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Progress in research on Chinese herbs with estrogen-like effects
Xiao-xiao Zhang, Sheng Liu, Xiao-hong Xue
Journal of Chinese Integrative Medicine    2005, 3 (2): 149-153.   DOI: 10.3736/jcim20050219
Abstract1085)   HTML12)    PDF(pc) (84KB)(2285)      
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Discussion on six errors of formulas corresponding to syndromes in using the classic formulas
Bao Yan-ju, Hua Bao-jin
Journal of Chinese Integrative Medicine    2012, 10 (12): 1363-1370.   DOI: 10.3736/jcim20121205
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The theory of formulas corresponding to syndromes is one of the characteristics of Treatise on Cold Damage and Miscellaneous Diseases (Shanghan Zabing Lun) and one of the main principles in applying classic prescriptions. It is important to take effect by following the principle of formulas corresponding to syndromes. However, some medical practitioners always feel that the actual clinical effect is far less than expected. Six errors in the use of classic prescriptions as well as the theory of formulas corresponding to syndromes are the most important causes to be considered, i.e. paying attention only to the local syndromes while neglecting the whole, paying attention only to formulas corresponding to syndromes while neglecting the pathogenesis, paying attention only to syndromes while neglecting the pulse diagnosis, paying attention only to unilateral prescription but neglecting the combined prescriptions, paying attention only to classic prescriptions while neglecting the modern formulas, and paying attention only to the formulas but neglecting the drug dosage. Therefore, not only the patients’ clinical syndromes, but also the combination of main syndrome and pathogenesis simultaneously is necessary in the clinical applications of classic prescriptions and the theory of prescription corresponding to syndrome. In addition, comprehensive syndrome differentiation, modern formulas, current prescriptions, combined prescriptions, and drug dosage all contribute to avoid clinical errors and improve clinical effects.

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Progress in research on pharmaceutics for intranasal medication
Tong Zhang, Lian-ying Xu
Journal of Chinese Integrative Medicine    2004, 2 (3): 223-225.   DOI: 10.3736/jcim20040324
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Accidents in acupuncture treatment: History and current state
Ren Zhang
Journal of Chinese Integrative Medicine    2004, 2 (4): 306-313.   DOI: 10.3736/jcim20040424
Abstract1040)   HTML7)    PDF(pc) (128KB)(3277)      

Acupuncture is widely used as an alternative therapy with few side effects because of its simple manipulation and low cost. However, accidents may occur if the practitioner uses it improperly. Early in the Qin dynastuy, the Canon of Medicine mentioned that improper use of acupuncture could cause injury to the body and even death, and it systematically described the occurrence and prevention of acupuncture accidents. Physicians in the successive dynasties frequently reported it, and nealized that the manipulation skills were significantly important in preventing the occurrence of acupuncture accidents.Since the 1950s, acupuncture accidents had been effectively prevented because of the improving of acupuncture instruments, enhancing of the quality of the practitioners, popularizing of sterilization and disseminating of anatomic knowledge. Nevertherless, with the renovating of acupuncture techniques, new accidents may occur constantly. The prevention of acupuncture accidents still should be an arduors task for acupuncturists. Nowadays, acupuncture therapy is being used in more than 140 countries, and acupuncture accidents due to improper application are incrcasing. Prevention of acupuncture accidents has become a global issue deserving of great attention.

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The study of intoxication and toxicity of Fructus Xanthii
Xue-mei Zhang, Zhong-hua Zhang
Journal of Chinese Integrative Medicine    2003, 1 (1): 71-74.   DOI: 10.3736/jcim20030129
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Fructus Xanthii is commonly used in rhinology, especially used in treatment of chronic rhinitis and sinusitis. But Fructus Xanthii is toxicant, and it maybe result in poisoning when used excessively, without preparation or in inappropriate preparation. This article reviewed all poisoning cases from 1960 to 2000, its toxicology and methods for detoxification.

