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Progress in research on pharmaceutics for intranasal medication
Tong Zhang, Lian-ying Xu
Journal of Chinese Integrative Medicine    2004, 2 (3): 223-225.   DOI: 10.3736/jcim20040324
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Three advantages of using traditional Chinese medicine to prevent and treat tumor
Chang-quan Ling​, Xiao-qiang Yue, Chen Ling​
Journal of Integrative Medicine    2014, 12 (4): 331-335.   DOI: 10.1016/S2095-4964(14)60038-8
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Traditional Chinese medicine (TCM), an important component of complementary and alternative medicine, has evolved over thousands of years with its own unique system of theories, diagnostics and therapies. TCM has been increasingly used in the last decades and become well known for its significant role in preventing and treating cancer. We believe that TCM possesses advantages over Western medicine in specific aspects at a certain stage of cancer treatment. Here we summarize the advantages of TCM from three aspects: preventing tumorigenesis; attenuating toxicity and enhancing the treatment effect; and reducing tumor recurrence and metastasis.

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Cited: Baidu(242)
Clinical and experimental studies on polyherbal formulations for diabetes: Current status and future prospective
Ahmad Ghorbani
Journal of Integrative Medicine    2014, 12 (4): 336-345.   DOI: 10.1016/S2095-4964(14)60031-5
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Diabetes is a leading cause of morbidity and mortality in the world. There is currently an active search for antidiabetic drugs with greater effectiveness with fewer and less adverse side effects. Although numerous individual herbs have been experimentally or clinically reported to possess antidiabetic effects, considerably less research has been conducted on polyherbal compounds. It is believed that herbal compounds containing multiple plant products have synergistic antidiabetic effects and could enhance the desired actions. Several polyherbal formulations have been studied as therapeutic agents in diabetes management. To describe the current state of research on polyherbal compounds in the treatment of diabetes, an extensive review of literature was undertaken on several major databases. This paper presents what is known about the efficacy of these polyherbal formulations and compare their antidiabetic effects with those of current oral hypoglycemic drugs as reference. The percent decrease in blood glucose, lipids and other biochemical parameters achieved by each product in diabetic animals and patients is reported. Also, the possible mechanisms responsible for hypoglycemic action of polyherbal formulations are discussed.

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Cited: Baidu(33)
Effects of summer acupoint application therapy in reducing exacerbation frequency of chronic lung diseases: protocol of a retrospective and prospective study
Peng Jin, Wu Xia-qiu, He Li-yun, Fang Yi-gong, Zi Ming-jie, Yan Shi-yan, Liu Bao-yan
Journal of Chinese Integrative Medicine    2012, 10 (1): 39-47.   DOI: 10.3736/jcim20120107
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BACKGROUND: Chronic lung diseases, including bronchial asthma, chronic obstructive pulmonary disease (COPD),chronic bronchitis, allergic rhinitis and repeated respiratory tract infection (RRTL) in infants, exacerbate frequently in winter because of respiratory viral infections and low temperature. Summer acupoint application therapy (SAAT) is thought to be effective in reducing exacerbation frequency of chronic lung diseases in winter. It is a kind of therapy using a herbal mixture for external application on special acupoints during summer. The herbal mixture basically contains Semen Sinapis Albae, Herba Asari,Radix Euphorbiae Kansui and Rhizoma Cory dal is. The acupoints include Feishu (BL13), Dazhui (GV14) and Danzhong (CV17). Through a large-scale multicenter trial based on three years of clinical observation, and retrospective and prospective analyses, this study aims to explore the efficacy of SAAT.METHODS AND DESIGN: In this clinical observation trial, patients who have been diagnosed with bronchial asthma,COPD,chronic bronchitis, allergic rhinitis or RRTL will be enrolled from 13 centers. All patients enrolled will be treated with SAAT over a two-year period by medical practitioners. After this, an initial case report form (CRF) will be completed and forwarded to the central study site (China Academy of Chinese Medical Sciences, Beijing, China). The CRF is designed to investigate patients’ history of medical treatment (including SAAT) and chronic lung disease exacerbation, also self-reported health condition. For retrospective analyses, the authors will focus on those who have accepted SAAT before enrollment and will collect their SAAT history and chronic lung disease exacerbation history, to evaluate the effects of SAAT. For prospective analyses, medical students will follow up with patients by phone interviews in winter once a year. The primary outcome is frequency of chronic lung disease exacerbation in winter. The secondary outcomes include conditions of lung disease recovery, non-SAAT therapy, and a self health report.DISCUSSION: The authors aim to collect 7 400 patients from July 2008 to August 2009. The final follow-up has been completed in December 2010. To reduce the selection bias, a total of 13 clinical centers from different areas of China have participated in this study. The results from this study will provide a high-quality evidence base for evaluating the efficacy of SAAT in reducing exacerbation frequency of chronic lung diseases in winter.TRIAL REGISTRATION NUMBER: This trial has been registered in Chinese Clinical Trial Registry (Identifier: ChiCTR-TNRC-10001292).

