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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (2): 125-127.doi: 10.3736/jcim20030212

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Effect of Boschniakia rossica extract on free radicals in brain of D-galactose induced senile rats

Long Piao1, Xue-wu Zhang2(), Xiang-zi Jin1, Shan-hua Li2   

  1. 1. Department of Histology and Embryology, College of Medicine, Yanbian University, Yanji, Jilin Province 133000, China
    2. Department of Biochmistry, College of Medicine, Yanbian University, Yanji, Jilin Province 133000, China
  • Received:2003-03-07 Online:2003-06-20 Published:2018-10-19

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Objective

To study the effect of Boschniakia rossica extract on free radicals in the brain of D-galactose induced senile rats.


Methods

Sixty Wistar rats were randomly divided into normal group, model group (48 mg·kg -1·d -1 D-galactose, SC), Boschniakia rossica group (100, 150, 200 mg/kg ig and 48 mg·kg -1·d -1 D-galactose, SC). After 40 days, the activities of SOD, MAO and the content of MDA were measured with colorimetric method, and the histological changes were synchronously observed by electronic microscope.


Results

Boschniakia rossica extract significantly increased the SOD activity, decreased the MDA content, and inhibited the MAO activity in the brain tissue. It was observed under microscope that Boschniakia rossica extract could retrieve the degeneration of mitochondrion.


Conclusion

Boschniakia rossica extract can clear the free radicals for D-galactose induced senile rats.

Key words: Boschniakia rossica, senility, rats, free radicals

CLC Number: 

  • R339.38

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组别 n SOD(U/mg pro) MAO(U/g pro) MDA(μmol/L)
正常组 10 3.72±0.74* 228.36±60.10* 96.6±14.9*
模型组 10 2.44±0.40 373.90±76.66 131.6±25.5
草苁蓉大剂量组 10 4.17±1.23* 143.11±15.48* 88.7±19.3*
草苁蓉中剂量组 10 4.30±0.77* 106.14±26.83* 85.4±9.7*
草苁蓉小剂量组 10 3.52±0.75* 183.01±21.80* 107.3±27.0*
人参皂甙组 10 3.89±0.70* 218.85±22.04* 95.7±17.6*
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