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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (5): 533-538.doi: 10.3736/jcim20080520

• Literature Review • Previous Articles     Next Articles

Kidney injury molecule-1 in acute kidney injury and renal repair: a review

Chimura Takaharu1, Shan Mou2()   

  1. 1. Renal Division, Havard Medical School, Brigham and Womens Hospital, Boston, MA 02115, USA
    2. Department of Nephrology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Received:2008-03-14 Online:2008-05-20 Published:2008-05-15
  • Contact: MOU Shan E-mail:shan_mou@hotmail.com

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Key words: kidney injury molecule-1, renal insufficiency, acute, recovery of function

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  • R692

Figure 1

Kidney injury molecule-1 Top: Structure of KIM-1 protein [4]. The ectodomain contains two domains, an Ig domain and mucin domain. The mucin domain is highly glycosylated with o-linked sugar chains [4]. Bottom left: Shedding of KIM-1 ectodomain. KIM-1 ectodomain is cleaved and shed in a metalloproteinase-dependent fashion [5]. Remnant peptide can be detected as a product of shedding [5]. Bottom right: Double-immunofluorescence staining of rat KIM-1 and vimentin. Contralateral and 48-hour postischemic rat kidney frozen sections were analyzed with R9 anti-rat KIM-1 polyclonal antibody. Note the apical KIM-1 staining with basolateral vimentin staining in the proximal tubules of the injured kidney (unpublished data)."