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Characteristics of English translation of traditional Chinese medicine
Chuan-yue Niu
Journal of Chinese Integrative Medicine    2004, 2 (2): 159-160.   DOI: 10.3736/jcim20040228
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Cited: Baidu(3)
Accidents in acupuncture treatment: History and current state
Ren Zhang
Journal of Chinese Integrative Medicine    2004, 2 (4): 306-313.   DOI: 10.3736/jcim20040424
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Acupuncture is widely used as an alternative therapy with few side effects because of its simple manipulation and low cost. However, accidents may occur if the practitioner uses it improperly. Early in the Qin dynastuy, the Canon of Medicine mentioned that improper use of acupuncture could cause injury to the body and even death, and it systematically described the occurrence and prevention of acupuncture accidents. Physicians in the successive dynasties frequently reported it, and nealized that the manipulation skills were significantly important in preventing the occurrence of acupuncture accidents.Since the 1950s, acupuncture accidents had been effectively prevented because of the improving of acupuncture instruments, enhancing of the quality of the practitioners, popularizing of sterilization and disseminating of anatomic knowledge. Nevertherless, with the renovating of acupuncture techniques, new accidents may occur constantly. The prevention of acupuncture accidents still should be an arduors task for acupuncturists. Nowadays, acupuncture therapy is being used in more than 140 countries, and acupuncture accidents due to improper application are incrcasing. Prevention of acupuncture accidents has become a global issue deserving of great attention.

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Dr. Miriam Lee: A heroine for the start of acupuncture as a profession in the State of California
Arthur Yin Fan, Ziyi Fan​
Journal of Integrative Medicine    2014, 12 (3): 182-186.   DOI: 10.1016/S2095-4964(14)60016-9
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Cited: Baidu(8)
Effects of language and translation on spreading of traditional Chinese medicine to the West
Chuan-yue Niu
Journal of Chinese Integrative Medicine    2004, 2 (1): 78-80.   DOI: 10.3736/jcim20040129
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Current status of blood lipid level and treatment of hyperlipoidemia in Chinese population
Hao-zhu Chen
Journal of Chinese Integrative Medicine    2004, 2 (2): 81-82.   DOI: 10.3736/jcim20040201
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Preferred reporting items for systematic reviews and meta-analyses:The PRISMA statement (Chinese edition)
David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G. Altman, The PRISMA Group
Journal of Chinese Integrative Medicine    2009, 7 (9): 889-896.   DOI: 10.3736/jcim20090918
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Successful use of Zhengwu Decoction in treating eye diseases: Case report
Ya-qin Ru
Journal of Chinese Integrative Medicine    2005, 3 (1): 61-62.   DOI: 10.3736/jcim20050119
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Effects of kidney-tonifying Chinese herbal medicine on hypothalamic-pituitary gonadotrophic function
Hao Shen, De-pei Cai, Bo-ying Chen
Journal of Chinese Integrative Medicine    2004, 2 (1): 53-57.   DOI: 10.3736/jcim20040120
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Objective: To observe the effects of kidney-tonifying Chinese herbal medicine on the synthesis and secretion of gonadotropin releasing hormone (GnRH) and the related neurotransmitters and neuropeptides, and to explore the mechanism of the regulative effect of Chinese herbal medicine on the hypothalamic-pituitary gonadotrophic function. Methods: Female Sprague-Dawley rats during the period of normal adolescent initiation (160-180 g, 1.5 monthes) were randomly divided into three groups. The control group was fed with normal saline and the two experimental groups were fed with Chinese herbal medicine for nourishing yin to reduce fire (Zi Yin Xie Huo, ZYXH) or nourishing kidney to replenish essence (Yi Shen Tian Jing, YSTJ) respectively. The dosage was 5 ml/d for 30 days by gastric gavage. Integrated optic densities of the GnRH and neuropeptide Y (NPY) in medial preoptic area (MPOA), arcuate nucleus (ARC) and median eminence (ME) of hypothalamus were determined by immunohistochemistry method and image processing. The content of GnRH in homogenate of hypothalamus preoptic area was determined by radioimmunoassay (RIA). The releasing amount of monoamine neurotransmitters from medial basal hypothalamus (MBH) was determined by brain slices incubation and high pressure liquid chromatography (HPLC). The releasing amount of GnRH and NPY from POA was determined by push-pull perfusion and RIA, and the releasing amount of monoamine neurotransmitters from this site was determined by HPLC.Results: ZYXH could inhibit the synthesis and secretion of GnRH from periodic and tonic secretory centers of GnRH, while YSTJ could stimulate the synthesis and secretion of GnRH from the both secretory centers of GnRH. ZYXH could inhibit the activity of GnRH neurons via diminishing the releasing of norepinephrine (NE) from tonic secretory center of GnRH, increasing the releasing of dopamine (DA) in periodic secretory center of GnRH and increasing the synthesis and releasing of NPY from the both secretory centers of GnRH, it hence inhibited the hypothalamic-pituitary gonadotrophic function. YSTJ could stimulate the activity of GnRH neurons via diminishing the synthesis and releasing of NPY from tonic secretory center of GnRH, it hence promoted the hypothalamic-pituitary gonadotrophic function.Conclusion: Chinese herbal medicine for tonifying the kidney could modulate hypothalamic-pituitary gonadotrophic function via regulating the synthesis and secretion of GnRH and the related neurotransmitters (NE, DA) and neuropeptides (NPY).

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Correlations of clinical symptoms and treatment efficacy in patients with rheumatoid arthritis treated with Chinese herbal drugs or Western medicine
Ai-ping Lv, Yi-ting He, Qing-lin Zha, Xiao-ping Yan, Li Su, Yue-jin Song, Sheng-ping Zeng, Wei Liu, Xing-hua Feng, Xian Qian, Wan-hua Zhu
Journal of Chinese Integrative Medicine    2005, 3 (6): 432-437.   DOI: 10.3736/jcim20050604
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Objective

To evaluate the correlations between clinical symptoms and treatment efficacy in patients with rheumatoid arthritis (RA).

