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Journal of Chinese Integrative Medicine ›› 2007, Vol. 5 ›› Issue (5): 514-516.doi: 10.3736/jcim20070507

Special Issue: Traditional Chinese Medicine

• Original Clinical Research • Previous Articles     Next Articles

Serum proteomics study of chronic gastritis with dampness syndrome in traditional Chinese medicine

Yi-qin Wang1, Fu-feng Li1,Wen-jing Wang2, Li-yu Zhao1, Li Guo1, Hui-fang Wang1   

  1. 1. Laboratory of Syndromes of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China
    2. Department of Molecular Biology for Public Health,Shanghai Municipal Center for Disease Control and Prevention ,Shang hai 200336,China
  • Online:2007-09-20 Published:2007-09-15

Objective: To explore microcosmic information in chronic gastritis dampness syndrome by using serum proteomics of patients with chronic gastritis dampness syndrome.Methods: Serum proteomics of 18 dampness syndrome cases, 17 non-dampness syndrome cases in chronic gastritis patients and 8 normal controls were analyzed by surface enhanced laser desorption/ionization-time of flight (SELDI-TOF) protein-chip. Results: There was a high expression trend in three ratios of charge (of an electron) to mass (M/S) of 3.2 kD, 6.4 kD and 8.1 kD of protein expression spectrum from patients with chronic gastritis dampness syndrome, and the wave peak value was over 10 units. There was a low expression trend in above-mentioned sites of protein expression spectrum from patients with chronic gastritis non-dampness syndrome and normal group. The wave peak value of patients with chronic gastritis non-dampness syndrome was about or below 10 units, and the wave peak value in normal group was below 5 units. Conclusion: There exists a certain significance to explore biologic theory basis of chronic gastritis dampness syndrome by analyzing the serum proteomics.

Key words: chronic gastritis, dampness syndrome, serum, proteomics

CLC Number: 

  • R573.3

Table 1

Screening test"

Screening test Patients with chronic gastritis Normal people
Positive(+) A B
Negative(–) C D

Figure 1

Protein expression spectrumA: Patients with chronic gastritis dampness syndrome; B: Patients with chronic gastritis non-dampness syndrome; C: Normal people."

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