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Analysis of studies on pattern recognition of tongue image in traditional Chinese medicine by computer technology
Xiao-qiang Yue, Qing Liu
Journal of Chinese Integrative Medicine    2004, 2 (5): 326-329.   DOI: 10.3736/jcim20040503
Abstract977)   HTML5)    PDF(pc) (75KB)(7341)      

The article analyzed the contemporary study of pattern recognition of tongue images in traditional Chinese medicine by computer technology from its key sectors. It regards that the methods of orthogonal design and evaluation of image quality should be introduced to get a high-quality and practicable condition. In the field of tongue image segmentation, multiple methods used together are expected to improve the effect of segmentation. A scientific and canonical standard of tongue diagnosis based on comprehensive experts' experience with Delphi evaluation method and multi-center experts diagnosis on internet are also very essential. The study of pattern recognition on tongue image is still concentrated on the color. Further study should be extended to achieve quantification. And a comprehensive diagnosis on pattern recognition of tongue image is the aim that should be focused on later.

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Accidents in acupuncture treatment: History and current state
Ren Zhang
Journal of Chinese Integrative Medicine    2004, 2 (4): 306-313.   DOI: 10.3736/jcim20040424
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Acupuncture is widely used as an alternative therapy with few side effects because of its simple manipulation and low cost. However, accidents may occur if the practitioner uses it improperly. Early in the Qin dynastuy, the Canon of Medicine mentioned that improper use of acupuncture could cause injury to the body and even death, and it systematically described the occurrence and prevention of acupuncture accidents. Physicians in the successive dynasties frequently reported it, and nealized that the manipulation skills were significantly important in preventing the occurrence of acupuncture accidents.Since the 1950s, acupuncture accidents had been effectively prevented because of the improving of acupuncture instruments, enhancing of the quality of the practitioners, popularizing of sterilization and disseminating of anatomic knowledge. Nevertherless, with the renovating of acupuncture techniques, new accidents may occur constantly. The prevention of acupuncture accidents still should be an arduors task for acupuncturists. Nowadays, acupuncture therapy is being used in more than 140 countries, and acupuncture accidents due to improper application are incrcasing. Prevention of acupuncture accidents has become a global issue deserving of great attention.

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Progress in research on Chinese herbs with estrogen-like effects
Xiao-xiao Zhang, Sheng Liu, Xiao-hong Xue
Journal of Chinese Integrative Medicine    2005, 3 (2): 149-153.   DOI: 10.3736/jcim20050219
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Medicinal potential of Passiflora foetida L. plant extracts: Biological and pharmacological activities
Md. Asadujjaman, Ahmed Ullah Mishuk, Md. Aslam Hossain, Utpal Kumar Karmakar
Journal of Integrative Medicine    2014, 12 (2): 121-126.   DOI: 10.1016/S2095-4964(14)60017-0
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Objective

To investigate analgesic, antidiarrhoeal and cytotoxic activities of the ethanol extract of Passiflora foetida L. (Passifloraceae) by three experimental methods. 

Methods

Analgesic activity of the ethanol extract of Passiflora foetida L. (EEPF) was carried out using acetic acid-induced writhing inhibition in mice. The method of castor oil-induced diarrhoea in mice was utilized to evaluate antidiarrhoeal activity. The cytotoxic activity of EEPF was explored with a brine shrimp lethality bioassay. 

Results

The extract showed 68.75% and 30.00% inhibition of writhe at the doses of 500 and 250 mg/kg body weight, respectively. The extract increased the mean latent period prior to diarrhoeal onset to about 1.55 h and 1.17 h, and decreased the mean number of stools to 4.4 and 5.6 at the doses of 500 and 250 mg/kg body weight. The extract also demonstrated cytotoxic activity in the brine shrimp lethality assay, and the median lethal concentration for brine shrimp nauplii was 80 μg/mL. 

Conclusion

The results suggest that the plant extract has analgesic and antidiarrhoeal activities, supporting its uses in traditional medicine. The results also demonstrate that the plant extract possesses cytotoxic activities.

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Cited: Baidu(15)
Facts about standardization of herbal medicine: A review
Vandana Garg, Vir Ji Dhar, Anupam Sharma, Rohit Dutt
Journal of Chinese Integrative Medicine    2012, 10 (10): 1077-1083.   DOI: 10.3736/jcim20121002
Online available: 15 October 2018

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Natural products, either as pure compounds or as standardized plant extracts, provide extensive opportunities for new drug leads because of the unmatched availability of chemical diversity. In contrast to modern medicines, herbal medicines are frequently used to treat chronic diseases. Standardization guarantees the content of one or more active constituents and marker compounds. The plant environment and genetic factors could significantly affect the biochemical components of the plant extract, in which plants are still the most abundant and cost-effective resource for drug innovation. Production of botanical drugs requires genetically uniform monocultures of the source plant in fully standardized conditions, to assure the biochemical consistency and to optimize the safety and efficacy of every crop. The present review article illustrates about the methods for standardization of herbal medicine and how the goal of preparing herbal medicines of consistent quality and effects can be achieved.