Methods

Four hundred and thirteen patients were included in the clinical trial from 9 clinical centers. They were randomly divided into Western medicine-treated group with 204 cases and Chinese herbal drug-treated group with 209 cases. Eighteen clinical symptoms were evaluated before and after treatment. The Western medicine therapy included voltaren extended release tablets, methotrexate and sulfasalazine. The Chinese herbal drug therapy included glucosidorum Tripterygii totorum tablets and Yishen Juanbi Tablets combined with treatment based on syndrome differentiation. The American college of rheumatology 20 (ACR20) was used as efficacy evaluation criteria.

Results

In the Chinese herbal drug-treated group, clinical symptoms such as arthralgia and tenderness of joints were positively correlated with the efficacy after 12-week treatment, while frequent urination at night was negatively correlated. In the same group, tenderness of joints and fever were positively correlated with the efficacy after 24-week treatment, while deep-colored and turbid urine was negatively correlated. In the Western medicine-treated group, tenderness of joints and thirst were positively correlated with the efficacy after 12-week treatment, while vertigo was negatively correlated. And in the same group, tenderness of joints was positively correlated with the efficacy after 24-week treatment, while heaviness of limbs was negatively correlated to the efficacy. The statistical results showed that the treatment efficacy was improved when the correlated symptoms were included in the indications.

Conclusion

The treatment efficacy of RA is correlated with some symptoms, so further studies should proceed on these correlations in order to achieve better treatment outcome.

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Treatment of IgA nephropathy based on syndrome differentiation: A report of 20 cases
Xing-gang Dong, Yi-ping Chen, Zeng-mei An, Yue-yi Deng, Jian Feng, Zhi-man Yu, Hai-yin wang
Journal of Chinese Integrative Medicine    2004, 2 (1): 35-35.   DOI: 10.3736/jcim20040113
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Cited: Baidu(1)
Professor Tang Han-Jun's experience in treating unhealed wound after mastectomy for breast cancer
Yi-qin Chen​
Journal of Chinese Integrative Medicine    2005, 3 (3): 238-239.   DOI: 10.3736/jcim20050322
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An overview of medicinal plant resource for decreasing blood glucose
Yun Zhu, Jin-rong Liu, Wei Zhang
Journal of Chinese Integrative Medicine    2004, 2 (1): 67-68.   DOI: 10.3736/jcim20040125
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Facial spectrum and color characteristics of five viscera reflecting on the face in sub-health status
Wu Hong-jin, Xu Jia-tuo, Lu Lu-ming, Chen Xiao, Tu Li-ping, Zhang Zhi-feng
Journal of Chinese Integrative Medicine    2012, 10 (1): 59-66.   DOI: 10.3736/jcim20120110
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OBJECTIVE: To observe the facial spectrum and color of different points, the positions of heart, liver, spleen, lung and kidney of traditional Chinese medicine reflecting on the face, in healthy participants and those with a sub-health status, so as to provide an objective basis for health evaluation.METHODS: The health condition of 470 subjects without acute and chronic conditions was assessed using the Health Evaluating Questionnaire H20 V2009. The subjects were diagnosed with health (more than 80 score) or sub-health (score between 60 and 80) status according to the questionnaire score. The subjects with a sub-health status were also analyzed using the five-viscera syndrome differentiation of traditional Chinese medicine using the form for collecting information according to the four examinations. Then for gathering the facial color information, CIE L*a*b and C values and reflections of wavelengths ranged from 400 to 700 nm were measured using a CM-2600D spectrophotometer on 8 points of the face, including the frontal part, glabellas, nose, mandible, two cheeks and eyelids.RESULTS: L value of the sub-health group was higher than that of the health group (P<0.05), and a, b and C values were lower than those of the health group (P<0.05), suggesting that the facial complexion of the sub-health group was pale/whiter than the health group. The reflectance rates of wavelengths (from 400 to 550 nm) of the sub-health group were higher than those of the health group (P<0.05), which suggested that the facial complexion of the sub-health group was partially green. The a, b and C values of the forehead, glabellas and nose of subjects in the sub-health group were apparently different from the health subjects. L values of five-viscera types were significantly different from people of a health status (P<0.05). There were some differences in color values among the five-viscera groups: lung group’s color values were significantly different from the others in terms of a, b and C values. The spectral reflectance of different viscera groups of the sub-health group also showed certain differences: reflectance of wavelengths at 400 to 490 nm in the lung group and at 520 to 580 nm in the spleen group showed significant difference from the other groups, and the lung group was lower and the spleen group was higher than the others.CONCLUSION: There are some differences in facial spectrum and color in different sites of the face in sub-health status of different viscera syndrome types, which can provide an objective basis for health evaluation.

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Weighting coefficients of symptoms and signs in the diagnosis of corresponding TCM syndrome elements of ulcerative colitis based on expert questionnaire investigation
Jia-jia Wang , Tian-fang Wang , Xiu-yan WU , Yah Zhao , Xiao-lin Xue , Qing-guo Wang
Journal of Chinese Integrative Medicine    2012, 10 (4): 398-405.   DOI: 10.3736/jcim20120408
Online available: 15 April 2018

