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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (5): 454-457.doi: 10.3736/jcim20080504

• Editorial • Previous Articles     Next Articles

Application of systems biology method in the research of traditional Chinese medicine

Ping Li(), Li-ping Yang   

  1. Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing 100029, China
  • Received:2008-04-09 Online:2008-05-20 Published:2008-05-15
  • Contact: LI Ping E-mail:lp8675@yahoo.com.cn

Systems biology is a new science of the 21st century, which resembles traditional Chinese medicine (TCM) in many aspects such as study method and design. Adoption of systems biology approach would do much help for exploring the scientific connotation of TCM syndrome and the modernization of Chinese herbal medicine. Its technological platforms, such as genomics, proteomics and metabonomics, provide powerful tools for the study of the essence of TCM syndrome and the function of herbal compound recipe. Compared with other molecular biological methods, such as genomics and proteomics, metabonomics method is more direct and more concise, especially for providing an effective method for the study of TCM therapy in preventing and treating kidney diseases.

Key words: systems biology, syndrome complex, modernization (traditional Chinese medicine), proteomics

CLC Number: 

  • R2-05
[1] Ideker T, Galitski T , Hood L.A new approach to decoding life: systems biology[J].Annu Rev Genomics Hum Genet, 2001, 2: 343-372.
doi: 10.1146/annurev.genom.2.1.343
[2] Poon AC, Ferrell JE Jr . Systems biology. A clock with a flip switch[J]. Science, 2007,318(5851):757-758
doi: 10.1126/science.1150740 pmid: 17975056
[3] Pennisi E . Systems biology. Tracing life's circuitry[J]. Science, 2003,302(5651):1646-1649
doi: 10.1126/science.302.5651.1646 pmid: 14657470
[4] Chen Z . Systems biology—the core dynamic force for the development of biology and medicine for the 21 st century[J]. Shi Jie Ke Xue, 2005,( 3):2-6
doi: 10.3969/j.issn.1000-0968.2005.03.001
陈竺 . 系统生物学——21世纪医学和生物学发展的核心驱动力[J]. 世界科学, 2005,( 3):2-6
doi: 10.3969/j.issn.1000-0968.2005.03.001
[5] Yang SL . The progress of systems biology. 2004; 19(1):.[J]. Zhongguo Ke Xue Yuan Yuan Kan, 2004,19(1):31-34
doi: 10.3969/j.issn.1000-3045.2004.01.008
杨胜利 . 系统生物学研究进展[J]. 中国科学院院刊, 2004,19(1):31-34
doi: 10.3969/j.issn.1000-3045.2004.01.008
[6] Yu ZY, Du J . Proteome and study on the essential of TCM syndromes[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2004,24(9):844-846
余宗阳, 杜建 . 蛋白质组学与中医证实质研究[J]. 中国中西医结合杂志, 2004,24(9):844-846
[7] Wang MQ, Feng R, Yan SL , et al. Analytic research on the macroscopic effect of 5 cases of cold zheng and 59 gene microarrays[J]. Zhejiang Zhong Yi Xue Yuan Xue Bao, 2003,27(6):60-63
doi: 10.3969/j.issn.1005-5509.2003.06.033
王米渠, 冯韧, 严石林 , 等. 5例寒证的宏观疗效及基因表达谱芯片分析研究[J]. 浙江中医学院学报, 2003,27(6):60-63
doi: 10.3969/j.issn.1005-5509.2003.06.033
[8] Chen MJ, Zhao LP, Jia W . Metabolomic study on the biochemical profiles of a hydrocortisone-induced animal model[J]. J Proteome Res, 2005,4(6):2391-2396
doi: 10.1021/pr050158o pmid: 16335992
[9] Zhai XX, Guo CG . Establishment of systematic theory of holistic efficacy of traditional Chinese medicine.[J]. Shandong Zhong Yi Yao Da Xue Xue Bao, 1998,22(2):104-106
翟晓翔, 国承钢 . 建立中药整体功效系统理论[J]. 山东中医药大学学报, 1998,22(2):104-106
[10] Perlman ZE, Mitchison TJ.Mayer TU . High-content screening and profiling of drug activity in an automated centrosome-duplication assay[J]. Chembiochem, 2005,6(1):145-151
doi: 10.1002/cbic.v6:1
[11] Humphery-Smith I, Cordwell SJ, Blackstock WP . Proteome research: complementarity and limitations with respect to the RNA and DNA worlds[J]. Electrophoresis, 1998,18(8):1217-1242
doi: 10.1002/elps.1150180804 pmid: 9298643
[12] Peng J, Gygi SP . Proteomics: the move to mixtures[J]. J Mass Spectrom, 2001,36(10):1083-1091
doi: 10.1002/jms.229 pmid: 11747101
[13] Aggarwal K, Lee KH . Functional genomics and proteomics as a foundation for systems biology[J]. Brief Funct Genomic Proteomic, 2003,2(3):175-184
doi: 10.1093/bfgp/2.3.175 pmid: 15239921
[14] Schmid MB . Structural proteomics: the potential of high-throughput structure determination[J]. Trends Microbiol, 2002,10(Suppl):27-31
doi: 10.1016/S0966-842X(02)02443-5 pmid: 12377565
[15] Patterson SD, Aebersold RH . Proteomics: the first decade and beyond[J]. Nat Genet, 2003,33(Suppl):311-323
doi: 10.1038/ng1106 pmid: 12610541
[16] Nicholson JK, Connelly J, Lindon JC , et al. Metabonomics: a platform for studying drug toxicity and gene function[J]. Nat Rev Drug Discov, 2002,1(2):153-161
doi: 10.1038/nrd728 pmid: 12120097
[17] Jia W, Jiang J, Liu P , et al. Application of metabonomics in complicated theory system research of traditional Chinese medicine[J]. Zhongguo Zhong Yao Za Zhi, 2006,31(8):621-624
贾伟, 蒋健, 刘平 , 等. 代谢组学在中医药复杂理论体系研究中的应用 中国中药杂志, 2006,31(8):621-624
[18] Yang J, Zhao X, Liu X , et al. High performance liquid chromatography-mass spectrometry for metabonomics: potential biomarkers for acute deterioration of liver function in chronic hepatitis B[J]. J Proteome Res, 2006,5(3):554-561
doi: 10.1021/pr050364w
[19] Jia L, Wang C, Kong H , et al. Effect of PA-MSHA vaccine on plasma phospholipids metabolic profiling and the ratio of Th2/Th1 cells within immune organ of mouse IgA nephropathy[J]. J Pharm Biomed Anal, 2007,43(2):646-654
doi: 10.1016/j.jpba.2006.07.040
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