健脾益肾方对小鼠移植性前胃癌术后复发转移及生存期的影响

doi:10.3736/jcim20060511

Abstract

Objective

To observe the effects of Jianpi Yishen Recipe (JPYSR), a compound Chinese herbal medicine, on recurrence, metastasis and life span of mice transplanted with proventriculus squamous carcinoma cells after tumorectomy.

Methods

JPYSR was orally administered to 615 mice transplanted with proventriculus squamous carcinoma cells in the palma of left hind limb after tumorectomy. The local tumor recurrence, lung metastasis and life span of the mice were evaluated and compared with those of the 5-FU-treated mice and untreated mice.

Results

The pulmonary metastasis rate was 94.4 % and the recurrence rate was 94.44 % in untreated group. The pulmonary metastasis rate was 68.4%, the inhibition rate of pulmonary metastasis was 27.5%, the recurrence rate was 78.95%, and the inhibition rate of tumor recurrence was 65.35% in JPYSR-treated group. The average and median life spans were obviously prolonged in JPYSR-treated group, as compared with those in untreated group. The life-prolonging rate was 100%.

Conclusion

JPYSR can effectively inhibit the local recurrence and pulmonary metastasis of the transplanted proventriculus squamous carcinoma in mice after tumorectomy, and prolong the life span.

Key words: Stomach cancer, Neoplasm recurrence, Metastasis, Life span, Jianpi Yishen Recipe

CLC Number:

R285.5

WJie Wu, Yu-qin Liu, Ji-hong Dong, Xiao-po Tang, Jie Li, Gui-zhi Sun. Effects of Jianpi Yishen Recipe on recurrence, metastasis and life span of mice transplanted with proventriculus squamous carcinoma after tumorectomy. Journal of Chinese Integrative Medicine, 2006, 4(5): 495-499.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20060511

http://www.jcimjournal.com/EN/Y2006/V4/I5/495

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References 3

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[2]	刘玉琴, 赵雪梅, 顾蓓 , 等. 金龙胶囊和蛇毒对小鼠子宫颈癌(U14)抗复发和转移的观察[J]. 中国肿瘤临床与康复, 2000,7(5):4-7 doi: 10.3969/j.issn.1005-8664.2000.05.002
[3]	徐叔云, 卞如濂, 陈修 . 药理实验方法学(第1版)[M]. 北京: 人民卫生出版社, 2002,( 第1版):1757-1784

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Group	n	Body weight	Weight of primary tumor
Untreated	20	21.90±1.94	0.32±0.07
5-FU-treated	20	21.94±2.09	0.31±0.06
JPYSR-treated	20	22.00±1.71	0.32±0.06

Group	n	Number of mice in different grades of pulmonary metastasis				Mean Rank	Metastasis rate (%)	Inhibition rate of metastasis (%)
Group	n	0	Ⅰ	Ⅱ	Ⅲ	Mean Rank	Metastasis rate (%)	Inhibition rate of metastasis (%)
Untreated	18	1	3	5	9	37.33	94.4
5-FU-treated	19	5	5	5	4	25.84*	73.7	21.9
JPYSG-treated	19	6	5	6	2	22.79*	68.4	27.5

Group	n	Body weight (?x±s , g)	Weight of recurrent tumor (?x±s , g)	Recurrence rate (%)	Inhibition rate of recurrence (%)
Untreated	18	20.30±2.18	1.01±0.93	94.44
5-FU-treated	19	21.30±2.05	0.26±0.52**	68.42	74.26
JPYSG-treated	19	22.07±1.87*	0.35±0.35**	78.95	65.35

Group	n	Survival time (d)		Mean survival time	Median survival period	Life-prolonging rate (%)
Group	n	Shortest	Longest	Mean survival time	Median survival period	Life-prolonging rate (%)
Untreated	15	8	33	17	17
5-FU-treated	15	9	60	28	25	64.71
JPYSG-treated	15	12	60	34	29	100.00

Effects of Jianpi Yishen Recipe on recurrence, metastasis and life span of mice transplanted with proventriculus squamous carcinoma after tumorectomy

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