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Cited: Baidu(16)
An overview of medicinal plant resource for decreasing blood glucose
Yun Zhu, Jin-rong Liu, Wei Zhang
Journal of Chinese Integrative Medicine    2004, 2 (1): 67-68.   DOI: 10.3736/jcim20040125
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Recognition on toxicity of traditional Chinese drugs
Chao-qin Yu
Journal of Chinese Integrative Medicine    2003, 1 (4): 252-254.   DOI: 10.3736/jcim20030405
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Our ancestor found that some of the Chinese herbal drugs were toxic during their clinical practice. They graded the toxicity of Chinese herbal drugs into three degrees and thought that the term "toxicity of the Chinese herbal drugs" could be used in a broad and a narrow sense. In modern times, toxic components of the Chinese herbal drugs and their toxic mechanisms, especially the toxicity on the kidney, were further revealed. The factors that affect the toxicity of the Chinese herbal drugs include the species, preparation, dose and environment. To prevent the toxicity of the Chinese herbal drugs, we must strengthen the management of the Chinese herbal drugs. On the other hand, doctors' recognition of the toxicity of Chinese herbal drugs should be enhanced. At the same time, patients should be told to decoct and take Chinese herbal drugs correctly.

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Clinical outcome assessment and the effect measure
Hong-wei Zhang, Jian-ping Liu, Xia Wan, Yan-ke Ai
Journal of Chinese Integrative Medicine    2007, 5 (5): 497-501.   DOI: 10.3736/jcim20070503
Abstract993)   HTML1)    PDF(pc) (1127KB)(1322)      

Effect of clinical intervention on human body is multistage and multifaceted, involving physiology, psychology, social function and the surrounding resources, etc. Therefore, the range of clinical outcome assessment includes patient, his or her family and care giver. The evaluation of clinical intervention mainly focuses on its effectiveness, safety and health economics. Effects of clinical interventions are measured by comparisons of the outcome of intervention and control groups. Different effect measures come from different comparisons.

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Cited: Baidu(5)
Prevention and treatment of pulmonary-fibrosis by traditional Chinese medicine
Chu-fang Yao, Shu-long Jiang
Journal of Chinese Integrative Medicine    2003, 1 (3): 234-238.   DOI: 10.3736/jcim20030327
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Pulmonary-fibrosis (PF) is the result of interstitial lung disease which has different causes and it is one of the most intractable diseases in respiratory system. The PF is characterized by progressive difficulty of breath and dying of respiratory failure, seriously threatening the health of people. Immunosuppressive drugs and glucocorticoids have been widely adopted as the main methods in treatment, but the results are not satisfactory and the side effects are obvious. Many specialists have tried traditional Chinese medicine in recent years with satisfactory effect, indicating that the prospect of using traditional Chinese medicine in the treatment of PF is optimistic. This article outlines the researches about using traditional Chinese medicine in the treatment of PF.

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Cited: Baidu(9)
Clinical application of explaining Ziwu Liuzhu therapy through diagrams
Zun-hui Guan, Li-ling Ding, Cui-ping Guo, Jian Ye, Rong Yi
Journal of Chinese Integrative Medicine    2003, 1 (4): 314-316.   DOI: 10.3736/jcim20030426
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Study on the mechanism of traditional Chinese medicines in promoting gastrointestinal peristalsis
Mu-xin Wei, Lan-fu Wei, Bai-cang Zhou, Guo-ping Zhao
Journal of Chinese Integrative Medicine    2004, 2 (3): 163-166.   DOI: 10.3736/jcim20040303
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Traditional Chinese medicine has accumlated rich experience in treating dysfunction of gastrointestinal peristalsis. In recent years, a large number of studies have been made on the mechanism and effects of traditional Chinese medicines on the gastrointestinal peristalsis, and the concept of "gastrointestinal promoting Chinese medicine" has been advocated. These traditional Chinese medicines can be divided into three types: promoting the gastrointestinal peristalsis, inhibiting the gastrointestinal peristalsis, and bi-directional modulating. The in vivo and/or in vitro experiments showed that some of the traditional Chinese medicines for activating blood or regulating qi could promote the stomach peristalsis, and the traditional Chinese medicines for moistening intestines to relieve constipation or invigorating spleen to promote digestion could accelerate the intestinal peristalsis. The mechanism lies in the neuroregulation and gut-peptide regulation. Further research on multi-regulation and of multi-target should be done, for the mechanism of the traditional Chinese medicines in regulating the gastrointestinal peristalsis is far more complicated.

