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Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (6): 495-497.doi: 10.3736/jcim20050621

• Review • Previous Articles     Next Articles

Progress in research on focal adhesion kinase signal transduction and cross-talk

Qin Bian, Yong-jun Wang,Qi Shi   

  1. Research Institute of Spine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
  • Received:2005-01-13 Online:2005-11-20 Published:2005-11-20
  • Contact: Yong-jun Wang E-mail:yjwang88@hotmail.com

Key words: Focal adhesion kinase, Signal transduction, Cross-talk

CLC Number: 

  • R349.54
[1] 查锡良 . 细胞粘附介导的信号分子——粘着斑激酶研究进展[J]. 生物化学与生物物理学报, 1999,31(1):5-8
[2] 杨红军, 丁彦青 . 整合素激活FAK介导的信号转导通路与大肠癌[J]. 国外医学·肿瘤学分册, 2003,30(3):221-225
[3] Lim Y, Han I, Jeon J , et al. Phosphorylation of focal adhesion kinase at tyrosine 861 is crucial for Ras transformation of fibroblasts[J]. J Bio1 Chem, 2004,279(28):29060-29065
doi: 10.1074/jbc.M401183200
[4] Fox MA, Alexander JK, Afshari FS , et al. Phosphodiesterase-I alpha/autotaxin controls cytoskeletal organization and FAK phosphorylation during myelination[J]. Mol Cell Neurosci, 2004,27(2):140-150
doi: 10.1016/j.mcn.2004.06.002
[5] Orr AW, Murphy-Ullrich JE . Regulation of endothelial cell function by FAK and PYK2[J]. Front Biosci, 2004,1(9):1254-1266
[6] 王连荣, 王菊光, 吴伟康 . 黏着斑激酶酪氨酸磷酸化在牵拉依赖的细胞形态改变中的作用[J]. 中山医科大学学报, 2002,23(4):241-244, 247
[7] Toutant M, Costa A, Studler JM , et al. Alternative splicing controls the mechanisms of FAK autophosphorylation[J]. Mol Cell Biol, 2002,22(22):7731-7743
doi: 10.1128/MCB.22.22.7731-7743.2002
[8] Leu TH, Maa MC . Tyr-863 phosphorylation enhances focal adhesion kinase autophosphorylation at Tyr-397[J]. Oncogene, 2002,21(46):6992-7000
doi: 10.1038/sj.onc.1205904
[9] Alahari SK, Reddig PJ , Juliano RL.Biological aspects of signal transduction by cell adhesion receptors[J].Int Rev Cytol, 2002, 220(): 145-184
[10] McLean GW, Avizienyte E, Frame MC . Focal adhesion kinase as a potential target in oncology[J]. Expert Opin Pharmacother, 2003,4(2):227-234
doi: 10.1517/14656566.4.2.227
[11] Suzawa M, Tamura Y, Fukumoto S , et al. Stimulation of Smad 1 transcriptional activity by Ras-extracellular signal-regulated kinase pathway: a possible mechanism for collagen-dependent osteoblastic differentiation[J]. J Bone Miner Res, 2002,17(2):240-248
doi: 10.1359/jbmr.2002.17.2.240
[12] Aikawa R, Nagai T, Kudoh S , et al. Integrins play a critical role in mechanical stress-induced p38 MAPK activation[J]. Hypertension, 2002,39(2):233-238
doi: 10.1161/hy0202.102699
[13] 王军, 姜宏卫, 董砚虎 . 磷脂酰肌醇3激酶与2型糖尿病[J]. 国外医学·内分泌学分册, 2001,21(6):294-296
[14] Hunger-Glaser I, Fan RS, Perez-Salazar E , et al. PDGF and FGF induce focal adhesion kinase(FAK) phosphorylation at Ser-910: dissociation from Tyr-397 phosphorylation and requirement for ERK activation[J]. J Cell Physiol, 2004,200(2):213-222
doi: 10.1002/(ISSN)1097-4652
[15] Armulik A, Velling T, Johansson S . The integrin beta1 subunit transmembrane domain regulates phosphatidylinositol 3-kinase-dependent tyrosine phosphorylation of Crk-associated substrate[J]. Mol Biol Cell, 2004,15(6):2558-2567
doi: 10.1091/mbc.e03-09-0700
[16] Chiarugi P, Pani G, Giannoni E , et al. Reactive oxygen species as essential mediators of cell adhesion: the oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion[J]. J Cell Bio1, 2003,161(5):933-944
doi: 10.1083/jcb.200211118
[17] Schaller MD . FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?[J]. J Cell Biol, 2004,166(2):157-159
doi: 10.1083/jcb.200406151
[18] Sood AK, Coffin JE, Schneider GB , et al. Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion[J]. Am J Pathol, 2004,165(4):1087-1095
doi: 10.1016/S0002-9440(10)63370-6
[19] Sundberg LJ, Galante LM, Bill HM , et al. An endogenous inhibitor of focal adhesion kinase blocks Rac1/JNK but not Ras/ERK-dependent signaling in vascular smooth muscle cells[J]. J Bio1 Chem, 2003,278(32):29783-29791
doi: 10.1074/jbc.M303771200
[20] Aguirre Ghiso JA . Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo[J]. Oncogene, 2002,21(16):2513-2524
doi: 10.1038/sj.onc.1205342
[21] You L, Ebner S, Kruse FE . Glial cell-derived neurotrophic factor(GDNF)-induced migration and signal transduction in corneal epithelial cells[J]. Invest Ophthalmol Vis Sci, 2001,42(11):2496-2504
[22] Parsons JT . Focal adhesion kinase: the first ten years[J]. J Cell Sci, 2003,116(Pt 8):1409-1416
doi: 10.1242/jcs.00373
[23] 杨长春, 温进坤, 韩梅 . 黄芪、当归对血管平滑肌细胞粘着斑激酶表达和细胞凋亡的影响[J]. 中国中西医结合杂志, 2003,23(3):201-203
[24] 刘丽, 姜慧卿, 张晓岚 . 丹参单体IH764-3对H2O2刺激肝星状细胞增殖和胶原合成的影响及其机制[J]. 中国应用生理学杂志, 2003,19(1):78-81
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