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Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (2): 99-102.doi: 10.3736/jcim20050205

• Original Clinical Research • Previous Articles     Next Articles

Ginsenosides combined with dexamethasone in preventing and treating postembolization syndrome following transcatheter arterial chemoembolization: A randomized, controlled and double-blinded prospective trial

Ying-lu Feng,Chang-quan Ling,De-zeng Zhu,Chao-qin Yu,Zhe Chen,Bai Li   

  1. Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Received:2005-01-18 Online:2005-03-20 Published:2005-03-20
  • Contact: Chang-quan Ling E-mail:lingchangquan@hotmail.com

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Objective

To observe the effect of ginsenosides (GS) and low dose glucocorticoid in preventing and treating the postembolization syndrome following transcatheter arterial chemoembolization (TACE).

Methods

Eighty patients with primary liver carcinoma were randomly divided into 4 double-blinded groups, with 20 patients in each group. Patients in groups A, B, C, D were treated with placebo, dexamethasone (Dex), GS, Dex and GS, respectively. The changes of clinical symptoms and laboratory tests after TACE were observed.

Results

Dex combined with GS markedly decreased the occurrence ratio and lasting time of the symptoms such as nausea, vomiting, fever and pain, and protected the function of liver as compared with the placebo (P<0.05). Single use of Dex or GS improved some symptoms as compared with the placebo, but it was not as good as the combination of Dex and GS.

Conclusion

ex combined with GS can effectively prevent and treat the postembolization syndrome following TACE.

Key words: Liver cancer, Transcatheter arterial chemoembolization, Dexamethasone, Ginsenosides

CLC Number: 

  • R735.1

Tab 1

General information of patients in each group"

Group n Gender (cases) Age (years) Stage [Cases (%)]
Male Female Stage Ⅱ Stage Ⅲ
Group A 20 15 5 54.4±11.4 14(70.0) 6(30.0)
Group B 20 12 8 50.4±12.7 17(85.0) 3(15.0)
Group C 20 14 6 52.1±11.1 15(75.0) 5(25.0)
Group D 20 14 6 58.3±9.9 14(70.0) 6(30.0)

Tab 2

Degrees of side effects after TACE in each group (Cases)"

Group n Nausea and vomiting degree Fever degree Pain degree
0 I Ⅱ Ⅲ 0 I Ⅱ Ⅲ 0 I Ⅱ Ⅲ
Group A 20 4 10 2 4 6 1 13 0 3 15 1 1
Group B 20 12 4 2 2 15 4 1 0 12 8 0 0
Group C 20 15 4 1 0 6 4 10 0 15 5 0 0
Group D 20 17 3 0 0 17 2 1 0 16 4 0 0

Tab 3

Lasting time of side effects after TACE in each group ($\bar{x}$±s, d)"

*P<0.05, vs group A
Group n Lasting time
Nausea and vomiting Fever Pain
Group A 20 2.61±1.42 4.38±2.31 5.16±2.77
Group B 20 1.78±1.23 1.75±1.16* 1.58±0.99*
Group C 20 1.28±0.94* 3.65±1.93 1.82±1.41*
Group D 20 1.02±0.76* 1.11±0.68* 1.34±0.89*

Tab 4

Stages of Child-Pugh before and after TACE in each group (Cases)"

Group n Stages of Child-Pugh
A B C
Group A
Before TACE 20 16 4 0
After TACE 20 8 9 3
Group B
Before TACE 20 17 3 0
After TACE 20 13 6 1
Group C
Before TACE 20 17 3 0
After TACE 20 12 7 1
Group D
Before TACE 20 15 5 0
After TACE 20 17 3 0
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