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Journal of Chinese Integrative Medicine ›› 2010, Vol. 8 ›› Issue (4): 358-362.doi: 10.3736/jcim20100410

• Original Experimental Research • Previous Articles     Next Articles

Antimotion sickness effects of ginsenosides combined with dexamethasone in rats

 Lin Jia, Wan-yin Wang, Li-mei Zhou, Feng-feng Mo, Min Li   

  1. Department of Military Hygiene, Second Military Medical University, Shanghai 200433, China
  • Received:2010-02-23 Accepted:2010-03-19 Online:2010-04-20 Published:2010-04-15
  • Contact: Min Li E-mail:linlimin115@hotmail.com

Objective

To investigate the antimotion sickness effects of ginsenosides combined with dexamethasone in rats.
Methods

Fifty SD rats were randomly divided into 5 groups: normal saline, scopolamine-treated, ginsenosides-treated, dexamethasone-treated and ginsenosides plus dexamethasone-treated groups. There were 10 rats in each group. The rats in each group were fed with corresponding ingredients respectively, and then the rats were exposed to abnormal acceleration for one hour. The motion sickness index, the level of kaolin consumption and the course and time of spontaneous activity were observed.
Results

The motion sickness index and the level of kaolin consumption of acceleration-exposed rats in ginsenosides plus dexamethasone-treated group were significantly lower than those in normal saline group. And the course and time of spontaneous activity of acceleration-exposed rats in ginsenosides plus dexamethasone-treated group were significantly higher than those in normal saline group. The level of body weight increment of acceleration-exposed rats in ginsenosides plus dexamethasone-treated group was significantly higher than that in dexamethasone-treated group.
Conclusion

Ginsenosides combined with dexamethasone can significantly increase tolerance to acceleration of rats, and the drug combination can decrease side effects of methylprednisolone, such as body weight loss.

Key words: Motion sickness, Panaxosides, Dexamethasone, Scopolamine, Rats

Table 1

Effects of DXMT plus GSS on motion sickness index in acceleration-exposed rats ($\bar{x}$±s)"

Group n Motion sickness index
Before exposure One-day exposure Two-day exposure Three-day exposure
Normal saline 10 1.07±0.91 7.70±1.09** 7.93±2.26** 6.40±1.79**
SPLM-treated 10 1.80±0.97 5.90±1.20** 5.00±1.57** 4.83±0.61**△
DXMT-treated 10 1.09±0.81 6.14±1.75** 4.69±2.19** 4.29±1.74**△
GSS-treated 10 1.28±0.43 7.44±2.01** 7.65±1.96** 7.03±2.04**
GSS plus DXMT-treated 10 1.31±0.94 4.23±1.24** 3.09±1.87** 2.97±1.00**△△▲▲□■■

Table 2

Effects of DXMT plus GSS on kaolin consumption in acceleration-exposed rats ($\bar{x}$±s, g/d)"

Group n Kaolin consumption
Before exposure One-day exposure Two-day exposure Three-day exposure
Normal saline 10 0.69±0.37 4.72±1.59** 3.80±1.27** 3.16±1.26**
SPLM-treated 10 0.83±0.59 2.46±0.82** 1.70±0.79 1.74±0.76△△
DXMT-treated 10 0.67±0.31 1.93±0.62** 2.07±0.72** 1.68±0.66**△△
GSS-treated 10 0.81±0.39 3.50±1.40** 3.13±1.59* 3.01±1.14**▲▲□□
GSS plus DXMT-treated 10 0.77±0.33 2.58±1.63** 1.49±0.93* 1.17±0.60△△▲□■■

Table 3

Effects of DXMT plus GSS on course of spontaneous activity in acceleration-exposed rats ($\bar{x}$±s, cm)"

Group n Course of spontaneous activity
Before exposure One-day exposure Two-day exposure Three-day exposure
Normal saline 10 209.58±51.23 32.60±13.20** 32.13±15.13** 22.60±8.76**
SPLM-treated 10 166.82±64.19 29.78±12.30** 10.98±6.11** 14.44±8.20**△
DXMT-treated 10 177.52±47.34 65.81±25.71** 55.86±11.76** 42.05±17.28**△△▲▲
GSS-treated 10 197.75±59.21 41.38±15.63** 31.15±10.85** 26.68±10.34**▲▲□
GSS plus DXMT-treated 10 200.07±63.42 65.09±48.64** 56.75±45.36** 46.66±19.38**△△▲▲■

Table 4

Effects of DXMT plus GSS on time of spontaneous activity in acceleration-exposed rats ($\bar{x}$±s, s)"

Group n Time of spontaneous activity
Before exposure One-day exposure Two-day exposure Three-day exposure
Normal saline 10 85.65±15.65 6.88±3.53** 4.57±2.39** 2.88±1.82**
SPLM-treated 10 69.73±19.21 9.48±2.89** 1.46±0.74** 1.40±0.62**△
DXMT-treated 10 63.03±18.74 16.94±4.43** 12.80±2.46** 10.33±2.85**△▲▲
GSS-treated 10 82.16±23.44 7.21±2.46** 5.11±1.15** 3.02±1.05**▲□□
GSS plus DXMT-treated 10 75.85±24.57 17.27±8.74** 17.09±10.12** 13.58±3.94**△▲▲■■

Table 5

Effects of DXMT plus GSS on body weight in acceleration-exposed rats ($\bar{x}$±s, g/d)"

Group
n Change of body weight
Before exposure One-day exposure Two-day exposure Three-day exposure
Normal saline 10 6.30±2.41 2.80±1.81** 5.30±4.62 3.20±1.32*
SPLM-treated 10 9.90±8.65 1.50±0.97* 4.80±1.75 3.90±1.85
DXMT-treated 10 9.63±6.12 –(14.75±4.62)** –(10.00±3.02)** –(3.62±1.19)**△△▲▲
GSS-treated 10 8.54±5.03 4.11±1.04 3.27±2.98* 4.67±3.26**□□
GSS plus DXMT-treated 10 7.67±3.81 –(9.56±2.29)** –(6.00±1.94)** 1.56±1.13**△△▲▲□□■■
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