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Journal of Chinese Integrative Medicine ›› 2007, Vol. 5 ›› Issue (3): 314-317.doi: 10.3736/jcim20070316

• Original Experimental Research • Previous Articles     Next Articles

Preparation of nano-liposome enveloping Flos Magnoliae volatile oil

Min Wu1, Juan Liu2, Xin Zhang1   

  1. 1. Department of Traditional Chinese Medicine, Xinhua Hospital, Medical School, Shanghai Jiaotong University, Shanghai 200092, China
    2. School of Material Science & Engineering, Tongji University, Shanghai 200092, China;
  • Online:2007-05-31 Published:2007-05-15

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Objective: To discuss the influences of the concentrations of sodium cholate, cholesterol and drug, preparation temperature, ultrasonic time and power on the particle size and encapsulation efficiency of Flos Magnoliae volatile oil nano-liposome through film-ultrasonic wave technique together with membrane filter method.Methods: The nano-liposomes were prepared by film-ultrasonic wave technique together with membrane filter method. The drug content in liposomes was determined by gas chromatography and the particle size was determined by laser light scattering granularity equipment.Result: By film-ultrasonic wave technique together with membrane filter method, the liposomes in the range of 30-40 nm were prepared. The prepared nano-liposomes demonstrated good decentralization and homogeneity, and the encapsulation efficiency was (91.7±3)%.Conclusion: Film-ultrasonic wave together with membrane filter method is a simple method to fabricate nano-magnoliae liposome.

Key words: Flos Magnoliae, oils, volatile, liposomes, preparation, technology

CLC Number: 

  • R931.6

Figure 1

Regression curve of Flos Magnoliae volatile oil"

Figure 2

Influence of sodium cholate on particle size of liposomes"

Figure 3

Influence of sodium cholate on encapsulation efficiency of liposomes"

Figure 4

Influence of Flos Magnoliae volatile oil on particle size of liposomes"

Figure 5

Influence of cholesterol on particle size of liposomes"

Figure 6

Influence of cholesterol on encapsulation efficiency of liposomes"

Figure 7

Influence of ultrasonic power on particle size of liposomes"

Figure 8

Influence of ultrasonic time on particle size of liposomes"

Figure 9

Transmission electron microscopy image of nano-liposomes at 200 000 magnification"

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