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Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (3): 199-202.doi: 10.3736/jcim20040314

• Original Experimental Research • Previous Articles     Next Articles

Influence of single leaf Asarum himalaicum on renal function of rabbits

Hai-xia Ming, Jia-jun Liu, Shi-zuo Huang   

  1. Department of Physiology, Gansu College of Traditional Chinese Medicine, Lanzhou, Gansu Province 730000, China
  • Online:2004-06-20 Published:2018-10-25

Objective: To study the influence of single leaf Asarum himalaicum on the renal function of rabbits. Methods: Rabbits were divided into three groups. Asarum himalaicum, Asarum heterotropoides and normal saline were intravenously administered to the rabbits of one group respectively. The urine volume per minute, urine pH, urine glucose, protein and red blood cells, BUN, SCr, TXB2, 6-keto-PGF1α, TXB2/6-keto-PGF1α, endothelin, p-aminohippuric acid clearance rate and phenolsulfonphthalein excretion rate were tested before and after the administration. Results: A certain dosage of single leaf Asarum himalaicum caused acute renal failure in rabbits. The indices tested were significantly diffrent between rabbits administered Asarum himalaicum and normal saline.As compared with the rabbits administered Asarum heterotropoides,the results of indices tested decreased, but without statistical significance, except for SCr. Conclusion: The single leaf Asarum himalaicum can cause renal damage to rabbits.Its renal toxicity is lower that that of Asarum heterotropoides.

Key words: Asarum himalaicum, Asarum heterotropoides, acute renal failure, animal, laboratory

CLC Number: 

  • R285.5

Table 1

Changes of renal function of rabbits (ヌ±S)"

Tab 2

Test results of p-aminohippuric acid clearance rate, TXB2, 6-keto-PGF1α, TXB2/6-keto-PGF1α and ET in rabbits (ヌ±S)"

Group n p-aminohippuric acid
clearance rate (ml/s)
TXB2(g/L) 6-keto-PGF (ng/L) TXB2/6-keto-PGF ET (ng/L)
Asarum himalaicum 7 0.0098±0.0049▲▲ 198.27±19.01▲▲ 138.65±23.91 1.43±0.37▲▲ 128.37±20.56▲△
Asarum heterotropoides 7 0.0072±0.0005▲▲ 224.08±22.43▲▲ 148.96±21.89 1.51±0.42▲▲ 155.28±21.67▲▲
Normal saline 7 0.0587±0.0298 112.80±20.51 127.18±25.07 0.90±0.27 117.89±19.01

Tab 3

Results of phenolsulfonphthalein excretion test in rabbits (ヌ±S)"

Group n 5 min 20 min 40 min
Blood concentration
PSP excretion rate
Blood concentration
PSP excretion rate
A sarum himalaicum 7 18.01±1.36 12.90±1.38 30.6±5.4 8.82±2.04 46.8±6.4
A sarum heterotropoides 7 17.78±1.28 14.03±1.36 22.1±5.0 10.81±2.34 39.6±5.9
Normal saline 7 19.25±2.61 7.89±1.51 57.3±9.4 4.40±1.39 75.9±8.0
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