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Strategy and approaches of pathological and pathophysiological research in integrated traditional Chinese and Western medicine
Qi-fu Huang
Journal of Chinese Integrative Medicine    2004, 2 (4): 245-251.   DOI: 10.3736/jcim20040402
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Pathology and pathophysiology are sciences studying the laws and mechanisms of the occurrence and developmont of diseases,linking up the preclinical and clinical medicine.Owing to the different perspectives and ways of thinking,the western medicine and the traditional Chinese medicine developed respectively their independent theoretical,diagnostic and therapeutic systems.Integrative medicine,combining the theories and treatments of both western medicine and traditional Chinese medicine,has become the developing trend of medicine along with the social development.For this reason,pathological and pathophysiological research in integrated traditional Chinese and western medicine is highly significant for revealing the internal relations between the clinical manifestation and the pathological changes,for expounding the causes,conditions.mechanisms and laws of the occurrence and development of diseases.In doing related research,we should combine the disease and the syndrome,combine the macro-level and the micro-level,combine the part and the whole.We should manage to systematize the clinical research,to establish animal models of the syndromes,and to integrate the animal models of syndromes with the clinical characteristics of disesses.We should apply the theories of traditional Chinese medicine to the pathological and pathophysiological research of modern medicine.

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Cited: Baidu(4)
History and development of spinology
Qi Shi, Yong-jun Wang
Journal of Chinese Integrative Medicine    2003, 1 (4): 304-308.   DOI: 10.3736/jcim20030423
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Spinal disease is the injury caused by congenital malformation, degeneration, inflammation and trauma. These injuries lead to structural lesion of spinal itself, intervertebral discs, spinal cord, nerve root and the attachment, and can cause spinal and associated diseases. Spinal diseases include some frequently encountered diseases, as well as some stubborn and serious diseases. These diseases may cause pain of head and neck, shoulder and arm, waist and leg when they are mild, and partial or thorough paralysis when they are serious. In this article, the history, development, foundations and research progress of non-surgical operation of spinal diseases and the developing tendency of modern spinology are introduced.

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Cited: Baidu(24)
Tongue conditions and constitution
Tiao-yuan Kuang
Journal of Chinese Integrative Medicine    2004, 2 (4): 264-264.   DOI: 10.3736/jcim20040407
Abstract958)   HTML4)    PDF(pc) (57KB)(1483)      
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Progress in research on hirudo
Rong-qing Huang, Xiao-dong Sun, Yang-ling Li, Hong Wang
Journal of Chinese Integrative Medicine    2004, 2 (5): 387-389.   DOI: 10.3736/jcim20040523
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Discussion of time and space differentiation of three-yin and three-yang in Shanghan Lun
Wen-hui Ma, Xiao-hong Sun
Journal of Chinese Integrative Medicine    2005, 3 (4): 257-259.   DOI: 10.3736/jcim20050402
Abstract1038)   HTML2)    PDF(pc) (57KB)(1972)      

The concept of "three-yin and three-yang" in Shanghan Lun (Treatise on Cold Pathogenic Diseases), a classic written by Zhang Zhongjing in Han Dynasty, has been always the focus of dispute in successive dynasties. The essence of "three-yin and three-yang" has not been fully revealed up till now. Through studying the six divisions of day and night, the six diseases, the combination of syndromes, the complicated diseases, the complete recovery time and the space division of "three-yin and three-yang", the authors draw a conclusion that the "three-yin and three-yang" in Shanghan Lun is a concept of time-sequence, which is associated with the location of disease in space. So it is suggested that the "six diseases" in Shanghan Lun is a categorization for exogenous febrile diseases, and this categorization reveals a sort of inner relationship between the emergence, development, transformation of the febrile diseases and the time.

