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Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (3): 182-184.doi: 10.3736/jcim20040309

• Original Clinical Research • Previous Articles     Next Articles

Influence of Jieyu Huoxue Decoction on rehabilitation of patients with depression after cerebral infarction

Bei-lei Feng1(), Qiao-chu Wang2, Zheng-yuan Li1   

  1. 1. Department of Neurology, Shanghai Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 200082, China
    2. Department of Sleep Disorder, Shanghai Hospital of Traditional Chinese Medicine, Shanghai 200071, China
  • Online:2004-06-20 Published:2018-10-25

Objective: To study the influence of Jieyu Huoxue Decoction on rehabilitation of patients with depression after cerebral infarction. Methods: Fifty four patients suffered from the depression after acute cerebral infarction were randomly divided into three groups: depression control group, fluoxetine treated group and Jieyu Huoxue Decoction treated group. Eighteen patients of cerebral infarction without depression were enrolled in the no depression control group randomly. The Zung self-rating depression scale (SDS), the modified Edinburgh-Scandinavia stroke scale (MESSS) and the activities of daily living (ADL) were evaluated before treatment, 30 and 60 days after treatment. Results: After 30 and 60 days of treatment, SDS evaluation of the Jieyu Huoxue Decoction treated group showed significant difference as compared with the condition before treatment and that of the depression control group (P<0.05 or P<0.01), MESSS evaluation and ADL evaluation also showed significant difference as compared with the condition before treatment and that of the depression control group (P<0.05 or P<0.01); there was no obvious difference between the fluoxetine treated group and the Jieyu Huoxue Decoction treated group, but the Jieyu Huoxue Decoction treated group showed fewer symptoms and less side effect. Conclusion: Jieyu Huoxue Decoction can not only relieve depression after cerebral infarction, but also improve neurological functions.

Key words: Jieyu Huoxue Decoction, cerebral infarction, depression, rehabilitation

CLC Number: 

  • R692

Tab 1

Changes of SDS score after treatment (ヌ±S)"

Group n Before treatment 30 d after treatment 60 d after treatment
No depression control 15 30.2±4.2 27.1±4.3 25.8±3.7
Depression control 16 48.8±5.7 43.5±5.2 41.1±4.7
Fluoxetine treated 16 48.1±6.13 6.9±4.3▲▲ 34.9±4.6△▲▲
Jieyu Huoxue Decoction treated 17 48.2±5.83 5.9±4.1▲▲ 32.9±5.1△▲▲

Tab 2

Changes of MESSS score after treatment (ヌ±S)"

Group n Before treatment 30 d after treatment 60 d after treatment
No depression control 15 21.1±5.2 14.6±4.2▲▲ 9.4±4.2△▲▲
Depression control 16 23.3±5.9 18.6±5.2 14.4±2.2
Fluoxetine treated 16 23.9±5.5 13.6±5.1▲▲ 9.1±3.2△▲▲
Jieyu Huoxue Decoction treated 17 23.5±6.2 13.9±4.9▲▲ 9.3±5.2 △▲▲

Tab 3

Changes of ADL after treatment (ヌ±S)"

Group n Before treatment 30 d after treatment 60 d after treatment
No depression control 15 25.4±3.5 21.8±2.6▲▲ 19.8±4.2△▲▲
Depression control 16 29.9±2.9 25.8±3.2 23.8±4.2
Fluoxetine treated 16 28.9±3.6 20.8±5.1▲▲ 19.1±3.2△▲▲
Jieyu Huoxue Decoction treated 17 28.5±4.5 20.3±4.2▲▲ 19.4±2.2△▲▲
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