人参皂苷联合地塞米松抗大鼠运动病的作用

doi:10.3736/jcim20100410

Abstract

Objective

To investigate the antimotion sickness effects of ginsenosides combined with dexamethasone in rats.
Methods

Fifty SD rats were randomly divided into 5 groups: normal saline, scopolamine-treated, ginsenosides-treated, dexamethasone-treated and ginsenosides plus dexamethasone-treated groups. There were 10 rats in each group. The rats in each group were fed with corresponding ingredients respectively, and then the rats were exposed to abnormal acceleration for one hour. The motion sickness index, the level of kaolin consumption and the course and time of spontaneous activity were observed.
Results

The motion sickness index and the level of kaolin consumption of acceleration-exposed rats in ginsenosides plus dexamethasone-treated group were significantly lower than those in normal saline group. And the course and time of spontaneous activity of acceleration-exposed rats in ginsenosides plus dexamethasone-treated group were significantly higher than those in normal saline group. The level of body weight increment of acceleration-exposed rats in ginsenosides plus dexamethasone-treated group was significantly higher than that in dexamethasone-treated group.
Conclusion

Ginsenosides combined with dexamethasone can significantly increase tolerance to acceleration of rats, and the drug combination can decrease side effects of methylprednisolone, such as body weight loss.

Key words: Motion sickness, Panaxosides, Dexamethasone, Scopolamine, Rats

Lin Jia, Wan-yin Wang, Li-mei Zhou, Feng-feng Mo, Min Li. Antimotion sickness effects of ginsenosides combined with dexamethasone in rats. Journal of Chinese Integrative Medicine, 2010, 8(4): 358-362.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20100410

http://www.jcimjournal.com/EN/Y2010/V8/I4/358

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References 10

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Group	n	Motion sickness index
Group	n	Before exposure	One-day exposure	Two-day exposure	Three-day exposure
Normal saline	10	1.07±0.91	7.70±1.09^**	7.93±2.26**	6.40±1.79^**
SPLM-treated	10	1.80±0.97	5.90±1.20^**	5.00±1.57^**	4.83±0.61^**△
DXMT-treated	10	1.09±0.81	6.14±1.75^**	4.69±2.19^**	4.29±1.74^**△
GSS-treated	10	1.28±0.43	7.44±2.01^**	7.65±1.96^**	7.03±2.04**
GSS plus DXMT-treated	10	1.31±0.94	4.23±1.24^**	3.09±1.87^**	2.97±1.00^{**△△▲▲□■■}

Group	n	Kaolin consumption
Group	n	Before exposure	One-day exposure	Two-day exposure	Three-day exposure
Normal saline	10	0.69±0.37	4.72±1.59^**	3.80±1.27^**	3.16±1.26^**
SPLM-treated	10	0.83±0.59	2.46±0.82^**	1.70±0.79	1.74±0.76^△△
DXMT-treated	10	0.67±0.31	1.93±0.62^**	2.07±0.72^**	1.68±0.66^**△△
GSS-treated	10	0.81±0.39	3.50±1.40^**	3.13±1.59^*	3.01±1.14^{**▲▲□□}
GSS plus DXMT-treated	10	0.77±0.33	2.58±1.63^**	1.49±0.93^*	1.17±0.60^{△△▲□■■}

Group	n	Course of spontaneous activity
Group	n	Before exposure	One-day exposure	Two-day exposure	Three-day exposure
Normal saline	10	209.58±51.23	32.60±13.20^**	32.13±15.13^**	22.60±8.76^**
SPLM-treated	10	166.82±64.19	29.78±12.30^**	10.98±6.11^**	14.44±8.20^**△
DXMT-treated	10	177.52±47.34	65.81±25.71^**	55.86±11.76^**	42.05±17.28^{**△△▲▲}
GSS-treated	10	197.75±59.21	41.38±15.63^**	31.15±10.85^**	26.68±10.34^**▲▲□
GSS plus DXMT-treated	10	200.07±63.42	65.09±48.64^**	56.75±45.36^**	46.66±19.38^{**△△▲▲■}

Group	n	Time of spontaneous activity
Group	n	Before exposure	One-day exposure	Two-day exposure	Three-day exposure
Normal saline	10	85.65±15.65	6.88±3.53**	4.57±2.39^**	2.88±1.82^**
SPLM-treated	10	69.73±19.21	9.48±2.89^**	1.46±0.74^**	1.40±0.62^**△
DXMT-treated	10	63.03±18.74	16.94±4.43^**	12.80±2.46^**	10.33±2.85^**△▲▲
GSS-treated	10	82.16±23.44	7.21±2.46^**	5.11±1.15^**	3.02±1.05^**▲□□
GSS plus DXMT-treated	10	75.85±24.57	17.27±8.74^**	17.09±10.12^**	13.58±3.94^{**△▲▲■■}

Group	n	Change of body weight
Group	n	Before exposure	One-day exposure	Two-day exposure	Three-day exposure
Normal saline	10	6.30±2.41	2.80±1.81^**	5.30±4.62	3.20±1.32^*
SPLM-treated	10	9.90±8.65	1.50±0.97^*	4.80±1.75	3.90±1.85
DXMT-treated	10	9.63±6.12	–(14.75±4.62)^**	–(10.00±3.02)^**	–(3.62±1.19)^{**△△▲▲}
GSS-treated	10	8.54±5.03	4.11±1.04	3.27±2.98^*	4.67±3.26^**□□
GSS plus DXMT-treated	10	7.67±3.81	–(9.56±2.29)^**	–(6.00±1.94)^**	1.56±1.13^{**△△▲▲□□■■}

Antimotion sickness effects of ginsenosides combined with dexamethasone in rats

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