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Journal of Integrative Medicine ›› 2023, Vol. 21 ›› Issue (4): 332-353.doi: 10.1016/j.joim.2023.05.001

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A comprehensive overview on the role of phytocompounds in human immunodeficiency virus treatment

Chinmayee Priyadarsani Mandhata, Chita Ranjan Sahoo, Rabindra Nath Padhy   

  1. Central Research Laboratory, Institute of Medical Sciences and SUM Hospital, Siksha O Anusandhan Deemed to be University, Bhubaneswar, Odisha 751003, India
  • Received:2022-08-02 Accepted:2023-03-21 Online:2023-07-17 Published:2023-05-15

Acquired immune deficiency syndrome (AIDS) is a worldwide epidemic caused by human immunodeficiency virus (HIV) infection. Newer medicines for eliminating the viral reservoir and eradicating the virus are urgently needed. Attempts to locate relatively safe and non-toxic medications from natural resources are ongoing now. Natural-product-based antiviral candidates have been exploited to a limited extent. However, antiviral research is inadequate to counteract for the resistant patterns. Plant-derived bioactive compounds hold promise as powerful pharmacophore scaffolds, which have shown anti-HIV potential. This review focuses on a consideration of the virus, various possible HIV-controlling methods and the recent progress in alternative natural compounds with anti-HIV activity, with a particular emphasis on recent results from natural sources of anti-HIV agents.

Key words: HIV, Latent reservoir, Antiretroviral agents, Plant extracts, Phytochemicals, Antiretroviral therapy, highly active, Gene therapy

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