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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (9): 897-901.doi: 10.3736/jcim20080904

• Original Clinical Research • Previous Articles     Next Articles

Correlation between syndrome factor combination and cardiac function as well as blood-lipid in coronary heart disease

Jie Wang, Qing-yong He(), Zhan Shi, Yan-wei Xing, Ji Li, Yu-tao Fang, Yan-li Tang   

  1. Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
  • Received:2007-12-08 Online:2008-09-20 Published:2008-09-15

Objective: To discuss the distribution laws of traditional Chinese medicine (TCM) syndrome factor and their combination in coronary heart disease (CHD), and to study the correlation between the TCM syndrome factor combination and cardiac function as well as blood-lipid.
Methods: The parameters of the cardiac function of 300 patients with a final diagnosis of CHD by coronary angiography were measured by echocardiography, and the levels of blood lipids in the CHD patients were detected. An analysis of the correlation was done between the TCM syndrome factor combination and cardiac function as well as blood-lipid in CHD.
Results: The TCM syndrome factor combinations of CHD were blood stasis due to qi deficiency, qi and yin deficiency, intermingled phlegm and blood stasis, and yang deficiency and blood stasis. The ejection fraction of CHD patients with yang deficiency and blood stasis was markedly decreased. The levels of triglyceride and low-density lipoprotein cholesterol in CHD patients with intermingled phlegm and blood stasis were markedly increased, and the level of triglyceride in CHD patients with qi and yin deficiency was markedly increased too.
Conclusion: The treatment of CHD should aim directly at the symptoms and causes. It is also proved that some compound traditional Chinese herbal medicines for supplementing qi and activating blood circulation, nourishing yin and resolving phlegm, and activating yang should be used in treatment of CHD. In cases of CHD with low cardiac function, particular emphasis should be laid on activating yang and blood circulation, while in cases of CHD with blood-lipid disturbance, particular emphasis should be laid on resolving phlegm and activating blood circulation, replenishing qi and nourishing yin.

Key words: coronary heart disease, arteriography, symptom complex

CLC Number: 

  • R541.4

Table 1

Distribution regularity of traditional Chinese medicine syndrome factors and their chief combination in coronary heart disease[Cases (%)]"

Syndrome factor and combination Frequency Syndrome factor and combination Frequency
Qi deficiency 226 (75.33%) Heat-stagnation 1(0.33%)
Blood stasis 175 (58.33%) Water-stagnation 0 (0.00%)
Yin deficiency 136 (45.33%) Syndrome of wind 0 (0.00%)
Turbid phlegm 125 (41.67%) Qi deficiency plus blood stasis 130(43.33%)
Yang deficiency 107 (35.67%) Qi deficiency plus yin deficiency 110 (36.67%)
Qi stagnation 4 (1.33%) Intermingled phlegm plus blood stasis 81 (27.00%)
Cold coagulation 3 (1.00%) Yang deficiency plus blood stasis 63 (21.00%)
Dampness pathogen 1 (0.33%)

Table 2

Parameters of cardiac function tested by echocardiography in coronary heart disease of different syndrome factor combinations (x±s, mm)"

Syndrome factor combination n IVS LVEDD LVESD PR
Blood stasis due to qi deficiency 130 10.75±3.32 47.51±8.85 33.65±8.01 7.74±3.69
Qi and yin deficiency 110 10.72±3.17 47.98±8.09 33.64±8.14 7.47±2.05
Intermingled phlegm and blood stasis 81 10.30±3.08 48.90±7.73 34.70±8.58 7.11±2.38
Yang deficiency and blood stasis 63 10.34±3.73 48.17±8.15 34.50±8.29 6.66±2.60
F value/P value 0.48/0.69 0.47/0.70 0.42/0.74 2.28/0.08

Table 3

NYHA grading and parameters of cardiac function tested by echocardiography in coronary heart disease of different syndrome factor combinations (x±s)"

Syndrome factor combination n OT (mm) LVEF E/A NYHA grade
Blood stasis due to qi deficiency 130 30.08±4.87 57.67±10.90 1.34±0.81 1.91±0.87
Qi and yin deficiency 110 29.93±4.53 57.78±11.32 1.33±0.77 2.38±1.09
Intermingled phlegm and blood stasis 81 30.36±4.55 55.70±10.90 1.20±0.60 2.31±1.03
Yang deficiency and blood stasis 63 28.31±4.85 52.46±9.78** 1.49±0.98 2.63±0.74
F value/P value 2.62/0.051 4.07/0.001 1.66/0.17 1.43/0.24

Table 4

Blood-lipid levels in coronary heart disease of different syndrome factor combinations (x±s, mmol/L)"

Syndrome factor combination n TC TG HDL-C LDL-C
Blood stasis due to qi deficiency 130 1 690.2±360.7 1 430.5±790.7 340.3±70.8 1 120.6±340.3
Qi and yin deficiency 110 1 740.7±390.0 1 670.2±900.9* 330.4±70.4 1 170.0±350.2
Intermingled phlegm and blood stasis 81 1 720.6±350.9 1 810.5±1 120.3* 330.3±60.2 1 260.1±340.6*
Yang deficiency and blood stasis 63 1 740.2±310.1 1 450.1±990.6 340.4±70.8 1 110.3±350.6
F value/P value 0.54/0.66 3.48/0.02 0.57/0.63 3.17/0.02
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