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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (12): 1226-1232.doi: 10.3736/jcim20081204

• Original Clinical Research • Previous Articles     Next Articles

Changes of endocrine and immune function in subjects of yang deficiency constitution

Qi Wang1(), Shi-lin Yao2, Jing Dong3, Hong-dong Wu1, Cheng-yu Wu4, Zhong-yuan Xia5, He-feng Shi6, Guo-ming Pan7, Qi-wei Pan8, Jian-xiong Zhao9, Jing Cai10, Zheng-zhi Cui11   

  1. 1. Research Center for Reproduction Medicine and Body Constitution in Traditional Chinese Medicine, School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
    2. Department of Scientific Research, Anhui College of Traditional Chinese Medicine, Hefei,Anhui Province 230038,China
    3. Department of Traditional Chinese Medicine, the General Hospital of the Air Force of People's Liberation Army, Beijing 100036,China
    4. School of Preclinical Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu Province 210046, China
    5. Department of Chinese Traditional Surgery, China-Japan Friendship Hospital, Beijing 100029, China
    6. Department of Urology, Henan Provincial Research Institute of Traditional Chinese Medicine, Zhengzhou, Henan Province 450004, China
    7. Special Department of Diabetes, the First Kaifeng Hospital of Traditional Chinese Medicine, Kaifeng,Henan Province 475001, China
    8. School of Traditional Chinese Medicine, Jiangxi High Training School of Traditional Chinese Medicine, Fuzhou, Jiangxi Province 344000, China
    9. Institute of Integrated Traditional Chinese and Western Medicine, Lanzhou University, Lanzhou, Gansu Province 730000, China
    10. Geriatrics Institute of Integrated Traditional Chinese and Western Medicine, Fujian College of Traditional Chinese Medicine,Fuzhou,Fujian Province 350003,China
    11. Special Department of Prostate Diseases, Hospital of Korea Medicine, Yanbian Institute of National Medicine, Yanbian, Jilin Province 133001, China
  • Received:2008-06-19 Online:2008-12-20 Published:2008-12-15

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Objective:

To investigate the changes of endocrine, cyclic nucleotide and immune systems in subjects of yang deficiency constitution, and to explore the relationship among characteristics and causes of yang deficiency constitution, the physiological and biochemical parameters.


Methods:

Based on the diagnostic criteria for the clinical epidemiological investigation, sixty subjects of yang deficiency constitution and fifty of normal constitution were selected. Eight milliliters venous blood were taken from overnight fasted subjects at 8:00-9:00. The sera were obtained by centrifugation of the blood at the speed of 3 000 r/min for 5 minutes, and they were stored at –70 ℃ until use. The serum levels of corticosterone, cortisol, adrenocorticotrophic hormone (ACTH), cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP), free triiodothyronine (FT3), free thyroxine (FT4), thyrotropic-stimulating hormone (TSH), interleukin-1β and interleukin-2 were measured by enzyme-linked immunosorbent assay; the cAMP/cGMP ratio was also computed; and the differences of the above indexes were compared between the two types of subjects.


Results: 

The serum levels of corticosterone, interleukin-1β, TSH and cAMP/cGMP ratio of yang deficiency constitution significantly increased as compared with those of normal constitution, and the serum levels of cortisol, ACTH, cGMP and FT4 of yang deficiency constitution significantly decreased in comparison with those of normal constitution.


Conclusion: 

Subjects of yang deficiency constitution may be not only related to hypothalamic-pituitary-adrenal axis and hypothalamic-pituitary-thyroid axis, but also related to the functional disorders of cyclic nucleotide and immune systems.

Key words: yang deficiency, body constitution, hypothalamo-hypophyseal system, cyclic nucleotide, immunity

CLC Number: 

  • R229

Table 1

Contents of corticosterone, cortisol and ACTH in the serum (x±s)"

Group n Corticosterone (nmol/L) Cortisol (μg/L) ACTH (ng/L)
Normal constitution 50 6.57±1.87 149.48±38.74 65.53±14.32
Yang-deficiency constitution 60 7.73±2.48** 99.34±28.61** 54.97±10.32**

Table 2

Contents of FT3, FT4 and TSH in the serum (x±s)"

Group n FT3 (pmol/L) FT4 (pmol/L) TSH (mIU/L)
Normal constitution 50 3.71±0.55 13.43±2.31 1.56±1.04
Yang-deficiency constitution 60 3.81±0.63 11.98±3.96* 2.12±1.44*
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