隔日禁食结合耐饥食饵对小鼠生理生化指标的影响

doi:10.3736/jcim20060609

Abstract

Objective

To observe the physiological and biochemical effects of intermittent fasting combined with hunger-resistant food on mice, and to evaluate the safety and beneficial effects of this regimen.

Methods

One hundred and forty-four adult ICR mice were divided into 4 groups: standard feed AL group (ad libitum intake of standard feed), hunger-resistant food AL group (ad libitum intake of hunger-resistant food), standard feed IF group (feeding standard feed and fasting on alternate days), and hunger-resistant food IF group (feeding hunger-resistant food and fasting on alternate days). The experiment lasted for 4-8 weeks and all mice drank water freely. The quality of life, body weight, fasting blood glucose, serum lipid, blood routine test, liver and kidney functions as well as the viscera indexes were examined.

Results

Compared to the standard feed AL group, the caloric taking and the increment of body-weight were reduced (P＜0.01), and the viscera indexes of the liver and kidney were elevated (P＜0.05) in the hunger-resistant food AL group and the hunger-resistant food IF group, the values of fasting blood glucose were reduced in standard feed IF group and hunger-resistant food IF group (P＜0.01), the value of triglycerides was reduced in hunger-resistant food IF group (P＜0.05), while the quality of life, blood routine test as well as the liver and kidney functions were not obviously affected in the hunger-resistant food AL group, standard feed IF group and hunger-resistant food IF group.

Conclusion

The regimen of intermittent fasting combined with hunger-resistant food is safe and beneficial to metabolic regulation, such as controlling body-weight and adjusting blood glucose and serum lipid. It is expected that development of this regimen will be helpful to the control of obesity and diabetes, etc.

Key words: Fasting, Body-weight, Blood glucose, Triglycerides, mice

CLC Number:

R363

Xiao-dong Shen, Wei-guo Hua, Wei-zhong Chu, Feng Xu, Yu-ying Wang, Hui-ju Chen. Physiological and biochemical effects of intermittent fasting combined with hunger-resistant food on mice. Journal of Chinese Integrative Medicine, 2006, 4(6): 589-595.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20060609

http://www.jcimjournal.com/EN/Y2006/V4/I6/589

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Figures/Tables 6

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References 9

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Feed	Protein (g/100 g)	Fat (g/100 g)	Caloric (kJ/100 g)	FER (％)
Standard feed	20	4.0	1 473	3.36
Hunger-resistant food	33	18.5	1 870	3.69

Group	n	Food-taking (g/d)	Caloric taking (kJ/d)
Standard feed AL	17	5.94±0.31	87.32±4.59
Hunger-resistant food AL	18	4.23±0.17**^△△	79.35±3.28**
Standard feed IF	24	5.55±0.34**	81.65±4.97**
Hunger-resistant food IF	27	3.63±0.25**^△△▲▲	67.87±4.87**^△△▲▲

Group	n	Body-weight at different time					Body-weight
Group	n	0 week	2 weeks	4 weeks	6 weeks	8 weeks	increment
Standard feed AL	17	31.50±0.96	40.33±2.24	41.44±2.57	41.88±2.75	40.06±2.50	8.56±2.16
Hunger-resistant food AL	18	31.24±1.87	39.54±2.56	40.47±2.54	40.00±2.60	37.64±2.88*	6.41±2.48**^△
Standard feed IF	24	30.67±2.06	34.06±2.47	34.98±3.41	36.34±3.01	38.63±3.29	7.95±2.35
Hunger-resistant food IF	27	31.36±2.25	33.18±2.20	34.76±2.63	35.16±1.42	37.51±2.99**	6.14±1.99**^△△

Group	n	Liver	Kidney	Spleen	Stomach	Testicle	Thyroid gland
Group	n	Liver	Kidney	(×10–1)	Stomach	(×10–1)	(×10–1)
Standard feed AL	17	4.01±0.25	1.88±0.22	2.37±0.32	1.56±0.44	7.14±0.93	5.96±0.60
Hunger-resistant food AL	18	4.57±0.24**^△△	2.01±0.16^△△	2.46±0.46	1.51±0.45	7.16±0.73	6.42±0.68*
Standard feed IF	24	4.14±0.28	1.74±0.19*	2.24±0.39	1.56±0.33	7.00±0.81	6.64±0.70**
Hunger-resistant food IF	27	4.43±0.35**^△△	1.90±0.22^△△	2.47±0.45	1.61±0.33	7.07±0.85	6.80±0.69**

Group	n	Glucose
Standard feed AL	17	8.50±1.47
Hunger-resistant food AL	18	8.20±1.10
Standard feed IF	24	6.00±1.36**^△△
Hunger-resistant food IF	27	6.20±0.84**^△△

Physiological and biochemical effects of intermittent fasting combined with hunger-resistant food on mice

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