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Journal of Chinese Integrative Medicine ›› 2006, Vol. 4 ›› Issue (1): 73-75.doi: 10.3736/jcim20060119

Special Issue: Acupuncture & Moxibustion

• Original Experimental Research • Previous Articles     Next Articles

Effects of electroacupuncture treatment on nitrergic neurotransmitter in bladder neck and detrusor of rats with unstable bladder

Yue-lai Chen, Jue Cen, Wen-guang Hou, Zhi-qiang Gao, Xian-min Yu, Xue-mei Ma   

  1. Department of Acupuncture and Moxibustion, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai Acupuncture-Moxibustion-Tuina Medical Center, Shanghai 200437, China
  • Online:2006-01-20 Published:2006-01-15


To observe the effects of electroacupuncture treatment on nitrergic neurotransmitter in bladder neck and detrusor of rats with unstable bladder.


Rat models of unstable bladder were established by operation to induce urethral obstruction. Electroacupuncture treatment was given by acupuncturing Huiyang and Zhonglüshu points for a week. Then the neuronal nitric oxide synthase (nNOS)-, endothelial nitric oxide synthase (eNOS)- and inducible nitric oxide synthase (iNOS)-positive cells in bladder neck and detrusor of the rats were observed.


The nitrergic neurotransmitter in bladder neck and detrusor were obviously decreased in rats with unstable bladder. The electroacupuncture treatment could significantly increase the contains of NOS in bladder tissue.


To promote the synthesis and secretion of nitrergic neurotransmitter in bladder tissue may be one of the mechanisms of acupuncture in adjusting bladder function.

Key words: Electroacupuncture, Unstable bladder, Nitrergic neurotransmitter, Animals experimentation

CLC Number: 

  • R245.115

Table 1

Effects of electroacupuncture on numbers of nNOS-, eNOS- and iNOS-positive cells in bladder neck and detrusor of rats(ヌ±S)"

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