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Cited: Baidu(19)
Prevention and treatment of pulmonary-fibrosis by traditional Chinese medicine
Chu-fang Yao, Shu-long Jiang
Journal of Chinese Integrative Medicine    2003, 1 (3): 234-238.   DOI: 10.3736/jcim20030327
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Pulmonary-fibrosis (PF) is the result of interstitial lung disease which has different causes and it is one of the most intractable diseases in respiratory system. The PF is characterized by progressive difficulty of breath and dying of respiratory failure, seriously threatening the health of people. Immunosuppressive drugs and glucocorticoids have been widely adopted as the main methods in treatment, but the results are not satisfactory and the side effects are obvious. Many specialists have tried traditional Chinese medicine in recent years with satisfactory effect, indicating that the prospect of using traditional Chinese medicine in the treatment of PF is optimistic. This article outlines the researches about using traditional Chinese medicine in the treatment of PF.

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Cited: Baidu(9)
Three advantages of using traditional Chinese medicine to prevent and treat tumor
Chang-quan Ling​, Xiao-qiang Yue, Chen Ling​
Journal of Integrative Medicine    2014, 12 (4): 331-335.   DOI: 10.1016/S2095-4964(14)60038-8
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Traditional Chinese medicine (TCM), an important component of complementary and alternative medicine, has evolved over thousands of years with its own unique system of theories, diagnostics and therapies. TCM has been increasingly used in the last decades and become well known for its significant role in preventing and treating cancer. We believe that TCM possesses advantages over Western medicine in specific aspects at a certain stage of cancer treatment. Here we summarize the advantages of TCM from three aspects: preventing tumorigenesis; attenuating toxicity and enhancing the treatment effect; and reducing tumor recurrence and metastasis.

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Cited: Baidu(242)
Gross conception of anatomical structure of zang-fu viscera in Huangdi Neijing
Ye-tao Gao, Hui-wei Pan​, Sheng-bing Wu​
Journal of Chinese Integrative Medicine    2006, 4 (4): 339-342.   DOI: 10.3736/jcim20060404
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The scientificalness of traditional Chinese medicine (TCM) is often doubted and criticized for the record in Huangdi Neijing that the liver is located in the left of the human body. The most popular explanation of this criticism is that the conception of zang-fu viscera in TCM is quite different from which defined in Western medicine. It means that the zang-fu viscera in TCM are not exactly the corresponding anatomical organs in modern human anatomy but reflect the functions of some systems in human body. According to the classical theories of TCM in Huangdi Neijing, we consider that the record of liver located in the left of the human body is based on the Ba Gua (Eight Diagrams) of traditional Chinese philosophy, not the human anatomy. In brief, the conception of zang-fu viscera is initially a gross anatomical conception, and in a sense the anatomic sites and functions of which are mostly similar to those described in Western medicine.

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Progress in research on pharmaceutics for intranasal medication
Tong Zhang, Lian-ying Xu
Journal of Chinese Integrative Medicine    2004, 2 (3): 223-225.   DOI: 10.3736/jcim20040324
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Discussion on six errors of formulas corresponding to syndromes in using the classic formulas
Bao Yan-ju, Hua Bao-jin
Journal of Chinese Integrative Medicine    2012, 10 (12): 1363-1370.   DOI: 10.3736/jcim20121205
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The theory of formulas corresponding to syndromes is one of the characteristics of Treatise on Cold Damage and Miscellaneous Diseases (Shanghan Zabing Lun) and one of the main principles in applying classic prescriptions. It is important to take effect by following the principle of formulas corresponding to syndromes. However, some medical practitioners always feel that the actual clinical effect is far less than expected. Six errors in the use of classic prescriptions as well as the theory of formulas corresponding to syndromes are the most important causes to be considered, i.e. paying attention only to the local syndromes while neglecting the whole, paying attention only to formulas corresponding to syndromes while neglecting the pathogenesis, paying attention only to syndromes while neglecting the pulse diagnosis, paying attention only to unilateral prescription but neglecting the combined prescriptions, paying attention only to classic prescriptions while neglecting the modern formulas, and paying attention only to the formulas but neglecting the drug dosage. Therefore, not only the patients’ clinical syndromes, but also the combination of main syndrome and pathogenesis simultaneously is necessary in the clinical applications of classic prescriptions and the theory of prescription corresponding to syndrome. In addition, comprehensive syndrome differentiation, modern formulas, current prescriptions, combined prescriptions, and drug dosage all contribute to avoid clinical errors and improve clinical effects.

