川芎嗪联合氨基胍对糖尿病大鼠肾脏血管内皮细胞生长因子表达的影响

doi:10.3736/jcim20040115

Abstract

Objective: To investigate the therapeutic mechanism of tetromethylpyrazine and aminoguanidine on diabetic nephropathy. Methods: Diabetic rats were induced by streptozotocin. They were divided into 5 groups: normal control group (group C), untreated diabetic group (group DM), tetromethylpyrazine treated group (group TMP), aminoguanidine treated group (group AG) and tetromethylpyrazine and aminoguanidine treated group (group TMP+AG). The expression of vascular endothelial growth factor (VEGF) in renal cortex of the rats in each group was observed by immunohistochemical staining after 12 weeks. Results: The expression of VEGF in renal cortex of the rats in group TMP+AG and group C was alike. The expression of VEGF in renal cortex of group TMP and group AG decreased significantly as compared with that of group C, but was still above normal level.Conclusion: The therapeutic mechanism of tetromethylpyrazine and aminoguanidine on diabetic nephropathy may be inhibiting the over-expression of VEGF in kidney of diabetic rats.

Key words: tetromethylpyrazine, aminoguanidine, diabetic nephropathy, vascular endothelial growth factor

CLC Number:

R587.24

Yan Huang, Shao-qiang Chen, Geng Zhang, Rui-hua Chen. Effect of tetromethylpyrazine and aminoguanidine on expression of vascular endothelial growth factor in kidney of diabetic rats. Journal of Chinese Integrative Medicine, 2004, 2(1): 39-41.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20040115

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References 8

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Group	n	Weight （g）			Blood sugar（mmol/L）
Group	n	4th week	8th week	12th week	4th week	8th week	12th week
Group C	10	281±15	301±12	316±11	3.9±1.1	4.2 ±1.5	4.3±0.8
Group DM	10	181±8**	169±11**	158±6**	21.4±2.3**	22.9±1.3**	22.8±1.9**
GroupTMP	10	203±7**^△△	198±9**^△△	193±9**^△△	19.1±1.8**^△△	17.3±1.5**^△△	20.3±2.7**^△△
Group AG	10	212±15**^△△	206±17**^△△	213±7**^△△	16.7±2.1**^△△	15.4±1.5**^△△	13.4±1.9**^△△
Group TMP+AG	10	205±14**^△△	214±13**^△△	219±9**^△△	12.3±1.7**^△△	10.4±1.2**^△△	5.4±1.5**^△△

Group	n	HbA1c（%）	24 h urinary protein （mg·24h-1）	Ccr（ml·min-1·kg-1）	Kidney weight/Body weight (×10-3)
Group C	10	0.760±0.540	4.25±0.57	3.25±0.41	6.89±0.53
Group DM	10	3.932±1.044**	28.68±1.89**	6.67±1.56**	15.28±1.47**
Group TMP	10	1.745±1.170**^△△	15.99±1.34**^△△	5.49±0.67**^△△	10.46±0.84**^△△
Group AG	10	1.840±0.941**^△△	13.15±0.76**^△△	4.82±0.71**^△△	9.33±1.05**^△△
Group TMP+AG	10	0.856±0.832**^△△	10.21±1.22**^△△	4.43±0.58**^△△	8.25±0.46**^△△

Effect of tetromethylpyrazine and aminoguanidine on expression of vascular endothelial growth factor in kidney of diabetic rats

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