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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (1): 62-65.doi: 10.3736/jcim20030126

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Morphological changes following airway remodeling in asthmatic rats

Li-xin Wang, Yin-gen Wu   

  1. Respiratory Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 20032, ChinaAbstract
  • Received:2003-03-26 Online:2003-03-20 Published:2018-10-19

Key words: asthma, airway remodeling, morphology, models, rats

CLC Number: 

  • R256.12

"

组别 厚度(d/Pi) 面积(WA/Pi2)
激发前 2.75±0.23 2.18±0.41
激发第2周 6.17±0.65Δ 5.62±0.85Δ
激发第4周 9.32±0.92Δ 8.75±0.59Δ
激发第6周 9.84±0.82Δ 9.22±1.03Δ
激发第8周 10.46±0.71Δ** 9.70±1.10Δ**

"

组别 厚度(d/Pi) 面积(WA/Pi2)
激发前 3.08±0.40 2.61±0.59
激发第2周 4.33±0.25Δ 3.56±0.43Δ
激发第4周 7.01±0.74Δ 5.91±0.82Δ
激发第6周 8.93±0.85Δ 7.64±1.08Δ
激发第8周 9.68±0.75Δ** 8.75±1.81Δ**

"

组别 厚度(d/Pi) 面积(WA/Pi2)
激发前 3.66±0.19 2.63±0.49
激发2周组 4.01±0.28 2.89±0.54
激发4周组 4.25±0.36Δ 3.05±0.64
激发6周组 5.55±0.57Δ 3.81±0.67Δ
激发8周组 8.04±0.84Δ** 5.71±0.20Δ**

"

组别 厚度(d/Pi) 面积(WA/Pi2)
激发前 2.78±0.30 2.25±0.39
激发第8周 2.98±0.42 2.38±0.62
[1] Salmon M, Walsh DA, Koto H , et al. Repeated allergen exposure of sensitized Brown-Norway rats induces airway cell DNA synjournal and remodeling[J]. Eur Respir J, 1999,14(3):633-641
doi: 10.1034/j.1399-3003.1999.14c25.x
[2] Palmans E, Kips JC, Pauwels RA . Prolonged allergen exposure induces structural airway changes in sensitized rats[J]. Am J Respir Crit Care Med, 2000,161(2):627-635
doi: 10.1164/ajrccm.161.2.9902094 pmid: 10673209
[3] Temelkovski J, Hogan SP, Shepherd DP , et al. An improved murine model of asthma:selective airway inflammation,epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen[J]. Thorax, 1998,53(10):849-856
doi: 10.1136/thx.53.10.849
[4] 龚志锦, 詹镕洲 . 病理组织制片和染色技术(第1版)[M]. 上海: 上海科学技术出版社, 1994,( 第1版):51-70
[5] Bai A, Eidelman DH, Hogg JC , et al. Proposed nomenclature for quantifying subdivisions of the bronchial wall[J]. J Appl Physiol, 1994,77(2):1011-1014
doi: 10.1016/0167-8760(94)90070-1 pmid: 8002485
[6] James AL, Hogg JC, Dunn LA , et al. The use of the internal primeter to compare airway size and to calculate smooth muscle shortening[J]. Am Rev Respir Dis, 1988,138(1):136-139
[7] Saetta M, Di SA, Rosina C , et al. Quantitative structural analysis of peripheral airways and arteries in sudden fatal asthma[J]. Am Rev Respir Dis, 1991,143(1):138-143
doi: 10.1164/ajrccm/143.1.138
[8] Du T, Sapienza S, Eidelman DH , et al. Morphometry of the airways during late responses to antigen challenging in the rat[J]. Am Rev Respir Dis, 1991,143(1):132-137
doi: 10.1164/ajrccm/143.1.132 pmid: 1986669
[9] Awadh N, Muller NL, Park CS , et al. Airway wall thickness in patients with near fatal asthma and control groups: assessment with high resolution computed tomographic scanning[J]. Thorax, 1998,53(4):248-253
doi: 10.1136/thx.53.4.248
[10] Gillis HL, Lutchen KR . Airway remodeling in asthma amplifies heterogeneities in smooth muscle shortening causing hyperresponsiveness[J]. J Appl Physiol, 1999,86(6):2001-2012
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