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System Reference
Human disease
Acute tubular necrosis Han [8]
Renal cell carcinoma Han [26]
Nephrotoxicant model
Transcription factor EC (rat) Ichimura [9]
Folic acid (rat) Ichimura [9]
Cisplatin (rat) Vaidya [7], Ichimura [9] and Amin [27]
Gentamycin (rat) Amin [27]
Disease model
Ischemia (rat, mouse) chimura [4], Vaidya [7], Park [28], Yoshida [29], Zahedi [30], Kieran [31]
5/6 nephrectomy (rat) Horiba [32]
Unilateral obstruction (mouse) Unpublished
Allograft transplantation (rat) Unpublished
Polycystic kidney disease 2 knockout mouse Kuehn [33]
Proteinuria (rat) Unpublished
Hypertension (rat) Unpublished
Brain dead rat Schuurs [34]
Estrogen-treated mouse Jelinsky [35]
Cell line
769P (human) Bailly [5], Kaplan [10]
Human kallikrein 2 (human) Bailly [5]
African green monkey kidney (monkey) Kaplan [10]
[1] Thadhani R, Pascual M, Bonventre JV . Acute renal failure[J]. N Engl J Med, 1996,334(22):1448-1460
doi: 10.1056/NEJM199605303342207
[2] Bonventre JV, Weinberg JM . Recent advances in the pathophysiology of ischemic acute renal failure[J]. J Am Soc Nephrol, 2003,14(8):2199-2210
doi: 10.1097/01.ASN.0000079785.13922.F6 pmid: 12874476
[3] Hubank M, Schatz DG . Identifying differences in mRNA expression by representational difference analysis of cDNA[J]. Nucleic Acids Res, 1994,22(25):5640-5648
doi: 10.1093/nar/22.25.5640
[4] Ichimura T, Bonventre JV, Bailly V , et al. Kidney injury molecule-1(KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury[J]. J Biol Chem, 1998,273(7):4135-4142
doi: 10.1074/jbc.273.7.4135
[5] Bailly V, Zhang Z, Meier W , et al. Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration[J]. J Biol Chem, 2002,277(42):39739-39748
doi: 10.1074/jbc.M200562200 pmid: 12138159
[6] Briskin MJ , McEvoy LM, Butcher EC.MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1[J]. Nature, 1993,363(6428):461-464
doi: 10.1038/363461a0
[7] Vaidya VS, Ramirez V, Ichimura T , et al. Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury. Am J Physiol Renal Physiol[J]. Am J Physiol Renal Physiol, 2006,290(2):517-529
[8] Han WK, Bailly V, Abichandani R , et al. Kidney injury molecule-1(KIM-1): a novel biomarker for human renal proximal tubule injury[J]. Kidney Int, 2002,62(1):237-244
doi: 10.1046/j.1523-1755.2002.00433.x pmid: 12081583
[9] Ichimura T, Hung CC, Yang SA , et al. Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury[J]. Am J Physiol Renal Physiol, 2004,286(3):552-563
doi: 10.1152/ajprenal.00285.2002 pmid: 14600030
[10] Kaplan G, Totsuka A, Thompson P , et al. Identification of a surface glycoprotein on African green monkey kidney cells as a receptor for hepatitis A virus[J]. EMBO J, 1996,15(16):4282-4296
doi: 10.1002/embj.1996.15.issue-16
[11] McIntire JJ, Umetsu SE, Akbari O , et al. Identification of Tapr(an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol J., 2001,2(12):1109-1116
doi: 10.1038/ni739
[12] Monney L, Sabatos CA, Gaglia JL , et al. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease[J]. Nature, 2002,415(6871):536-541
doi: 10.1038/415536a
[13] Kumanogoh A, Marukawa S, Suzuki K , et al. Class Ⅳ semaphorin Sema4A enhances T-cell activation and interacts with Tim-2[J]. Nature, 2002,419(6907):629-633
doi: 10.1038/nature01037 pmid: 12374982
[14] Sabatos CA, Chakravarti S, Cha E , et al. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance[J]. Nat Immunol, 2003,4(11):1102-1110
doi: 10.1038/ni988
[15] Sánchez-Fueyo A, Tian J, Picarella D , et al. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance[J]. Nat Immunol, 2003,4(11):1093-1101
doi: 10.1038/ni987
[16] Kumanogoh A, Kikutani H . Immune semaphorins: a new area of semaphorin research[J]. J Cell Sci, 2003,116(Pt 17):3463-3470
doi: 10.1242/jcs.00674 pmid: 12893810
[17] Kikutani H, Kumanogoh A . Semaphorins in interactions between T cells and antigen-presenting cells[J]. Nat Rev Immunol, 2003,3(2):159-167
doi: 10.1038/nri1003 pmid: 12563299
[18] Chakravarti S, Sabatos CA, Xiao S , et al. Tim-2 regulates T helper type 2 responses and autoimmunity[J]. J Exp Med, 2005,202(3):437-444
