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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (4): 331-335.doi: 10.3736/jcim20080401

• Editorial •     Next Articles

Design, implementation and methodological issues in cohort study

Jian-ping Liu()   

  1. Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029
  • Received:2008-02-26 Online:2008-04-20 Published:2008-04-15
  • Contact: LIU Jian-ping

Cohort study is graded as level Ⅱ in evidence grading system of evidence-based medicine, secondary to randomized controlled trial. It is one of the important evidence for the evaluation of health care interventions, and it has been applied recently in the evaluation of traditional medicine. The author of the article introduces the basic concept, principle, design, and implementation as well as relevant methodological issues when applied in traditional Chinese medicine.

Key words: cohort studies, evidence-based medicine, evaluation studies

CLC Number: 

  • R-31


队列研究 随机对照试验
观察性研究 干预研究
按照常规形成队列 采用随机分组
简化纳入和排除标准 严格的纳入和排除标准
适用于复杂治疗 适用于简单干预
评价终点结局 评价结局以替代指标为主
评价复杂治疗的综合效果 评价干预措施的特异性疗效
样本量较大 样本量较小
不违背伦理学原则 有伦理学问题
研究结果的推广应用性较大 研究结果的推广应用性有限



[1] Lau JT, Leung PC, Wong EL , et al. The use of an herbal formula by hospital care workers during the severe acute respiratory syndrome epidemic in Hong Kong to prevent severe acute respiratory syndrome transmission, relieve influenza-related symptoms, and improve quality of life: a prospective cohort study[J]. J Altern Complement Med, 2005,11(1):49-55
doi: 10.1089/acm.2005.11.49
[2] Walsh B, Maguire H, Carrington D . Outbreak of hepatitis B in an acupuncture clinic[J]. Commun Dis Public Health, 1999,2(2):137-140
pmid: 10402750
[3] Laupland KB, Kirkpatrick AW, Church DL , et al. Intensive-care-unit-acquire bloodstream infections in a regional critically ill population[J]. J Hosp Infect, 2004,58(2):137-145
doi: 10.1016/j.jhin.2004.06.007 pmid: 15474185
[4] Nong YB, Lin Q, Duan WH , et al. Constructing a Cox proportional hazard regression model of prognosis factors of acute myocardial infarction by retrospective cohort study[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2004,24(9):781-784
doi: 10.7661/CJIM.2004.9.781
农一兵, 林谦, 段文慧 , 等. 从回顾性队列研究构建急性心肌梗死远期预后因素的Cox比例风险回归模型[J]. 中国中西医结合杂志, 2004,24(9):781-784.
doi: 10.7661/CJIM.2004.9.781
[5] Upshur RE . Evidence-based medicine, reasoned medicine or both? Commentary on Jenicek, M.(2006) 'The hard art of soft science'[J]. J Eval Clin Pract, 2006,12(4):420-422
doi: 10.1111/j.1365-2753.2006.00720.x
[6] Liu JP. Clinical research methodology for evidence-based Chinese medicine[M]. Beijing: People's Medical Publishing House, 2006: 82-85
刘建平 . 循证中医药临床研究方法学[M]. 北京: 人民卫生出版社, 2006: 82-85
[7] Zhao ZT. Study method and application for epidemiology(2nd ed)[M]. Beijing: Science Press, 2005,( 2nd ed):116
赵仲堂 . 流行病学研究方法与应用(第2版)[M]. 北京: 科学出版社, 2005,( 第2版):116
[8] White E, Patterson RE, Kristal AR , et al. VITamins and lifestyle cohort study: study design and characteristics of supplement users[J]. Am J Epidemiol, 2004,159(1):83-93
doi: 10.1093/aje/kwh010 pmid: 14693663
[9] Yang G, Shu XO, Li H , et al. Prospective cohort study of green tea consumption and colorectal cancer risk in women[J]. Cancer Epidemiol Biomarkers Prev, 2007,16(6):1219-1223
doi: 10.1158/1055-9965.EPI-07-0097 pmid: 17548688
[10] Freedman ND, Park Y, Subar AF , et al. Fruit and vegetable intake and esophageal cancer in a large prospective cohort study[J]. Int J Cancer, 2007,121(12):2753-2760
doi: 10.1002/ijc.22993 pmid: 202020202020202020202020202020
[11] Luo J, Inoue M, Iwasaki M , et al. Green tea and coffee intake and risk of pancreatic cancer in a large-scale, population-based cohort study in Japan(JPHC study)[J]. Eur J Cancer Prev, 2007,16(6):542-548
doi: 10.1097/CEJ.0b013e32809b4d30
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