疏肝利胆中药防止胆固醇结石形成的实验研究

doi:10.3736/jcim20060115

Abstract

Objective

To explore the mechanism of the inhibiting effects of recipe for dispersing stagnated liver qi to promote bile flow (Danshijing Tablets) on cholesterol gallstone formation and provide experimental evidence for its clinical application.

Methods

Eighty guinea pigs were randomly divided into 4 groups, which were normal control group, untreated group, ursodeoxycholic acid (UDCA)-treated group and Danshijing Tablets-treated group. The gallstones in guinea pigs were induced by high-cholesterol diet. UDCA and Danshijing Tablets were given orally to guinea pigs in the corresponding group respectively for seven weeks. Then the physical signs of the guinea pigs, the rates of gallstone formation and the histomorphological changes of the gallbladder were examined.

Results

The behavior of guinea pigs in the Danshijing Tablets-treated group was obviously improved and the rate of gallstone formation was significantly decreased as compared with those in both untreated and UDCA-treated groups (P＜0.05). The inflammation reaction of mucous membrane in gallbladder was evidently reduced in the Danshijing Tablets-treated group and its morphological appearance turned to be approximately normal.

Conclusion

Recipe for dispersing stagnated liver qi to promote bile flow may decrease gallstone formation. Its mechanism may be related to reducing pathologic changes in gallbladder tissues, which will reduce the damages of cholesterol to the smooth muscle in gallbladder and enhance the contractility of gallbladder.

Key words: Gallstones, Cholesterol, Dispersing stagnated liver qi to promote bile flow

CLC Number:

R575.62

Bang-jiang Fang, Pei-ting Zhu, Jing-zhe Zhang, Xin-jun Pei, Ying-xin Yang, Xiao-qiang Liang. Inhibiting effects of recipe for dispersing stagnated liver qi to promote bile flow on cholesterol gallstone formation in guinea pigs. Journal of Chinese Integrative Medicine, 2006, 4(1): 56-59.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20060115

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References 17

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Group	n	Body weight (g)	Number of guinea pigs with gallstone	Rate of stone formation (%)
Normal control	19	389.42±39.59	1	5.26
Untreated	17	276.35±26.67**	14	82.35**
UDCA-treated	18	316.22±29.77**^△△	7	38.89^△
Danshijing Tablets-treated	18	356.51±30.42**^△△▲▲	5	27.78^△

Inhibiting effects of recipe for dispersing stagnated liver qi to promote bile flow on cholesterol gallstone formation in guinea pigs

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