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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (5): 458-462.doi: 10.3736/jcim20080505

• Review • Previous Articles     Next Articles

Pay close attention to drug-induced lupus

Min-jie Zhou, Zhao-hui Ni()   

  1. Department of Nephrology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Received:2008-03-14 Online:2008-05-20 Published:2008-05-15
  • Contact: NI Zhao-hui E-mail:profnizh@126.com

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Drug-induced lupus (DIL) is a lupus-like illness that has been recognized as a side effect of over 80 drugs since its first description in association with sulfadiazine in 1945. The epidemiology and clinical course of idiopathic systemic lupus erythematosus and DIL differ markedly, and prognosis is generally favorable in the latter although occasional life-threatening cases have been reported in the literature. Constant pharmacovigilance is crucial for prompt diagnosis and cessation of offending therapy, hence achieving the best outcome. This review discusses the clinical presentation, diagnosis and treatment of DIL so as to call for vigilance of medical workers.

Key words: drugs, lupus, nephrosis

CLC Number: 

  • R593.242

"

明确相关 可能相关 可疑相关 个案报道
肼苯哒嗪 柳氮磺胺吡啶 抗生素 因福利美
普鲁卡因酰胺 抗惊厥药 非甾体类抗炎药 依那西普
异烟肼 抗甲状腺药 降压药 白细胞介素2
甲基多巴 他汀类药 锂剂 扎鲁司特
奎尼丁 特比萘芬 干扰素 氯巴占
米诺环素 D-青霉胺 氯金化钠 妥卡尼
氯丙嗪 氟尿嘧啶 赖诺普利
氢氯噻嗪 丁氨苯丙酮

"

特征 DIL SLE
起病年龄 老年（50岁左右） 育龄期（20~40岁）
女∶男 1∶1 9∶1
人种 非黑色人种 所有人种
病程 停药后自愈 慢性,易复发
乙酰化表现型 慢乙酰化者易发生 快、慢乙酰化者发生概率均等
起病速度 急骤 逐渐
症状严重度 通常中度 中度到重度
全身受累 50％ 83％
皮肤受累 紫癜和结节性红斑 颧部盘状红斑、光敏感和口腔溃疡
关节痛和关节炎 95％ 90％
浆膜炎和心包炎 50％ 50％
肝肿大 25％ 25％
肾脏受累 5％ 53％
中枢神经系统受累 0％ 32％
血液异常 罕见 常见
血清学特点
ANA 95％（均质型） 95％（均质型或斑点型）
LE细胞 90％ 90％
抗核糖核蛋白抗体 20％ 40%~50％
抗Sm抗体 罕见 20%~30％
抗dsDNA抗体 <5％ 50%~70％
抗组蛋白抗体 >95％ >50％
补体 正常 降低
免疫复合物 正常 增高
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