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Analysis of studies on pattern recognition of tongue image in traditional Chinese medicine by computer technology
Xiao-qiang Yue, Qing Liu
Journal of Chinese Integrative Medicine    2004, 2 (5): 326-329.   DOI: 10.3736/jcim20040503
Abstract1050)   HTML6)    PDF(pc) (75KB)(15002)      

The article analyzed the contemporary study of pattern recognition of tongue images in traditional Chinese medicine by computer technology from its key sectors. It regards that the methods of orthogonal design and evaluation of image quality should be introduced to get a high-quality and practicable condition. In the field of tongue image segmentation, multiple methods used together are expected to improve the effect of segmentation. A scientific and canonical standard of tongue diagnosis based on comprehensive experts' experience with Delphi evaluation method and multi-center experts diagnosis on internet are also very essential. The study of pattern recognition on tongue image is still concentrated on the color. Further study should be extended to achieve quantification. And a comprehensive diagnosis on pattern recognition of tongue image is the aim that should be focused on later.

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Comparative study on WHO Western Pacific Region and World Federation of Chinese Medicine Societies international standard terminologies on traditional medicine: An analysis of the Diagnostics (Part 4)
Zhao-guo Li
Journal of Chinese Integrative Medicine    2009, 7 (12): 1193-1196.   DOI: 10.3736/jcim20091220
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Treatment of diabetes through liver syndrome differentiation
Li Zhao
Journal of Chinese Integrative Medicine    2004, 2 (4): 303-305.   DOI: 10.3736/jcim20040423
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Placebo control and clinical trial of Chinese medicine
J Wu
Journal of Chinese Integrative Medicine    2010, 8 (10): 906-910.   DOI: 10.3736/jcim20101001
Abstract974)   HTML2)    PDF(pc) (1166KB)(977)      

World Health Organization aims to develop safe, effective and practical traditional medicine. Traditional Chinese medicine (TCM) and other complementary and alternative medicine are being recognized in the whole world nowadays. However, the definite effect of Chinese medicine is still in need of scientific research proof. Placebo control is of equal importance to active control and blank control in clinical trial of TCM. This article briefly reviewed the importance of placebo control and commented on its present situation in clinical trial of TCM. This article also brought up the preliminary proposals of placebo application in TCM clinical trial. We should emphasize scientific placebo preparation and good design of placebo-controlled trial, which are directed by International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use. A good clinical trial project will avoid unnecessary wastes and provide safe and effective treatment for people.

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Cited: Baidu(14)
Analysis of the English translation of meridians’ path in Miraculous Pivot
Ke Cheng , Fan Wu , Meng-hu Guo , Ling Zhao , Hai-ping Deng , Hai-meng Zhang , Li-zhen Wang , Yao Xu , Mactavish James , Xue-yong ShenCheng Ke, Wu Fan, Guo Meng-hu, Zhao Ling, Deng Hai-ping, Zhang Hai-meng, Wang Li-zhen, Xu Yao, James Mactavish, Shen Xue-yong
Journal of Chinese Integrative Medicine    2012, 10 (12): 1502-1506.   DOI: 10.3736/jcim20121226
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Gross conception of anatomical structure of zang-fu viscera in Huangdi Neijing
Ye-tao Gao, Hui-wei Pan​, Sheng-bing Wu​
Journal of Chinese Integrative Medicine    2006, 4 (4): 339-342.   DOI: 10.3736/jcim20060404
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The scientificalness of traditional Chinese medicine (TCM) is often doubted and criticized for the record in Huangdi Neijing that the liver is located in the left of the human body. The most popular explanation of this criticism is that the conception of zang-fu viscera in TCM is quite different from which defined in Western medicine. It means that the zang-fu viscera in TCM are not exactly the corresponding anatomical organs in modern human anatomy but reflect the functions of some systems in human body. According to the classical theories of TCM in Huangdi Neijing, we consider that the record of liver located in the left of the human body is based on the Ba Gua (Eight Diagrams) of traditional Chinese philosophy, not the human anatomy. In brief, the conception of zang-fu viscera is initially a gross anatomical conception, and in a sense the anatomic sites and functions of which are mostly similar to those described in Western medicine.

