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Journal of Chinese Integrative Medicine ›› 2011, Vol. 9 ›› Issue (3): 246-251.doi: 10.3736/jcim20110304

• Methodology • Previous Articles     Next Articles

Introduction of dynamic balancing randomization method and its application

Zhao-lan Liu1, Bao-quan Liu2, Lan-hua Li3, Jian-ping Liu1()   

  1. 1. Center for Evidence-based Medicine,Beijing University of Chinese Medicine, Beijing 100029, China
    2. Administrative Office of Information System, Information Center, Agricultural Bank of China, Beijing 100005, China
    3. Department of Preventive Medicine, Weifang Medical College, Weifang 261053, Shandong Province, China
  • Received:2010-12-03 Accepted:2011-01-06 Online:2011-03-20 Published:2011-03-15
  • Contact: Liu Jian-ping E-mail:jianping_l@hotmail.com

Following the development of clinical trials, the methodology of clinical trials has developed a great deal, including randomization method and blinding method, etc. The method of randomization includes simple randomization, stratification randomization, etc. Dynamic randomization is also considered as a method of randomization. Two dynamic randomization methods are introduced in this paper, including a method considering the balance of numbers in each group and a method considering prognostic factors. This paper also demonstrates the procedure of dynamic randomization of the above two methods by simulations and actual examples.

Key words: statistics, random allocation, biased coin design, urn model

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