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Journal of Chinese Integrative Medicine ›› 2011, Vol. 9 ›› Issue (8): 834-.doi: 10.3736/jcim20110804

• Methodology • Previous Articles     Next Articles

The control principle in scientific research

 Liang-ping Hu(), Xiao-lei  Bao, Qi Wang    

  1. Consulting Center of Biomedical Statistics, Academy of Military Medical Sciences, Beijing 100850, China
  • Received:2011-06-14 Accepted:2011-06-16 Online:2011-08-20 Published:2011-08-15

The control principle is one of the four basic principles of research design. Without a control group, the conclusion of research will be unconvincing; furthermore, if the control group is not set properly, the conclusion will be unreliable. Generally, there is more than one control group in a multi-factor design. Problems like incomplete control and excessive control should be avoided. This article introduces the meaning and function of the control principle, common forms of control, common errors that researchers tend to make as well as analysis and differentiation of these errors.

Key words: tatistics, medical, research design, controlled clinical trial, control groups

[1] 胡良平 . 口腔医学科研设计与统计分析[M]. 北京: 人民军医出版社,2007,(): 79-82
Hu LP. Research design and statistical analysis of stomatology[M]. Beijing: People’s Military Medical Press, 2007: 79-82
[2] Liu GF. Medical statistics(2nd ed)[M]. Beijing: Peking Union Medical College Press, 2007: 167-169
刘桂芬 . 医学统计学(第2版)[M]. 北京: 中国协和医科大学出版社, 2007,( 第2版):167-169
[3] Hu LP. The application of statistical triple-type theory in experimental designs[M]. Beijing: People’s Military Medical Press, 2006: 20-23
胡良平 . 统计学三型理论在实验设计中的应用[M]. 北京: 人民军医出版社, 2006: 20-23
[4] Huang SL, Sun SJ, Guo AX, Xiang Y, Wei AH, Xiao JW, Han FY . Traditional Chinese medicine combined with low-dose chemotherapy in treating chronic idiopathic myelofibrosis: a report of 10 cases[J]. J Chin Integr Med, 2008,6(10):1059-1062
黄世林, 孙淑君, 郭爱霞, 向阳, 魏艾红, 肖景文, 韩福英 . 中药加小剂量化疗治疗慢性原发性骨髓纤维化10例的临床观察[J]. 中西医结合学报, 2008,6(10):1059-1062
[5] Wang YF, Li BH, Zhang M, Xu WB, Zhou R, Zhou M . Stage-based treatment of gouty arthritis by combination therapy of traditional Chinese and Western medicines: a randomized controlled trial[J]. J Chin Integr Med, 2008,6(6):576-580
王一飞, 李伯华, 张明, 徐文彬, 周蓉, 周敏 . 中西医结合分期综合治疗痛风性关节炎的随机对照临床研究[J]. 中西医结合学报, 2008,6(6):576-580
[6] Chen QG, Zeng YS, Tang JY, Qin YJ, Chen SJ, Zhong ZQ . Effects of Rhodiola rosea on body weight and intake of sucrose and water in depressive rats induced by chronic mild stress[J]. J Chin Integr Med, 2008,6(9):952-955
陈巧格, 曾园山, 唐久余, 秦雅静, 陈穗君, 钟志强 . 红景天对慢性应激导致的抑郁大鼠体质量和摄取糖、水量的影响[J]. 中西医结合学报, 2008,6(9):952-955
[7] Pei LP, Hui BL, Dong FH . Influence of canthaxanthin on D-galactose induced osseous changes of rat[J]. Zhongguo Gu Shang, 2008,21(8):613-616
doi: doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz
裴凌鹏, 惠伯棣, 董福慧 . 斑蝥黄质对D-半乳糖老龄大鼠骨质影响[J]. 中国骨伤, 2008,21(8):613-616
doi: doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz
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