doi: 10.1084/jem.20050308 pmid: 22130761
[19] Meyers JH, Sabatos CA, Chakravarti S , et al. The TIM gene family regulates autoimmune and allergic diseases[J]. Trends Mol Med, 2005,11(8):362-369
doi: 10.1016/j.molmed.2005.06.008 pmid: 16002337
[20] Meyers JH, Chakravarti S, Schlesinger D , et al. TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation is the ligand for[J]. Nat Immunol, 2005,6(5):455-464
doi: 10.1038/ni1185
[21] Khademi M, Illés Z, Gielen AW , et al. T cell Ig- and mucin-domain-containing molecule-3(TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis[J]. J Immunol, 2004,172(11):7169-7176
doi: 10.4049/jimmunol.172.11.7169
[22] Umetsu SE, Lee WL , McIntire JJ, et al.TIM-1 induces T cell activation and inhibits the development of peripheral tolerance[J]. Nat Immunol, 2005,6(5):447-454
doi: 10.1038/ni1186 pmid: 15793575
[23] Umetsu DT , Dekruyff RH.Regulation of tolerance in the respiratory tract: TIM-1, hygiene, the environment[J].Ann N Y Acad Sci, 2004, 1029: 88-93
doi: 10.1196/annals.1309.012 pmid: 15681748
[24] Umetsu DT, McIntire JJ, DeKruyff RH.TIM-1, hepatitis A virus and the hygiene theory of atopy: association of TIM-1 with atopy[J].J Pediatr Gastroenterol Nutr, 2005, 40 Suppl 1: S43
doi: 10.1097/00005176-200504001-00026 pmid: 15805850
[25] Kuchroo VK, Umetsu DT , DeKruyff RH, et al.The TIM gene family: emerging roles in immunity and disease[J]. Nat Rev Immunol, 2003,3(6):454-462
doi: 10.1038/nri1111 pmid: 12776205
[26] Han WK, Alinani A, Wu CL , et al. Human kidney injury molecule-1 is a tissue and urinary tumor marker of renal cell carcinoma[J]. J Am Soc Nephrol, 2005,16(4):1126-1134
doi: 10.1681/ASN.2004070530 pmid: 15744000
[27] Amin RP, Vickers AE, Sistare F , et al. Identification of putative gene based markers of renal toxicity[J]. Environ Health Perspect, 2004,112(4):465-479
doi: 10.1289/txg.6683 pmid: 15033597
[28] Park KM, Byun JY, Kramers C , et al. Inducible nitric-oxide synthase is an important contributor to prolonged protective effects of ischemic preconditioning in the mouse kidney[J]. J Biol Chem, 2003,278(29):27256-27266
doi: 10.1074/jbc.M301778200
[29] Yoshida T, Kurella M, Beato F , et al. Monitoring changes in gene expression in renal ischemia-reperfusion in the rat[J]. Kidney Int, 2002,61(5):1646-1654
doi: 10.1046/j.1523-1755.2002.00341.x pmid: 11967014
[30] Zahedi K, Wang Z, Barone S , et al. Expression of SSAT, a novel biomarker of tubular cell damage, increases in kidney ischemia-reperfusion injury[J]. Am J Physiol Renal Physiol, 2003,284(5):F1046-1055
doi: 10.1152/ajprenal.00318.2002
[31] Kieran NE, Doran PP, Connolly SB , et al. Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog[J]. Kidney Int, 2003,64(2):480-492
doi: 10.1046/j.1523-1755.2003.00106.x
[32] Horiba N, Masuda S, Takeuchi A , et al. Gene expression variance based on random sequencing in rat remnant kidney[J]. Kidney Int, 2004,66(1):29-45
doi: 10.1111/j.1523-1755.2004.00704.x pmid: 15200410
[33] Kuehn EW, Park KM, Somlo S , et al. Kidney injury molecule-1 expression in murine polycystic kidney disease[J]. Am J Physiol Renal Physiol, 2002,283(6):F1326-1336
doi: 10.1152/ajprenal.00166.2002 pmid: 12388382
[34] Schuurs TA , Gerbens F, van der Hoeven JA, et al.Distinct transcriptional changes in donor kidneys upon brain death induction in rats: insights in the processes of brain death[J]. Am J Transplant, 2004,4(12):1972-1981
doi: 10.1111/ajt.2004.4.issue-12
[35] Jelinsky SA, Harris HA, Brown EL , et al. Global transcription profiling of estrogen activity: estrogen receptor alpha regulates gene expression in the kidney[J]. Endocrinology, 2003,144(2):701-710
doi: 10.1210/en.2002-220728
[36] Bonventre JV .Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure[J].J Am Soc Nephrol, 2003, 14 Suppl 1(): S55-61
doi: 10.1097/01.ASN.0000067652.51441.21 pmid: 12761240
[37] Wallin A, Zhang G, Jones TW , et al. Mechanism of the nephrogenic repair response. Studies on proliferation and vimentin expression after 35S-1, 2-dichlorovinyl-L-cysteine nephrotoxicity in vivo and in cultured proximal tubule epithelial cells37Wallin A, Zhang G, Jones TW, et al. Mechanism of the nephrogenic repair response. Studies on proliferation and vimentin expression after 35S-1, 2-dichlorovinyl-L-cysteine[J]. Lab Invest, 1992,66(4):474-484