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Objective: To define the weighting coefficients of the symptoms and signs in the diagnosis of corresponding traditional Chinese medicine (TCM) syndrome elements of ulcerative colitis based on expert questionnaire investigation.
Methods: The questionnaire included eight syndrome elements of location and 11 syndrome elements relating to disease characteristics. Experts who answered the questionnaire were titled as associate chief physician or above, and had been practicing as professionals in general practice of medicine of digestive system for a long time. They came from 15 third-grade class-A hospitals (6 provinces and Beijing) in China. The weighting coefficients of the symptoms and signs in the diagnosis of corresponding TCM syndrome elements of ulcerative colitis were identified preliminarily based on consent degree of the experts (mean value and variation coefficient).
Results: There were 9, 6, 14, 5, 9, 8, 12 and 2 symptoms and signs corresponding to 8 TCM syndrome elements related to disease location and the ranges of weighting coefficients were listed as follows: liver, from 7.49 to 4.18; heart, from 6.90 to 5.51; spleen, from 7.96 to 5.55; lung, from 6.30 to 5.27; kidney, from 7.82 to 5.71; stomach, from 7.53 to 6.15; large intestine, from 8.40 to 6.70; bowel collaterals, from 8.49 to 6.41. Numbers of symptoms and signs corresponding to 11 TCM syndrome elements related to disease nature were 13, 8, 17, 18, 17, 18, 6, 11, 2, 10 and 11 and the ranges of weighting coefficients were listed as follows: qi deficiency, from 7.44 to 5.60; blood deficiency, from 7.90 to 5.59; yin deficiency, from 6.88 to 4.91; yang deficiency, from 7.54 to 5.57; dampness, from 7.91 to 4.96; excess heat (fire), from 7.13 to 5.69; excess cold, from 7.51 to 6.14; qi stagnation, from 7.38 to 5.88; qi sinking, from 7.65 to 7.43; blood stasis, from 7.60 to 5.79; fluid retention, from 7.08 to 4.46.
Conclusion: On the basis of previous document research and clinical research in ulcerative colitis, the expert questionnaire can collect consensus opinions of experts. The weighting coefficients of the symptoms and signs in the diagnosis of corresponding TCM syndrome elements of ulcerative colitis are defined preliminarily. Thereby it will lay the foundation for establishing differentiation criteria of ulcerative colitis based on TCM syndrome elements.

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Progress in research on Ganoderma lucidium spore
Wei Zhang, Yuan-shan Zeng
Journal of Chinese Integrative Medicine    2004, 2 (6): 463-465.   DOI: 10.3736/jcim20040620
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Cited: Baidu(9)
Qualitative research of the elderly real experience of long-term adherence to Tai Chi exercise
Xue Qiao, Yu-fang Hao
Journal of Chinese Integrative Medicine    2012, 10 (12): 1388-1393.   DOI: 10.3736/jcim20121209
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Objective: To explore the experience of the process of Tai Chi exercise
Methods: The study was conducted in a local park in Beijing of China where varying numbers of community members gathered to practice Tai Chi every day. Volunteers meeting the inclusion and exclusion criteria were recruited after signed an informed consent form. In-depth interview and the participatory observation were used to know of the real feeling of practicing Tai Chi. The qualitative data obtained from the interviews were analyzed by using Colaizzi seven-step method to find the subjects.
Results: Six volunteers having a long-time Tai Chi exercise were recruited in this qualitative study, and their real experience was summarized in the physiological level, psychological level, social level and cultural level. In the physiological level, Tai Chi improves the health and exercise of Tai Chi assists the elderly to develop good living habits. In the psychological level, Tai Chi practice guides the person to inner peace, relieves tension, improves depressive mood state, and makes the elderly regain self worth. In the social level Tai Chi is a good form of community practice. In the cultural level, Tai Chi roots in yin and yang culture and integrates internal and external exercises.
Conclusion: Tai Chi is good for body and mind health and the community of practice is very important for practitioners. Tai Chi gains popularity for its benefits to health and psychological adjustments, and its cultural connotation.

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Treatment of temporomandibular joint disorder by traditional Chinese medicine
Guo-heng Li
Journal of Chinese Integrative Medicine    2003, 1 (4): 258-258.   DOI: 10.3736/jcim20030407
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Facts about standardization of herbal medicine: A review
Vandana Garg, Vir Ji Dhar, Anupam Sharma, Rohit Dutt
Journal of Chinese Integrative Medicine    2012, 10 (10): 1077-1083.   DOI: 10.3736/jcim20121002
Online available: 15 October 2018

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Natural products, either as pure compounds or as standardized plant extracts, provide extensive opportunities for new drug leads because of the unmatched availability of chemical diversity. In contrast to modern medicines, herbal medicines are frequently used to treat chronic diseases. Standardization guarantees the content of one or more active constituents and marker compounds. The plant environment and genetic factors could significantly affect the biochemical components of the plant extract, in which plants are still the most abundant and cost-effective resource for drug innovation. Production of botanical drugs requires genetically uniform monocultures of the source plant in fully standardized conditions, to assure the biochemical consistency and to optimize the safety and efficacy of every crop. The present review article illustrates about the methods for standardization of herbal medicine and how the goal of preparing herbal medicines of consistent quality and effects can be achieved.

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Cited: Baidu(19)
Application of Delphi method in traditional Chinese medicine clinical research
Ying-fei Bi, Jing-yuan Mao
Journal of Chinese Integrative Medicine    2012, 10 (3): 264-270.   DOI: 10.3736/jcim20120304
Online available: 15 April 2018

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In recent years, Delphi method has been widely applied in traditional Chinese medicine (TCM) clinical research. This article analyzed the present application situation of Delphi method in TCM clinical research, and discussed some problems presented in the choice of evaluation method, classification of observation indexes and selection of survey items. On the basis of present application of Delphi method, the author analyzed the method on questionnaire making, selection of experts, evaluation of observation indexes and selection of survey items. Furthermore, the author summarized the steps of application of Delphi method in TCM clinical research.

