
doi: 10.1634/theoncologist.9-suppl_2-9
[2] Qin SK, Gong XL . Chemotherapy of advanced gastric carcinoma: current status and prospects[J]. Lin Chuang Zhong Liu Xue Za Zhi, 2006,11(9):641-652
秦叔逵, 龚新雷 . 晚期胃癌化疗的现状和新进展[J]. 临床肿瘤学杂志, 2006,11(9):641-652
[3] Sun DZ, Xu L, Jiang LD, Wei PK . Evaluation of the quality of clinical literatures of traditional Chinese medicine for gastric carcinoma[J]. Zhongguo Lin Chuang Yi Xue, 2003,10(6):833-835
孙大志, 许玲, 姜林娣, 魏品康 . 中医药治疗胃癌临床研究文献质量的调查评价[J]. 中国临床医学, 2003,10(6):833-835
[4] Chinese Anticancer Association. New criteria for diagnosis and treatment of common malignant tumors[J]. Beijing: Peking Union Medical College Press, 1999
中国抗癌协会. 新编常见恶性肿瘤诊治规范[J].北京: 中国协和医科大学出版社, 1999
[5] Shimada K, Ajani JA . Adjuvant therapy for gastric carcinoma patients in the past 15 years: a review of Western and oriental trials[J]. Cancer, 1999,86(9):1657-1668
doi: 10.1002/(ISSN)1097-0142
[6] Shen ZY, Wang WJ . Reference criteria for differentiation of deficiency syndromes in traditional Chinese medicine[J]. Zhong Xi Yi Jie He Za Zhi, 1986,5(10):698
沈自尹, 王文健 . 中医虚证辨证参考标准[J]. 中西医结合杂志, 1986,5(10):698
[7] Ministry of Health of the People's Republic of China. Guidelines for clinical research on Chinese new herbal medicines(trial implementation)[J]. Beijing: Medical Science and Technology Publishing House of China, 2002
中华人民共和国卫生部. 中药新药临床研究指导原则(试行)[J].北京: 中国医药科技出版社, 2002
[8] Jin ML . Chemotherapy of advanced gastric cancer[J]. Zhongguo Shi Yong Wai Ke Za Zhi, 2000,20(10):628-630
金懋林 . 晚期胃癌的化学治疗[J]. 中国实用外科杂志, 2000,20(10):628-630
[9] Koizumi W, Narahara H, Hara T, Takagane A, Akiya T, Takagi M, Miyashita K, Nishizaki T, Kobayashi O, Takiyama W, Toh Y, Nagaie T, Takagi S, Yamamura Y, Yanaoka K, Orita H, Takeuchi M . S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer(SPIRITS trials): a phase Ⅲ trial[J]. Lancet Oncol, 2008,9(3):215-221
doi: 10.1016/S1470-2045(08)70035-4
[10] Cunningham D, Starling N, Rao S, Iveson T, Nicolson M, Coxon F, Middleton G, Daniel F, Oates J, Norman AR . Upper Gastrointestinal Clinical Studies Group of the National Cancer Research Institute of the United Kingdom. Capecitabine and oxaliplatin for advanced esophagogastric cancer[J]. N Engl J Med, 2008,358(1):36-46
doi: 10.1056/NEJMoa073149
[11] Van Cutsem E, Moiseyenko VM, Tjulandin S, Majlis A, Constenla M, Boni C, Rodrigues A, Fodor M, Chao Y, Voznyi E, Risse ML, Ajani JA ; V325 Study Group.Phase Ⅲ study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first line therapy for advanced gastric cancer[J]. a report of the V325 study group. J Clin Oncol, 2006,24(31):4991-4997
[12] U.S. Department of Health and Human Service, U. S.Food and Drug Administration[J]. Guidance for industry: clinical trial endpoints for the approval of cancer drugs and biologics, 2007
[13] Yang JK, Zheng J . Academic experience of Qiu Jiaxin in treating malignant tumor of digestive track[J]. Shanghai Zhong Yi Yao Za Zhi, 1995,200:8-10
杨金坤, 郑坚 . 邱佳信治疗消化道恶性肿瘤的学术经验[J]. 上海中医药杂志, 1995,200:8-10
[14] Yang JK, Zhao AG, Zhao HL . Experimental study of Weichang’an in inducing apoptosis in human gastric cancer[J]. Zhong Yi Yao Xue Kan, 2003,21(6):908-909
杨金坤, 赵爱光, 赵海磊 . 胃肠安诱导人胃癌细胞凋亡的实验研究[J]. 中医药学刊, 2003,21(6):908-909
[15] Zhao HL, Zhao AG, You SF, Gu Y, Tang LD, Yang JK . Growth-inhibiting and anti-metastasis effects of Weichang’an Decoction on orthotopic transplant nude mouse model of human gastric cancer[J]. J Chin Integr Med, 2005,3(5):378-381
赵海磊, 赵爱光, 尤圣富, 顾缨, 唐莱娣, 杨金坤 . 健脾中药复方胃肠安对人胃癌裸小鼠原位移植瘤生长和转移的影响[J]. 中西医结合学报, 2005,3(5):378-381
[16] Zheng J, Gu Y, Zhou H, Zhu YJ, Han YY, Shen KP . Effects of traditional Chinese herbal drugs for strengthening spleen on the living period, metastasis and recurrence of the advanced gastric cancer[J]. Liaoning Zhong Yi Za Zhi, 2003,30(8):683-685
郑坚, 顾缨, 周浩, 朱莹杰, 韩颖盈, 沈克平 . 健脾中药对进展期胃癌生存期及转移复发状况的作用[J]. 辽宁中医杂志, 2003,30(8):683-685
[17] Yang JK, Shen KP, Zhao HL . Tube infusion of traditional Chinese herbal medicine in treatment of 56 cases of obstructive alimentary malignant tumor[J]. Shanghai Zhong Yi Yao Za Zhi, 2001,( 6):15-16
杨金坤, 沈克平, 赵海磊 . 中药导管滴入法治疗56例梗阻性消化道恶性肿瘤[J]. 上海中医药杂志, 2001,( 6):15-16
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