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Analysis of studies on pattern recognition of tongue image in traditional Chinese medicine by computer technology
Xiao-qiang Yue, Qing Liu
Journal of Chinese Integrative Medicine    2004, 2 (5): 326-329.   DOI: 10.3736/jcim20040503
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The article analyzed the contemporary study of pattern recognition of tongue images in traditional Chinese medicine by computer technology from its key sectors. It regards that the methods of orthogonal design and evaluation of image quality should be introduced to get a high-quality and practicable condition. In the field of tongue image segmentation, multiple methods used together are expected to improve the effect of segmentation. A scientific and canonical standard of tongue diagnosis based on comprehensive experts' experience with Delphi evaluation method and multi-center experts diagnosis on internet are also very essential. The study of pattern recognition on tongue image is still concentrated on the color. Further study should be extended to achieve quantification. And a comprehensive diagnosis on pattern recognition of tongue image is the aim that should be focused on later.

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Progress in pharmacotherapy of integrated traditional Chinese and western medicine for virus infection in respiratory tract
Yu-hua Liu, Jing-cheng Dong
Journal of Chinese Integrative Medicine    2004, 2 (3): 226-227.   DOI: 10.3736/jcim20040325
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History and development of spinology
Qi Shi, Yong-jun Wang
Journal of Chinese Integrative Medicine    2003, 1 (4): 304-308.   DOI: 10.3736/jcim20030423
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Spinal disease is the injury caused by congenital malformation, degeneration, inflammation and trauma. These injuries lead to structural lesion of spinal itself, intervertebral discs, spinal cord, nerve root and the attachment, and can cause spinal and associated diseases. Spinal diseases include some frequently encountered diseases, as well as some stubborn and serious diseases. These diseases may cause pain of head and neck, shoulder and arm, waist and leg when they are mild, and partial or thorough paralysis when they are serious. In this article, the history, development, foundations and research progress of non-surgical operation of spinal diseases and the developing tendency of modern spinology are introduced.

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Cited: Baidu(24)
Accidents in acupuncture treatment: History and current state
Ren Zhang
Journal of Chinese Integrative Medicine    2004, 2 (4): 306-313.   DOI: 10.3736/jcim20040424
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Acupuncture is widely used as an alternative therapy with few side effects because of its simple manipulation and low cost. However, accidents may occur if the practitioner uses it improperly. Early in the Qin dynastuy, the Canon of Medicine mentioned that improper use of acupuncture could cause injury to the body and even death, and it systematically described the occurrence and prevention of acupuncture accidents. Physicians in the successive dynasties frequently reported it, and nealized that the manipulation skills were significantly important in preventing the occurrence of acupuncture accidents.Since the 1950s, acupuncture accidents had been effectively prevented because of the improving of acupuncture instruments, enhancing of the quality of the practitioners, popularizing of sterilization and disseminating of anatomic knowledge. Nevertherless, with the renovating of acupuncture techniques, new accidents may occur constantly. The prevention of acupuncture accidents still should be an arduors task for acupuncturists. Nowadays, acupuncture therapy is being used in more than 140 countries, and acupuncture accidents due to improper application are incrcasing. Prevention of acupuncture accidents has become a global issue deserving of great attention.

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Progress of research on mechanism of salvia miltiorrhiza and its chemical ingredients against liver fibrosis
Yan-yan Tao, Cheng-hai Liu
Journal of Chinese Integrative Medicine    2004, 2 (2): 145-148.   DOI: 10.3736/jcim20040223
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Progress in research on Chinese herbs with estrogen-like effects
Xiao-xiao Zhang, Sheng Liu, Xiao-hong Xue
Journal of Chinese Integrative Medicine    2005, 3 (2): 149-153.   DOI: 10.3736/jcim20050219
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A study on English translation of antithesis in Neijing
Ping Li, Yun-zhong Shi
Journal of Chinese Integrative Medicine    2012, 10 (7): 832-836.   DOI: 10.3736/jcim20120716
Online available: 15 July 2018

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Successful use of Zhengwu Decoction in treating eye diseases: Case report
Ya-qin Ru
Journal of Chinese Integrative Medicine    2005, 3 (1): 61-62.   DOI: 10.3736/jcim20050119
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Progress in research on hirudo
Rong-qing Huang, Xiao-dong Sun, Yang-ling Li, Hong Wang
Journal of Chinese Integrative Medicine    2004, 2 (5): 387-389.   DOI: 10.3736/jcim20040523
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Establishment of Caco-2 cell monolayer model and standard operation procedure for assessing intestinal absorption of chemical components of traditional Chinese medicine
Xiu-wei Yang, Xiao-da Yang, Ying Wang, Lian Ma, Yue Zhang, Xiao-gai Yang, Kui Wang
Journal of Chinese Integrative Medicine    2007, 5 (6): 634-641.   DOI: 10.3736/jcim20070607
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Objective: To establish Caco-2 (a human colon adenocarcinoma cell line) cell monolayer model and the standard operation procedure for studying and assessing intestinal absorption of chemical components of traditional Chinese medicine.Methods: Caco-2 cell monolayer model was established and evaluated by morphology feature using scanning electron microscope, inverted microscope and transepithelial electrical resistance (TEER) assay. Additionally, the model was further tested for the activity of alkaline phosphatase and the apparent permeability (Papp) of standard compounds, i.e. propranolol and atenolol, which were the control substances for high and poor transcellular transport marker, respectively.Results: The integrality of cell monolayer, cell differentiation (reflected by expression of alkaline phosphatase and cell monolayer morphology), and the Papp value of standard compounds in the established Caco-2 cell model were satisfactory. All parameters tested were in good agreement with those reported in the literature.Conclusion: The established Caco-2 cell model can be used to study the intestinal absorption of orally administrated chemical components of traditional Chinese medicine and their absorption mechanism.