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Practice and exploration on clinical evaluations of hospital-made Chinese herbal formulas in the Pudong New Area of Shanghai
Jie-ning Wang, Sheng Ye, Dong-hai Yu, Hui Zhao, Le-yi Du
Journal of Chinese Integrative Medicine    2012, 10 (10): 1084-1087.   DOI: 10.3736/jcim20121003
Online available: 15 October 2018

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Chinese herbal formulas can well present the characteristics of traditional Chinese medicine (TCM) with their simple, convenient, inexpensive and effective uses. However, due to the high cost of production, manufacturing pharmacies inside the hospital closed down one after another, which rendered the difficult situation of developing preparation of Chinese herbal formulas. The Pudong New Area of Shanghai, as a pilot region for comprehensive reforms on national development of TCM, vigorously explores the standardized research on and application of hospital-made Chinese herbal formulas. The Health Bureau of the Pudong New Area, based on the Shuguang Hospital, has established a clinical evaluation center for hospital-made Chinese herbal formulas. Through screening, manufacturing, quality control, unified allocation, and standardized clinical evaluation, the clinical evaluation center has summarized its experience on these processes.

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Pharmacological effects and active phytoconstituents of Swietenia mahagoni: A review
Yelaware Puttaswamy Naveen, Gunashekar Divya Rupini, Faiyaz Ahmed, Asna Urooj
Journal of Integrative Medicine    2014, 12 (2): 86-93.   DOI: 10.1016/S2095-4964(14)60018-2
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The usage of Swietenia mahagoni, a popular medicinal plant in India and some African countries, dates back to ancient times for its curative properties in diseases like malaria, diabetes, and diarrhea. It is also used as an anti-pyretic, bitter tonic and astringent. Its pharmacological activities are being widely explored. Although many important groups of phytochemicals have been identified and isolated from various parts of the plant, most of these researches have been focused on seeds. Toxicological studies have established the safety of many of these plant extracts, and found insignificant side effects. Here we present a comprehensive review of all the pharmacological effects and constituent phytochemicals of the plant.

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Cited: Baidu(11)
Analysis on content of serum monoamine neurotransmitters in macaques with anger-in-induced premenstrual syndrome and liver-qi depression syndrome
Sheng Wei, Jin-liang Hou, Yu-bin Chao, Xi-yang Du, Shao-bo Zong
Journal of Chinese Integrative Medicine    2012, 10 (8): 925-931.   DOI: 10.3736/jcim20120814
Online available: 15 August 2018

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Objective: To observe the changes in content of monoamine neurotransmitters in the serum of rhesus macaques, and explore the role of serum monoamine neurotransmitters in premenstrual syndrome (PMS) and liver-qi depression induced by anger-in emotion.

Methods: Social level pressure was applied on 24 female macaques to induce the angry emotional reaction, and then nine of the low-status macaques with anger-in emotional reaction were screened out and were divided into anger-in emotion group, PMS and liver-qi depression group (model group) and Jingqianshu Granule group. Macaques in the last two groups were suffered extruding in a pack cage for inducing PMS liver-qi depression. After 5 d of extruding, experimental animals were evaluated according to the emotional evaluation scale, meanwhile, macaque serum of follicular phase and middle-late luteal phase was collected to analyze the content of serum norepinephrine, dopamine, and 5-hydroxytryptamine.

Results: Compared with the normal control group, the scores of depression of the model group and the anger-in emotion group evaluated with emotional evaluation scale were significantly increased (P<0.01, P<0.05); while the score of the model group was significantly higher than that of the anger-in emotion group (P<0.05), and it returned to normal after Jingqianshu Granule treatment. As compared to the normal control group, serum monoamine neurotransmitter levels of the model group and the anger-in emotion group were increased (P<0.05, P<0.01), and the serum monoamine neurotransmitter levels of the model group were significantly higher than those of the anger-in emotion group (P<0.05), while there was no significant difference when compared with the normal control group after the treatment.

Conclusion: Anger-in emotion can induce liver-qi depression syndrome which is related to the changes in monoamine neurotransmitters.

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Tongue conditions and constitution
Tiao-yuan Kuang
Journal of Chinese Integrative Medicine    2004, 2 (4): 264-264.   DOI: 10.3736/jcim20040407
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Treatment of diabetes through liver syndrome differentiation
Li Zhao
Journal of Chinese Integrative Medicine    2004, 2 (4): 303-305.   DOI: 10.3736/jcim20040423
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A brief introduction to Appraisal of Guidelines for Research and Evaluation Ⅱ
Xie Li-min, Wang Wen-yue
Journal of Chinese Integrative Medicine    2012, 10 (2): 160-165.   DOI: 10.3736/jcim20120206
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Clinical practice guidelines play an important role in practitioner and patient decisions regarding appropriate clinical health care and in health policy formation. In the guideline development process, inappropriate methodologies and development strategies significantly influence the quality of guidelines; therefore, research and evaluation of guidelines have great significance. The original Appraisal of Guidelines for Research and Evaluation (AGREE) instrument was published in 2003 by a group of international guideline developers and researchers. AGREE has important significance for the quality guarantee and successful implementation of guidelines, and has extensively achieved endorsement since 2003. In 2009, The AGREE Collaboration has developed the AGREE Ⅱ by refining the original AGREE instrument. At present, the AGREE Ⅱ has already replaced the original AGREE instrument; however, related introduction regarding AGREE Ⅱ has not been found in China. The authors of this article briefly introduce the AGREE Ⅱ, and believe that it will add value to research and evaluation of the guidelines.

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Puzzle of hormone replacement therapy and prospect of the role of traditional Chinese medicine in treating postmenopausal syndrome
Ming-dao Chen, Ying Yang
Journal of Chinese Integrative Medicine    2003, 1 (1): 9-11.   DOI: 10.3736/jcim20030105
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In July 2002, the Women's Heath Initiative (WHI) clinical trial, designed to clarify the risks and benefits of combination hormone replacement therapy (HRT) to the postmenopausal women declared that interim safety review after an average follow-up of 5.2 years found that a combination of estrogen and progestin frequently prescribed to postmenopausal women in USA increased the risk of invasive breast cancer, heart disease, stroke, and pulmonary embolism while reduced bone fractures and colorectal cancer. The overall risks of HRT outweigh the benefits, which provides an opportunity for traditional Chinese medicine (TCM) going abroad. A variety of clinical and experimental evidences have showed that TCM exerts quite satisfactory effect on relieving postmenopausal symptoms with little adverse effect, hence a potential role to replace or to improve HRT or to reduce the side effect induced by HRT.

