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Journal of Chinese Integrative Medicine ›› 2006, Vol. 4 ›› Issue (1): 73-75.doi: 10.3736/jcim20060119

Special Issue: Acupuncture & Moxibustion

• Original Experimental Research • Previous Articles     Next Articles

Effects of electroacupuncture treatment on nitrergic neurotransmitter in bladder neck and detrusor of rats with unstable bladder

Yue-lai Chen, Jue Cen, Wen-guang Hou, Zhi-qiang Gao, Xian-min Yu, Xue-mei Ma   

  1. Department of Acupuncture and Moxibustion, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai Acupuncture-Moxibustion-Tuina Medical Center, Shanghai 200437, China
  • Online:2006-01-20 Published:2006-01-15

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Objective

To observe the effects of electroacupuncture treatment on nitrergic neurotransmitter in bladder neck and detrusor of rats with unstable bladder.

Methods

Rat models of unstable bladder were established by operation to induce urethral obstruction. Electroacupuncture treatment was given by acupuncturing Huiyang and Zhonglüshu points for a week. Then the neuronal nitric oxide synthase (nNOS)-, endothelial nitric oxide synthase (eNOS)- and inducible nitric oxide synthase (iNOS)-positive cells in bladder neck and detrusor of the rats were observed.

Results

The nitrergic neurotransmitter in bladder neck and detrusor were obviously decreased in rats with unstable bladder. The electroacupuncture treatment could significantly increase the contains of NOS in bladder tissue.

Conclusion

To promote the synthesis and secretion of nitrergic neurotransmitter in bladder tissue may be one of the mechanisms of acupuncture in adjusting bladder function.

Key words: Electroacupuncture, Unstable bladder, Nitrergic neurotransmitter, Animals experimentation

CLC Number: 

  • R245.115

Table 1

Effects of electroacupuncture on numbers of nNOS-, eNOS- and iNOS-positive cells in bladder neck and detrusor of rats（ヌ±S）"

[1] 金锡御, 宋波 . 临床尿动力学(第1版)[M]. 北京: 人民卫生出版社, 2001,( 第1版):165-175
[2] Malmgren A, Sjogren C, Uvelius B , et al. Cystometrical evaluation of bladder instability in rats with infravesical outflow obstruction[J]. J Urol, 1987,137(6):1291-1294
[3] 林文注, 王佩 . 实验针灸学(第1版)[M]. 上海: 上海科学技术出版社, 1994,( 第1版):284-288
[4] Chapple CR, Smith D . The pathophysiological changes in the bladder obstructed by benign prostatic hyperplasia[J]. Br J Urol, 1994,73(2):117-123
doi: 10.1111/j.1464-410X.1994.tb16570.x pmid: 7510572
[5] 曹润福, 彭轼平, 张时纯 . 逼尿肌不稳定发病机制研究进展[J]. 中华泌尿外科杂志, 1998,19(9):572-574
doi: 10.3760/j:issn:1000-6702.1998.09.017
[6] 郑蕙田 . 深刺会阳、中膂俞为主治疗排尿功能障碍性疾病及机理探讨[J]. 上海针灸杂志, 1993,12(2):64-65
[7] 陈跃来, 钟蕾, 刘光雯 . 针刺调节膀胱功能的神经机制研究进展[J]. 上海中医药大学学报, 2002,16(1):63-65
doi: 10.3969/j.issn.1008-861X.2002.01.020
[8] 陈跃来, 宗蕾, 陈国美 , 等. 针刺对28例不稳定膀胱患者尿动力学影响的临床观察[J]. 浙江中医杂志, 2002,37(11):490-491
doi: 10.3969/j.issn.0411-8421.2002.11.019
[9] 陈跃来, 陈国美, 申鹏飞 . 不同穴位对不稳定膀胱尿动力学影响的临床研究[J]. 上海针灸杂志, 2003,22(3):63-65
[10] Chen Y . The anatomical physiology and clinical application of the points huiyang and zonglushu[J]. J Tradit Chin Med, 2002,22(3):180-182
doi: 10.3969/j.issn.0255-2922.2002.03.005 pmid: 12400420
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