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Three advantages of using traditional Chinese medicine to prevent and treat tumor
Chang-quan Ling​, Xiao-qiang Yue, Chen Ling​
Journal of Integrative Medicine    2014, 12 (4): 331-335.   DOI: 10.1016/S2095-4964(14)60038-8
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Traditional Chinese medicine (TCM), an important component of complementary and alternative medicine, has evolved over thousands of years with its own unique system of theories, diagnostics and therapies. TCM has been increasingly used in the last decades and become well known for its significant role in preventing and treating cancer. We believe that TCM possesses advantages over Western medicine in specific aspects at a certain stage of cancer treatment. Here we summarize the advantages of TCM from three aspects: preventing tumorigenesis; attenuating toxicity and enhancing the treatment effect; and reducing tumor recurrence and metastasis.

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Cited: Baidu(242)
Progress in research on pharmaceutics for intranasal medication
Tong Zhang, Lian-ying Xu
Journal of Chinese Integrative Medicine    2004, 2 (3): 223-225.   DOI: 10.3736/jcim20040324
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Progress in research on Chinese herbs with estrogen-like effects
Xiao-xiao Zhang, Sheng Liu, Xiao-hong Xue
Journal of Chinese Integrative Medicine    2005, 3 (2): 149-153.   DOI: 10.3736/jcim20050219
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Accidents in acupuncture treatment: History and current state
Ren Zhang
Journal of Chinese Integrative Medicine    2004, 2 (4): 306-313.   DOI: 10.3736/jcim20040424
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Acupuncture is widely used as an alternative therapy with few side effects because of its simple manipulation and low cost. However, accidents may occur if the practitioner uses it improperly. Early in the Qin dynastuy, the Canon of Medicine mentioned that improper use of acupuncture could cause injury to the body and even death, and it systematically described the occurrence and prevention of acupuncture accidents. Physicians in the successive dynasties frequently reported it, and nealized that the manipulation skills were significantly important in preventing the occurrence of acupuncture accidents.Since the 1950s, acupuncture accidents had been effectively prevented because of the improving of acupuncture instruments, enhancing of the quality of the practitioners, popularizing of sterilization and disseminating of anatomic knowledge. Nevertherless, with the renovating of acupuncture techniques, new accidents may occur constantly. The prevention of acupuncture accidents still should be an arduors task for acupuncturists. Nowadays, acupuncture therapy is being used in more than 140 countries, and acupuncture accidents due to improper application are incrcasing. Prevention of acupuncture accidents has become a global issue deserving of great attention.

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Dr. Miriam Lee: A heroine for the start of acupuncture as a profession in the State of California
Arthur Yin Fan, Ziyi Fan​
Journal of Integrative Medicine    2014, 12 (3): 182-186.   DOI: 10.1016/S2095-4964(14)60016-9
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Cited: Baidu(8)
Prevention and treatment of pulmonary-fibrosis by traditional Chinese medicine
Chu-fang Yao, Shu-long Jiang
Journal of Chinese Integrative Medicine    2003, 1 (3): 234-238.   DOI: 10.3736/jcim20030327
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Pulmonary-fibrosis (PF) is the result of interstitial lung disease which has different causes and it is one of the most intractable diseases in respiratory system. The PF is characterized by progressive difficulty of breath and dying of respiratory failure, seriously threatening the health of people. Immunosuppressive drugs and glucocorticoids have been widely adopted as the main methods in treatment, but the results are not satisfactory and the side effects are obvious. Many specialists have tried traditional Chinese medicine in recent years with satisfactory effect, indicating that the prospect of using traditional Chinese medicine in the treatment of PF is optimistic. This article outlines the researches about using traditional Chinese medicine in the treatment of PF.

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Cited: Baidu(9)
The study of intoxication and toxicity of Fructus Xanthii
Xue-mei Zhang, Zhong-hua Zhang
Journal of Chinese Integrative Medicine    2003, 1 (1): 71-74.   DOI: 10.3736/jcim20030129
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Fructus Xanthii is commonly used in rhinology, especially used in treatment of chronic rhinitis and sinusitis. But Fructus Xanthii is toxicant, and it maybe result in poisoning when used excessively, without preparation or in inappropriate preparation. This article reviewed all poisoning cases from 1960 to 2000, its toxicology and methods for detoxification.

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Cited: Baidu(16)
Gross conception of anatomical structure of zang-fu viscera in Huangdi Neijing
Ye-tao Gao, Hui-wei Pan​, Sheng-bing Wu​
Journal of Chinese Integrative Medicine    2006, 4 (4): 339-342.   DOI: 10.3736/jcim20060404
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The scientificalness of traditional Chinese medicine (TCM) is often doubted and criticized for the record in Huangdi Neijing that the liver is located in the left of the human body. The most popular explanation of this criticism is that the conception of zang-fu viscera in TCM is quite different from which defined in Western medicine. It means that the zang-fu viscera in TCM are not exactly the corresponding anatomical organs in modern human anatomy but reflect the functions of some systems in human body. According to the classical theories of TCM in Huangdi Neijing, we consider that the record of liver located in the left of the human body is based on the Ba Gua (Eight Diagrams) of traditional Chinese philosophy, not the human anatomy. In brief, the conception of zang-fu viscera is initially a gross anatomical conception, and in a sense the anatomic sites and functions of which are mostly similar to those described in Western medicine.