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Clinical and experimental studies on polyherbal formulations for diabetes: Current status and future prospective
Ahmad Ghorbani
Journal of Integrative Medicine    2014, 12 (4): 336-345.   DOI: 10.1016/S2095-4964(14)60031-5
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Diabetes is a leading cause of morbidity and mortality in the world. There is currently an active search for antidiabetic drugs with greater effectiveness with fewer and less adverse side effects. Although numerous individual herbs have been experimentally or clinically reported to possess antidiabetic effects, considerably less research has been conducted on polyherbal compounds. It is believed that herbal compounds containing multiple plant products have synergistic antidiabetic effects and could enhance the desired actions. Several polyherbal formulations have been studied as therapeutic agents in diabetes management. To describe the current state of research on polyherbal compounds in the treatment of diabetes, an extensive review of literature was undertaken on several major databases. This paper presents what is known about the efficacy of these polyherbal formulations and compare their antidiabetic effects with those of current oral hypoglycemic drugs as reference. The percent decrease in blood glucose, lipids and other biochemical parameters achieved by each product in diabetic animals and patients is reported. Also, the possible mechanisms responsible for hypoglycemic action of polyherbal formulations are discussed.

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Cited: Baidu(33)
English translation of cultural aspects of the titles of traditional Chinese medicine classics based on the skopos theory
Ji Chen, Qin Pan, Li-shuang Ye, Jia-ling Huang
Journal of Chinese Integrative Medicine    2012, 10 (11): 1316-1320.   DOI: 10.3736/jcim20121117
Online available: 15 November 2018

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Cited: Baidu(1)
Introduction of the World Health Organization project of the International Classification of Traditional Medicine
Peng-fei Gao, Kenji Watanabe
Journal of Chinese Integrative Medicine    2011, 9 (11): 1161-1164.   DOI: 10.3736/jcim20111101
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The World Health Organization plans to incorporate "traditional medicine" into the next revision of its International Classification of Diseases — Version 11 (ICD-11). If traditional medicine is included in ICD-11, it is definitely an epoch-making issue. The expected result is the International Classification of Traditional Medicine, China, Japan and Korea Version (ICTM-CJK). The intention of the ICTM project is not only beneficial for traditional medical components, but also might be beneficial for Western biomedicine. For this shared purpose, China, Japan and Korea must understand the meaning of this project and collaborate to develop it.

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Pharmacological effects and active phytoconstituents of Swietenia mahagoni: A review
Yelaware Puttaswamy Naveen, Gunashekar Divya Rupini, Faiyaz Ahmed, Asna Urooj
Journal of Integrative Medicine    2014, 12 (2): 86-93.   DOI: 10.1016/S2095-4964(14)60018-2
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The usage of Swietenia mahagoni, a popular medicinal plant in India and some African countries, dates back to ancient times for its curative properties in diseases like malaria, diabetes, and diarrhea. It is also used as an anti-pyretic, bitter tonic and astringent. Its pharmacological activities are being widely explored. Although many important groups of phytochemicals have been identified and isolated from various parts of the plant, most of these researches have been focused on seeds. Toxicological studies have established the safety of many of these plant extracts, and found insignificant side effects. Here we present a comprehensive review of all the pharmacological effects and constituent phytochemicals of the plant.

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Cited: Baidu(11)
Dr. Miriam Lee: A heroine for the start of acupuncture as a profession in the State of California
Arthur Yin Fan, Ziyi Fan​
Journal of Integrative Medicine    2014, 12 (3): 182-186.   DOI: 10.1016/S2095-4964(14)60016-9
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Cited: Baidu(8)
Discussion of time and space differentiation of three-yin and three-yang in Shanghan Lun
Wen-hui Ma, Xiao-hong Sun
Journal of Chinese Integrative Medicine    2005, 3 (4): 257-259.   DOI: 10.3736/jcim20050402
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The concept of "three-yin and three-yang" in Shanghan Lun (Treatise on Cold Pathogenic Diseases), a classic written by Zhang Zhongjing in Han Dynasty, has been always the focus of dispute in successive dynasties. The essence of "three-yin and three-yang" has not been fully revealed up till now. Through studying the six divisions of day and night, the six diseases, the combination of syndromes, the complicated diseases, the complete recovery time and the space division of "three-yin and three-yang", the authors draw a conclusion that the "three-yin and three-yang" in Shanghan Lun is a concept of time-sequence, which is associated with the location of disease in space. So it is suggested that the "six diseases" in Shanghan Lun is a categorization for exogenous febrile diseases, and this categorization reveals a sort of inner relationship between the emergence, development, transformation of the febrile diseases and the time.