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Pathogenetic characteristics and therapeutic approaches of aplastic anemia
Yong-ming Zhou, Ming-hui Hu
Journal of Chinese Integrative Medicine    2003, 1 (1): 74-76.   DOI: 10.3736/jcim20030130
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According to TCM theory of the wholistic concept and the principles of sydrome differentiation and treatment, the characteristics of the pathogenesis of aplastic anemia (AA) were summarized and corresponding treatment was put forward on the basis of clinical observation and the study of literature. In the pathogenesis of AA, the deficiency of spleen and kidney is the primary aspect, fire attacking blood vessels is the secondary aspect and there is change because of blood stasis. In treatment,the method of invigorating spleen and tonifying kidney is adopted in order to get at the root, and releasing fire to stop bleeding is adopted in order to bring about a temporary solution, and activating blood circulation to dissipate blood stasis is adopted in order to produce blood. The outline should be caught hold of that consumption is primary aspect and fire is secondary aspect and there is change because of blood stasis in order to obtain satisfactory curative effect.

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Characteristics of English translation of traditional Chinese medicine
Chuan-yue Niu
Journal of Chinese Integrative Medicine    2004, 2 (2): 159-160.   DOI: 10.3736/jcim20040228
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Cited: Baidu(3)
Dr. Miriam Lee: A heroine for the start of acupuncture as a profession in the State of California
Arthur Yin Fan, Ziyi Fan​
Journal of Integrative Medicine    2014, 12 (3): 182-186.   DOI: 10.1016/S2095-4964(14)60016-9
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Cited: Baidu(8)
Progress in pharmacotherapy of integrated traditional Chinese and western medicine for virus infection in respiratory tract
Yu-hua Liu, Jing-cheng Dong
Journal of Chinese Integrative Medicine    2004, 2 (3): 226-227.   DOI: 10.3736/jcim20040325
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Experience of Professor LI Guo-Heng in treating degenerative osteoarthrosis of k nee joint
Fei-yue Li, Xiao-bing Xi, Shi-hua Luo, Tao Liu
Journal of Chinese Integrative Medicine    2003, 1 (4): 295-295.   DOI: 10.3736/jcim20030420
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Progress in research on chronic fatigue syndrome
Shu-yun Jiang, Jun-tao Yan, Min Fang
Journal of Chinese Integrative Medicine    2004, 2 (6): 459-463.   DOI: 10.3736/jcim20040619
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Progress in research on Ganoderma lucidium spore
Wei Zhang, Yuan-shan Zeng
Journal of Chinese Integrative Medicine    2004, 2 (6): 463-465.   DOI: 10.3736/jcim20040620
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Cited: Baidu(9)
Relationship between symptom stratification and syndrome differentiation of traditional Chinese medicine for depressive episode
Sui Yue Hu, Su E Wang, Chun Hu Zhang
Journal of Chinese Integrative Medicine    2011, 9 (9): 933-936.   DOI: 10.3736/jcim20110902
Abstract1073)   HTML3)    PDF(pc) (1023KB)(845)      

On the basis of medical literature review and clinical research experience, the authors analyzed the reasons for low recognition rate of depression and poor progress of traditional Chinese medicine (TCM) differentiation of depression in this paper and put forward that depressive episode symptoms and the corresponding common terminology classification of Chinese and Western medicine should be the breakthrough points. Through symptom stratification and combination, as well as distinguishing between primary and secondary symptoms, the comprehensive integrative medicine clinical assessment of depression was explored so as to further obtain expert consensus and provide a methodology reference for the TCM differentiation of depression and the research of etiology and pathogenesis.

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Research on quantified diagnosis and combining diseases with syndrome of blood stasis
Jie Wang, Jian-Sheng Li, Kui-Wu Yao, Yong-Xia Wang, Jing-bai Zhong
Journal of Chinese Integrative Medicine    2003, 1 (1): 21-24.   DOI: 10.3736/jcim20030110
Abstract991)   HTML1)    PDF(pc) (70KB)(587)      

Objective

To explore the way of quantified diagnosis of blood stasis syndrome (BSS) and the essence of BSS.


Methods

Using t-test and logistic regression to analyze the symptoms, signs, and objective indexes of BSS in clinical test.


