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Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (2): 99-102.doi: 10.3736/jcim20050205

• Original Clinical Research • Previous Articles     Next Articles

Ginsenosides combined with dexamethasone in preventing and treating postembolization syndrome following transcatheter arterial chemoembolization: A randomized, controlled and double-blinded prospective trial

Ying-lu Feng,Chang-quan Ling,De-zeng Zhu,Chao-qin Yu,Zhe Chen,Bai Li   

  1. Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Received:2005-01-18 Online:2005-03-20 Published:2005-03-20
  • Contact: Chang-quan Ling E-mail:lingchangquan@hotmail.com

Objective

To observe the effect of ginsenosides (GS) and low dose glucocorticoid in preventing and treating the postembolization syndrome following transcatheter arterial chemoembolization (TACE).

Methods

Eighty patients with primary liver carcinoma were randomly divided into 4 double-blinded groups, with 20 patients in each group. Patients in groups A, B, C, D were treated with placebo, dexamethasone (Dex), GS, Dex and GS, respectively. The changes of clinical symptoms and laboratory tests after TACE were observed.

Results

Dex combined with GS markedly decreased the occurrence ratio and lasting time of the symptoms such as nausea, vomiting, fever and pain, and protected the function of liver as compared with the placebo (P<0.05). Single use of Dex or GS improved some symptoms as compared with the placebo, but it was not as good as the combination of Dex and GS.

Conclusion

ex combined with GS can effectively prevent and treat the postembolization syndrome following TACE.

Key words: Liver cancer, Transcatheter arterial chemoembolization, Dexamethasone, Ginsenosides

CLC Number: 

  • R735.1

Tab 1

General information of patients in each group"

Group n Gender (cases) Age (years) Stage [Cases (%)]
Male Female Stage Ⅱ Stage Ⅲ
Group A 20 15 5 54.4±11.4 14(70.0) 6(30.0)
Group B 20 12 8 50.4±12.7 17(85.0) 3(15.0)
Group C 20 14 6 52.1±11.1 15(75.0) 5(25.0)
Group D 20 14 6 58.3±9.9 14(70.0) 6(30.0)

Tab 2

Degrees of side effects after TACE in each group (Cases)"

Group n Nausea and vomiting degree Fever degree Pain degree
0 I 0 I 0 I
Group A 20 4 10 2 4 6 1 13 0 3 15 1 1
Group B 20 12 4 2 2 15 4 1 0 12 8 0 0
Group C 20 15 4 1 0 6 4 10 0 15 5 0 0
Group D 20 17 3 0 0 17 2 1 0 16 4 0 0

Tab 3

Lasting time of side effects after TACE in each group ($\bar{x}$±s, d)"

*P<0.05, vs group A

Group n Lasting time
Nausea and vomiting Fever Pain
Group A 20 2.61±1.42 4.38±2.31 5.16±2.77
Group B 20 1.78±1.23 1.75±1.16* 1.58±0.99*
Group C 20 1.28±0.94* 3.65±1.93 1.82±1.41*
Group D 20 1.02±0.76* 1.11±0.68* 1.34±0.89*

Tab 4

Stages of Child-Pugh before and after TACE in each group (Cases)"

Group n Stages of Child-Pugh
A B C
Group A
Before TACE 20 16 4 0
After TACE 20 8 9 3
Group B
Before TACE 20 17 3 0
After TACE 20 13 6 1
Group C
Before TACE 20 17 3 0
After TACE 20 12 7 1
Group D
Before TACE 20 15 5 0
After TACE 20 17 3 0
[1] Attele AS, Wu JA, Yuan CS . Ginseng pharmacology: multiple constituents and multiple actions[J]. Biochem Pharmacol, 1999,58(11):1685-1693
doi: 10.1016/S0006-2952(99)00212-9
[2] Kong X, Hu Y, Rui R , et al. Effects of Chinese herbal medicinal ingredients on peripheral lymphocyte proliferation and serum antibody titer after vaccination in chicken[J]. Int Immunopharmacol, 2004,4(7):975-982
doi: 10.1016/j.intimp.2004.03.008
[3] 中国抗癌协会肝癌专业委员会. 原发性肝癌的临床诊断与分期标准[J]. 中华肝脏病杂志, 2001,9(6):324
[4] 王建华, 周康荣 . 肝癌综合性介入治疗规范化方案(草案)[J]. 临床放射学杂志, 2002,21(7):497-500
doi: 10.3969/j.issn.1001-9324.2002.07.004
[5] 周际昌 . 实用肿瘤内科学(第1版)[M]. 北京: 人民卫生出版社, 2003,( 第1版):424
[6] 权启镇 . 新肝脏病学(第1版)[M]. 济南: 山东科学技术出版社, 2003,( 第1版):111
[7] 吴一萍, 张毅 . 糖皮质激素在肿瘤并发症中的应用[J]. 临床肿瘤学杂志, 2001,6(4):387-388
[8] 陈颖, 陈燕茹 . 防治肝癌介入术后迟发性恶心呕吐的观察[J]. 护士进修杂志, 2003,18(4):374-375
[9] Yun TK .Experimental and epidemiological evidence on non-organ specific cancer preventive effect of Korean ginseng and identification of active compounds[J].Mutat Res, 2003, 523-524: 63-74
[10] Lee EJ, Ko E, Lee J , et al. Ginsenoside Rg1 enhances CD4+ T-cell activities and modulates Th1/Th2 differentiation[J]. Int Immunopharmacol, 2004,4(2):235-244
doi: 10.1016/j.intimp.2003.12.007 pmid: 14996415
[11] 窦德强, 靳玲, 陈英杰 . 人参的化学成分及药理活性的研究进展与展望[J]. 沈阳药科大学学报, 1999,16(2):151-155
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