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Antidiabetic and hypolipidemic activities of Dillenia indica extract in diabetic rats
Sunil Kumar, Vipin Kumar, Om Prakash
Journal of Chinese Integrative Medicine    2011, 9 (5): 570-574.   DOI: 10.3736/jcim20110517
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Objective: The present study was carried out to investigate the antidiabetic and hypolipidemic activities of bioactive fraction (ethyl acetate fraction) of Dillenia indica methanolic extract in experimental diabetic Wistar rats.
Methods: Type-1 diabetes was induced by single intraperitoneal injection of streptozotocin (60 mg/kg body weight), and type-2 diabetes was induced by single intraperitoneal injection of streptozotocin (60 mg/kg body weight), 15 min after the intraperitoneal injection of 120 mg/kg nicotinamide. The rats were treated by administering graded oral doses of isolated ethyl acetate fraction of methanolic extract of D. indica (DIEE), 200 and 400 mg/kg body weight, respectively, for 21 d. The blood glucose level was estimated at weekly intervals by glucometer. Serum cholesterol, triglycerides and high-density lipoprotein cholesterol (HDL-C) were also evaluated in normal and diabetic rats by an autoanalyzer.
Results: In both experimental models, daily oral treatment with DIEE for 21 d resulted in a significant reduction in blood glucose (P<0.01), serum cholesterol (P<0.05) and triglycerides (P<0.05) levels whereas HDL-C level was found to be increased (P<0.05) as compared with the diabetic control group.
Conclusion: DIEE at 400 mg/kg body weight has prominent antidiabetic effect in experimental type-1 and type-2 diabetes models in rats. It may therefore be used as an alternative remedy for the treatment of diabetes mellitus.

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Progress in pharmacotherapy of integrated traditional Chinese and western medicine for virus infection in respiratory tract
Yu-hua Liu, Jing-cheng Dong
Journal of Chinese Integrative Medicine    2004, 2 (3): 226-227.   DOI: 10.3736/jcim20040325
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Chemical components of Centella asiatica and their bioactivities
Cheng-jian Zheng, Lu-ping Qin
Journal of Chinese Integrative Medicine    2007, 5 (3): 348-351.   DOI: 10.3736/jcim20070324
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Cited: Baidu(143)
Successful use of Zhengwu Decoction in treating eye diseases: Case report
Ya-qin Ru
Journal of Chinese Integrative Medicine    2005, 3 (1): 61-62.   DOI: 10.3736/jcim20050119
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Renoprotective effects of Moringa oleifera pods in 7,12-dimethylbenz[a]anthracene-exposed mice
Veena Sharma, Ritu Paliwal, Pracheta Janmeda, Shatruhan Sharma
Journal of Chinese Integrative Medicine    2012, 10 (10): 1171-1178.   DOI: 10.3736/jcim20121015
Online available: 15 October 2018

Abstract988)   HTML1)    PDF(pc) (1449KB)(302)      

Objective: To investigate the potential of hydroethanolic extract of Moringa oleifera (MOHE) against 7, 12-dimethylbenz[a]anthracene (DMBA)-induced toxicity in male Swiss albino mice. .

Methods: Experimental mice were respectively pretreated with 200 and 400 mg/kg of MOHE, and 0.5% and 1% of butylated hydroxyanisole (BHA) for two weeks prior to the administration of 15 mg/kg of DMBA, respectively. Levels of xenobiotic metabolizing enzymes such as cytochrome (Cyt) P450 and Cyt b5, activities of reduced glutathione (GSH) and glutathione-S-transferase (GST) and renal aspartate aminotransaminase (AST), alanine aminotransaminase (ALT) and alkaline phosphatase (ALP), and content of protein and total cholesterol were measured to determine the nephrotoxicity caused by DMBA and to elucidate the ameliorating role of M. oleifera.

Results: Single oral administration of 15 mg/kg of DMBA resulted in significant increases in Cyt P450 and Cyt b5 (P<0.01). The toxic effect of DMBA was justified by the significant decreases in the activities of GSH and GST in renal tissues (P<0.05). The levels of renal AST, ALT and ALP and protein content which are indicative of renocellular damage were also found decreased along with significant increase in total cholesterol content in DMBA-treated mice (P<0.01). The DMBA-induced alterations in the tissues were significantly reversed after pretreatment with 200 and 400 mg/kg of MOHE orally for 14 d (P<0.01).

Conclusion: The effects of MOHE in enhancing the levels of antioxidants and enhancing the levels of biochemical assays in DMBA-induced carcinogenesis are by reducing the formation of free radicals. This study rationalizes the ethnomedicinal use of M. oleifera for the protection against nephrotoxicity induced by chemical carcinogens.