Results

(1) The levels of endothelin, nitric oxide, and t-PA between 182 patients with BSS and non-BSS had notable difference. (2) The stepwise regression analysis about hemoglobin, triglyceride, total cholesterol, endothelin, nitric oxide, and t-PA in 170 patients with BSS or non-BSS revealed that the order of these indexes considering their importance was: endothelin, hemoglobin, t-PA, nitric oxide. However, the triglyceride and total cholesterol could not enter the regression equations. (3) The stepwise regression analysis about 40 symptoms and signs in 601 patients with BSS or non-BSS revealed that the 18 items had the very contribution to diagnose the BSS when the F value was 6, and so a regression equation was available. The total coincidence ratio was 94.24% when the other quantified data about BSS were tested in the equation.


Conclusion

The standardized TCM syndrome, which accorded with the criteria of combining diseases with syndrome,was made up of symptoms, signs, and objective indexes.The standard could be obtained by multi-center, prospective, random and controlled clinical epidemiological survey and clinical test.

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Cited: Baidu(22)
Pondering on the diagnosis and treatment criteria for syndromes of epilepsy in traditional Chinese medicine
Jin-min Liu, Tao Jiang
Journal of Chinese Integrative Medicine    2006, 4 (6): 572-574.   DOI: 10.3736/jcim20060605
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International League Against Epilepsy announced the new International Classification of Epilepsy in 2001. One of the main objectives of the project is to adopt standard terms to describe seizure phenomena according to the terminological database. The project may profit academic communication and resource integration, and provide evidence for the individual treatment for epilepsy. Treatment based on syndrome differentiation is one of the characteristics of the treatment for epilepsy in traditional Chinese medicine (TCM). As far as the individuation on diagnosis and treatment is concerned, TCM and Western medicine present to reach the same goal by different routes gradually for the treatment of epilepsy. But for TCM, the diagnosis and treatment criteria for epilepsy are imperfect and the experts, opinions are not unified, so that the treatment based on syndrome differentiation becomes confused, hence the credit of treatment based on TCM is restricted accordingly. It is necessary to formulate advanced diagnosis and treatment criteria for syndromes of epilepsy in TCM.

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Successful use of Zhengwu Decoction in treating eye diseases: Case report
Ya-qin Ru
Journal of Chinese Integrative Medicine    2005, 3 (1): 61-62.   DOI: 10.3736/jcim20050119
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Progress of research on mechanism of salvia miltiorrhiza and its chemical ingredients against liver fibrosis
Yan-yan Tao, Cheng-hai Liu
Journal of Chinese Integrative Medicine    2004, 2 (2): 145-148.   DOI: 10.3736/jcim20040223
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Status of study about Chinese medicine in protecting cerebral ischemia injury
Ming-hang Wang, Jian-sheng Li, Ke Liu
Journal of Chinese Integrative Medicine    2004, 2 (4): 299-300.   DOI: 10.3736/jcim20040421
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Clinical application of eight-magic-turtle acupuncture technique elucidated through diagrams
Zun-hui Guan, Li-ling Ding, Cui-ping Guo, Jian Ye, Rong Yi
Journal of Chinese Integrative Medicine    2004, 2 (2): 141-143.   DOI: 10.3736/jcim20040221
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Comments on some issues concerning the English translation of traditional Chinese medicine
Chuan-yue Niu, La-ping Wang
Journal of Chinese Integrative Medicine    2006, 4 (5): 544-547.   DOI: 10.3736/jcim20060524
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Application of the theory of damp-heat in spleen and stomach in treatment of kidney diseases
Li-qun He
Journal of Chinese Integrative Medicine    2004, 2 (1): 7-9.   DOI: 10.3736/jcim20040104
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There exists close relationship between the damp-heat and the occurrence, development, treatment and prognosis of kidney diseases. The occurrence of damp-heat is based on water and wetness, which may come from outside or may be caused by internal damage. The water and wetness can change into heat if they are stored in the body for a long period, and the combination of water and wetness and heat may cause damp-heat syndrome. The function of spleen and stomach plays the most important role in the water metabolism of sanjiao. Kidney diseases are mainly caused by damp-heat of spleen and stomach resulted from internal damage of spleen and stomach, and symptoms of damp-heat of middle-jiao are commonly seen in most patients of chronic kidney diseases. During the development from renal function damage to renal failure, the remaining of damp-heat in san-jiao can affect the function of spleen and stomach for transportation, transformation and digestion, resulting in the symptoms of dysfunction of spleen and stomach. Regulating the function of spleen and stomach is one of the most important therapeutic methods for kidney diseases.

