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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (2): 128-131.doi: 10.3736/jcim20030213

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Inhibition of tumor growth in vitro by the extract of Fagopyrum cymosum

Chan Pui-Kwong   

  1. Department of Pharmacology, Baylor College of Medicine,One Baylor Plaza, Houston, TX, 77030 USADepartment of Pharmacology, Baylor College of Medicine,One Baylor Plaza, Houston, TX, 77030 USA
  • Received:2003-06-27 Online:2003-06-20 Published:2018-10-19


Fagopyrum cymosum (Trev.) Meisn has long been used in China to treat various ailments of the lung, including lung tumors. This study investigated whether Fagopyrum cymosum extract (Fago-c) has effects on other organs.


Human cancer cells derived from 10 different organs were employed, and their growths as affected by Fago-c were investigated.


It was found that the growth of cancer cells from lung, liver, colon, leukocytes and bone is inhibited by Fago-c. However, cancer cells derived from prostate, cervix, ovary and brain are not sensitive to Fago-c, and the extract stimulates the growth of cancer cells from breast (MCF-7). Synergistic inhibition effect of Fago-c and daunomycin was observed in human lung cancer cells (H460). Cellular proteins from H460 cells treated with Fago-c were analyzed by 2D-gel electrophoresis. A protein (M.W./pI =20 K/5.9) was induced. The Fago-c extract was analyzed by High Performance Liquid Chromatography (HPLC). Four major and twenty minor components were identified.


These studies indicate the effect of Fago-c in inhibiting the growth of cell lines derived from certain organs.

Key words: tumor, Fagopyrum cymosum, human organs

CLC Number: 

  • R73-3
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