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The study of intoxication and toxicity of Fructus Xanthii
Xue-mei Zhang, Zhong-hua Zhang
Journal of Chinese Integrative Medicine    2003, 1 (1): 71-74.   DOI: 10.3736/jcim20030129
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Fructus Xanthii is commonly used in rhinology, especially used in treatment of chronic rhinitis and sinusitis. But Fructus Xanthii is toxicant, and it maybe result in poisoning when used excessively, without preparation or in inappropriate preparation. This article reviewed all poisoning cases from 1960 to 2000, its toxicology and methods for detoxification.

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Cited: Baidu(16)
Cantharidin patches and intravenous administration of vitamin C in the concomitant treatment of herpes zoster: A case report
Schencking Martin, Kraft Karin
Journal of Chinese Integrative Medicine    2011, 9 (4): 410-413.   DOI: 10.3736/jcim20110410
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Professor TANG Han-Jun's thinking in syndrome differentiation and experience in treating breast cancer
Hai-guang Qin
Journal of Chinese Integrative Medicine    2004, 2 (4): 297-298.   DOI: 10.3736/jcim20040420
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Progress in research on Ganoderma lucidium spore
Wei Zhang, Yuan-shan Zeng
Journal of Chinese Integrative Medicine    2004, 2 (6): 463-465.   DOI: 10.3736/jcim20040620
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Cited: Baidu(9)
Analysis on acupuncture treatment characteristics for tumor in ancient medical literature
Li-gong Liu, Jie Gu, Dong-xing Fang
Journal of Chinese Integrative Medicine    2003, 1 (4): 319-320.   DOI: 10.3736/jcim20030428
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Necessary conditions for the globalization of traditional Chinese medicine
Bei-bei Yu, Xiu-lin Gong
Journal of Chinese Integrative Medicine    2011, 9 (3): 341-348.   DOI: 10.3736/jcim20110318
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With the current trend of globalization, unprecedented opportunities and enormous changes have emerged for the global development of traditional Chinese medicine (TCM). However, many old and new challenges and problems still remain, including partial or limited comprehension of acupuncture, oriental medicine and TCM, the existence of non-standardized institutes of TCM and acupuncture training schools, unqualified TCM practitioners, and problems concerning Chinese herbal medicine and inexperience in conducting TCM business. These problems will doubtlessly impede the further development of TCM worldwide in the foreseeable future. It is also clear that the globalization of TCM will require a large scale systematic project and constitute an arduous historical task. This paper aims to consolidate 6 strategic development modes to reinforce and facilitate the process of TCM globalization through a detailed analysis of both the present status and existing problems concerning the development of TCM in the United States.

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Cited: Baidu(5)
An updated review on the Oenothera genus
Sumitra Singh, Rupinder Kaur, Surendra Kr. Sharma
Journal of Chinese Integrative Medicine    2012, 10 (7): 717-725.   DOI: 10.3736/jcim20120701
Online available: 15 July 2018

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Oenothera genus (Onagraceae) has been used as a folk remedy since ancient times for the treatment of asthma, gastrointestinal disorders, neuralgia, skin diseases, and hepatic and kidney diseases. Different chemical constituents like lipids, flavonoids, tannins, steroids and triterpenes have been isolated from this genus. The various notable pharmacological activities reported from the genus are antioxidant, cytotoxic, antibacterial, antiviral, anti-inflammatory, antihyperlipidaemic, thrombolytic and antidiarrhoeal. The present paper is to summarize the worldwide reported biological activities and phytoconstituents associated with this genus for about 50 years and highlight the medicinally important species belonging to this genus so that these species can be further explored and used as therapeutic agents for various diseases.

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Cited: Baidu(25)
Treatment of diabetes through liver syndrome differentiation
Li Zhao
Journal of Chinese Integrative Medicine    2004, 2 (4): 303-305.   DOI: 10.3736/jcim20040423
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Progress in research on hirudo
Rong-qing Huang, Xiao-dong Sun, Yang-ling Li, Hong Wang
Journal of Chinese Integrative Medicine    2004, 2 (5): 387-389.   DOI: 10.3736/jcim20040523
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Application of Bayesian network in syndrome differentiation system of traditional Chinese medicine
Wen-feng Zhu, Jun-feng Yan, Bi-qun Huang
Journal of Chinese Integrative Medicine    2006, 4 (6): 567-571.   DOI: 10.3736/jcim20060604
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The concept of syndrome in traditional Chinese medicine (TCM) is a nonlinear, open and complicated huge system. Syndrome differentiation in TCM belongs to cognitive and noetic science. To establish a new syndrome differentiation system based on the key elements of the syndrome is necessary for TCM practitioners to promote differentiation ability and reach consensus on differentiation method. With combination of experience and computation models, the Bayesian network was used in the study of the relationship between the key elements of syndrome and the symptoms, and the relationship among different key elements, in which the computing diagnosis result was identical to the result from an experienced TCM doctor. The study showed that Bayesian network is a good method to deal with the information of symptoms and signs for syndrome differentiation, but it is also not to reflect comprehensively the thinking ability of TCM doctors in doing syndrome differentiation.