[38] Ichimura T, Maier JA, Maciag T , et al. FGF-1 in normal and regenerating kidney: expression in mononuclear, interstitial, and regenerating epithelial cells[J]. Am J Physiol, 1995,269(5 Pt 2):F653-662
[39] Shimizu A, Kitamura H, Masuda Y , et al. Apoptosis in the repair process of experimental proliferative glomerulonephritis[J]. Kidney Int, 1995,47(1):114-121
doi: 10.1038/ki.1995.13
[40] Lauber K, Blumenthal SG, Waibel M , et al. Clearance of apoptotic cells: getting rid of the corpses[J]. Mol Cell, 2004,14(3):277-287
doi: 10.1016/S1097-2765(04)00237-0
[41] Greaves DR, Gordon S . Thematic review series: the immune system and atherogenesis. Recent insights into the biology of macrophage scavenger receptors[J]. J Lipid Res, 2005,46(1):11-20
doi: 10.1194/jlr.R400011-JLR200
[42] Gordon S . Pattern recognition receptors: doubling up for the innate immune response[J]. Cell, 2002,111(7):927-930
doi: 10.1016/S0092-8674(02)01201-1
[43] Peiser L, Mukhopadhyay S, Gordon S . Scavenger receptors in innate immunity[J]. Curr Opin Immunol, 2002,14(1):123-128
doi: 10.1016/S0952-7915(01)00307-7 pmid: 11790542
[44] Savill J, Gregory C, Haslett C . Cell biology: Eat me or die[J]. Science, 2003,302(5650):1516-1517
doi: 10.1126/science.1092533 pmid: 14645835
[45] Savill J, Fadok V . Corpse clearance defines the meaning of cell death[J]. Nature, 2000,407(6805):784-788
doi: 10.1038/35037722 pmid: 11048729
[46] Duffield JS . The inflammatory macrophage: a story of Jekyll and Hyde[J]. Clin Sci (Lond)., 2003,104(1):27-38
doi: 10.1042/ pmid: 12519085
[47] Potter PK, Cortes-Hernandez J, Quartier P , et al. Lupus-prone mice have an abnormal response to thioglycolate and an impaired clearance of apoptotic cells[J]. J Immunol, 2003,170(6):3223-3232
doi: 10.4049/jimmunol.170.6.3223
[48] Duffield JS, Forbes SJ, Constandinou CM , et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair[J]. J Clin Invest, 2005,115(1):56-65
doi: 10.1172/JCI200522675
[49] Golpon HA, Fadok VA, Taraseviciene-Stewart L , et al. Life after corpse engulfment: phagocytosis of apoptotic cells leads to VEGF secretion and cell growth[J]. FASEB J, 2004,18(14):1716-1718
doi: 10.1096/fj.04-1853fje
[50] Monks J, Rosner D, Geske FJ , et al. Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release[J]. Cell Death Differ, 2005,12(2):107-114
doi: 10.1038/sj.cdd.4401517
[51] Morimoto K, Amano H, Sonoda F , et al. Alveolar macrophages that phagocytose apoptotic neutrophils produce hepatocyte growth factor during bacterial pneumonia in mice[J]. Am J Respir Cell Mol Biol, 2001,24(5):608-615
doi: 10.1165/ajrcmb.24.5.4292
[52] Burne-Taney MJ, Yokota N, Rabb H . Persistent renal and extrarenal immune changes after severe ischemic injury[J]. Kidney Int, 2005,67(3):1002-1009
doi: 10.1111/j.1523-1755.2005.00163.x
[53] Bonventre JV . The kidney proteome: a hint of things to come[J]. Kidney Int, 2002,62(4):1470-1471
doi: 10.1111/j.1523-1755.2002.kid592.x pmid: 12234321
[54] Park KM, Byun JY, Kramers C , et al. Inducible nitric-oxide synthase is an important contributor to prolonged protective effects of ischemic preconditioning in the mouse kidney[J]. J Biol Chem, 2003,278(29):27256-27266
doi: 10.1074/jbc.M301778200
[55] Park KM, Chen A, Bonventre JV . Prevention of kidney ischemia/reperfusion-induced functional injury and JNK, p38, and MAPK kinase activation by remote ischemic pretreatment[J]. J Biol Chem, 2001,276(15):11870-11876
doi: 10.1074/jbc.M007518200
[56] Park KM, Kramers C, Vayssier-Taussat M , et al. Prevention of kidney ischemia/reperfusion-induced functional injury, MAPK and MAPK kinase activation, and inflammation by remote transient ureteral obstruction[J]. J Biol Chem, 2002,277(3):2040-2049
doi: 10.1074/jbc.M107525200
[57] Ichimura T, Asseldonk EJ, Humphreys BD , et al. Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells[J]. J Clin Invest, 2008,118(5):1657-1668
doi: 10.1172/JCI34487
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