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Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (5): 340-342.doi: 10.3736/jcim20040509

• Original Clinical Research • Previous Articles     Next Articles

Observation on intestinal flora in patients of irritable bowel syndrome after treatment of Chinese integrative medicine

Xu Sun1(), Gan Cai2, Wen-jian Wang3   

  1. 1. Department of Gastroenterology,Huashan Hospital, Fudan University, Shanghai 200040, China
    2. Department of Internal Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China
    3. Department of Traditional Chinese Medicine,Huashan Hospital, Fudan University, Shanghai 200040, China
  • Received:2003-05-19 Online:2004-09-20 Published:2018-10-20

Objective: To observe the clinical efficacy of the combination of traditional Chinese medicine and western medicine in treating irritable bowel syndrome (IBS) and the result of intestinal flora regulation.Methods: Sixty IBS patients, 36 males and 24 females, were divided into two groups, with 30 patients in each group. Herbal formula of TongxieYaofang and clostridium butyricum (Cb) were used in the first group for four weeks, while only Cb was used for four weeks in the second group. We observed the changes of coliform group, enterococcus, lactobacillus, bifidobacterium after treatment.Results: The effective rate of the Tongxie Yaofang and Cb treated group was significantly higher than that of the Cb treated group (P<0.05). The numbers of bifidobacterium and lactobacillus increased, while the numbers of coliform group and enterococcus decreased after the treatment, and the changes of intestinal flora in the integrative medicine treated group were significantly greater than those in the Cb treated group.Conclusion: After treatment with the combination of traditional Chinese medicine and western medicine, the intestinal flora can be regulated to equilibrium state.

Key words: irritable bowel syndrome, intestinal flora, Tongxie Yaofang Recipe, combination of TCM and western medicine treatment

CLC Number: 

  • R541.77

Tab 1

Flora in feces before and after treatment ($\bar{x}$±s, log10n/g)"

Group n Coli-group Enterococci Lactobacilli Bifidobacteria
TongxieYaofang and clostridium butyricum group
Before treatment 30 9.13±0.38 4.91±0.29 6.47±0.78 4.35±0.89
After treatment 30 8.23±0.47** 3.76±0.34** 8.86±0.36** 9.03±0.61**
Clostridium butyricum group
Before treatment 30 9.09±0.49 5.11±0.21 6.58±0.57 4.81±0.67
After treatment 30 8.63±0.34* 4.72±0.14* 7.66±0.42* 7.18±0.35*
[1] Drossman DA, Whitehead WE, Camilleri M . Irritable bowel syndrome: a technical review for practice guideline development[J]. Gastroenterology, 1997,112(6):2120-2137
doi: 10.1053/gast.1997.v112.agast972120 pmid: 9178709
[2] 袁耀宗 . 肠易激综合征(第2版)[M]. 上海: 上海科学技术文献出版社, 2002,( 第2版):67-69
[3] 张达荣, 董晓旭, 包幼甫 . 肠易激综合征患者服用酪酸菌制剂前后肠道菌群状况[J]. 中国微生态学杂志, 1999,11(3):164-166
doi: 10.3969/j.issn.1005-376X.1999.03.015
[4] 李菊莲 . 综合治疗肠易激综合征50例[J]. 甘肃中医学院学报, 2001,18(1):33-34
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