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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (9): 952-955.doi: 10.3736/jcim20080915

• Original Experimental Research • Previous Articles     Next Articles

Effects of Rhodiola rosea on body weight and intake of sucrose and water in depressive rats induced by chronic mild stress

Qiao-ge Chen, Yuan-shan Zeng(), Jiu-yu Tang, Ya-jing Qin, Sui-jun Chen, Zhi-qiang Zhong   

  1. Division of Neuroscience, Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China
  • Received:2008-01-25 Online:2008-09-20 Published:2008-09-15

Objective: To explore the effects of Rhodiola rosea on the body weight and the intake of sucrose and water in depressive rats induced by chronic mild stress.
Methods: A total of 70 male SD rats were divided into seven groups, including normal control group (treated with 0.5% sodium carboxymethycellulose), untreated group, negative control group (treated with 0.5% sodium carboxymethycellulose), positive control group (treated with fluoxetine), low-, medium- and high-dose Rhodiola rosea group (treated with 1.5, 3, 6 g/kg Rhodiola rosea respectively). Except for rats in normal control group, the other sixty rats endured chronic stress for 4 weeks to establish the depression model. After that, rats were administered Rhodiola rosea for 3 weeks. During the whole experiment, the body weight, and sucrose intake, tap water intake of all rats were examined once a week.
Results: After the termination of the stress regime, compared with the normal control group, the body weight and 1% sucrose intake in depressive rats were decreased. After 3-week Rhodiola rosea treatment, the body weight and 1% sucrose intake increased in rats of the low-dose Rhodiola rosea group and recovered to the level of the normal control group.
Conclusion: Low-dose Rhodiola rosea can increase the body weight and sucrose intake of depressive rats, making them recover to normal status.

Key words: chronic mild stress, depression, Rhodiola rosea, body weight, behaviors

CLC Number: 

  • R749

Table 1

Changes of the body weight of rats in seven groups after intragastric administration (x±s, g)"

Group n Body weight
4th week 5th week 6th week 7th week
Normal control 10 313±8.0 326±8.0 345±9.0 358±6.0
Untreated 10 304±13.0* 314±14.0* 333±12.0* 348±12.0*
Negative control 10 301±8.0* 309±8.0* 329±7.0* 349±6.0*
Positive control 10 303±7.0* 320±8.0 342±10.0* 362±10.0
Low-dose Rhodiola rosea 10 303±8.0* 324±7.0 339±7.0* 367±8.0
Medium-dose Rhodiola rosea 10 305±9.0* 325±4.0 349±6.0 364±9.0
High-dose Rhodiola rosea 10 305±7.0* 328±7.0 344±6.0 360±6.0

Table 2

Changes of the sucrose intake of rats in seven groups after intragastric administration (x±s, g)"

Group n Sucrose intake
4th week 5th week 6th week 7th week
Normal control 10 11.8±2.2 12.5±0.9 13.8±1.0 15.5±1.6
Untreated 10 7.4±0.9* 9.1±0.9* 10.8±1.3* 12.1±0.9*
Negative control 10 8.2±1.1* 9.8±1.2* 10.8±1.0* 11.9±0.8*
Positive control 10 7.7±0.8* 11.6±0.9* 13.4±0.7 14.8±1.2
Low-dose Rhodiola rosea 10 7.4±0.7* 9.4±0.6* 12.3±1.0* 15.4±1.1
Medium-dose Rhodiola rosea 10 7.2±0.7* 9.9±1.3* 12.3±1.0* 13.3±1.0*△▲
High-dose Rhodiola rosea 10 7.2±0.8* 8.4±1.3* 9.3±0.6* 12.3±1.1*△▲
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