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History and causes of acupuncture advancing towards the world
Gen-cheng Wu, Xiao-ding Cao
Journal of Chinese Integrative Medicine    2003, 1 (4): 247-251.   DOI: 10.3736/jcim20030403
Abstract1008)   HTML3)    PDF(pc) (84KB)(858)      

Acupuncture therapy is one of the original innovations in traditional Chinese medicine. The study of acupuncture has gradually advanced towards the world since 1970s. In these years the most important events might be the influence of acupuncture anesthesia, the attention of the World Health Organization, the establishment and development of the World Federation of Acupuncture and Moxibustion Societies, and the consensus development conference on acupuncture held by the National Institutes of Health in America, and so on. The reasons why acupuncture is accepted by the world are both the convinced curative effects and the scientific foundations, due to the great efforts of medical stuff in China guided by the principle of integration of traditional Chinese and western medicine. This article poses several proposals about further extending the influence of acupuncture. In brief, acupuncture research is one of the few fields that authentically impact the western scientific technology. It is of very important responsibility in the new century to impulse the acupuncture study to further progress and expand the international influence of acupuncture.

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Progress of research on apoptosis of breast cancer cells
Cui-yan Lv, Xin-yi Chen
Journal of Chinese Integrative Medicine    2003, 1 (3): 226-229.   DOI: 10.3736/jcim20030325
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This article reviewed information related to the apoptosis of breast cancer cells. Breast cancer is a common malignant tumor in women. Apoptosis is related to the response and resistance to treatment in breast cancer. Here we summarized and integrated the data on apoptosis and its role in the development, prognosis, and treatment of breast cancer. Further study on apoptosis in breast cancer can help find more candidates for predictors and indices of response. Such study will also develop treatment regimens that are tailored to individual tumors and thereby maximize survival.

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Cited: Baidu(8)
Study of genes related with kidney deficiency syndrome
Xiao-shan Zhao, Ren Luo
Journal of Chinese Integrative Medicine    2003, 1 (1): 18-20.   DOI: 10.3736/jcim20030109
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Study of kidney deficiency syndrome may utilize the modern molecular biology technique, such as gene chip, representational difference analysis (RDA) and genes sequence analysis, to clone the different genes of kidney deficiency syndrome from single TCM syndrome type of the disease, to investigate the inner connection between the various phenotypes of kidney deficiency syndrome and their genes expression pattern and their function products, then to definite the related genes of kidney deficiency syndrome. The research method may also be used for the study of other TCM syndrome types.

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Traditional Chinese medicine for cancer pain
Ju-yong Wang, Ling Xu, Rui-xin Zhang, Lixing Lao
Journal of Chinese Integrative Medicine    2011, 9 (2): 129-134.   DOI: 10.3736/jcim20110202
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Pain is one of the common symptoms of cancer which seriously affects the quality of life of the patients. Cancer pain is mainly treated with the three-step method, biological therapy or nerve block therapy based on antitumor therapy. However, up to 50 percent of patients with cancer-related pain do not receive adequate pain relief, affecting their physical and psychological well-being, and leading to a lower quality of life for the patient after conventional treatment. Clinical observation suggests that traditional Chinese medicine may alleviate cancer-related pain either by oral administration, topical administration, acupuncture or other means with continuing non-addictive and non-drug-resistant qualities. However, scientific evaluation of the efficacy of herbs in the treatment of pain is insufficient; the underlying mechanisms are unclear and, safety and toxicity remain a concern.

