益气化瘀方对大鼠腰神经根损伤后花生凝集素结合分子和施万细胞的作用

doi:10.3736/jcim20040513

Abstract

Objective: To study the effect of Yiqi Huayu Recipe on peanut agglutinin-binding molecules (PNA-BMs) and Schwann's cells (Sc) of the neuromuscular junction after L5 nerve root compression in rats.Methods: The rats were given Yiqi Huayu Recipe at the 10th, 20th, 30th and 60th day after L5 nerve root compression. Using immunohistochemistry and confocal laser scanning techniques, we observed the distributions of PNA-BMs and S-100 in the soleus muscle. The overlap area of PNA-BMs and S-100 was measured with NIH image technique.Results: The extracellular matrix (ECM) recognized by PNA played an important role in guiding the sprouting and extending of the Schwann' s cells. The agglomeration, sprouting and extension of the terminal Sc and the overlap area of Sc with PNA-BMs in the Yiqi Huayu Recipe group were better than those in the control group.Conclusion: Yiqi Huayu Recipe can promote the growth of ECM and Schwann's cells and accelerate the nerve regeneration process.

Key words: spinal nerve roots, nerve regeneration, peanut agglutinin, Schwann’ s cells;, Yiqi Huayu Recipe

CLC Number:

R289.5

Chong-jian Zhou, Jun-ren Su, Yong-jun Wang, Bao-xing Hou, Mei Liu, Qi Shi. Effect of Yiqi Huayu Recipe on peanut agglutinin-binding molecules and Schwann's cells in rats after lumbar nerve root compression. Journal of Chinese Integrative Medicine, 2004, 2(5): 353-357.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20040513

http://www.jcimjournal.com/EN/Y2004/V2/I5/353

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[1]	Lee MA, Blamire AM, Pendlebury S , et al. Axonal injury or loss in the internal capsule and motor impairment in multiple sclerosis[J]. Arch Neurol, 2000,57(1):65-70 doi: 10.1001/archneur.57.1.65 pmid: 10634450
[2]	Matsumura K, Nakasu S, Nioka H , et al. Lectin histochemistry of normal and neoplastic peripheral nerve sheath.1.Lectin binding pattern of normal peripheral nerve in man[J]. Acta Neuropathol(Berl), 1993,86(6):554-558 doi: 10.1007/BF00294292
[3]	Zhou CJ, Kawabuchi M, He JW , et al. Changes in the distribution of peanut agglutinin(PNA) binding molecules during muscle reinnervation following nerve crush injury[J]. Arch Histol Cytol, 1999,62(3):261-272 doi: 10.1679/aohc.62.261
[4]	Petratos S, Butzkueven H, Shipham K , et al. Schwann cell apoptosis in the postnatal axotomized sciatic nerve is mediated via NGF through the low-affinity neurotrophin receptor[J]. J Neuropathol Exp Neurol, 2003,62(4):398-411 doi: 10.1093/jnen/62.4.398
[5]	周重建, 施杞, 王拥军 , 等. 腰神经根损伤后神经肌肉接头施旺细胞的作用和表现[J]. 安徽医科大学学报, 2001,36(4):271-274 doi: 10.3969/j.issn.1000-1492.2001.04.008
[6]	Tomaselli KJ, Reichardt LF, Bixby JL . Distinct molecular interactions mediate neuronal process outgrowth on non-neuronal cell surfaces and extracellular matrices[J]. J Cell Biol, 1986,103(6):2659-2672 doi: 10.1083/jcb.103.6.2659
[7]	王拥军, 万超, 沈培芝 , 等. 实验性腰神经根压迫模型的建立[J]. 中国中医骨伤科杂志, 1999,7(1):9-12 doi: 10.3969/j.issn.1005-0205.1999.01.004
[8]	Hirata K, Zhou C, Nakamura K , et al. Postnatal development of Schwann cells at neuromuscular junctions, with special reference to synapse elimination[J]. J Neurocytol, 1997,26(12):799-809 doi: 10.1023/A:1018570500052
[9]	Chiu AY, Espinosa de los-Monteros A, Cole RA , et al. Laminin and s-laminin are produced and released by astrocytes, Schwann cells and Schwannomas in culture[J]. Glia, 1991,4(1):11-24 doi: 10.1002/(ISSN)1098-1136
[10]	Smith DV, Klevitsky R, Akeson RA , et al. Expression of the neural cell adhesion molecule(NCAM) and polysialic acid during taste bud degeneration and regeneration[J]. J Comp Neurol, 1994,347(2):187-196 doi: 10.1002/(ISSN)1096-9861
[11]	Harada T, Harada C, Kohsaka S , et al. Microglia-Muller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration[J]. J Neurosci, 2002,22(21):9228-9236 doi: 10.1523/JNEUROSCI.22-21-09228.2002
[12]	周重建, 王拥军, 施杞 , 等. 益气化瘀方对大鼠腰神经根神受压后神经肌肉终板再生修复的作用[J]. 中西医结合学报, 2003,1(4):277-280
	Zhou CJ, Wang YJ, Shi Q , et al. Effect of Yiqi Recipe on regeneration process after L5 nerve root compression in rats[J]. Zhong Xi Yi Jie He Xue Bao, 2003,1(4):277-280
[13]	黄正良 . 麝香的药理作用及临床应用研究[J]. 中成药研究, 1987,6(5):23-26

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Effect of Yiqi Huayu Recipe on peanut agglutinin-binding molecules and Schwann's cells in rats after lumbar nerve root compression

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