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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (8): 788-792.doi: 10.3736/jcim20080804

• Original Clinical Research • Previous Articles     Next Articles

Factor analysis of traditional Chinese medicine syndromes in 815 patients with unstable angina

Jie Wang, Qing-yong He(), Hai-xia Li, Yu-tao Fang   

  1. Department of Cardiology,Guanganmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China
  • Received:2007-12-25 Online:2008-08-20 Published:2008-08-15

Objectiye: To explore the laws of tracitional Chinese medane (TCM) syndromes in unstable angna, and to establish the prelim'nary dagnostic criteria for TCM syndromes .
Methods: Multi-center prospective research on TCM syndromes in 815 cases cf unstable ang'na was done with the nonlinear dmenson reduction by factor analyss .
Results: There were five extracted factors in factor analyss : F1, F2, F3, F4 and F5 . F1 was yin defidency of heart and kichey, F2 was defidency of both heart and spleen , F3 was interm'n^ed phlegm and blood stass, F4 was q Cefidency and blood stass, and F5 was yang Cefidency and coagilated cold . Q Cefidency and blood stass (F4) syndrome accounted for the maximum proportion . The diagnostic criteria for TCM syndromes were prelimnarily and respectively established.
Conclusion: Q defi0-910/ and blood stasis is the key factor of pathogenesis . The factor analysis can help us cassify tracitional Chinese mecione syndromes and establish the preliminary ciagnostic criteria.

Key words: angna, unstable, syncTome complex, factor anayss, reference standards

CLC Number: 

  • R541.42

Table 1

Factor analysis of traditional Chinese medicine syndromes in 815 UA patients"

Common factor 1 Common factor 2 Common factor 3 Common factor 4 Common factor 5
Symptom Weight Symptom Weight Symptom Weight Symptom Weight Symptom Weight
X2 0.689 9 X26 0.545 5 X38 0.610 4 X65 0.344 6 X6 0.444 5
X31 0.672 0 X14 0.496 9 X72 0.724 2 X12 0.334 7 X52 0.496 9
X30 0.632 0 X12 0.429 2 X5 0.594 9 X72 0.319 8 X54 0.387 1
X17 0.530 9 X18 0.480 8 X75 0.597 9 X56 0.276 8 X55 0.301 0
X19 0.534 3 X27 0.496 8 X65 0.463 8 X48 0.280 8 X53 0.317 9
X62 0.508 7 X35 0.455 8 X1 0.493 4 X17 0.254 2 X4 0.295 5
X74 0.528 4 X56 0.430 0 X22 0.359 4 X71 0.249 0 X68 0.259 3
X9 0.493 5 X25 0.447 3 X57 0.350 3 X32 0.224 2 X63 0.209 8
X4 0.420 5 X24 0.445 7 X61 0.326 5 X50 0.224 9 X42 0.212 7
X52 0.421 0 X15 0.363 4 X48 0.393 6 X7 0.215 0 X32 0.202 2
X64 0.448 3 X21 0.390 2 X39 0.313 9 X55 0.217 8 X5 0.164 8
X73 0.394 9 X28 0.383 2 X20 0.299 5 X3 0.233 2 X51 0.187 9
X54 0.394 3 X13 0.403 1 X70 0.297 9 X69 0.201 0 X66 0.172 6
X45 0.362 4 X3 0.391 8 X51 0.292 5 X33 0.198 2 X70 0.156 9
X15 0.363 4 X8 0.367 2 X25 0.263 9 X8 0.184 5 X12 0.129 5

Table 2

Composition ratio of five traditional Chinese medicine syndromes in 815 UA patients"

Factor Syndrome n Constituent ratio (%)
F1 Yin deficiency of heart and kidney 145 17.79
F2 Deficiency of both heart and spleen 37 4.54
F3 Intermingled phlegm and blood stasis 200 24.54
F4 Deficiency of heart qi and blood stasis 270 33.13
F5 Yang deficiency and coagulated cold 163 20.00

Table 3

Correlation among the five factors (syndromes)"

Factor F1 F2 F3 F4 F5
F1 –0.487 51 0.117 61 0.005 93 0.303 67
F2 0.327 37 –0.043 76 0.409 78 0.366 99
F3 –0.210 18 –0.137 64 0.504 76 0.010 01
F4 0.009 07 0.299 39 0.511 87 0.273 00
F5 –0.438 55 –0.255 82 –0.200 62 0.059 28
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