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A family survey of syndromes of traditional Chinese medicine in patients with β-thalassemia
Wen-juan Wang , Zhi-kui Wu , Xin-hua Zhang , Wen-jun Liu , Yong-mei Liu , Su-ping Fang , Rong-xin Wang , Chong Zhang , Ping-ping Li , Rui-gui Luo
Journal of Chinese Integrative Medicine    2009, 7 (2): 116-120.   DOI: 10.3736/jcim20090204
Abstract897)   HTML2)    PDF(pc) (1050KB)(74)      

Objective

To explore the relationship between syndromes of traditional Chinese medicine (TCM) and genetic background in patients with β-thalassemia.
Methods

TCM syndromes were surveyed in the selected 78 patients with β-thalassemia intermedia including 120 parents. The gene mutations were detected separately. The frequency and score of TCM syndromes between the offspring and their parents in different family types were analyzed, and the differences were compared.
Results

The 73 families were divided into two family types by hereditary characteristics. Family type one meant that genotypes of one of the parents were normal, while the offspring genotypes were heterozygous and were exactly the same as another parent. In the 22 families of type one, the heterozygous offspring manifested 6 high-frequency symptoms and signs such as spontaneous perspiration, dry mouth and dry throat, pale or sallow complexion, tidal fever and night sweating, lassitude and pale fingernails. The heterozygous parents manifested 5 high-frequency symptoms and signs such as lassitude in loins and knees, dizziness, aversion to cold and cold limbs, tinnitus, dry mouth and dry throat. The normal parents manifested 3 high-frequency symptoms and signs such as lassitude in loins and knees, dizziness, and spontaneous perspiration. TCM syndrome score in the heterozygous offspring was higher than that in the heterozygous and normal parents, but there was no significant difference (P>0.05). Family type two meant that genotypes of both parents were heterozygous, while the offspring genotypes were heterogenic duplex heterozygotes. In the 51 families of type two, the offspring manifested 9 high-frequency symptoms and signs such as pale or sallow complexion, spontaneous perspiration, dry mouth and dry throat, pale fingernails, tidal fever and night sweating, lassitude, frequent attack of common cold, dysphoria with feverish sensation in chest, and yellow discoloration of the skin and sclera. The parents manifested 3 high-frequency symptoms and signs such as lassitude in loins and knees, dizziness, aversion to cold and cold limbs. TCM syndrome score in the offspring was significant higher than that in the parents (P<0.01).
Conclusion

In the two family types, TCM syndrome in the offspring is of yin-blood deficiency, while the syndrome of the parents is of kidney deficiency. The differences of TCM syndromes between the offspring and the parents may have some relations to the type of mutant genes and genetically modified ingredients. This research provides scientific evidence to TCM syndrome differentiation treatment of thalassemia.

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Cited: Baidu(3)
Progress in research on Ganoderma lucidium spore
Wei Zhang, Yuan-shan Zeng
Journal of Chinese Integrative Medicine    2004, 2 (6): 463-465.   DOI: 10.3736/jcim20040620
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Cited: Baidu(9)
Preferred reporting items for systematic reviews and meta-analyses:The PRISMA statement (Chinese edition)
David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G. Altman, The PRISMA Group
Journal of Chinese Integrative Medicine    2009, 7 (9): 889-896.   DOI: 10.3736/jcim20090918
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Pharmacological effects and active phytoconstituents of Swietenia mahagoni: A review
Yelaware Puttaswamy Naveen, Gunashekar Divya Rupini, Faiyaz Ahmed, Asna Urooj
Journal of Integrative Medicine    2014, 12 (2): 86-93.   DOI: 10.1016/S2095-4964(14)60018-2
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The usage of Swietenia mahagoni, a popular medicinal plant in India and some African countries, dates back to ancient times for its curative properties in diseases like malaria, diabetes, and diarrhea. It is also used as an anti-pyretic, bitter tonic and astringent. Its pharmacological activities are being widely explored. Although many important groups of phytochemicals have been identified and isolated from various parts of the plant, most of these researches have been focused on seeds. Toxicological studies have established the safety of many of these plant extracts, and found insignificant side effects. Here we present a comprehensive review of all the pharmacological effects and constituent phytochemicals of the plant.

