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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (2): 125-127.doi: 10.3736/jcim20030212

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Effect of Boschniakia rossica extract on free radicals in brain of D-galactose induced senile rats

Long Piao1, Xue-wu Zhang2(), Xiang-zi Jin1, Shan-hua Li2   

  1. 1. Department of Histology and Embryology, College of Medicine, Yanbian University, Yanji, Jilin Province 133000, China
    2. Department of Biochmistry, College of Medicine, Yanbian University, Yanji, Jilin Province 133000, China
  • Received:2003-03-07 Online:2003-06-20 Published:2018-10-19

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Objective

To study the effect of Boschniakia rossica extract on free radicals in the brain of D-galactose induced senile rats.


Methods

Sixty Wistar rats were randomly divided into normal group, model group (48 mg·kg -1·d -1 D-galactose, SC), Boschniakia rossica group (100, 150, 200 mg/kg ig and 48 mg·kg -1·d -1 D-galactose, SC). After 40 days, the activities of SOD, MAO and the content of MDA were measured with colorimetric method, and the histological changes were synchronously observed by electronic microscope.


Results

Boschniakia rossica extract significantly increased the SOD activity, decreased the MDA content, and inhibited the MAO activity in the brain tissue. It was observed under microscope that Boschniakia rossica extract could retrieve the degeneration of mitochondrion.


Conclusion

Boschniakia rossica extract can clear the free radicals for D-galactose induced senile rats.

Key words: Boschniakia rossica, senility, rats, free radicals

CLC Number: 

  • R339.38

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组别 n SOD(U/mg pro) MAO(U/g pro) MDA(μmol/L)
正常组 10 3.72±0.74* 228.36±60.10* 96.6±14.9*
模型组 10 2.44±0.40 373.90±76.66 131.6±25.5
草苁蓉大剂量组 10 4.17±1.23* 143.11±15.48* 88.7±19.3*
草苁蓉中剂量组 10 4.30±0.77* 106.14±26.83* 85.4±9.7*
草苁蓉小剂量组 10 3.52±0.75* 183.01±21.80* 107.3±27.0*
人参皂甙组 10 3.89±0.70* 218.85±22.04* 95.7±17.6*
[1] 尹宗柱, 金海玲, 李天洙 , 等. 草苁蓉甲醇提取物对二乙基亚硝胺诱发大鼠肝脏癌前病变的抑制作用[J]. 中国中药杂志, 1998,23(7):424-426
[2] 沈明花, 尹宗柱 . 草苁蓉提取物对二乙基亚硝胺诱发的肝脏癌前病变大鼠抗氧化活力的影响[J]. 中国中药杂志, 1999,24(12):746– 748
doi: 10.3321/j.issn:1001-5302.1999.12.015
[3] Yin ZZ, Jin HL, Shen MH , et al. Inhibitory effect of BR on DEN-induced precancerous hepatic foci and antioxidative activities in rats[J]. Chin J Cancer Res, 1999,11(3):169-173
doi: 10.1007/s11670-999-0004-0
[4] 郑荣梁 . 衰老的自由基学说[J]. 实用老年医学, 1992,6(1):31-33
[5] Giardino R, Giavaresi G, Fini M , et al. The role of different chemical modifications of superoxide dismutase in preventing a prolonged muscular ischemia/reperfusion injury[J]. Artif Cells Blood Substit Immobil Biotechnol, 2002,30(3):189-198
doi: 10.1081/BIO-120004339
[6] 崔云华, 王晓玲, 刘晴 , 等. 丹参酸乙的抗氧化作用对大鼠肝星状细胞增生的影响[J]. 世界华人消化杂志, 2002,10(3):317-319
doi: 10.3969/j.issn.1009-3079.2002.03.017
[7] 曹国华, 陈吉棣, 刘小鹏 , 等. 缺锌及补锌对鼠脂质过氧化与超氧化物歧化酶的影响[J]. 中华医学杂志, 1991,71(11):623-626
[8] Bianchi P, Seguelas MH, Parini A , et al. Activation of pro-apoptotic cascade by dopamine in renal epithelial cells is fully dependent on hydrogen peroxide generation by monoamine oxidases[J]. J Am Soc Nephrol, 2003,14(4):855-862
doi: 10.1097/01.ASN.0000058909.00567.5C
[9] 许士凯 . 抗衰老药物的药理与作用(第1版)[M]. 上海: 上海中医学院出版社, 1987,( 第1版):118
[10] Zhang Z, Yu CX . Effect of melatonin on leanring and memory impairment induced by aluminum chloride and its mechanism[J]. Yao Xue Xue Bao, 2002,37(9):682-686
[11] Brusque AM, Borba R, Schuck PF , et al. Inhibition of the mitochondrial respiratory chain complex activities in rat cerebral cortex by methylmalonic acid[J]. Neurochem Int, 2002,40(7):593-601
doi: 10.1016/S0197-0186(01)00130-9
[12] 吴春福 . 依据自由基学说研究人参茎叶皂甙的抗衰老作用[J]. 沈阳药学院学报, 1992,9(1):37-40
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