益气养阴法防治癌转移的实验研究

doi:10.3736/jcim20040118

Abstract

Objective: To study the effect of Qi-replenishing and Yin-nourishing in inhibiting tumor metastasis. Methods: Fifty mice were randomly divided into replenishing Qi group, replenishing Yin group, replenishing Qi and Yin group, chemotherapy group and control group. Models of Lewis lung cancer and B16 melanoma were observed in vivo. The tumor weight inhibiting rate, metastatic lung tumor, concentrations of t-PA and TXB2 in tumor tissue and IL-2 and TNF-α in spleen were observed. Results: The tumor weight inhibiting rates of replenishing Qi and Yin group for Lewis lung cancer and B16 melanoma were both 42.9％. Replenishing Qi and Yin could decrease the contents of TXB2 and 6-keto-PGF1α, and increase the levels of IL-2 and TNF-α.Conclusion: Replenishing Qi and Yin can promote the healthy energy to inhibiting tumor metastasis.

Key words: replenishing Qi and Yin, carcinoma, neoplasm metastasis, drugs, Chinese herbal, animals, laboratory

CLC Number:

R730.52

Yong-jian Li. Experimental study on Qi-replenishing and Yin-nourishing in inhibiting tumor metastasis. Journal of Chinese Integrative Medicine, 2004, 2(1): 49-52.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20040118

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References 7

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Group	n	Lewis lung cancer		B16 melanoma
Group	n	Tumor weight（g）	Inhibiting rate（％）	Tumor weight（g）	Inhibiting rate（％）
Replenishing Qi	10	1.9±0.6**	45.7	1.6±0.3**	42.9
Replenishing Yin	10	2.7±0.7	22.9	2.4±0.6	14.1
Replenishing Qi and Yin	10	2.0±0.4**	42.9	1.6±0.4**	42.9
Chemotherapy	10	3.4±0.9	2.9	2.4±0.5	14.3
Control	10	3.5±1.0		2.8±0.5

Group	n	Lewis lung cancer		B16 melanoma
Group	n	Tumor weight（g）	Inhibiting rate（％）	Tumor weight（g）	Inhibiting rate（％）
Replenishing Qi	10	9.8±2.2	22.8	19.5±4.1	11.4
Replenishing Yin	10	9.2±2.1	27.6	14.6±5.3**	33.6
Replenishing Qi and Yin	10	8.7±2.7*	31.5	13.9±4.1**	36.8
Chemotherapy	10	10.4±2.6	18.1	22.0±6.8	1.8
Control	10	12.7±3.1		22.4±5.8

Group	n	Lewis lung cancer			B16 melanoma
Group	n	TXB2	t-PA	6-Keto-PGF1α	TXB2	t-PA	6-Keto-PGF1α
Replenishing Qi	10	185.8±14.7	97.75±7.2**	45.9±27.4	92.7±31.2*	23.3±2.1**	63.1±5.2*
Replenishing Yin	10	157.2±45.6*	82.37±18.5*	44.7±24.6	82.7±3.5**	18.8±1.5	53.2±2.9**
Replenishing Qi and Yin	10	131.7±40.1**	104.10±10.3**	39.3±26.7	70.3±36.2**	22.1±2.9**	50.4±19.8**
Chemotherapy	10	195.3±38.9	49.25±9.2	50.4±19.8	114.2±19.6	18.1±1.5	66.3±4.5
Control	10	206.5±27.3	40.2 ±16.1	55.6±22.4	115.1±14.8	15.7±1.4	69.7±5.8

Group	n	Lewis lung cancer		B16 melanoma
Group	n	IL-2	TNF-α	IL-2	TNF-α
Replenishing Qi	10	0.30±0.13*	0.15±0.11*	0.19±0.05	0.13±0.02*
Replenishing Yin	10	0.25±0.08*	0.12±0.06	0.23±0.09*	0.09±0.07*
Replenishing Qi and Yin	10	0.24±0.06*	0.23±0.14*	0.23±0.06*	0.23±0.13**
Chemotherapy	10	0.18±0.08	0.07±0.04	0.16±0.07	0.04±0.01
Control	10	0.18±0.03	0.09±0.05	0.15±0.04	0.03±0.02

Experimental study on Qi-replenishing and Yin-nourishing in inhibiting tumor metastasis

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