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Cited: Baidu(11)
Correlations of clinical symptoms and treatment efficacy in patients with rheumatoid arthritis treated with Chinese herbal drugs or Western medicine
Ai-ping Lv, Yi-ting He, Qing-lin Zha, Xiao-ping Yan, Li Su, Yue-jin Song, Sheng-ping Zeng, Wei Liu, Xing-hua Feng, Xian Qian, Wan-hua Zhu
Journal of Chinese Integrative Medicine    2005, 3 (6): 432-437.   DOI: 10.3736/jcim20050604
Abstract1009)   HTML2)    PDF(pc) (116KB)(509)      

Objective

To evaluate the correlations between clinical symptoms and treatment efficacy in patients with rheumatoid arthritis (RA).

Methods

Four hundred and thirteen patients were included in the clinical trial from 9 clinical centers. They were randomly divided into Western medicine-treated group with 204 cases and Chinese herbal drug-treated group with 209 cases. Eighteen clinical symptoms were evaluated before and after treatment. The Western medicine therapy included voltaren extended release tablets, methotrexate and sulfasalazine. The Chinese herbal drug therapy included glucosidorum Tripterygii totorum tablets and Yishen Juanbi Tablets combined with treatment based on syndrome differentiation. The American college of rheumatology 20 (ACR20) was used as efficacy evaluation criteria.

Results

In the Chinese herbal drug-treated group, clinical symptoms such as arthralgia and tenderness of joints were positively correlated with the efficacy after 12-week treatment, while frequent urination at night was negatively correlated. In the same group, tenderness of joints and fever were positively correlated with the efficacy after 24-week treatment, while deep-colored and turbid urine was negatively correlated. In the Western medicine-treated group, tenderness of joints and thirst were positively correlated with the efficacy after 12-week treatment, while vertigo was negatively correlated. And in the same group, tenderness of joints was positively correlated with the efficacy after 24-week treatment, while heaviness of limbs was negatively correlated to the efficacy. The statistical results showed that the treatment efficacy was improved when the correlated symptoms were included in the indications.

Conclusion

The treatment efficacy of RA is correlated with some symptoms, so further studies should proceed on these correlations in order to achieve better treatment outcome.

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Development of international standardization of traditional Chinese medical terminologies: A review of WHO’s second conference on International Classification of Traditional Medicine held in Tokyo
Zhao-guo Li
Journal of Chinese Integrative Medicine    2011, 9 (1): 113-115.   DOI: 10.3736/jcim20110119
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Introducing Considerations in the Translation of Chinese Medicine
Sonya E. Pritzker, Ka-Kit Hui
Journal of Integrative Medicine    2014, 12 (4): 394-396.   DOI: 10.1016/S2095-4964(14)60032-7
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This article introduces the document, Considerations in the Translation of Chinese Medicine, published in PDF form online in both Chinese and English. This 20-page document includes several sections describing why the Considerations is necessary, the specificity of texts in Chinese medicine; the history of translation in Chinese medicine; who constitutes an ideal translator of Chinese medicine; what types of language exist in Chinese medicine; and specific issues in the translation of Chinese medicine, such as domestication versus foreignization, technical terminology, period-specific language, style, polysemy, and etymological translation. The final section offers a brief advisory for consumers, and concludes with a call to further discussion, and action, specifically in the development of international collaborative efforts towards the creation of more rigorous guidelines for the translation of Chinese medicine. The current article provides an overview of several of these sections, and includes links to the original document.

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Cited: Baidu(13)
Characteristics of English translation of traditional Chinese medicine
Chuan-yue Niu
Journal of Chinese Integrative Medicine    2004, 2 (2): 159-160.   DOI: 10.3736/jcim20040228
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Cited: Baidu(3)
A study on English translation of antithesis in Neijing
Ping Li, Yun-zhong Shi
Journal of Chinese Integrative Medicine    2012, 10 (7): 832-836.   DOI: 10.3736/jcim20120716
Online available: 15 July 2018

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Effect of Kangxianling Decoction on expression of hepatocyte growth factor mRNA and phosphorylations of extracellular signal-regulated protein kinase 1/2 and p38 in renal tissue of rats with unilateral ureteral obstruction
Yue Zhang, Yu-min Liu, Hai-ying Lu, Ke-jian Liu, Jing Li, Li-qun He, Min Lin, Li Zhou
Journal of Chinese Integrative Medicine    2007, 5 (6): 656-660.   DOI: 10.3736/jcim20070611
Abstract903)   HTML0)    PDF(pc) (1238KB)(129)      

