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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (5): 533-538.doi: 10.3736/jcim20080520

• Literature Review • Previous Articles     Next Articles

Kidney injury molecule-1 in acute kidney injury and renal repair: a review

Chimura Takaharu1, Shan Mou2()   

  1. 1. Renal Division, Havard Medical School, Brigham and Womens Hospital, Boston, MA 02115, USA
    2. Department of Nephrology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Received:2008-03-14 Online:2008-05-20 Published:2008-05-15
  • Contact: MOU Shan

Key words: kidney injury molecule-1, renal insufficiency, acute, recovery of function

CLC Number: 

  • R692

Figure 1

Kidney injury molecule-1 Top: Structure of KIM-1 protein [4]. The ectodomain contains two domains, an Ig domain and mucin domain. The mucin domain is highly glycosylated with o-linked sugar chains [4]. Bottom left: Shedding of KIM-1 ectodomain. KIM-1 ectodomain is cleaved and shed in a metalloproteinase-dependent fashion [5]. Remnant peptide can be detected as a product of shedding [5]. Bottom right: Double-immunofluorescence staining of rat KIM-1 and vimentin. Contralateral and 48-hour postischemic rat kidney frozen sections were analyzed with R9 anti-rat KIM-1 polyclonal antibody. Note the apical KIM-1 staining with basolateral vimentin staining in the proximal tubules of the injured kidney (unpublished data)."


System Reference
Human disease
Acute tubular necrosis Han [8]
Renal cell carcinoma Han [26]
Nephrotoxicant model
Transcription factor EC (rat) Ichimura [9]
Folic acid (rat) Ichimura [9]
Cisplatin (rat) Vaidya [7], Ichimura [9] and Amin [27]
Gentamycin (rat) Amin [27]
Disease model
Ischemia (rat, mouse) chimura [4], Vaidya [7], Park [28], Yoshida [29], Zahedi [30], Kieran [31]
5/6 nephrectomy (rat) Horiba [32]
Unilateral obstruction (mouse) Unpublished
Allograft transplantation (rat) Unpublished
Polycystic kidney disease 2 knockout mouse Kuehn [33]
Proteinuria (rat) Unpublished
Hypertension (rat) Unpublished
Brain dead rat Schuurs [34]
Estrogen-treated mouse Jelinsky [35]
Cell line
769P (human) Bailly [5], Kaplan [10]
Human kallikrein 2 (human) Bailly [5]
African green monkey kidney (monkey) Kaplan [10]
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