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Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (12): 1164-1166.doi: 10.3736/jcim20091214

• Original Experimental Research • Previous Articles     Next Articles

Effects of Qingshi Cream on chronic dermatitis-eczema in mice

 Yong-mei Li, Xiao-rui Li   

  1. Department of Dermatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
  • Received:2009-09-02 Accepted:2009-10-30 Online:2009-12-20 Published:2009-12-15
  • Contact: Yong-mei Li E-mail:liyongmei2006@126.com

Objective

To explore the effects of Qingshi Cream, a compound traditional Chinese herbal medicine, on chronic dermatitis-eczema in mice induced by 2,4-dinitrochlorobenzene (DNCB).
Methods

Thirty BALB/C mice were randomly divided into vaseline group, 0.1% mometasone furoate cream group and Qingshi Cream group. Right ears of BALB/C mice were repeatedly challenged with 0.1% DNCB every three days for five times and previously sensitized with 7% DNCB to induce chronic dermatitis-eczema. Mice in different groups were applied Qingshi Cream, 0.1% mometasone furoate cream and vaseline respectively after each challenge. Weight difference of two ears, pathological change of right ear and dermal inflammatory cell number were used to assess the effects of the drugs.
Results

After the 5th challenge, weight differences of two ears in the 0.1% mometasone furoate cream group and the Qingshi Cream group were significantly decreased as compared with that in the vaseline group. Changes such as ear swelling thickening and cellular infiltration in dermis were observed, and these features seemed to be more significant in the vaseline group as compared with the 0.1% mometasone furoate cream group and the Qingshi Cream group.
Conclusion

Qingshi Cream has an obvious effect in treatment of chronic dermatitis-eczema in mice.

Key words: Chronic dermatitis-eczema, Qingshi Cream, Mice

Table 1

Weight difference of two ears of mice in different groups ($\bar{x}$±s,mg)"

Group n Weight difference of two ears
Vaseline 10 8.98±0.204
0.1% mometasone furoate cream 10 1.59±0.137**
Qingshi Cream 10 1.52±0.155**

Table 2

Dermal inflammatory cell number of right ear of mice in different groups ($\bar{x}$±s,cells/mm2)"

Group n Dermal inflammatory cell number of right ear
Vaseline 6 84.0±4.10
0.1% mometasone furoate cream 6 32.0±3.57**
Qingshi Cream 6 28.5±4.23**

Figure 1

Pathological change of right ear in mice observed by light microscopy(HE staining, ×200) A: Vaseline group; B: 0.1% mometasone furoate cream group; C: Qingshi Cream group; D: Normal tissue."

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