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Re-discussion on the translating principles of traditional Chinese medicine
Chuan-yue Niu
Journal of Chinese Integrative Medicine    2004, 2 (3): 235-238.   DOI: 10.3736/jcim20040328
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Cited: Baidu(4)
Application of traditional Chinese medicine in treating acute infection of throat
Zhong-hua Zhang
Journal of Chinese Integrative Medicine    2004, 2 (1): 52-52.   DOI: 10.3736/jcim20040119
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Cited: Baidu(6)
Discussion on six errors of formulas corresponding to syndromes in using the classic formulas
Bao Yan-ju, Hua Bao-jin
Journal of Chinese Integrative Medicine    2012, 10 (12): 1363-1370.   DOI: 10.3736/jcim20121205
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The theory of formulas corresponding to syndromes is one of the characteristics of Treatise on Cold Damage and Miscellaneous Diseases (Shanghan Zabing Lun) and one of the main principles in applying classic prescriptions. It is important to take effect by following the principle of formulas corresponding to syndromes. However, some medical practitioners always feel that the actual clinical effect is far less than expected. Six errors in the use of classic prescriptions as well as the theory of formulas corresponding to syndromes are the most important causes to be considered, i.e. paying attention only to the local syndromes while neglecting the whole, paying attention only to formulas corresponding to syndromes while neglecting the pathogenesis, paying attention only to syndromes while neglecting the pulse diagnosis, paying attention only to unilateral prescription but neglecting the combined prescriptions, paying attention only to classic prescriptions while neglecting the modern formulas, and paying attention only to the formulas but neglecting the drug dosage. Therefore, not only the patients’ clinical syndromes, but also the combination of main syndrome and pathogenesis simultaneously is necessary in the clinical applications of classic prescriptions and the theory of prescription corresponding to syndrome. In addition, comprehensive syndrome differentiation, modern formulas, current prescriptions, combined prescriptions, and drug dosage all contribute to avoid clinical errors and improve clinical effects.

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Major institutions conducting researches on complementary and alternative medicine in the United Kingdom: University of Leeds, University of Westminster and University of York
Jun-ying Fu
Journal of Chinese Integrative Medicine    2009, 7 (5): 495-499.   DOI: 10.3736/jcim20090518
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Effects of acupuncture at Shenmen (HT7) or Taiyuan (LU9) on P3a and P3b of event-related potentials in healthy young adults
Cai Rong-lin, Hu Ling, Wu Zi-jian, Wang Ke-ming, He Lu, Zhou Yi-ping, Zhao Lun, Hu Wu-bin
Journal of Chinese Integrative Medicine    2012, 10 (1): 48-53.   DOI: 10.3736/jcim20120108
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OBJECTIVE: To investigate the effects of manual acupuncture at Shenmen (HT7) or Taiyuan (LU9) on the attention function of the brain, and to lay an experimental foundation for researching brain function and integration mechanisms of the human brain in relation to acupuncture stimulation.METHODS: Ten healthy young college students were selected as experimental subjects. P3a and P3b potentials were induced by novel stimulation and target stimulation with vision and were observed using Neuroscan event-related potentials system at time windows of ms 330-430 or 400-600 ms for observing the change of intensity distribution of P300 after manual acupuncture at HT7 or LU9.RESULTS: The amplitude of P3a and P3b decreased significantly after manual acupuncture at HT7 or LU9, but the degree of decreases affected by the acupoints was different. The decrease of the amplitude of P3a due to acupuncture at HT7 was more significant than acupuncture at LU9 (P<0.05).CONCLUSION: The attention function of the brain is affected by manual acupuncture at HT7 or LU9 and manual acupuncture at HT7 has a greater influence on the attention function of the brain.

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Adequate application of quantitative and qualitative statistic analytic methods in acupuncture clinical trials
Ming T. Tan , Jian-ping Liu , Lixing Lao
Journal of Chinese Integrative Medicine    2012, 10 (8): 847-852.   DOI: 10.3736/jcim20120803
Online available: 15 August 2018

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Recently, proper use of the statistical methods in traditional Chinese medicine (TCM) randomized controlled trials (RCTs) has received increased attention. Statistical inference based on hypothesis testing is the foundation of clinical trials and evidence-based medicine. In this article, the authors described the methodological differences between literature published in Chinese and Western journals in the design and analysis of acupuncture RCTs and the application of basic statistical principles. In China, qualitative analysis method has been widely used in acupuncture and TCM clinical trials, while the between-group quantitative analysis methods on clinical symptom scores are commonly used in the West. The evidence for and against these analytical differences were discussed based on the data of RCTs assessing acupuncture for pain relief. The authors concluded that although both methods have their unique advantages, quantitative analysis should be used as the primary analysis while qualitative analysis can be a secondary criterion for analysis. The purpose of this paper is to inspire further discussion of such special issues in clinical research design and thus contribute to the increased scientific rigor of TCM research.

