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Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (1): 19-22.doi: 10.3736/jcim20050107

• Original Clinical Research • Previous Articles     Next Articles

Relationship between hepatitis B virus in gastric mucosa and syndrome of disharmony between liver and stomach in patients with chronic hepatitis B

Jin-yu Xia1,Yao-yong Zhou2,You-yun Zhao3   

  1. 1. Department of Infectious Diseases, The fifth affiliated Hospital, SUN Yat-sen University, Zhuhai, Guangdong Province 519000, China
    2. Department of Integrated Traditional Chinese and Western Medicine, Tianjin Municipal Hospital of Infectious Diseases, Tianjin 300192, China
    3. Division of Molecular Biology, Department of Clinical Laboratories, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei Province 430061, China
  • Received:2004-09-23 Online:2005-01-20 Published:2005-01-20
  • Contact: Jin-yu Xia E-mail:xiajinyu@hotmail.com

Objective

To study the relationship between the infection of hepatitis B virus (HBV) in gastric mucosa and the syndrome of disharmony between liver and stomach.

Methods

Subjects were divided into 2 groups: 30 patients with chronic hepatitis B (CHB) and the syndrome of disharmony between liver and stomach in hepatitis group, and 30 patients with chronic gastritis and the syndrome of disharmony between liver and stomach in gastritis group. Liver function and the markers of HBV were detected. The contents of HBV-DNA in serum and in gastric mucosa were assayed respectively by fluorescence quantitative polymerase chain reaction (FQ-PCR).

Results

(1) The incidence of gastric mucosal lesion in hepatitis group was up to 96.7% (29/30). (2) Scores of the syndrome of disharmony between liver and stomach in hepatitis group were significantly lower than those in gastritis group (P<0.05). The positive rates of HBV-DNA in serum, gastric fundus, body and antrum were 56.7%, 76.7%, 76.7% and 70.0%, respectively. (3) A positive correlation was found not only among the content of HBV-DNA in serum and the contents of HBV-DNA in gastric mucosa (r=0.66-0.94, P< 0.01), but also among the contents of HBV-DNA in serum, gastric mucosa and the total score of the syndrome of disharmony between liver and stomach in hepatitis group (r=0.36-0.52, P<0.05).

Conclusion

The infection of HBV is involved in the syndrome of disharmony between liver and stomach. Gastric mucosal lesion is universal in CHB patients with the syndrome of disharmony between liver and stomach.

Key words: Chronic hepatitis B, Chronic gastritis, Syndrome of disharmony between liver and stomach, Hepatitis B virus

CLC Number: 

  • R512.62

Tab 1

Contents of HBV-DNA in serum and gastric mucosa in hepatitis B patients with different liver function ($\bar{x}$±s, lg copies/g)"

Liver function n Content of HBV-DNA
Serum Gastric antrum Gastric body Gastric fundus
Mildly abnormal 21 3.06±1.82 4.16±1.45 4.01±1.50 4.44±1.76
Moderately abnormal 9 4.61±2.07 4.91±1.63* 4.92±1.66 5.13±1.84*

Tab 2

Scores of syndrome of disharmony between liver and stomach in hepatitis B patients with different liver function ($\bar{x}$±s)"

Liver function n Score
Distention or movable pain in hypochondrium
and stomach
Eructation
or hiccup
Gastric upset
and acid
regurgitation
Irritability Taut pulse Total
Mildly abnormal 21 1.67±0.73 1.05±1.12 1.24±1.18 1.81±1.29 2.14±0.91 7.90±2.23
Moderately abnormal 9 1.22±0.44 1.78±1.48 1.11±1.05 1.67±1.22 2.33±1.00 8.11±2.20

Tab 3

Scores of syndrome of disharmony between liver and stomach in gastritis group and hepatitis group ($\bar{x}$±s)"

Group n Score
Distention or movable
pain in hypochondrium
and stomach
Eructation
or hiccup
Gastric upset
and acid
regurgitation
Irritability Taut pulse Total
Gastritis 30 2.20±1.00 2.60±1.25 1.67±1.18 1.63±1.35 2.37±0.89 10.47±3.15
Hepatitis 30 1.53±0.68** 1.27±1.26** 1.20±1.13 1.77±1.25 2.20±0.93 7.97±2.19**
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