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Recognition on toxicity of traditional Chinese drugs
Chao-qin Yu
Journal of Chinese Integrative Medicine    2003, 1 (4): 252-254.   DOI: 10.3736/jcim20030405
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Our ancestor found that some of the Chinese herbal drugs were toxic during their clinical practice. They graded the toxicity of Chinese herbal drugs into three degrees and thought that the term "toxicity of the Chinese herbal drugs" could be used in a broad and a narrow sense. In modern times, toxic components of the Chinese herbal drugs and their toxic mechanisms, especially the toxicity on the kidney, were further revealed. The factors that affect the toxicity of the Chinese herbal drugs include the species, preparation, dose and environment. To prevent the toxicity of the Chinese herbal drugs, we must strengthen the management of the Chinese herbal drugs. On the other hand, doctors' recognition of the toxicity of Chinese herbal drugs should be enhanced. At the same time, patients should be told to decoct and take Chinese herbal drugs correctly.

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Traditional Chinese medicine in prevention and treatment of liver cancer: function, status and existed problems
Meng-chao Wu
Journal of Chinese Integrative Medicine    2003, 1 (3): 163-164.   DOI: 10.3736/jcim20030302
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Clinical outcome assessment and the effect measure
Hong-wei Zhang, Jian-ping Liu, Xia Wan, Yan-ke Ai
Journal of Chinese Integrative Medicine    2007, 5 (5): 497-501.   DOI: 10.3736/jcim20070503
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Effect of clinical intervention on human body is multistage and multifaceted, involving physiology, psychology, social function and the surrounding resources, etc. Therefore, the range of clinical outcome assessment includes patient, his or her family and care giver. The evaluation of clinical intervention mainly focuses on its effectiveness, safety and health economics. Effects of clinical interventions are measured by comparisons of the outcome of intervention and control groups. Different effect measures come from different comparisons.

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Cited: Baidu(5)
Origination and development of syndrome concept in traditional Chinese medicine
Lei Guo​, Yong-yan Wang​, Zhi-bin Zhang​, Jun-long Zhang​
Journal of Chinese Integrative Medicine    2006, 4 (4): 335-338.   DOI: 10.3736/jcim20060403
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In the opinion of dialectical materialism, concept is developing with the deepening and broadening of human being's mind. The developing process of syndrome concept in traditional Chinese medicine also takes the same way. In the Sui and Tang Dynasties, the connotation of syndrome concept was defined and the embryonic form of syndrome differentiation of zang-fu viscera was formed. In the Song, Jin and Yuan Dynasties, the development of syndrome concept embodied in optimizing the theoretical research based on clinical practice and experiences according to many medical masters in different denominations. The syndrome differentiation of eight principles was established to standardize and perfect the principles of syndrome differentiation in the Qing Dynasty. Modern research of syndrome concept is manifested in objectifying the process of research of syndrome and diseaes in different levels and aspects by use of advanced scientific technology.

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Cited: Baidu(13)
Efficacy of ginsenosides combined with prednisone in patients with systemic lupus erythematosus: a prospective, randomized, double-blind, placebo-controlled trial
Yan-liYou, Ying-lu Feng, Qing Cai, Jian-long Guan, Lan-ling Zhang, Mei-juan Xu, Xia Xu , Chang-quan Ling
Journal of Chinese Integrative Medicine    2010, 8 (8): 762-766.   DOI: 10.3736/jcim20100806
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Background

The side effects of glucocorticoid in treatment of systemic lupus erythematosus (SLE) have been the focus of debate, and our preliminary study indicates that ginsenosides can enhance the efficacy of dexamethasone.
Objective

To observe the effects of ginsenosides combined with prednisone in SLE patients.
Design, setting, participants and interventions

A total of 60 SLE patients from Department of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, were randomly divided into treatment group and control group, with 30 patients in each group. Patients in the treatment group were given routine treatment with prednisone plus ginsenosides, while those in the control group were given routine treatment with prednisone plus placebo. They were all treated for 3 months.
Main outcome measures

After three-month treatment, syndrome score in traditional Chinese medicine (TCM), total response rate and symptom improvement rate were measured and evaluated.
Results

Twenty-eight cases in treatment group and twenty-seven cases in control group were included in analysis. The total response rates in the treatment group and control group were 89.28% and 66.67% respectively, and there was a significant difference between the two groups (P<0.05). After treatment, the TCM syndrome scores in the two groups were lower than those before treatment (P<0.01), and prednisone plus ginsenosides was better in decreasing the TCM syndrome score than prednisone plus placebo (P<0.05). The symptoms were improved in the treatment group as compared with the control group (P<0.05).
Conclusion

Prednisone combined with ginsenosides can increase the clinical effective rate and improve the clinical symptoms of SLE patients.

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Principles for English translation of the terms in traditional Chinese medicine
Chuan-yue Niu
Journal of Chinese Integrative Medicine    2004, 2 (6): 474-476.   DOI: 10.3736/jcim20040622
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Historical change of the meaning of words and its influence on the translation of traditional Chinese medicine
Chuan-yue Niu
Journal of Chinese Integrative Medicine    2005, 3 (5): 411-415.   DOI: 10.3736/jcim20050522
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Distribution characteristics of common syndrome types and syndrome elements extracted by experts' experience in perimenopausal and postmenopausal women
Yi Xin, Tian-fang Wang, Cai-feng Du, Li Li, Jie Ren, Zhe Jin, Hong Zhao, Xiao-juan Zou , Hong-qi Liu, Ying Chen, Li-na Wang, Rui-fen Liu, Qing-guo Wang
Journal of Chinese Integrative Medicine    2009, 7 (6): 522-526.   DOI: 10.3736/jcim20090606
Abstract930)   HTML3)    PDF(pc) (1085KB)(111)      

Objective

To compare the distribution characteristics of common syndrome types and syndrome elements of menopause syndrome in perimenopausal and postmenopausal women on the basis of standardized syndrome differentiation extracted by experts' experiences.