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Multicenter clinical study about the action of Fuzheng Huayu Capsule against liver fibrosis with chronic hepatitis B
Ping Liu, Yi-yang Hu, Cheng Liu, Lie-ming Xu, Cheng-hai Liu, Ke-wei Sun, De-chang Hu, You-kuan Yin, Xia-qiu Zhou, Mo-bin Wan, Xiong Cai, Zhi-\qing Zhang, Jun Ye, Bao-zhang Tang, Jia He
Journal of Chinese Integrative Medicine    2003, 1 (2): 89-98.   DOI: 10.3736/jcim20030204
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Objective

To study the efficacy and safety of Fuzheng Huayu Capsule (FZHY Capsule) against liver fibrosis with chronic hepatitis B.


Methods

Multicentric, randomized, double blinded and paralleled control led trial was conducted on patients (aged between 18 and 65) with liver fibrosis in chronic hepatitis B.Indexes observed: (1) hepatic histological changes and HBV markers were observed at 0 and 24th week during the treatment; serological indexes (HA, LN, P-Ⅲ-P, Ⅳ-C) were determined and B ultrasound examination of spleen and liver was taken at 0, 12th, 24th week; liver function (during the period of follow-up, liver function and serological indexes for liver fibrosis were evaluated) were observed at 0, 6th, 12th, 18th, 24th week; (2) indexes for safety: blood and urine routine tests, renal function and ECG were examined.


Results

(1) Enrollment and demographic data: There was no significant difference between the trial (110 cases) and control group (106 cases) in demographic feature, vital signs, course of illness,history for drug anaphylaxis, history of previous therapy, liver function, serological indexes for liver fibrosis, liver histological examination (99 cases for test group, 96 cases for control group), HBV markers, and renal function, etc. (2) Histological pathological examination: 93 cases of liver histological examination were taken, of these 50 cases for the trial group and 43 cases for control group which turned out to be at S mean value of 2.33 and 2.11 respectively pretreatment according to criteria for liver fibrosis staging. Post-treatment, the trial showed a significant decrease with S value of 1.80 compared to that of pretreatment; however, there was no significant improvement in control group before and after the treatment with S mean value of 2.14. There was significant difference in reversing rate (decrease at least 1 stage according to criteria for liver fibrosis staging) between the trial (52%) and control (23.3%) after liver biopsy. The trial had a rather good effect on improving inflammatory activity and was superior to control group with a marked decrease of mean value of inflammatory activity and score of inflammation (P<0.05). (3) Serological indexes for liver fibrosis: There was a significant decrease in HA, LN, P-Ⅲ-P, Ⅳ-C content in test group after 12 and 24 weeks' treatment compared to that of pretreatment; the differences of HA, LN, P-Ⅲ-P, Ⅳ-C between 12 , 24 weeks' treatment and pretreatment were significantly greater than control group (P<0.01 or 0.05); the effectual was defined as 2 of 4 indexes lowered more than 30% of the baseline, according to this criteria, the trial was 72.7%, while control group 27.4% (P<0.01). (4) Liver function: Obvious improvement of serum Alb, ALT, AST, GGT was seen in 2 groups; compared with control group, marked improvement of GGT and Alb in the trial (P<0.05); the effective rate of serum ALT in the trial group was 72.7%, while control 59.4%. (5) No changes of significant difference between pre- and post-treatment in routine tests for blood and urine, renal function and ECG, etc. There was also no difference in the stable rate of ALT and serological indexes for liver fibrosis between the trial and control group 12 weeks after withdrawal (P<0.05).


Conclusion

Fuzheng Huayu Capsule has good effect on alleviating liver fibrosis in chronic hepatitis B without any adverse effect and is superior to Heluo Shugan Capsule. Fuzheng Huayu Capsule is a safe and effective medicine for the treatment of liver fibrosis in chronic hepatitis B.

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The study of intoxication and toxicity of Fructus Xanthii
Xue-mei Zhang, Zhong-hua Zhang
Journal of Chinese Integrative Medicine    2003, 1 (1): 71-74.   DOI: 10.3736/jcim20030129
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Fructus Xanthii is commonly used in rhinology, especially used in treatment of chronic rhinitis and sinusitis. But Fructus Xanthii is toxicant, and it maybe result in poisoning when used excessively, without preparation or in inappropriate preparation. This article reviewed all poisoning cases from 1960 to 2000, its toxicology and methods for detoxification.

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Cited: Baidu(16)
Development of international standardization of traditional Chinese medical terminologies: A review of WHO’s second conference on International Classification of Traditional Medicine held in Tokyo
Zhao-guo Li
Journal of Chinese Integrative Medicine    2011, 9 (1): 113-115.   DOI: 10.3736/jcim20110119
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Professor TANG Han-Jun's thinking in syndrome differentiation and experience in treating breast cancer
Hai-guang Qin
Journal of Chinese Integrative Medicine    2004, 2 (4): 297-298.   DOI: 10.3736/jcim20040420
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Progress in research on hirudo
Rong-qing Huang, Xiao-dong Sun, Yang-ling Li, Hong Wang
Journal of Chinese Integrative Medicine    2004, 2 (5): 387-389.   DOI: 10.3736/jcim20040523
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Progress of study on Th1/Th2 balance related to research on traditional Chinese medicine
Zi-jun Chen, Yun-sen Li, Yi-kui Li
Journal of Chinese Integrative Medicine    2004, 2 (2): 149-150.   DOI: 10.3736/jcim20040224
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Relationship between symptom stratification and syndrome differentiation of traditional Chinese medicine for depressive episode
Sui Yue Hu, Su E Wang, Chun Hu Zhang
Journal of Chinese Integrative Medicine    2011, 9 (9): 933-936.   DOI: 10.3736/jcim20110902
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On the basis of medical literature review and clinical research experience, the authors analyzed the reasons for low recognition rate of depression and poor progress of traditional Chinese medicine (TCM) differentiation of depression in this paper and put forward that depressive episode symptoms and the corresponding common terminology classification of Chinese and Western medicine should be the breakthrough points. Through symptom stratification and combination, as well as distinguishing between primary and secondary symptoms, the comprehensive integrative medicine clinical assessment of depression was explored so as to further obtain expert consensus and provide a methodology reference for the TCM differentiation of depression and the research of etiology and pathogenesis.

