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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (3): 199-201.doi: 10.3736/jcim20030316

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Correlation between TXB2, 6-Keto-PGF1α and liver metastasis in rats model with blood stasis

Zhen Chen(), Lu-ming Liu, Yi-bei He   

  1. Department of Traditional Chinese Medicine, Cancer Hospital, Fudan University, Shanghai 200032, China
  • Received:2003-05-26 Online:2003-09-20 Published:2003-09-20

Objective

To observe the correlation between serum level of TXB2, 6-Keto-PGF and liver metastasis.


Methods

The metastatic model was made by injection of W256 carcinosarcoma. Rats were randomly divided into two groups: rats with blood stasis group and control group. Rats in control group were given normal saline via abdominal cavity once a day. Rats in blood stasis group were injected adrenalin in the fourteenth day. Tumor size and liver metastasis were observed. Serum TXB2 and 6-Keto-PGFwere tested by radioimmunoassay.


Results

Tumor size in rats with blood stasis was significantly smaller than that of the control group (P<0.01). Occurrence of liver metastasis in rats with blood stasis was significantly lower than that of the control group (P<0.01). The values of 6-Keto-PGF, TXB2, and TXB2/6-Keto-PGF were higher in the group with blood stasis.


Conclusion

In the status of blood stasis, W256 carcinosarcoma grows slowly, and liver metastasis increases insignificantly, with the elevations of 6-Keto-PGF, TXB2 and TXB2/6-Keto-PGF1α.

Key words: liver neoplasms, neoplasm metastasis, blood stasis, TXB2, 6-Keto-PGF1α

CLC Number: 

  • R73-37

"

组别 n 脾脏瘤重(g) 肝转移灶数
对照组 10 0.514±0.118 2.6±2.12
血瘀证组 10 0.240±0.121** 2.0±1.33*

"

组别 n TXB2 6-Keto-PGF
对照组 10 943.60±108.98 285.73±102.10
血瘀证组 10 2118.08±460.21** 402.28±61.31**
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