Methods

A total of 1 582 outpatients with menopause syndrome who met with the diagnosis and inclusion criteria in seven grade 3 hospitals from October 2006 to June 2007 were included. A clinical epidemiological survey in the patients was carried out. The syndrome elements of disease location and characteristics were extracted and analyzed statistically by standardizing the syndrome differentiation of experts' experience in traditional Chinese medicine.
Results

There were 105 syndrome types after initial standardization, and the common syndrome types were kidney yin deficiency, deficiency of liver and kidney yin, stagnation of liver qi, and deficiency of both kidney yin and yang. Six syndrome elements of the disease location were extracted, among which the common elements were kidney, liver, spleen and heart. Seventeen syndrome elements of the disease characteristics were extracted, among which the common elements were yin deficiency, qi stagnation, qi deficiency, yang deficiency and deficiency. Syndrome types of stagnation of liver qi, deficiency of spleen and kidney, and qi stagnation were more frequently diagnosed during perimenopausal period, while the syndrome type of kidney yin deficiency was more frequently diagnosed during postmenopausal period, and the kidney was the main disease location. The distribution characteristics of the other syndrome types and elements were similar during the two periods.
Conclusion

The syndrome type distribution in women with menopause syndrome is complex, while the syndrome element distribution is simple. Generally, the syndrome type and syndrome element distributions during perimenopausal and postmenopausal periods are similar, but there are significant differences in some syndrome types and syndrome elements between the two periods. All of these can give support for revealing the distribution rule of the common syndrome types and syndrome elements and give a theoretical basis for clinical treatment of menopause syndrome.

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The study of intoxication and toxicity of Fructus Xanthii
Xue-mei Zhang, Zhong-hua Zhang
Journal of Chinese Integrative Medicine    2003, 1 (1): 71-74.   DOI: 10.3736/jcim20030129
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Fructus Xanthii is commonly used in rhinology, especially used in treatment of chronic rhinitis and sinusitis. But Fructus Xanthii is toxicant, and it maybe result in poisoning when used excessively, without preparation or in inappropriate preparation. This article reviewed all poisoning cases from 1960 to 2000, its toxicology and methods for detoxification.

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Cited: Baidu(16)
Tongue conditions and constitution
Tiao-yuan Kuang
Journal of Chinese Integrative Medicine    2004, 2 (4): 264-264.   DOI: 10.3736/jcim20040407
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Progress in research on chronic fatigue syndrome
Shu-yun Jiang, Jun-tao Yan, Min Fang
Journal of Chinese Integrative Medicine    2004, 2 (6): 459-463.   DOI: 10.3736/jcim20040619
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Review and reflection on history of English translation of traditional Chinese medicine
Deng-feng Zhang, Jun-mei Xue, Yang Tian, Lin Li
Journal of Chinese Integrative Medicine    2006, 4 (5): 548-550.   DOI: 10.3736/jcim20060525
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Cited: Baidu(1)
Relationship between symptom stratification and syndrome differentiation of traditional Chinese medicine for depressive episode
Sui Yue Hu, Su E Wang, Chun Hu Zhang
Journal of Chinese Integrative Medicine    2011, 9 (9): 933-936.   DOI: 10.3736/jcim20110902
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On the basis of medical literature review and clinical research experience, the authors analyzed the reasons for low recognition rate of depression and poor progress of traditional Chinese medicine (TCM) differentiation of depression in this paper and put forward that depressive episode symptoms and the corresponding common terminology classification of Chinese and Western medicine should be the breakthrough points. Through symptom stratification and combination, as well as distinguishing between primary and secondary symptoms, the comprehensive integrative medicine clinical assessment of depression was explored so as to further obtain expert consensus and provide a methodology reference for the TCM differentiation of depression and the research of etiology and pathogenesis.

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Pondering on the diagnosis and treatment criteria for syndromes of epilepsy in traditional Chinese medicine
Jin-min Liu, Tao Jiang
Journal of Chinese Integrative Medicine    2006, 4 (6): 572-574.   DOI: 10.3736/jcim20060605
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International League Against Epilepsy announced the new International Classification of Epilepsy in 2001. One of the main objectives of the project is to adopt standard terms to describe seizure phenomena according to the terminological database. The project may profit academic communication and resource integration, and provide evidence for the individual treatment for epilepsy. Treatment based on syndrome differentiation is one of the characteristics of the treatment for epilepsy in traditional Chinese medicine (TCM). As far as the individuation on diagnosis and treatment is concerned, TCM and Western medicine present to reach the same goal by different routes gradually for the treatment of epilepsy. But for TCM, the diagnosis and treatment criteria for epilepsy are imperfect and the experts, opinions are not unified, so that the treatment based on syndrome differentiation becomes confused, hence the credit of treatment based on TCM is restricted accordingly. It is necessary to formulate advanced diagnosis and treatment criteria for syndromes of epilepsy in TCM.

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Effects of Wenshen Jianpi Recipe on chronic wound healing in rats
Yong-qing Cao, Chun-mei He, Jin-gen Lu
Journal of Chinese Integrative Medicine    2005, 3 (3): 220-223.   DOI: 10.3736/jcim20050315
Abstract967)   HTML2)    PDF(pc) (92KB)(112)      

Objective

To study the effects of Wenshen Jianpi Recipe (WSJPR, a traditional Chinese medicine for warming kidney and invigorating spleen) on chronic wound healing and the mechanism.

Methods

Ninety-six SD rats were randomly divided into 4 groups, with 24 rats in each group, and back wound was made in the rats. For rats in 3 of the 4 groups, hydrocortisone injection was administered to induce chronic wound. Rats in 2 of the 3 groups were treated with WSJPR and Xinpukang Granules (XPKG) respectively, and the rats in the other group were untreated. The rats in the fourth group were taken as control. The wound healing time and the width of new epidermis were observed, and the histomorphological changes and cell cycle of the granulation tissue, and the protein expressions of epidermal growth factor (EGF), transforming growth factor-β1 (TGF-β1) and fibronectin (FN) in the granulation tissue were tested with immunohistochemical technique and flow cytometry.

