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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (8): 827-829.doi: 10.3736/jcim20080811

• Original Experimental Research • Previous Articles     Next Articles

Effects of Feiji Formula on lung cancer metastasis in mice

Jian-hui Tian1(), Zhi-ming Shi1, Zhi-yi Zhou1, Yun-sheng Huang2, Lin Wang3   

  1. 1. Department of Oncology, Shanghai Municipal Clinical Medicine Center for Chinese Traditional Oncology, Longhua Hospi¬tal, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China;
    2. Department of Internal Medicine, Central Hospital of Nanhui District, Shanghai 201300, China
    3. Department of Internal Medicine,Longhua hospital, Shanghai University of Traditional Chinese Medicine,Shanghai 200032, China
  • Received:2007-11-13 Online:2008-08-20 Published:2008-08-15

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Objective: To observe the effects of Feiji Formula, a compound traditional Chinese herbal medicine, on lung cancer metastasis in mice.
Methods: The lung cancer metastasis model of mice was established in this experiment study. Twenty-four mice were randomly divided into three groups: untreated group, cisplatin group and Feiji Formula group. Mice in the Feiji Formula group were treated with Feiji Formula decoction; in cisplatin group, with cisplatin by intraperitoneal injection; and in the untreated group, with normal saline (NS). After twenty-day treatment, the body and tumor weights as well as the number of metastatic tumors in both lungs of each mouse were measured.
Results: The body weight of mice in cisplatin group was significantly less than that of Feiji Formula group and untreated group (P<0.01); the tumor weight of mice in cisplatin group and Feiji Formula group was markedly lower than that of untreated group (P<0.01); and the number of metastatic tumors in cisplatin group and Feiji Formula group was markedly lower than that of the untreated group (P<0.01), no significant difference between the Feiji Formula group and cisplatin group in terms of the weights and the numbers of metastatic tumors in bilateral lungs.
Conclusion: Feiji Formula can suppress tumor growth and decrease the number of lung metastatic tnmors in the mice, and maintain the body weight of the mice.

Key words: lung cancer, metastasis, traditional Chinese medicine, Feiji Formula, mice

CLC Number: 

  • R730.52

Table 1

Weights of body, solid tumor and lung and number of lung metastatic tumors in three groups（x±s）"

Group n Body weight (g) Solid tumor weight (g) Lung weight (mg) Number of lung metastatic tumors
Untreated 8 22.92±1.22 3.54±1.21 170±2 28.37±10.87
Cisplatin 8 18.92±2.67** 1.94±1.71** 150±2 12.63±6.58**
Feiji Formula 8 23.65±1.65△△ 2.11±0.99** 150±3 19.13±8.47**

Figure 1

Solid tumor size after Feiji Formula treatment A: Cisplatin group; B: Untreaed group; C: Feiji Formula group."

Figure 2

Metastatic tumor located at periphery part of the lung"

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