Objective: To study the effect of Kangxianling Decoction (KXLD), a compound traditional Chinese herbal medicine, on expression of hepatocyte growth factor (HGF) mRNA and phosphorylations of extracellular signal-regulated protein kinase 1/2 (ERK 1/2) and p38 in renal tissue of rats with unilateral ureteral obstruction (UUO).Methods: Eighteen male SD rats were randomly divided into 3 groups: sham-operated group, untreated group and KXLD-treated group. A rat model of renal interstitial fibrosis was established by UUO. Rats with UUO were sacrificed after intragastric administration of KXLD for 14 days, and the parameters such as serum creatinine (SCr), blood urea nitrogen (BUN) and hydroxyproline in the kidney of rats in 3 groups were analyzed. The expression of HGF mRNA in kidney tissue was determined by reverse transcription polymerase chain reaction. The expressions of c-Met protein, ERK1/2 protein, p38 protein and the phosphorylations of ERK1/2 and p38 were determined by Western blotting method.Results: The levels of SCr, BUN and hydroxyproline in the untreated group were significantly increased as compared with those in the sham-operated group (P<0.05). The expression of HGF mRNA in the untreated group was significantly down-regulated. The expression of c-Met protein and the phosphorylations of ERK1/2 and p38 in the kidney tissue of rats with UUO in the untreated group were significantly up-regulated. After intervention with KXLD, the phosphorylations of ERK1/2 and p38 were all significantly inhibited except for c-Met expression. The HGF mRNA was increased in KXLD-treated group.Conclusion: KXLD can decrease the level of collagen in the obstructed kidney of rats with UUO and alleviate the renal interstitial fibrosis in rats with UUO through enhancing the HGF mRNA expression and inhibiting the phosphorylations of ERK1/2 and p38.

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Discussion on definition of "traditional Chinese medicine and western medicine integration" and "integrated traditional Chinese and western medicine"
Shi-kui Chen
Journal of Chinese Integrative Medicine    2003, 1 (4): 241-243.   DOI: 10.3736/jcim20030401
Abstract874)   HTML2)    PDF(pc) (52KB)(143)      

Objective

To discuss the definition of "traditional Chinese medicine and western medicine integration" and "integrated traditional Chinese and western medicine".


Methods

Logic methods.


Results

It was found that there were a lot of problems on the definition of "traditional Chinese medicine and western medicine integration" and "integrated traditional Chinese and western medicine".


Conclusion

The understanding of the concepts of "traditional Chinese medicine and western medicine integration" and "integrated traditional Chinese and western medicine" was improved after the extensive discussion.

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Clinical observation of 41 cases of senile ischemic heart disease treated by losarton, carvadilol and Shenmai Injection
Jing-li Chi, Xu-tao Sui, Shang-ai Li, Jing Li
Journal of Chinese Integrative Medicine    2003, 1 (4): 317-318.   DOI: 10.3736/jcim20030427
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Cited: Baidu(1)
Discussion of time and space differentiation of three-yin and three-yang in Shanghan Lun
Wen-hui Ma, Xiao-hong Sun
Journal of Chinese Integrative Medicine    2005, 3 (4): 257-259.   DOI: 10.3736/jcim20050402
Abstract921)   HTML2)    PDF(pc) (57KB)(493)      

The concept of "three-yin and three-yang" in Shanghan Lun (Treatise on Cold Pathogenic Diseases), a classic written by Zhang Zhongjing in Han Dynasty, has been always the focus of dispute in successive dynasties. The essence of "three-yin and three-yang" has not been fully revealed up till now. Through studying the six divisions of day and night, the six diseases, the combination of syndromes, the complicated diseases, the complete recovery time and the space division of "three-yin and three-yang", the authors draw a conclusion that the "three-yin and three-yang" in Shanghan Lun is a concept of time-sequence, which is associated with the location of disease in space. So it is suggested that the "six diseases" in Shanghan Lun is a categorization for exogenous febrile diseases, and this categorization reveals a sort of inner relationship between the emergence, development, transformation of the febrile diseases and the time.

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An experimental study on distribution of musk into the brain through blood brain barrier
Wen-kai Chen, Yu-fang Huang, Hai-dong Wang
Journal of Chinese Integrative Medicine    2004, 2 (4): 288-291.   DOI: 10.3736/jcim20040417
Abstract933)   HTML4)    PDF(pc) (100KB)(176)      

Objective: To study the possible pathway of the effect of musk on brain disorder,distributing into the brain through blood brain barrier.Methods: We used the musk ketone (muscone), a main composition of musk,to inject through the tail vein of the rats into the blood and took the brain and other organs at different times to make samples. Then gas chromatography was used to measure the distribution of muscone in the brain and other organs.Results: Muscone could pass through the normal rat's blood brain barrier into the brain and soon reached the highest peak and remained in higher concentration, and more slowly metabolized as compared with other organs.Conclusion: Musk distributing into the brain through blood brain barrier provides the basis for its effect in treating brain disorders. Chromatography is an effective method to study the active composition of Chinese herbal medicine distributing through the blood brain barrier into the brain.

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In-house preparation and characterization of an Ayurvedic bhasma: Praval bhasma
Amrita Mishra, Arun K. Mishra, Om Prakash Tiwari, Shivesh Jha
Journal of Integrative Medicine    2014, 12 (1): 52-58.   DOI: 10.1016/S2095-4964(14)60005-4
Abstract1186)   HTML    PDF(pc) (2057KB)(231)      

Objective

To prepare the Praval bhasma (PB) and to perform its characterization. 