Results

The wound healing time of the WSJPR-treated and XPKG-treated groups was (17.0±1.9) and (18.8±1.9) d respectively, much shorter than that of the untreated and control groups (P<0.05). On the 14th experiment day, the width of new epidermis of the WSJPR-treated and XPKG-treated groups was (3.73±0.19) and (3.21±0.15) mm respectively, much wider than that of the untreated and control groups (P<0.05). The numbers of angiogenesis, fibroblasts and cells in the S phase in WSJPR-treated and XPKG-treated groups were much higher than those in the untreated and control groups (P<0.05). Compared with the untreated and control groups, the protein expressions of EGF, TGF-β1 and FN in WSJPR-treated and XPKG-treated groups were higher (P<0.05).

Conclusion

WSJPR can enhance the wound healing. It was likely through accelerating the cell proliferation and up-regulating the expressions of EGF, TGF-β1 and FN.

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A study of the mechanism of Qingre Huatan therapy in treatment of acute exacerbation of chronic obstructive pulmonary disease by improving airway inflammation and mucus hypersecretion
Weng Li, Bing Mao, Gang Wang, Lei Wang, Jing Chang, Ying Zhang, Mei-hua Wan, Jia Guo
Journal of Chinese Integrative Medicine    2008, 6 (8): 799-805.   DOI: 10.3736/jcim20080806
Abstract997)   HTML2)    PDF(pc) (1376KB)(97)      

Objective: To explore the effects of Tanreqing injection, a traditional Chinese herbal preparation for clearing heat and resolving phlegm, in treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) by improving airway inflammation and airway mucus hypersecretion.
Methods: A randomized controlled trial (RCT) was designed. Ninety AECOPD patients were randomly divided into Tanreqing group, ambroxol hydrochloride group and control group. The patients in the three groups were all treated with conventional therapy. Furthermore, intravenous drip infusion of 20 ml Tanreqing injection (once daily) and 15 mg ambroxol hydrochloride injection (twice daily) were administered respectively to the patients in the Tanreqing group and ambroxol hydrochloride group. They were all treated for 10 days. Symptom score of traditional Chinese medicine (TCM), plasma concentrations of interleukin-8 (IL-8), IL-10 and neutrophil elastase (NE) were detected before and after treatment.
Results: Cough, sputum amount, expectoration, dyspnea, fever, coated tongue and pulse tracings were improved obviously in Tanreqing group (P<0.05), and the effects of Tanreqing on improving cough, sputum amount and expectoration were better than the conventional therapy (P<0.05), while there was no significant difference between Tanreqing group and ambroxol hydrochloride group (P>0.05). Compared with ambroxol hydrochloride group and the control group, the coated tongue was improved obviously in Tanreqing group (P<0.05). After treatment, plasma concentrations of IL-8, IL-10 and NE were decreased in Tanreqing group and ambroxol hydrochloride group (P<0.05), and the levels of IL-8 and IL-10 in the control group were decreased (P<0.05). The change of IL-8 level before and after treatment in Tanreqing group was greater than that in ambroxol hydrochloride group and the control group. The changes of IL-10 and NE levels in ambroxol hydrochloride group were greater than those in Tanreqing group and the control group, while there was no significant difference in the changes of serum levels of IL-8, IL-10 and NE among the three groups (P>0.05). Total response rates in Tanreqing group and ambroxol hydrochloride group were higher than that in the control group (P<0.05), while there was no significant difference in total response rate between Tanreqing group and ambroxol hydrochloride group (P>0.05). There was no significant difference in total response rate among the three groups (P>0.05).
Conclusion: Tanreqing injection can improve TCM signs and symptoms in AECOPD patients, and the mechanism may be due to the decrease of serum levels of IL-8 and NE and improvement of IL-10 level.

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Cited: Baidu(23)
Rule of tonifying the kidney in regulating T lymphocyte apoptosis in syndrome of kidney-yang deficiency—plasticity of gene balance
Zi-yin Shen
Journal of Chinese Integrative Medicine    2004, 2 (5): 321-322.   DOI: 10.3736/jcim20040501
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Dr. Miriam Lee: A heroine for the start of acupuncture as a profession in the State of California
Arthur Yin Fan, Ziyi Fan​
Journal of Integrative Medicine    2014, 12 (3): 182-186.   DOI: 10.1016/S2095-4964(14)60016-9
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Cited: Baidu(8)
Three-factor designs unable to examine the interactions (Part 1)
Liang-ping Hu, Xiao-lei Bao
Journal of Chinese Integrative Medicine    2012, 10 (10): 1088-1091.   DOI: 10.3736/jcim20121004
Online available: 15 October 2018

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Three-factor designs that are unable to examine the interactions include crossover design and Latin square design, which can examine three factors, namely, an experimental factor and two block factors. Although the two design types are not quite frequently used in practical research, an unexpected research effect will be achieved if they are correctly adopted on appropriate occasions. Due to the limit of space, this article introduces two forms of crossover design.

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Prevention and treatment of pulmonary-fibrosis by traditional Chinese medicine
Chu-fang Yao, Shu-long Jiang
Journal of Chinese Integrative Medicine    2003, 1 (3): 234-238.   DOI: 10.3736/jcim20030327
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Pulmonary-fibrosis (PF) is the result of interstitial lung disease which has different causes and it is one of the most intractable diseases in respiratory system. The PF is characterized by progressive difficulty of breath and dying of respiratory failure, seriously threatening the health of people. Immunosuppressive drugs and glucocorticoids have been widely adopted as the main methods in treatment, but the results are not satisfactory and the side effects are obvious. Many specialists have tried traditional Chinese medicine in recent years with satisfactory effect, indicating that the prospect of using traditional Chinese medicine in the treatment of PF is optimistic. This article outlines the researches about using traditional Chinese medicine in the treatment of PF.

