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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (9): 902-906.doi: 10.3736/jcim20080905

• Original Clinical Research • Previous Articles     Next Articles

Efficacy evaluation of Shengmai Injection in treating coronary heart disease based on random walk model

Zhu-ye Gao1, Hao Xu2(), Ke-ji Chen1,2, Da-zhuo Shi1, Li-zhi Li1, Xue-zhong Zhou3   

  1. 1. Department of Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
    2. National Integrated Center of Cardiovascular Disease, China-Japan Friendship Hospital, Beijing 100029, China
    3. School of Computer and Information Technology, Beijing Jiaotong University, Beijing 100044, China
  • Received:2008-03-17 Online:2008-09-20 Published:2008-09-15

Objective: To evaluate the clinical effects of Shengmai Injection in treating coronary heart disease (CHD) based on correct syndrome differentiation and incorrect syndrome differentiation.
Methods: The patients' information was collected by a system of individual diagnosis and treatment of CHD. The score of main symptoms was calculated and recorded during the treatment. Patients were divided into two groups (incorrect syndrome and correct syndrome groups) on the basis of syndrome differentiation treatment or not. The clinical therapeutic effects of the two treatments were evaluated based on statistic theory combined with random walk method.
Results: There were 273 patients in the correct syndrome group and 4 patients died (case-fatality rate was 1.47%). There were 297 patients in the incorrect syndrome group and 7 patients died (case-fatality rate was 2.36%). In the correct syndrome group, random fluctuation peak of comprehensive evaluation index, walk steps, positive growth rate of walk, ratio, random fluctuation power-law, increase rate and record times of comprehensive evaluation index were 1 472, 13 617, 0.108 1, 9.25, 0.674 2, 0.470 6 and 3 128 respectively, while in the incorrect syndrome group, 1 030, 14 588, 0.070 6, 14.16, 0.660 6, 0.312 8 and 3 293 respectively. The random fluctuation power-law in both groups exceeded 0.5.
Conclusion: There is a long-range correlation between the comprehensive evaluation index and therapeutic method as the CHD patients were treated with Shengmai Injection. The clinical therapeutic effects of Shengmai Injection under correct syndrome differentiation are better than the effects of Shengmai Injection under incorrect syndrome differentiation.

Key words: Shengmai Injection, coronary disease, treatment effectiveness, random walk model

CLC Number: 

  • R541.4

Table 1

Basic information of patients with coronary artery disease in two groups"

Group n Sex (male/female) Age (x±s, year) AMI AP CA CHF DM HLP HP OMI
Incorrect syndrome 297 146/151 69.19±10.95 83 122 82 67 72 32 199 48
Correct syndrome 273 139/134 70.74±9.97 55* 114 99 61 82 29 150 60

Table 2

Dosage of Shengmai Injection and combined medication"

Group n Shengmai Injection ASP ACEI/ARB CCB β-receptor blocker LMH
Dosage
(x±s, ml/d)
Treatment course
(x±s, day)
Incorrect syndrome 297 39.29±16.25 8.44±5.12 249 187 117 205 179
Correct syndrome 273 37.32±14.84 7.81±4.73 254 172 102 193 154

Figure 1

Evaluation of Shengmai Injection based on random walk model"

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