Methods

The preparation was performed strictly as per method prescribed in Ayurvedic formulary of India followed by preliminary tests including Nischandratva, Rekhapurnatvam, Varitaramtavm, Nisvadutvam and Amla pariksha. The physicochemical characterization was done with the use of instrumental techniques such as Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), X ray diffraction (XRD), and energy dispersive X-ray (EDAX). 

Results

The FTIR bands appearing in final product spectra showed a significant shift in infrared vibration frequency as well as intensity when compared with the raw material, which was indicative of formulation of bhasma. The XRD analysis revealed that raw material contained CaCO3 whereas in case of final product of bhasma, CaO was identified. SEM analysis revealed the difference in particles size of bhasma (10-15 μm) and raw material (100-150 μm). The EDAX analysis showed presence of different concentration of carbon in both the samples. 

Conclusion

It may be concluded that modern analytical techniques may be involved to evaluate the quality aspects of PB. The findings of the present research work may be helpful for further formulation and standardization of PB in routine analysis.

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Cited: Baidu(12)
Progress of study on the regulation of endothelin and nitrix oxide with Chinese medical herbs
Xu-hui Ma, Jie Zhang
Journal of Chinese Integrative Medicine    2004, 2 (2): 152-153.   DOI: 10.3736/jcim20040226
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A review of chemical and biological profile of genus Michelia
Kumar Dinesh, Kumar Sunil, Taprial Seema, Kashyap Deepak, Kumar Ajay, Prakash Om
Journal of Chinese Integrative Medicine    2012, 10 (12): 1336-1340.   DOI: 10.3736/jcim20121203
Abstract967)   HTML2)    PDF(pc) (937KB)(92)      

The genus Michelia, belonging to family Magnoliaceae, consists of about 80 plant species mainly distributed in South Asian countries. The plants of this genus have been traditionally used in curing various diseases like fever, colic, leprosy, eye disorders, inflammation, antidote for scorpion, etc. Ninety-four compounds isolated from nine species of the genus Michelia like sesquiterpenes, steroids, flavonoids, aporphines, phenols, esters, benzenoids and alkaloids have antibacterial, anticancer and antiplasmodial activities. This review presents first time detailed information on chemical and biological properties of constituents isolated from the genusMichelia.

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Tongue conditions and constitution
Tiao-yuan Kuang
Journal of Chinese Integrative Medicine    2004, 2 (4): 264-264.   DOI: 10.3736/jcim20040407
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Treatment of diabetes through liver syndrome differentiation
Li Zhao
Journal of Chinese Integrative Medicine    2004, 2 (4): 303-305.   DOI: 10.3736/jcim20040423
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Influence of cervical curvature change on the nerve root and vertebral artery of patients with cervical spondylosis and clinical observation of manipulation treatment
Gui-kang Wei, Jian Wei, Hong-hai Zhou, Bin-bin Zhou, Feng Chen, Rong Huang, Xin-jiao Li
Journal of Chinese Integrative Medicine    2003, 1 (4): 259-261.   DOI: 10.3736/jcim20030408
Abstract884)   HTML1)    PDF(pc) (51KB)(73)      

Objective

To observe the influence of the change of cervical curvature on the nerve root and the vertebral artery of the patients with cervical spondylosis and the curative effect of therapeutic manipulations.


Methods

Sixty cases of cervical spondylosis with the change of cervical curvature, 60 cases of cervical spondylosis without the change of cervical curvature and 60 normal people were chosen. They were clinically observed and the cervical spondylosis was treated by manipulations and the data was processed according to the principle of statistics.


Results

The change of cervical curvature affected the nerve root and the vertebral artery and therapeutic manipulations produced a satisfactory curative effect.


Conclusion

Cervical spondylosis with change of cervical curvature has special characteristics in the etiology, course and state of the disease. The change of cervical curvature produces an effect on the nerve root and the vertebral artery. Selected therapeutic manipulations produce a better curative effect.

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Progress of research on apoptosis of breast cancer cells
Cui-yan Lv, Xin-yi Chen
Journal of Chinese Integrative Medicine    2003, 1 (3): 226-229.   DOI: 10.3736/jcim20030325
Abstract893)   HTML0)    PDF(pc) (78KB)(76)      

This article reviewed information related to the apoptosis of breast cancer cells. Breast cancer is a common malignant tumor in women. Apoptosis is related to the response and resistance to treatment in breast cancer. Here we summarized and integrated the data on apoptosis and its role in the development, prognosis, and treatment of breast cancer. Further study on apoptosis in breast cancer can help find more candidates for predictors and indices of response. Such study will also develop treatment regimens that are tailored to individual tumors and thereby maximize survival.

