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Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (10): 947-951.doi: 10.3736/jcim20091007

• Original Experimental Research • Previous Articles     Next Articles

Effects of extract of Bulbus Allii Caespitosi on cardiocyte viability of swines with myocardial reperfusion injury evaluated by 18F-fluorodeoxyglucose positron emission tomography/computed tomography

Jie-mei Zhanga,Yu-he Kea,Jian-jun Haoa, Hao Xiab,Zhi-jian Wuc,Xin Tud,Teng Wange,Bin Wuf,Xu Zhua,ZHU Haoa   

  1. a Key Research Institute of the State Administration of Traditional Chinese Medicine, Wuhan Integrated TCM and Western Medicine Hospital, Wuhan 430022, Hubei Province, China
    b Department of Cardiology,People’s Hospital,Wuhan University,Wuhan 430060,Hubei Province, China;
    c PET Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430003, Hubei Province, China
    d College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei province, China
    e Experimental Center, Peopled Hospital, Wuhan University, Wuhan 430060, Hubei Province, China
    f Department of Cardiology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, Hubei Province, China
  • Received:2009-05-31 Accepted:2009-08-18 Online:2009-10-20 Published:2009-10-15
  • Contact: Jian-jun Hao E-mail:haojianjun03@163.com

Objective

To investigate the effects of extract of Bulbus Allii Caespitosi on cardiocyte viability of swines with myocardial reperfusion injury by analyzing the 18F-fluorodeoxyglucose (18F-FDG) position emission tomography (PET) imaging.
Methods

Twenty-four swines were randomly divided into sham-operated group, untreated group, trimethazine group and extract of Bulbus Allii Caespitosi group. Myocardial reperfusion injury was induced by plugging the anterior descending coronary artery of swine with sacculus. Bulbus Allii Caespitosi or trimetazidine was given twice daily for 28 days. Then myocardial perfusion was detected with 18F-FDG PET/CT and the radioactivity distribution was evaluated.
Results

Compared with the untreated group, Bulbus Allii Caespitosi and trimetazidine could improve the activity of myocardial cells after myocardial infarction (P<0.01), and there were no significant differences between Bulbus Allii Caespitosi and trimetazidine (P>0.05). Conclusion: Bulbus Allii Caespitosi can improve myocardial metabolism after ischemia and reperfusion in swines.

Key words: Myocardial reperfusion injury, Myocytes, Cardiac, Positron emission tomography, Bulbus Allii Caespitosi, Trimetazidine, Swines

Figure 1

Simulation graph of segments of left ventricle"

Table 1

Number of no vitality myocardial segments and radioactivity distribution ($\bar{x}$±s)"

Group n Number of
myocardial segments
Number of no vitality
myocardial segments
Radioactivity score
Sham-operated 6 102 0 2.67±0.52
Untreated 6 102 55.50±3.62** 0.67±0.51**
Trimetazidine 6 102 27.33±2.50△△ 2.04±0.55△△
Extract of Bulbus Allii Caespitosi 6 102 27.50±3.86△△ 2.33±0.52△△

Figure 2

Imaging of myocardial metabolism in myocardial segments observed by 18F-FDG PET/CT after reperfusion A: Sham-operated group; B: Untreated group; C: Trimetazidine group; D: Extract of Bulbus Allii Caespitosi group."

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