山刺玫果抗脂质过氧化作用的实验研究

doi:10.3736/jcim20040516

Abstract

Objective: To study the anti-lipid peroxidation action of Rosa davurica Pall. fruit.Methods: The contents of malondialdehyde (MDA) of the tissue homogenate of the liver, heart, kidney, brain and of the red blood cells induced by hydrogen peroxide in mice were measured. The contents of MDA and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) of ischemic myocardium of mice were measured.Results: 0.2 g/L Rosa davurica Pall. fruit could decrease significantly the contents of MDA of the all tissue (P<0.05). Inhibition rate of 6.7 g/L Rosa davurica Pall. fruit on MDA of the red blood cells induced by hydrogen peroxide was 89.2%. Administration of this extraction successively for six days (ig, 2.0 g·kg ^-1·d ^-1) can significantly reduce the content of MDA (P<0.01) and augment the activities of SOD and GHS-Px (P<0.05) in the ischemic myocardium of mice. Conclusion: Rosa davurica Pall. fruit can significantly prevent the lipid peroxidation.

Key words: Rosa davurica Pall. fruit, lipid peroxides, superoxide dismutase, glutathione peroxidase

CLC Number:

R285

Shu-ping Jiao, Biao Chen, Pei-ge Du. Anti-lipid peroxidation effect of Rosa davurica Pall. fruit. Journal of Chinese Integrative Medicine, 2004, 2(5): 364-366.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20040516

http://www.jcimjournal.com/EN/Y2004/V2/I5/364

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Group	n	Heart		Liver		Kidney		Brain
Group	n	MDA (nmol/g)	Inhibition (%)	MDA (nmol/g)	Inhibition (%)	MDA (nmol/g)	Inhibition (%)	MDA (nmol/g)	Inhibition (%)
Control	5	571.3±88.1		826.3±113.1		447.2±91.3		845.2±103.3
Rosa davurica Pall.（0.2 g/L）	5	472.4±91.4*	17.3	567.4±93.4*	31.7	328.6±84.9*	24.4	563.4±89.6*	33.4
Rosa davurica Pall.（0.4 g/L）	5	137.2±83.6**	77.1	103.6±86.7**	87.5	128.3±87.9**	71.4	113.8±84.9**	86.6

Group	n	MDA (nmol/g)	SOD (U/mg)	GSH-Px (U/mg)
Control group	10	483.5±113.7	3.45±0.71	27.6±5.1
Model group	10	815.6±135.5**	2.24±0.38**	18.3±5.1**
Rosa davurica Pall. (4.0 g/kg)	10	503.7±121.9^ΔΔ	3.64±0.77^ΔΔ	28.9±6.2^ΔΔ
Rosa davurica Pall. (2.0 g/kg)	10	596.2±122.3^Δ	3.06±0.68^Δ	23.3±4.7^Δ

Anti-lipid peroxidation effect of Rosa davurica Pall. fruit

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