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Cited: Baidu(9)
Antinociceptive, anti-inflammatory and antidiarrheal activities of ethanolic calyx extract of Hibiscus sabdariffa Linn. (Malvaceae) in mice
Khadem Ali Md., Ashraf Ayesha, Nath Biswas Nripendra, Kumar Karmakar Utpal, Afroz Shamima
Journal of Chinese Integrative Medicine    2011, 9 (6): 626-631.   DOI: 10.3736/jcim20110608
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Objective: To evaluate the antinociceptive, anti-inflammatory and antidiarrheal activities of the ethanolic calyx extract of Hibiscus sabdariffa Linn. in mice.
Methods: In the present study, the dried calyxes of H. sabdariffa were subjected to extraction with 95% ethanol and the extract was used to investigate the possible activities. Antinociceptive activity of the extract was evaluated by using the acetic acid-induced writhing test. The anti-inflammatory effect of the extract was tested by using the xylene-induced ear edema model mice. Castor oil-induced diarrheal model mice were used to evaluate the antidiarrheal activity of the extract.
Results: In acetic acid-induced writhing test, the extract produced inhibited writhing in mice siginificantly compared with the blank control (P<0.01). The extract showed significant inhibition of ear edema formation in xylene-induced ear edema model mice in a dose-related manner compared with the blank control (P<0.01). The extract demonstrated a significant antidiarrheal activity against castor oil-induced diarrheal in mice in which it decreased the frequency of defecation and increased the mean latent period at the doses of 250 and 500 mg/kg body weight (P<0.01).
Conclusion: The above mentioned findings indicate that the calyx extract of H. sabdarif fa possesses significant antinociceptive, anti-inflammatory and antidiarrheal activities that support its uses in traditional medicine.

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Effects of taraxerol and taraxeryl acetate on cell cycle and apoptosis of human gastric epithelial cell line AGS
Bao Tan, Hai-lian Shi, Guang Ji, Jian-qun Xie
Journal of Chinese Integrative Medicine    2011, 9 (6): 638-642.   DOI: 10.3736/jcim20110610
Abstract1034)   HTML3)    PDF(pc) (820KB)(251)      

Objective: To investigate the effects of taraxerol and taraxeryl acetate on cell cycle and apoptosis of human gastric epithelial cell line AGS cells.
Methods: The inhibitory effects of taraxerol and taraxeryl acetate at different concentrations on AGS cell growth were measured by 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method and the concentrations of taraxerol and taraxeryl acetate to be used in following experiments were decided. Then, cell cycle analysis was performed by FACScan flow cytometry after culture with taraxerol or taraxeryl acetate. Annexin V-fluorescein isothiocyanate/propidium iodide staining was used to measure cell apoptosis.
Results: Taraxerol significantly inhibited AGS cell proliferation in a dose- and time-dependent manner. Taraxerol arrested the AGS cells at G2/M stage. 110 μmol/L taraxerol elevated the population of AGS cells arrested in G2/M phase compared with solvent (P<0.05). Taraxerol also promoted early cell apoptosis in AGS cells. 110 μmol/L taraxerol increased the early cell apoptosis rate from 4.45% to 10.29%, which was 1.31 times higher than that of the untreated cells. However, taraxeryl acetate had a lower inhibitory effect than taraxerol, and it showed a tendency of G2/M arrest and apoptosis promotion but with no statistical significance (P>0.05).
Conclusion: Taraxerol has inhibitory effects on AGS cell growth through inducing G2/M arrest and promotion of cell apoptosis. Taraxeryl acetate has less effect on cell cycle arrest and apoptosis of AGS cells than taraxerol.

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Multicenter clinical study about the action of Fuzheng Huayu Capsule against liver fibrosis with chronic hepatitis B
Ping Liu, Yi-yang Hu, Cheng Liu, Lie-ming Xu, Cheng-hai Liu, Ke-wei Sun, De-chang Hu, You-kuan Yin, Xia-qiu Zhou, Mo-bin Wan, Xiong Cai, Zhi-\qing Zhang, Jun Ye, Bao-zhang Tang, Jia He
Journal of Chinese Integrative Medicine    2003, 1 (2): 89-98.   DOI: 10.3736/jcim20030204
Abstract991)   HTML3)    PDF(pc) (199KB)(317)      

Objective

To study the efficacy and safety of Fuzheng Huayu Capsule (FZHY Capsule) against liver fibrosis with chronic hepatitis B.


Methods

Multicentric, randomized, double blinded and paralleled control led trial was conducted on patients (aged between 18 and 65) with liver fibrosis in chronic hepatitis B.Indexes observed: (1) hepatic histological changes and HBV markers were observed at 0 and 24th week during the treatment; serological indexes (HA, LN, P-Ⅲ-P, Ⅳ-C) were determined and B ultrasound examination of spleen and liver was taken at 0, 12th, 24th week; liver function (during the period of follow-up, liver function and serological indexes for liver fibrosis were evaluated) were observed at 0, 6th, 12th, 18th, 24th week; (2) indexes for safety: blood and urine routine tests, renal function and ECG were examined.


Results

(1) Enrollment and demographic data: There was no significant difference between the trial (110 cases) and control group (106 cases) in demographic feature, vital signs, course of illness,history for drug anaphylaxis, history of previous therapy, liver function, serological indexes for liver fibrosis, liver histological examination (99 cases for test group, 96 cases for control group), HBV markers, and renal function, etc. (2) Histological pathological examination: 93 cases of liver histological examination were taken, of these 50 cases for the trial group and 43 cases for control group which turned out to be at S mean value of 2.33 and 2.11 respectively pretreatment according to criteria for liver fibrosis staging. Post-treatment, the trial showed a significant decrease with S value of 1.80 compared to that of pretreatment; however, there was no significant improvement in control group before and after the treatment with S mean value of 2.14. There was significant difference in reversing rate (decrease at least 1 stage according to criteria for liver fibrosis staging) between the trial (52%) and control (23.3%) after liver biopsy. The trial had a rather good effect on improving inflammatory activity and was superior to control group with a marked decrease of mean value of inflammatory activity and score of inflammation (P<0.05). (3) Serological indexes for liver fibrosis: There was a significant decrease in HA, LN, P-Ⅲ-P, Ⅳ-C content in test group after 12 and 24 weeks' treatment compared to that of pretreatment; the differences of HA, LN, P-Ⅲ-P, Ⅳ-C between 12 , 24 weeks' treatment and pretreatment were significantly greater than control group (P<0.01 or 0.05); the effectual was defined as 2 of 4 indexes lowered more than 30% of the baseline, according to this criteria, the trial was 72.7%, while control group 27.4% (P<0.01). (4) Liver function: Obvious improvement of serum Alb, ALT, AST, GGT was seen in 2 groups; compared with control group, marked improvement of GGT and Alb in the trial (P<0.05); the effective rate of serum ALT in the trial group was 72.7%, while control 59.4%. (5) No changes of significant difference between pre- and post-treatment in routine tests for blood and urine, renal function and ECG, etc. There was also no difference in the stable rate of ALT and serological indexes for liver fibrosis between the trial and control group 12 weeks after withdrawal (P<0.05).


