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Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (4): 258-261.doi: 10.3736/jcim20040405

• Original Clinical Research • Previous Articles     Next Articles

Effect of Baisuifang Granule on cognitive malfunction after cerebral infarction

Lan Zheng1, Xiao-heng Shen1, Ying Wang2, Wei Li3, Yu Zhai3, Xue-mei Tang3, Chan-xing Yuan4, Yun Chen4, Jun Li4, Xiang Xia1#br#   

  1. 1. Department of Traditional Chinese Medicine,RuiJin Hospital, Shanghai Second Medical University,Shanghai 200025,China
    2. Department of Neurology,RuiJin Hospital, Shanghai Second Medical University,Shanghai 200025,China
    3. Department of Neurology,Shanghai 9thPeople’s Hospital, Shanghai Second Medical University,Shanghai 200011,China;
    4. Department of Neurology,Longhua Hospital, Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China
  • Received:2004-06-05 Online:2004-07-20 Published:2018-10-20

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Objective: To explore the mechanism of Baisuifang Granule in treating cognitive malfunction after cerebral infarction.Methods: One hundred and sixty patients with cerebral infarction were divided randomly into two groups. Eighty patients were treated with Baisuifang Granule and 80 with nimodipine for two months. Clinical observation and laboratory examinations were performed for Mini-Mental State Examination (MMSE), clinical symptoms, Chinese Stroke Scale (CSS), hemorrheological indexes and fibrinogen before and after the treatment.Results: Baisuifang Granule could improve MMSE, reduce the scores of clinical symptoms and CSS, and meliorate the blood rheology. The total effective rate for clinical symptoms in the Baisuifang treated group accounted to 76.25%, with statistical difference comparing to 58.75% of nimodipine treated group (P<0.05). There was significant difference in symptom integral, CSS and whole blood viscosity at the high shear rate, respectively (P<0.01).Conclusion: Baisuifang Granule is an effective Chinese medicine for treating cognitive malfunction after cerebral infarction.

Key words: Baisuifang Granule, cerebral infarction, cognition disorders, nimodipine

CLC Number: 

  • R289.5

Tab 1

Scores of MMSE before and after treatment ($\bar{x}$±s )"

Group n Before treatment After treatment Difference of before and after treatment
Baisuifang Granule treated 80 20.93±6.30 24.40±5.66** 3.50±2.33
Nimodipine treated 80 22.20±4.71 25.44±4.20** 3.31±2.11

Tab 2

Scores of clinical symptoms before and after treatment ($\bar{x}$±s )"

Group n Before treatment After treatment Difference of before and after treatment
Baisuifang Granule treated 80 19.13±6.23 11.83±7.71** 7.29±3.43△
Nimodipine treated 80 18.91±7.74 13.01±7.48** 5.90±3.60

Tab 3

Scores of clinical symptoms associated with qi deficiency symdrome before and after treatment ($\bar{x}$±s )"

Group Hemianesthesia Dizziness Amnesia Palpitation and shortness of breath Fatigue
Baisuifang Granule treated
Before treatment 1.68±0.76 1.71±0.77 1.78±0.80 1.64±0.82 1.71±0.81
After treatment 0.75±0.70** 0.83±0.65** 0.99±0.72** 0.84±0.58** 0.81±0.55**
Difference of before and after treatment 0.93±0.76 0.89±0.97 0.79±1.11 0.80±0.93△ 0.90±1.03△
Nimodipine treated
Before treatment 1.85±0.80 1.69±0.82 1.95±0.81 1.84±0.82 1.89±0.83
After treatment 1.09±0.83** 0.94±0.68** 1.75±0.77* 1.35±0.66** 1.30±0.68**
Difference of before and after treatment 0.76±0.62 0.75±1.03 0.20±0.96 0.49±0.95 0.59±1.03

Tab 4

Scores of CSS before and after treatment ($\bar{x}$±s )"

Group n Before treatment After treatment Difference of before and after treatment
Baisuifang Granule treated 80 11.94±6.50 7.04±5.41** 5.00±3.24△△
Nimodipine treated 80 11.08±7.61 7.31±6.44** 3.81±3.00

Tab 5

Hemorrheological indexes tested before and after treatment ($\bar{x}$±s )"

Group Whole blood viscosity(mPa·s) Plasma viscosity
(mPa·s)		 Hematocrit(%) Fibrinogen(g/L)
At high shear rate At low shear rate
Baisuifang Granule treated
Before treatment 4.69±1.14 8.37±2.26 1.29±0.15 42.03±4.46 3.75±1.41
After treatment 4.21±0.69** 8.18±1.41 1.25±0.12** 40.55±3.78** 3.93±1.21
Difference of before and after treatment 0.48±0.92△△ 0.19±1.89 0.04±0.14 1.48±3.62 0.17±1.40
Nimodipine treated
Before treatment 4.51±1.00 8.27±1.93 1.32±0.38 42.32±4.38 3.87±1.12
After treatment 4.42±0.82 8.25±1.77 1.26±0.40 40.33±3.89** 3.62±1.16
Difference of before and after treatment 0.08±0.83 0.01±1.37 0.05±0.50 2.00±3.09 0.25±1.27
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