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Placebo control and clinical trial of Chinese medicine
J Wu
Journal of Chinese Integrative Medicine    2010, 8 (10): 906-910.   DOI: 10.3736/jcim20101001
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World Health Organization aims to develop safe, effective and practical traditional medicine. Traditional Chinese medicine (TCM) and other complementary and alternative medicine are being recognized in the whole world nowadays. However, the definite effect of Chinese medicine is still in need of scientific research proof. Placebo control is of equal importance to active control and blank control in clinical trial of TCM. This article briefly reviewed the importance of placebo control and commented on its present situation in clinical trial of TCM. This article also brought up the preliminary proposals of placebo application in TCM clinical trial. We should emphasize scientific placebo preparation and good design of placebo-controlled trial, which are directed by International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use. A good clinical trial project will avoid unnecessary wastes and provide safe and effective treatment for people.

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Cited: Baidu(14)
Clinical obs ervation on manipulation without syndrome differentiation in treating infantile diarrhea
Wei-qiong Hu
Journal of Chinese Integrative Medicine    2004, 2 (3): 220-221.   DOI: 10.3736/jcim20040322
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Clinical research on effects of Bushen Huoxue Decoction in treating infertility owing to ovary dysfunction
Gui-yun Yang
Journal of Chinese Integrative Medicine    2004, 2 (2): 138-139.   DOI: 10.3736/jcim20040219
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Modern testing theory and its application in the field of health measurement
Da-rong Wu
Journal of Chinese Integrative Medicine    2012, 10 (3): 271-278.   DOI: 10.3736/jcim20120305
Online available: 15 April 2018

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This paper briefly introduces item response theory (IRT) as a typical representation of modern testing theory (MTT), and systematically reviews the processes and contents of the application of IRT in the area of health measurement, including, for example, item bank development, scale revision and computerized adaptive testing. The author presents the potential benefits and the notable problems during health measuring by IRT. Then, the author asserts the need for thorough assessment of feasibility when using the IRT in patient-reported outcome research. Further research based on IRT and computerized adaptive testing in health measurement will be carried out in the field of medical care including traditional Chinese medicine and integrative medicine.

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Stratified analysis of the relationship between traditional Chinese medicine constitutional types and health status in the general population based on data of 8448 cases
Yan-bo Zhu, Qi Wang, Ke-fan Chen, Yu-e Wu, Wei-li Hong, Li Liu
Journal of Chinese Integrative Medicine    2011, 9 (4): 382-389.   DOI: 10.3736/jcim20110406
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Objective: To examine the relationship between traditional Chinese medicine (TCM) constitutional types and health status among groups of different age or gender in the general population of China.
Methods: Data of 8 448 cases were randomly sampled from a database of 21 948 cases of a cross-sectional survey on the TCM constitutional types and health status which was carried out in 9 provinces or municipalities of China (Jiangsu, Anhui, Gansu, Qinghai, Fujian, Beijing, Jilin, Jiangxi and Henan) according to gender and age structure of the Chinese population in 2005. Scores of health-related quality of life scale — the Medical Outcomes Study 36-Item Short-Form Health Survey (MOS SF-36) — were analyzed by Nemenyi test to compare the health status of individuals with different constitutional types.
Results: Compared with the gentleness type, the MOS SF-36 scores of the 8 types of pathological constitution were significantly low (P<0.05) among groups of different age or gender. The MOS SF-36 score was the lowest in men of the qi-deficiency, qi-depression and blood-stasis types, while it was the lowest in women of the phlegm-dampness, qi-depression and qi-deficiency types. For the age group of 15 to 34, the special diathesis, qi-depression and blood-stasis types had the lowest MOS SF-36 scores; for the age group of 35 to 59, the qi-deficiency, qi-depression and blood-stasis types had the lowest MOS SF-36 scores; for the age group of over 60, the qi-deficiency, qi-depression and phlegm-dampness types had the lowest MOS SF-36 scores.
Conclusion: In groups of different gender or age, the MOS SF-36 scores of the 8 types of pathological constitution were significantly lower than that of the gentleness type, indicating a deficient health status. The health status of different types of constitution showed different characteristics in groups of different gender or age.

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Tactics of acupuncture for migraine prophylaxis
Jia Guo
Journal of Chinese Integrative Medicine    2010, 8 (3): 210-214.   DOI: 10.3736/jcim20100302
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In order to provide some more scientific and practical advice and tactics for acupuncture in prevention of migraine in clinic, a computer-based information search was conducted in MEDLINE database, and the current reports of clinical trials were summarized and a comparison of Western and Chinese research designs was made. The significant role of acupuncture for prevention of migraine has not been applied in wide range in China until the present day. However, it has been paid great attention in Western countries. This situation might be related to the differences of efficacy assessment of acupuncture between China and Western countries; meanwhile, in the past traditional acupuncturists put much stress on the therapeutic approaches for acute attacks of headache but less on prevention. It is necessary for Chinese doctors to learn from research method in the West and emphasize more on acupuncture for preventing migraine and conduct high-level clinical trials as well. The author recommends that Chinese doctors should select acupuncture points mainly according to meridian syndrome differentiation and apply long term intermittent interventions.

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ISSN 2095-4964
CN 31-2083/R

Editors-in-Chief:
Lixing Lao, Virginia, USA
Frequency: 6 issues per year
Publisher: Science Press, China

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