Conclusion

Fuzheng Huayu Capsule has good effect on alleviating liver fibrosis in chronic hepatitis B without any adverse effect and is superior to Heluo Shugan Capsule. Fuzheng Huayu Capsule is a safe and effective medicine for the treatment of liver fibrosis in chronic hepatitis B.

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Effects of Astragalus membranaceus and Potentilla discolor mixture on insulin resistance and its related mRNA expressions in KKAy mice with type 2 diabetes
Dong-mei Zhang, Li-xia Lou, Ai-ming Wu, Xi-ying Lü, Zhao-juan Hu, Yan-hong Zhang, Hong-fang Liu
Journal of Chinese Integrative Medicine    2012, 10 (7): 821-826.   DOI: 10.3736/jcim20120714
Online available: 15 July 2018

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Objective: To investigate the effects of Astragalus membranaceus and Potentilla discolor mixture (APM) on insulin resistance (IR) and mRNA expressions of IR-related genes, including phosphatidylinositol 3-kinase (PI3-K), phosphoenolpyruvate carboxykinase (PEPCK) and peroxisome proliferator-activated receptor γ coactivator 1 (PGC1) in KKAy mice with early type 2 diabetes and to explore the gene regulation mechanisms of AMP.
Methods: After giving short-term high-fat and high-calorie diet to induce type 2 diabetes, male KKAy mice were randomly divided into model and APM groups. Nine C57BL/6J mice were used as normal control in addition. The mice in the APM group were treated with 830 g/L of the APM liquid by gastric infusion while the mice in the model group and the normal control group were given 0.05% sodium carboxymethyl cellulose at a dose of 0.1 mL/g body weight once per day. After four weeks, fasting plasma glucose (FPG) was tested using tail vein blood. Fasting serum insulin (FINS) was tested by radioimmunoassay. Insulin sensitivity index (ISI) was calculated as the natural logarithm of the product of FPG and FINS. The mRNA expressions of PI3-K, PEPCK and PGC1 in liver tissues were tested by real-time fluorescence quantitative polymerase chain reaction assay.
Results: Both the levels of FPG and FINS in the model group and the APM group were increased, while the ISI values were decreased when compared to those of the normal control group (P<0.01). The level of FPG in the APM group was decreased, while ISI was increased when compared to those of the model group (P<0.05). All of the mRNA expressions of PI3-K, PEPCK, and PGC1 in liver tissue of the model group were decreased compared with the normal control group (P<0.01). The mRNA expressions of PI3-K and PGC1 in the liver tissue of the APM group were higher than those in the model group (P<0.05).
Conclusion: APM can improve the insulin resistance of mice with type 2 diabetes. The mechanism may be related to increasing the mRNA expressions of PI3-K and PGC1 in the liver tissue.

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Medicinal potential of Passiflora foetida L. plant extracts: Biological and pharmacological activities
Md. Asadujjaman, Ahmed Ullah Mishuk, Md. Aslam Hossain, Utpal Kumar Karmakar
Journal of Integrative Medicine    2014, 12 (2): 121-126.   DOI: 10.1016/S2095-4964(14)60017-0
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Objective

To investigate analgesic, antidiarrhoeal and cytotoxic activities of the ethanol extract of Passiflora foetida L. (Passifloraceae) by three experimental methods. 

Methods

Analgesic activity of the ethanol extract of Passiflora foetida L. (EEPF) was carried out using acetic acid-induced writhing inhibition in mice. The method of castor oil-induced diarrhoea in mice was utilized to evaluate antidiarrhoeal activity. The cytotoxic activity of EEPF was explored with a brine shrimp lethality bioassay. 

Results

The extract showed 68.75% and 30.00% inhibition of writhe at the doses of 500 and 250 mg/kg body weight, respectively. The extract increased the mean latent period prior to diarrhoeal onset to about 1.55 h and 1.17 h, and decreased the mean number of stools to 4.4 and 5.6 at the doses of 500 and 250 mg/kg body weight. The extract also demonstrated cytotoxic activity in the brine shrimp lethality assay, and the median lethal concentration for brine shrimp nauplii was 80 μg/mL. 

Conclusion

The results suggest that the plant extract has analgesic and antidiarrhoeal activities, supporting its uses in traditional medicine. The results also demonstrate that the plant extract possesses cytotoxic activities.

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Cited: Baidu(15)
Comparative study on WHO Western Pacific Region and World Federation of Chinese Medicine Societies international standard terminologies on traditional medicine: Diseases of Gynecology and Obstetrics (Part 1)
Zhao-guo Li
Journal of Integrative Medicine    2014, 12 (2): 127-130.   DOI: 10.1016/S2095-4964(14)60014-5
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Heroea
Xun Li, Jian-ping Liu
Journal of Chinese Integrative Medicine    2007, 5 (6): 720-720.  
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Pondering on integration of traditional Chinese and Western medicine
Wen-jian Wang
Journal of Chinese Integrative Medicine    2006, 4 (2): 114-116.   DOI: 10.3736/jcim20060202
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Integration of traditional Chinese and Western medicine (ITCWM) plays an important role in developing traditional Chinese medicine. Implementing ITCWM is necessary in accordance with the developing rule of medical sciences and the optimum profits pursued in medical areas. In the face of challenge and problems, collaborating with international academic researchers interested in ITCWM, striving to resolve some problems and puzzles in basic and clinical research of ITCWM, introducing new methods and techniques from any other subjects into the research of ITCWM, and encouraging communication and cooperation among investigators from different scientific areas are suggested to be carried out. It is actually a great opportunity to develop ITCWM at present.

