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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (3): 266-269.doi: 10.3736/jcim20080309

• Original Clinical Research • Previous Articles     Next Articles

Diagnostic value of assay of brain natriuretic peptide in patients with sepsis of blood-stasis syndrome

Chen Yue(), Liang Zhu, Yi-ming Qian   

  1. Department of Emergency, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
  • Received:2007-08-17 Online:2008-03-20 Published:2008-03-15
  • Contact: Y Chen

Objective: To explore the diagnostic value of brain natriuretic peptide (BNP) level in patients with sepsis of blood-stasis syndrome.Methods: The prospective method of clinical diagnostic test and evaluation principles of diagnostic test were applied. One hundred and seventy-four patients with sepsis were divided into two groups: blood-stasis syndrome group and non blood-stasis syndrome group. The levels of serum BNP in two groups were detected.Results: The level of BNP in sepsis patients was related to blood-stasis syndrome (P<0.01). BNP cut-off level was 150 ng/L, sensitivity was 85.3%, specificity was 81%, the maximum value of Youden index was 0.663, and the area under the receiver operating characteristic curve (ROC) value was (0.886±0.025).Conclusion: BNP can be used as an objective index of blood-stasis syndrome diagnosis for sepsis, and BNP with boundary value of 150 ng/L is an optimal biological index.

Key words: sepsis, blood stasis, peptides, routine diagnostic tests, clinical research

CLC Number: 

  • R446.62

Table 1

BNP of sepsis and gold standard of blood-stasis syndrome"

BNP diagnosis Gold standard of syndrome of blood stasis
Meet the diagnostic criteria Not meet the diagnostic criteria Total
Meet the diagnostic criteria 86 35 121
Not meet the diagnostic criteria 9 44 53
Total 95 79 174

Figure 1

ROC for BNP value in patients with sepsis of blood-stasis syndrome "

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