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Cited: Baidu(8)
Progress in research on hirudo
Rong-qing Huang, Xiao-dong Sun, Yang-ling Li, Hong Wang
Journal of Chinese Integrative Medicine    2004, 2 (5): 387-389.   DOI: 10.3736/jcim20040523
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Puzzle of hormone replacement therapy and prospect of the role of traditional Chinese medicine in treating postmenopausal syndrome
Ming-dao Chen, Ying Yang
Journal of Chinese Integrative Medicine    2003, 1 (1): 9-11.   DOI: 10.3736/jcim20030105
Abstract932)   HTML2)    PDF(pc) (56KB)(301)      

In July 2002, the Women's Heath Initiative (WHI) clinical trial, designed to clarify the risks and benefits of combination hormone replacement therapy (HRT) to the postmenopausal women declared that interim safety review after an average follow-up of 5.2 years found that a combination of estrogen and progestin frequently prescribed to postmenopausal women in USA increased the risk of invasive breast cancer, heart disease, stroke, and pulmonary embolism while reduced bone fractures and colorectal cancer. The overall risks of HRT outweigh the benefits, which provides an opportunity for traditional Chinese medicine (TCM) going abroad. A variety of clinical and experimental evidences have showed that TCM exerts quite satisfactory effect on relieving postmenopausal symptoms with little adverse effect, hence a potential role to replace or to improve HRT or to reduce the side effect induced by HRT.

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Professor TANG Han-Jun's thinking in syndrome differentiation and experience in treating breast cancer
Hai-guang Qin
Journal of Chinese Integrative Medicine    2004, 2 (4): 297-298.   DOI: 10.3736/jcim20040420
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Discussion on necessity of introduction of qualitative research into clinical research of tradictional Chinese medicine
Ya-nan Han, Dong-bo Fu
Journal of Chinese Integrative Medicine    2004, 2 (5): 330-332.   DOI: 10.3736/jcim20040504
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Currently, the model of the research evaluation system of traditional Chinese medicine (TCM) is set up through imitating that of western medicine. The application of quantitative research to TCM does promote the advance of modernization of TCM, which explore the part of TCM that can be measured in quantitative method. However, TCM has a background of profound philosophy and culture. The priority of TCM can not be expressed through quantitative research alone. On the contrary, qualitative research is more suitable to most research area of TCM. In TCM clinical research, the priority of TCM should be fully explored. It is very significant to set up the effectiveness evaluation system of TCM, especially by applying qualitative research to the diagnosis and the evaluation of treatment results and combining quantitative research.

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Cited: Baidu(6)
Application of Bayesian network in syndrome differentiation system of traditional Chinese medicine
Wen-feng Zhu, Jun-feng Yan, Bi-qun Huang
Journal of Chinese Integrative Medicine    2006, 4 (6): 567-571.   DOI: 10.3736/jcim20060604
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The concept of syndrome in traditional Chinese medicine (TCM) is a nonlinear, open and complicated huge system. Syndrome differentiation in TCM belongs to cognitive and noetic science. To establish a new syndrome differentiation system based on the key elements of the syndrome is necessary for TCM practitioners to promote differentiation ability and reach consensus on differentiation method. With combination of experience and computation models, the Bayesian network was used in the study of the relationship between the key elements of syndrome and the symptoms, and the relationship among different key elements, in which the computing diagnosis result was identical to the result from an experienced TCM doctor. The study showed that Bayesian network is a good method to deal with the information of symptoms and signs for syndrome differentiation, but it is also not to reflect comprehensively the thinking ability of TCM doctors in doing syndrome differentiation.

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Cited: Baidu(44)
Pre-administ ration of Ganoderma lucidum spore reduces incidence ofneural tube defects induced by retinoic acid in pregnant mice
Wei Zhang, Yuan-Shan Zeng, Yi Xiong, Sui-Jun Chen, Zhi-qiang Zhong
Journal of Chinese Integrative Medicine    2006, 4 (4): 368-373.   DOI: 10.3736/jcim20060410
Abstract899)   HTML0)    PDF(pc) (159KB)(44)      

Objective

To explore whether pre-administrat ion of Ganoderma lucidum spore (GASP) can reduce incidence of neural tube defects (NTDs) induced by all-trans retinoic acid ( ATRA) in pregnant mice.

Methods

Twenty pregnant mice were randomly divided into four groups: normal control group , solventtreated group, ATRA-induced group , and GASP-treated plus ATRA-induced group . GASP solut ion, which wasprepared with solvent ( sodium carboxymethyl cellulose) , was fed to the pregnant mice in the GASP-treated plus ATRA-induced group twice a day from embryo (E) 0 d to E10 .5 d . The same dose of solvent was given to the pregnant mice in the solvent- treated group . At E7 .75 d, ATRA ( 50 mg/ kg) was given to the pregnant mice in both ATRA-induced group and GASP-treated plus ATRA-induced group for single t ime . Embryos were sampled from pregnant mice at E10 .5 d . Then the incidence rate of NTDs in mouse embryo was calculated and the crown-rump length of mouse embryo was measured . The positive rate of nestin expression and the distribution of cell cycle of embryonic neural tube neuroepithelial cells were detected by histochemical stainingtechnique and flow cytometry respectively .Reverse transcription-polymerase chain reaction method was used to detect the gene expressions of cyclin-dependent protein kinase 2 (Cdk2) and Cdk4 mRNAs .