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Cited: Baidu(44)
Effects of Tuina and Chinese patent drug Shuxuetong injection on deep venous thrombosis and functional rehabilitation after total knee arthroplasty
Jun-lin Hu, Gui-lin Ouyang, Da-peng Han, Qing Xia, Yong He, Zheng Huang, Fei Zhu, Song-tao Sun
Journal of Chinese Integrative Medicine    2011, 9 (10): 1088-1093.   DOI: 10.3736/jcim20111009
Abstract980)   HTML2)    PDF(pc) (1031KB)(275)      

Objective: To evaluate the efficacy of Tuina and Chinese patent drug Shuxuetong injection in preventing patients undergoing total knee arthroplasty from deep venous thrombosis and in functional rehabilitation.

Methods: A total of 120 patients with diagnosed rheumatoid arthritis in the Department of Orthopaedic Surgery, Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine in China were enrolled for this study. The patients underwent total knee arthroplasty and were divided into treatment group (n=60) and control group (n=60) after surgery. Patients in the control group received conventional rehabilitation training, including using a continuous passive motion machine and training of muscle contractions of the lower limb. Patients in the treatment group were administered Shuxuetong injection and Tuina based on the conventional rehabilitation training. The course of treatment lasted for 2 weeks. Hospital for Special Surgery (HSS) knee score, rate of deep venous thrombosis and range of motion of the knee joint were evaluated before and after treatment.

Results: There was no significant difference in HSS knee score and range of motion as compared before and after treatment in two group (P>0.05). The rate of deep venous thrombosis of the treatment group was 13.33%, which was lower than 20% of the control group (P<0.05).

Conclusion: Tuina combined with Shuxuetong injection treatment can prevent deep venous thrombosis in patients with rheumatoid arthritis after total knee arthroplasty.

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Cited: Baidu(5)
Monomer drug's special effect and application of western medicine based on the theory of traditional Chinese medicine
Hai-zhong Jia
Journal of Chinese Integrative Medicine    2003, 1 (1): 15-17.   DOI: 10.3736/jcim20030108
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The concepts of monomer medicine and the Chinese traditional medicine were introduced in this article. The different effects of a monomer drug between different types of syndromes of traditional Chinese medicine (TCM) were explained based on the author's clinical experience and related literature. The aim, significance and methods about the application of western medical drugs according to the theory of TCM were pointed out.And the feasibility of the application was analyzed.

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The control principle in scientific research
Liang-ping Hu, Xiao-lei Bao, Qi Wang
Journal of Chinese Integrative Medicine    2011, 9 (8): 834-.   DOI: 10.3736/jcim20110804
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The control principle is one of the four basic principles of research design. Without a control group, the conclusion of research will be unconvincing; furthermore, if the control group is not set properly, the conclusion will be unreliable. Generally, there is more than one control group in a multi-factor design. Problems like incomplete control and excessive control should be avoided. This article introduces the meaning and function of the control principle, common forms of control, common errors that researchers tend to make as well as analysis and differentiation of these errors.

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Cited: Baidu(2)
Traditional Chinese medicine in prevention and treatment of liver cancer: function, status and existed problems
Meng-chao Wu
Journal of Chinese Integrative Medicine    2003, 1 (3): 163-164.   DOI: 10.3736/jcim20030302
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Application of differential proteomics in mechanism research of acupuncture
Lin-na Yu, Jian Pei
Journal of Chinese Integrative Medicine    2011, 9 (8): 819-823.   DOI: 10.3736/jcim20110802
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Proteomics, a new branch of science, has been used to study protein expressions on the molecular level with a dynamic perspective. Organisms under varying states may express different proteins, which results in the set-up of differential proteomics. Research methods of differential proteomics include the separation and identification of proteins. Differential proteomics has a rapid development in recent years. In the study of acupuncture, researchers have reached certain achievements using differential proteomics to investigate the mechanisms of acupuncture treatment for some diseases, including acute spinal cord injury, ischemic cerebrovascular disease, Parkinson’s disease and neuralgia.