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Cited: Baidu(35)
Progress in research on phytoestrogens and their effect targets
Shu-fang Shi, Chao-qin Yu​
Journal of Chinese Integrative Medicine    2005, 3 (5): 408-410.   DOI: 10.3736/jcim20050521
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Biological research evaluating the Chinese medical theory of the association of the kidney with the ears
Dong Yang, Shi Jian-rong
Journal of Chinese Integrative Medicine    2012, 10 (2): 128-134.   DOI: 10.3736/jcim20120202
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“Association of the kidney with the ears” is central to the traditional Chinese medical (TCM) theory of the viscera and their manifestations. Previous studies have shown that thyroxin, aldosterone, calcium and iron might be the material basis of the correlation between the kidney and the ears. Due to restriction in research techniques and methods, there has been no further progress in this research field, whose modern biological mechanisms and scientific connotations have not been explained clearly. In recent years, the progress of biological techniques and research on kidney essence provided promising opportunities for research of the association between the kidney and the ears. This article summarized the study progress of “association of the kidney with the ears” theory and posed some meaningful study thoughts. Presbycusis is a kind of degenerative disease caused by aging, which is one aspect of aging of the human body. Because aging is considered as physiological “kidney deficiency”, presbycusis can be regarded as a model of “kidney deficiency” deafness. In conclusion, investigating the correlation between “kidney deficiency” and presbycusis using biotechnology systems combined with “essence of kidney”, should provide a sound basis for study of the theory of the relationship between the kidney and the ears. This will provide new and valuable information for the modern biological research about the theory of visceral associations in TCM.

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Cited: Baidu(4)
Evaluation of clinical therapeutic effect for traditional Chinese medicine
Ke-ji Chen
Journal of Chinese Integrative Medicine    2005, 3 (1): 1-2.   DOI: 10.3736/jcim20050101
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Origin and development of microcosmic syndrome differentiation
Jia-xu Chen, Fei-fei Xue
Journal of Chinese Integrative Medicine    2005, 3 (5): 342-346.   DOI: 10.3736/jcim20050502
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The suggestion of microcosmic syndrome differentiation is to meet the needs of clinical diagnosis and treatment of traditional Chinese medicine (TCM), the needs of evidence based medicine and the needs of the development of syndrome differentiation in TCM. The possibility of microcosmic syndrome differentiation might be the development of integration of traditional Chinese and Western medicine as well as modern science and technology. Microcosmic syndrome differentiation has its superiority and limitation. There are some problems in developing microcosmic syndrome differentiation, such as lack of standard for syndrome differentiation, contradiction between single microcosmic index and the entirety, non-specificity of the relationship between microcosmic indexes and syndromes, and the influence of disease on microcosmic syndrome differentiation, discrepancy between the essence study of TCM syndromes and the clinical practice. It is suggested that the concept of TCM syndrome is a certain pathological process during the onset and development of disease, composed of some subjective and objective indexes. The objective indexes include the macrocosmic and the microcosmic indexes, the entirety and the part.

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Researches into the modernization of tongue diagnosis: in retrospect and prospect
Qing Liu, Xiao-qiang Yue, Chang-quan Ling
Journal of Chinese Integrative Medicine    2003, 1 (1): 66-70.   DOI: 10.3736/jcim20030128
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With the further development of clinical modernization of traditional Chinese medicine (TCM), new request to tongue diagnosis for objectivity and quantification is raised. Many researchers have devoted themselves to this field and have achieved some accomplishments since 1950's. Especially in recent years, the revolution of information technique derived from computer industry brings the research new chances. The research history of the past five decades can be divided into three stages: (1) looking for micro-markers by newly-developed medical technique; (2) quantifying traditional markers by new technique; (3) further development based on information technique and corporation of multiple subjects. This article reviewed the three stages and described its prospect.

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Cited: Baidu(19)
Research strategy and clinical significance of anorectum manometry
Lin Zhu, Wen-fu Tang, Ping Ren, Xi Huang
Journal of Chinese Integrative Medicine    2005, 3 (3): 240-242.   DOI: 10.3736/jcim20050323
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Current status of blood lipid level and treatment of hyperlipoidemia in Chinese population
Hao-zhu Chen
Journal of Chinese Integrative Medicine    2004, 2 (2): 81-82.   DOI: 10.3736/jcim20040201
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Analysis on acupuncture treatment characteristics for tumor in ancient medical literature
Li-gong Liu, Jie Gu, Dong-xing Fang
Journal of Chinese Integrative Medicine    2003, 1 (4): 319-320.   DOI: 10.3736/jcim20030428
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ISSN 2095-4964
CN 31-2083/R

Editors-in-Chief:
Chang-quan Ling, Shanghai, China
Guang Ji, Shanghai, China
Frequency: 6 issues per year
Publisher: Science Press, China

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