Results

The incidence rates of NTDs in mouse embryos in the ATRA-induced group and the GASP-treated plus ATRA-induced group were 79 .41% and 21 .67% respectively , while the crown-rump length of mouse embryos in these two groups were (3 .62±1 .27) mm and (5 .84±0 .92) mm respectively .The positive rate of nestin expression in embryonic neural tube neuroepi thelial cells of mouse embryo at E10 .5 d in the ATRA-induced group was 32 .44% , while that in the GASP-treated plus ATRA-induced group was 77 .65% . The cell cycle of embryonic neural tube neuroepithelial cells was obviously arrested at G0/ G1 phase in the ATRA-induced group as compared wi th that in the GASP-treated plus ATRA-induced group . The Cdk4 mRNA was transcripted at a high level in embryonic neural tube in the GASP-treated plus ATRA-induced group, but the Cdk2 mRNA wasnot detected in this group.

Conclusion

Pre-administrat ion of GASP can reduce the incidence of NTDs induced by ATRA in pregnant mice .

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An overview of medicinal plant resource for decreasing blood glucose
Yun Zhu, Jin-rong Liu, Wei Zhang
Journal of Chinese Integrative Medicine    2004, 2 (1): 67-68.   DOI: 10.3736/jcim20040125
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Comparison of animal models of hyperlipidemia
Xue-mei Liu, Fu-huo Wu
Journal of Chinese Integrative Medicine    2004, 2 (2): 132-134.   DOI: 10.3736/jcim20040217
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Objective: To select the proper experimental animal model for research on prevention and treatment of hyperlipidemia.Methods: Hyperlipidemia models of mouse, rat, golden hamster, guinea pig, rabbit, pigeon and quail often used in the last ten years were compared.Results: Golden hamster and guinea pig models are similar to human beings in lipid metabolism and have unique superiority in experimental study, while the models of rat, mouse, pigeon and quail have significant difference as compared with human beings. Rabbit is one of the best animal models in studying new drugs for regulating lipid and treating arteriosclerosis.Conclusion: Factors such as the required time, indexes, the duration of making models, and the cost and feeding of animals should be considered in selecting animal models according with the experimental requirements.

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Syndromes and pathological mechanism of insulin resistance in traditional Chinese medicine
Qin Feng, Yi-yang Hu
Journal of Chinese Integrative Medicine    2005, 3 (1): 63-65.   DOI: 10.3736/jcim20050120
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Treatment of complex high anal fistula with combined use of anatomical fistulectomy and thread-drawing therapy: A report of 36 cases
Dong-lin Ren, Zhan-bin Luo
Journal of Chinese Integrative Medicine    2005, 3 (3): 229-230.   DOI: 10.3736/jcim20050318
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Cited: Baidu(6)
Research strategy and clinical significance of anorectum manometry
Lin Zhu, Wen-fu Tang, Ping Ren, Xi Huang
Journal of Chinese Integrative Medicine    2005, 3 (3): 240-242.   DOI: 10.3736/jcim20050323
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Treatment of temporomandibular joint disorder by traditional Chinese medicine
Guo-heng Li
Journal of Chinese Integrative Medicine    2003, 1 (4): 258-258.   DOI: 10.3736/jcim20030407
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Analysis on acupuncture treatment characteristics for tumor in ancient medical literature
Li-gong Liu, Jie Gu, Dong-xing Fang
Journal of Chinese Integrative Medicine    2003, 1 (4): 319-320.   DOI: 10.3736/jcim20030428
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Protective effects of Chailing Guiqi Decoction combined with lumbrukinase on renal function in rats with adriamycin nephropathy
Fen-fang Zhang, Xi-dong Wang, Huan-fang Fan, Zhi-qiang Chen, Zhi-wei Yin, Wei Zhang
Journal of Chinese Integrative Medicine    2005, 3 (4): 294-298.   DOI: 10.3736/jcim20050414
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Objective

To study the protective efffects of Chailing Guiqi Decoction (CLGQD) combined with lumbrukinase on renal function in rats with adriamycin nephropathy.

Methods

Thirty-six SD rats were randomly divided into four groups: normal control group, untreated group, simvastatin-treated group and CLGQD -treated group. Adriamycin nephropathy was induced by intravenous injection with 5 mg/kg adriamycin. After seven-day treatment, quantitative measurement of 24-h urine protein was determined with trichloroacetic acid, and serum total protein (TP), albumin (Alb), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), creatinine (Cr) and blood urea nitrogen (BUN) were assessed using automatic biochemistry analyzer. The pathomorphological changes of renal tissues were observed with light and electron microscopes.