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Tongue conditions and constitution
Tiao-yuan Kuang
Journal of Chinese Integrative Medicine    2004, 2 (4): 264-264.   DOI: 10.3736/jcim20040407
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Characteristics of English translation of traditional Chinese medicine
Chuan-yue Niu
Journal of Chinese Integrative Medicine    2004, 2 (2): 159-160.   DOI: 10.3736/jcim20040228
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Progress of research on mechanism of salvia miltiorrhiza and its chemical ingredients against liver fibrosis
Yan-yan Tao, Cheng-hai Liu
Journal of Chinese Integrative Medicine    2004, 2 (2): 145-148.   DOI: 10.3736/jcim20040223
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Pathogenesis and prevention tactics of aspirin resistance
Ren-gang Zhang, Jun-ping Zhang
Journal of Chinese Integrative Medicine    2007, 5 (3): 259-262.   DOI: 10.3736/jcim20070306
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Aspirin (acetylsalicylic acid) is a nonsteroidal anti-inflammatory drug. Despite its wide uses for more than 100 years, knowledge about mechanism of action and therapeutic issues of aspirin are still under discussion. The use of aspirin has been changed from an analgesic, anti-pyretic and anti-inflammatory agent to an anti-thrombotic agent, especially in secondary prevention of cardiovascular events. Aspirin has reduced the risk of cardiovascular events by 25%. However, the phenomenon of "aspirin resistance" has been described that in 5%-60% of patients aspirin may not achieve adequate efficacy of suppressing platelet activity. The convinced causes of this phenomenon are still unknown. It is probably due to drugs interaction, inadequate dosage and so on. By far the existing studies of aspirin are insufficient to explain all phenomena of aspirin resistance. And the results are not always uniform about the same research. Therefore, the characteristics in different population with aspirin resistance may account for the complexity. It is unrealistic to elucidate all aspirin resistance by only one pathway. More studies are required to investigate the mechanisms in different population respectively. According to the theory of traditional Chinese medicine and the trait of cadiovascular disease, which often relapses and has a long history, aspirin resistance should be considered as collaterals disease. It can be treated with aspirin and traditional Chinese drugs which have the power to strengthen body resistance, reduce phlegm, remove blood stasis and toxic materials from meridians. The problem of aspirin resistance might be solved by this way, because the traditional Chinese medicine has the superiority of selecting appropriate therapeutic methods based on syndrome differentiation for different population and regulating the whole body's function. Subsequently, cadiovascular disease might be effectively prevented.

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Development of international standardization of traditional Chinese medical terminologies: A review of WHO’s second conference on International Classification of Traditional Medicine held in Tokyo
Zhao-guo Li
Journal of Chinese Integrative Medicine    2011, 9 (1): 113-115.   DOI: 10.3736/jcim20110119
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A study on English translation of antithesis in Neijing
Ping Li, Yun-zhong Shi
Journal of Chinese Integrative Medicine    2012, 10 (7): 832-836.   DOI: 10.3736/jcim20120716
Online available: 15 July 2018

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In vitro and in vivo evaluation of the inhibitory effect of Limnophila indica (Linn.) Druce on shigellosis
Sandhya Subhadra, Gouthami Gade, Vinod Kombath Ravindran, Vidya Sravanthi Emani, Saikumar Parre, David Banji
Journal of Chinese Integrative Medicine    2012, 10 (5): 538-545.   DOI: 10.3736/jcim20120509
Online available: 15 June 2018

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Objective: The research aimed to evaluate the anti-Shigella and antacid activities of the methanolic extract of Limnophila indica.

Methods: The whole plant of L. indica was extracted using methanol and then subjected to preliminary chemical screening. The in vitro antibacterial screening on two Gram-positive and two Gram-negative bacteria as well as threeShigella species of which two bacteria were antibiotic-resistant were evaluated by disc diffusion method. Castor oil-induced diarrhoea on Wistar albino rats was performed by using loperamide as a standard control. The in vitroantacid activity was tested by artificial stomach model. The neutralization efficiency, capacity, volume and hydrogen ions consumed were also evaluated.

Results: The preliminary chemical screening on methanolic extract of L.indica showed the presence of phenolic compounds, flavonoids, alkaloids, fats and oils. It was proved to be a potent antibacterial agent against the four bacterial strains. Screening against Shigella species revealed that it was a powerful antibacterial agent towards antibiotic-resistant Shigella species. In the case of in vivo antidiarrheal activity, the plant has shown a dose-dependent activity and the lowest dose at 100 mg/kg gave a much better result than loperamide (P<0.01). The in vitro antacid study showed a mild activity.

Conclusion: As the plant L. indica has been proved to be a competent antibacterial as well as a compelling antidiarrheal agent with mild antacid activity, this plant can be very well suggested to be an eminent substitute for the various synthetic anti-dysentery and antidiarrheal agents available in the market.

