单叶细辛对家兔肾功能的影响

doi:10.3736/jcim20040314

Abstract

Objective: To study the influence of single leaf Asarum himalaicum on the renal function of rabbits. Methods: Rabbits were divided into three groups. Asarum himalaicum, Asarum heterotropoides and normal saline were intravenously administered to the rabbits of one group respectively. The urine volume per minute, urine pH, urine glucose, protein and red blood cells, BUN, SCr, TXB₂, 6-keto-PGF₁_α, TXB₂/6-keto-PGF₁_α, endothelin, p-aminohippuric acid clearance rate and phenolsulfonphthalein excretion rate were tested before and after the administration. Results: A certain dosage of single leaf Asarum himalaicum caused acute renal failure in rabbits. The indices tested were significantly diffrent between rabbits administered Asarum himalaicum and normal saline.As compared with the rabbits administered Asarum heterotropoides,the results of indices tested decreased, but without statistical significance, except for SCr. Conclusion: The single leaf Asarum himalaicum can cause renal damage to rabbits.Its renal toxicity is lower that that of Asarum heterotropoides.

Key words: Asarum himalaicum, Asarum heterotropoides, acute renal failure, animal, laboratory

CLC Number:

R285.5

Hai-xia Ming, Jia-jun Liu, Shi-zuo Huang. Influence of single leaf Asarum himalaicum on renal function of rabbits. Journal of Chinese Integrative Medicine, 2004, 2(3): 199-202.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20040314

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Group	n	p-aminohippuric acid clearance rate (ml/s)	TXB₂(g/L)	6-keto-PGF_1α (ng/L)	TXB₂/6-keto-PGF_1α	ET (ng/L)
Asarum himalaicum	7	0.0098±0.0049^▲▲	198.27±19.01^▲▲	138.65±23.91^▲	1.43±0.37^▲▲	128.37±20.56^▲△
Asarum heterotropoides	7	0.0072±0.0005^▲▲	224.08±22.43^▲▲	148.96±21.89^▲	1.51±0.42^▲▲	155.28±21.67^▲▲
Normal saline	7	0.0587±0.0298	112.80±20.51	127.18±25.07	0.90±0.27	117.89±19.01

Group	n	5 min	20 min		40 min
Group	n	Blood concentration (mg/L)	Blood concentration (mg/L)	PSP excretion rate (%)	Blood concentration (mg/L)	PSP excretion rate (%)
A sarum himalaicum	7	18.01±1.36	12.90±1.38	30.6±5.4^▲	8.82±2.04^▲	46.8±6.4^▲
A sarum heterotropoides	7	17.78±1.28	14.03±1.36	22.1±5.0	10.81±2.34	39.6±5.9
Normal saline	7	19.25±2.61	7.89±1.51	57.3±9.4	4.40±1.39	75.9±8.0

Influence of single leaf Asarum himalaicum on renal function of rabbits

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