Results

In the untreated group, the 24-h urine protein excretion, serum TC, TG, LDL, Cr and BUN were significantly higher than those in the normal control group (P<0.05 or P<0.01), while the serum TP, Alb, HDL were significantly lower than those in the normal control group (P<0.01). In the CLGQD-treated group, the 24-h urine protein excretion, serum TC, TG, LDL, Cr and BUN were significantly lower as compared with those in the untreated group (P<0.05 or P<0.01), while the serum TP, Alb and HDL were significantly higher as compared with those in the untreated group (P<0.05 or P<0.01). The pathomorphological findings of the renal tissues under the light microscope in the untreated group showed focal segmental glomerulosclerosis in a few of glomerulus, degenerated and swelled proximal tubular epithelial cells, proteins in cast formation in some renal tubules and scattered fibrosis in interstitial tissues of the kidney, while the electron microscope images showed the fusion of foot processes in glomerular epithelial cells. The pathomorphological changes in the CLGQD-treated group were slighter than those in the untreated group.

Conclusion

CLGQD combined with lumbrukinase can reduce proteinuria, regulate lipid metabolism, protect renal function, and delay progressive renal damage in rats.

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Pathogenetic characteristics and therapeutic approaches of aplastic anemia
Yong-ming Zhou, Ming-hui Hu
Journal of Chinese Integrative Medicine    2003, 1 (1): 74-76.   DOI: 10.3736/jcim20030130
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According to TCM theory of the wholistic concept and the principles of sydrome differentiation and treatment, the characteristics of the pathogenesis of aplastic anemia (AA) were summarized and corresponding treatment was put forward on the basis of clinical observation and the study of literature. In the pathogenesis of AA, the deficiency of spleen and kidney is the primary aspect, fire attacking blood vessels is the secondary aspect and there is change because of blood stasis. In treatment,the method of invigorating spleen and tonifying kidney is adopted in order to get at the root, and releasing fire to stop bleeding is adopted in order to bring about a temporary solution, and activating blood circulation to dissipate blood stasis is adopted in order to produce blood. The outline should be caught hold of that consumption is primary aspect and fire is secondary aspect and there is change because of blood stasis in order to obtain satisfactory curative effect.

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Research advances in the mechanisms of antitumor activity of Epimedium brevicornum Maxim. and its effective components
Jian-yun Yin, Hong-feng Chen
Journal of Chinese Integrative Medicine    2009, 7 (12): 1184-1187.   DOI: 10.3736/jcim20091218
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Successful use of Zhengwu Decoction in treating eye diseases: Case report
Ya-qin Ru
Journal of Chinese Integrative Medicine    2005, 3 (1): 61-62.   DOI: 10.3736/jcim20050119
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Professor Tang Han-Jun's experience in treating postoperative fistulas
Wei Shan, Han-jun Tang, Chong-yu Zhang
Journal of Chinese Integrative Medicine    2005, 3 (3): 235-237.   DOI: 10.3736/jcim20050321
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Qualitative research of the elderly real experience of long-term adherence to Tai Chi exercise
Xue Qiao, Yu-fang Hao
Journal of Chinese Integrative Medicine    2012, 10 (12): 1388-1393.   DOI: 10.3736/jcim20121209
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Objective: To explore the experience of the process of Tai Chi exercise
Methods: The study was conducted in a local park in Beijing of China where varying numbers of community members gathered to practice Tai Chi every day. Volunteers meeting the inclusion and exclusion criteria were recruited after signed an informed consent form. In-depth interview and the participatory observation were used to know of the real feeling of practicing Tai Chi. The qualitative data obtained from the interviews were analyzed by using Colaizzi seven-step method to find the subjects.
Results: Six volunteers having a long-time Tai Chi exercise were recruited in this qualitative study, and their real experience was summarized in the physiological level, psychological level, social level and cultural level. In the physiological level, Tai Chi improves the health and exercise of Tai Chi assists the elderly to develop good living habits. In the psychological level, Tai Chi practice guides the person to inner peace, relieves tension, improves depressive mood state, and makes the elderly regain self worth. In the social level Tai Chi is a good form of community practice. In the cultural level, Tai Chi roots in yin and yang culture and integrates internal and external exercises.
Conclusion: Tai Chi is good for body and mind health and the community of practice is very important for practitioners. Tai Chi gains popularity for its benefits to health and psychological adjustments, and its cultural connotation.

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Traditional Chinese medicine in prevention and treatment of liver cancer: function, status and existed problems
Meng-chao Wu
Journal of Chinese Integrative Medicine    2003, 1 (3): 163-164.   DOI: 10.3736/jcim20030302
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Progress in experimental research on apoptosis of hepatic cancer cells induced by Chinese herbs
Jian Chen
Journal of Chinese Integrative Medicine    2004, 2 (4): 301-303.   DOI: 10.3736/jcim20040422
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Cited: Baidu(2)
ISSN 2095-4964
CN 31-2083/R

Editors-in-Chief:
Changquan Ling, Shanghai, China
Lixing Lao, Virginia, USA
Frequency: 6 issues per year
Publisher: Science Press, China

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