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Cited: Baidu(19)
Progress in research on pharmaceutics for intranasal medication
Tong Zhang, Lian-ying Xu
Journal of Chinese Integrative Medicine    2004, 2 (3): 223-225.   DOI: 10.3736/jcim20040324
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Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis
Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen
Journal of Chinese Integrative Medicine    2008, 6 (1): 41-44.   DOI: 10.3736/jcim20080109
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Objective:To investigate the expression of α-smooth muscle action (α-SMA) in the renal tubulointerstitium in patients with kidney collateral stasis.

Methods:The expression of α-SMA in the renal biopsy specimens from 54 patients with kidney collateral stasis was examined by immunohistochemical method.

Results:The degree of kidney collateral stasis was increased with the increasing of the degree of renal interstitial fibrosis (P<0.05), and there was significant positive correlation between kidney collateral stasis and α-SMA expression (P<0.05).

Conclusion:Kidney collateral stasis is one of the main reasons of renal fibrosis. With the increasing of kidney collateral stasis, MFBs in the renal interstitium proliferate obviously, becoming one of the most important causes of renal interstitial fibrosis.

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Pondering the standardization of basic terms in traditional Chinese medicine
Jian-pu Zheng, Ka Bian, Yan Ke
Journal of Chinese Integrative Medicine    2005, 3 (2): 166-168.   DOI: 10.3736/jcim20050223
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A brief introduction to Appraisal of Guidelines for Research and Evaluation Ⅱ
Xie Li-min, Wang Wen-yue
Journal of Chinese Integrative Medicine    2012, 10 (2): 160-165.   DOI: 10.3736/jcim20120206
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Clinical practice guidelines play an important role in practitioner and patient decisions regarding appropriate clinical health care and in health policy formation. In the guideline development process, inappropriate methodologies and development strategies significantly influence the quality of guidelines; therefore, research and evaluation of guidelines have great significance. The original Appraisal of Guidelines for Research and Evaluation (AGREE) instrument was published in 2003 by a group of international guideline developers and researchers. AGREE has important significance for the quality guarantee and successful implementation of guidelines, and has extensively achieved endorsement since 2003. In 2009, The AGREE Collaboration has developed the AGREE Ⅱ by refining the original AGREE instrument. At present, the AGREE Ⅱ has already replaced the original AGREE instrument; however, related introduction regarding AGREE Ⅱ has not been found in China. The authors of this article briefly introduce the AGREE Ⅱ, and believe that it will add value to research and evaluation of the guidelines.

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Discussion on six errors of formulas corresponding to syndromes in using the classic formulas
Bao Yan-ju, Hua Bao-jin
Journal of Chinese Integrative Medicine    2012, 10 (12): 1363-1370.   DOI: 10.3736/jcim20121205
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The theory of formulas corresponding to syndromes is one of the characteristics of Treatise on Cold Damage and Miscellaneous Diseases (Shanghan Zabing Lun) and one of the main principles in applying classic prescriptions. It is important to take effect by following the principle of formulas corresponding to syndromes. However, some medical practitioners always feel that the actual clinical effect is far less than expected. Six errors in the use of classic prescriptions as well as the theory of formulas corresponding to syndromes are the most important causes to be considered, i.e. paying attention only to the local syndromes while neglecting the whole, paying attention only to formulas corresponding to syndromes while neglecting the pathogenesis, paying attention only to syndromes while neglecting the pulse diagnosis, paying attention only to unilateral prescription but neglecting the combined prescriptions, paying attention only to classic prescriptions while neglecting the modern formulas, and paying attention only to the formulas but neglecting the drug dosage. Therefore, not only the patients’ clinical syndromes, but also the combination of main syndrome and pathogenesis simultaneously is necessary in the clinical applications of classic prescriptions and the theory of prescription corresponding to syndrome. In addition, comprehensive syndrome differentiation, modern formulas, current prescriptions, combined prescriptions, and drug dosage all contribute to avoid clinical errors and improve clinical effects.

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An overview of medicinal plant resource for decreasing blood glucose
Yun Zhu, Jin-rong Liu, Wei Zhang
Journal of Chinese Integrative Medicine    2004, 2 (1): 67-68.   DOI: 10.3736/jcim20040125
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Discussion of time and space differentiation of three-yin and three-yang in Shanghan Lun
Wen-hui Ma, Xiao-hong Sun
Journal of Chinese Integrative Medicine    2005, 3 (4): 257-259.   DOI: 10.3736/jcim20050402
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The concept of "three-yin and three-yang" in Shanghan Lun (Treatise on Cold Pathogenic Diseases), a classic written by Zhang Zhongjing in Han Dynasty, has been always the focus of dispute in successive dynasties. The essence of "three-yin and three-yang" has not been fully revealed up till now. Through studying the six divisions of day and night, the six diseases, the combination of syndromes, the complicated diseases, the complete recovery time and the space division of "three-yin and three-yang", the authors draw a conclusion that the "three-yin and three-yang" in Shanghan Lun is a concept of time-sequence, which is associated with the location of disease in space. So it is suggested that the "six diseases" in Shanghan Lun is a categorization for exogenous febrile diseases, and this categorization reveals a sort of inner relationship between the emergence, development, transformation of the febrile diseases and the time.