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An overview of medicinal plant resource for decreasing blood glucose
Yun Zhu, Jin-rong Liu, Wei Zhang
Journal of Chinese Integrative Medicine    2004, 2 (1): 67-68.   DOI: 10.3736/jcim20040125
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Ryodoraku as a tool monitoring the effects of walking exercise
Se-Der Wu, Jen-Tzer Gau, Yuh-Hai Wang
Journal of Chinese Integrative Medicine    2011, 9 (12): 1319-1325.   DOI: 10.3736/jcim20111207
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Objective: To investigate the possibility of using Ryodoraku as a tool to indicate sympathetic neuronal activity.
Methods: Twenty-two female college students were assigned to an treadmill exercise program (three times a week for six weeks), and another 25 were assigned as controls. Skin conductance levels of the subjects were measured at 24 Ryodoraku points on the wrists and the ankles, along with heart rate variability (HRV) analysis, during and after the treadmill exercise period.
Results: The six-week exercise training resulted in a significant elevation of the average electrical conductance, which returned to the pre-training level after three months of cessation of the exercise training.
Conclusion: HRV data have shown no similar changes, suggesting that Ryodoraku is a useful tool in detecting subtle, non-cardiovascular physical responses.

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Dr. Wu: A beautiful, moving and meditative song — In memory of Dr. Jing Nuan Wu, a pioneer of acupuncture and a Chinese medicine doctor in the United States
Fan Yin, Ziyi Fan
Journal of Chinese Integrative Medicine    2012, 10 (8): 837-840.   DOI: 10.3736/jcim20120801
Online available: 15 August 2018

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Clinical application of eight-magic-turtle acupuncture technique elucidated through diagrams
Zun-hui Guan, Li-ling Ding, Cui-ping Guo, Jian Ye, Rong Yi
Journal of Chinese Integrative Medicine    2004, 2 (2): 141-143.   DOI: 10.3736/jcim20040221
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Progress in research on chronic fatigue syndrome
Shu-yun Jiang, Jun-tao Yan, Min Fang
Journal of Chinese Integrative Medicine    2004, 2 (6): 459-463.   DOI: 10.3736/jcim20040619
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Progress in research on the treatment of primary liver cancer with traditional Chinese medicine for activating blood to resolve stasis
Li-xia Ju, Zhe Chen, Rong-zheng Ren
Journal of Chinese Integrative Medicine    2005, 3 (6): 491-494.   DOI: 10.3736/jcim20050620
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Quantitative evaluation of the degrees of traditional Chinese medicine qualitative syndromes of osteoporosis
Dong-tao Li, Jian Wang , Hong-yang Jiang , Feng-lei Shi , Fu-yu Li , Ji-hong Liu , Yong-mei Cheng , Nan Yan , Ai-hua Hu, Mei-zeng Zhang , Jie Li, Ling-bo Wei , Rong-qin Jiang
Journal of Chinese Integrative Medicine    2012, 10 (11): 1254-1262.   DOI: 10.3736/jcim20121109
Online available: 15 November 2018

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Objective: To establish a quantitative estimate model for diagnosing traditional Chinese medicine (TCM) syndromes of patients with osteoporosis.

Methods: Symptoms and signs of osteoporosis and methodology related to syndrome research were collected by reviewing medical literature.The symptoms and sighs were quantitatively classified into three, two or one category according to a 100-mm visual analog scale. Fuzzy comprehensive evaluation model of TCM qualitative syndromes was performed based on analytic hierarchy process. Then “Hall for Workshop of Metasynthetic Engineering” expert symposium was held on subjects of syndrome quantification method and weight of evaluation indices in different levels for developing the analysis model of common syndromes. For clinical verification, the created models were applied to patients with osteoporosis for discriminating syndromes. Syndrome of each patient was also identified by 8 experts major in integrative medicine treating osteoporosis for comparing the coincidence rate using a self-made clinical questionnaire.

Results: Through literature reviewing, symptoms and signs quantification and expert discussing, the authors formed estimate models of essence deficit, qi deficiency, yin deficiency, yang deficiency, and blood stasis. A total of 220 patients with osteoporosis were enrolled and filled the clinical questionnaire. All 8 experts completed and returned the questionnaire (1 760 cases), and 1 545 of them were filled in completely. Experts’ opinion on syndrome differentiation was exactly coincidence to estimate model in 611 cases and almost coincidence in 639 cases. The total coincidence rate reached to 94.05%.

Conclusion: The estimate model for syndrome differentiation of osteoporosis has a high-coincidence rate with the fuzzy evaluation from experts, with good rationality and feasibility, and is worthy of promotion in the clinical study.

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ISSN 2095-4964
CN 31-2083/R

Editors-in-Chief:
Changquan Ling, Shanghai, China
Lixing Lao, Virginia, USA
Frequency: 6 issues per year
Publisher: Science Press, China

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