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English translation of cultural aspects of the titles of traditional Chinese medicine classics based on the skopos theory
Ji Chen, Qin Pan, Li-shuang Ye, Jia-ling Huang
Journal of Chinese Integrative Medicine    2012, 10 (11): 1316-1320.   DOI: 10.3736/jcim20121117
Online available: 15 November 2018

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Cited: Baidu(1)
Qualitative research of the elderly real experience of long-term adherence to Tai Chi exercise
Xue Qiao, Yu-fang Hao
Journal of Chinese Integrative Medicine    2012, 10 (12): 1388-1393.   DOI: 10.3736/jcim20121209
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Objective: To explore the experience of the process of Tai Chi exercise
Methods: The study was conducted in a local park in Beijing of China where varying numbers of community members gathered to practice Tai Chi every day. Volunteers meeting the inclusion and exclusion criteria were recruited after signed an informed consent form. In-depth interview and the participatory observation were used to know of the real feeling of practicing Tai Chi. The qualitative data obtained from the interviews were analyzed by using Colaizzi seven-step method to find the subjects.
Results: Six volunteers having a long-time Tai Chi exercise were recruited in this qualitative study, and their real experience was summarized in the physiological level, psychological level, social level and cultural level. In the physiological level, Tai Chi improves the health and exercise of Tai Chi assists the elderly to develop good living habits. In the psychological level, Tai Chi practice guides the person to inner peace, relieves tension, improves depressive mood state, and makes the elderly regain self worth. In the social level Tai Chi is a good form of community practice. In the cultural level, Tai Chi roots in yin and yang culture and integrates internal and external exercises.
Conclusion: Tai Chi is good for body and mind health and the community of practice is very important for practitioners. Tai Chi gains popularity for its benefits to health and psychological adjustments, and its cultural connotation.

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Study strategies for acupuncture treatment of chronic nonbacterial prostatitis
Zhuo-xin Yang, Peng-dian Chen, Hai-bo Yu, Min Pi, Wen-shu Luo, Yuan-yuan Zhuo
Journal of Chinese Integrative Medicine    2012, 10 (3): 293-297.   DOI: 10.3736/jcim20120307
Online available: 15 April 2018

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By retrospectively reviewing the current status of traditional Chinese medicine (TCM) and Western medicine treatments of chronic nonbacterial prostatitis (CNP), the TCM understanding of its etiologies and pathogenesis, the therapeutic principles and the mechanisms of acupuncture treatment of CNP, the clinical study strategies of acupuncture treatment for CNP were further proposed, which could provide more scientific basis and support for the definite longer-term therapeutic efficacy of acupuncture treatment of CNP. Breakthrough in the treatment of CNP will be achieved with the application of acupuncture therapy both in clinical practice and experimental research.

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Analysis on pulse diagram characteristics of subjects with subhealth state
Gui-xiang Chu, Qing-guang Chen, Jia-tuo Xu , Bo Yu , Min Zhang , Long-tao Cui , Hong-jin Wu , Zhao-fu Fei
Journal of Chinese Integrative Medicine    2012, 10 (10): 1099-1105.   DOI: 10.3736/jcim20121006
Online available: 15 October 2018

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Objective: To study the pulse diagram parameters of subjects with subhealth state and to find the pulse parameters for subhealth state evaluation. .

Conclusion: A total of 1 275 subjects without diagnosed diseases were recruited and their health conditions were assessed with Health Evaluating Questionnaire H20 V2009. The subjects were assigned to health group or subhealth group according to the scale score. Subjects’ syndrome in the subhealth group was differentiated using score of “subhealth state of syndrome differentiation V2010”. Another 121 patients with cardiovascular diseases were enrolled as a control. The pulse information was collected with YJJ-101 subhealth pulse monitoring system and the parameters include amplitude of main wave (h1), amplitude of repeat wave (h5) and its front wave (h3), 1/3 or 1/5 width of main wave (w1) or (w2), time of rapid ejection phase (t2), period of pulse (t), pulse pressure (Pp), square (S), area in systole (As) and area in diastole (Ad) of pulse diagram and ratios of h3/h1, h5/h1, w1/t, w2/t and h1/t1.

Results: Pulse diagram analysis showed significant differences among health, subhealth and disease group in Pp, h1, S and As and ratios of h5/h1 and w2/t. Compared with the health group, the values of w1/t and w2/t of the subhealth group increased (P<0.05), and Pp, h1, h5, h5/h1, S, As and Ad decreased (P<0.05). Compared with health group, the parameters of pulse of the subhealth group were increased in Pp and h5/h1 (P<0.05) and decreased in h1, w2/t, S and As (P<0.05). Compared with health group, pulse parameters h3/h1, w1, w1/t, w2/t of excess and deficiency syndrome group increased, and h1, h5, h1/t1 and h5/h1 decreased. Among different syndromes of subhealth state, pulse diagram parameters h1, h5, h3/h1, h5/h1 and w1/t of yin deficiency, qi deficiency, liver stagnation and excess heat group were significantly different (P<0.05) from the health group, for example, pulse parameters h1 and h5 of stagnation, yin deficiency, qi deficiency and excess heat group declined in order, and pulse parameters h3/h1 and w1/t of liver stagnation, excess heat, yin deficiency and qi deficiency group increased in order. Pulse index h1 in the kidney deficiency group was higher than that in the health group and the other syndrome groups.

Conclusion: Results of analyzing sphygmogram parameters showed different characteristics among different health status and the subhealth state due to different syndromes. Sphygmogram parameters may be used for objective evaluation of health status or subhealth syndrome differentiation.

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Gross conception of anatomical structure of zang-fu viscera in Huangdi Neijing
Ye-tao Gao, Hui-wei Pan​, Sheng-bing Wu​
Journal of Chinese Integrative Medicine    2006, 4 (4): 339-342.   DOI: 10.3736/jcim20060404
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The scientificalness of traditional Chinese medicine (TCM) is often doubted and criticized for the record in Huangdi Neijing that the liver is located in the left of the human body. The most popular explanation of this criticism is that the conception of zang-fu viscera in TCM is quite different from which defined in Western medicine. It means that the zang-fu viscera in TCM are not exactly the corresponding anatomical organs in modern human anatomy but reflect the functions of some systems in human body. According to the classical theories of TCM in Huangdi Neijing, we consider that the record of liver located in the left of the human body is based on the Ba Gua (Eight Diagrams) of traditional Chinese philosophy, not the human anatomy. In brief, the conception of zang-fu viscera is initially a gross anatomical conception, and in a sense the anatomic sites and functions of which are mostly similar to those described in Western medicine.

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ISSN 2095-4964
CN 31-2083/R

Editors-in-Chief:
Changquan Ling, Shanghai, China
Lixing Lao, Virginia, USA
Frequency: 6 issues per year
Publisher: Science Press, China

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