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Journal of Chinese Integrative Medicine ›› 2007, Vol. 5 ›› Issue (1): 61-64.doi: 10.3736/jcim20070112

• Original Experimental Research • Previous Articles     Next Articles

Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1

ZHOU Yang,GU Jie,XU Lie-ming   

  1. Institute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Online:2007-01-31 Published:2018-10-21

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Objective: To investigate the effects of salvianolic acid B (SA-B) on portal hypertension induced by endothelin-1 in rats. Methods: Twenty-eight Sprague-Dawley rats were randomly divided into four groups: ET-1 group, ET-1+SA-B group, ET-1+ETAR blocker (BQ-123) group and ET-1+ETBR blocker (BQ-788) group. The rats of ET-1+SA-B group underwent intragastrical administration of salvianolic acid B for five days before ET-1 injection, while in three other groups' drinking water was given. In BQ-123 group or BQ-788 group, an intravenous injection of BQ-123 or BQ-788 via femoral vein was administered 30 minutes prior to ET-1 injection. Then changes of portal pressure, cervical artery pressure and heart rate were monitored continuously. Results: After ET-1 injection, the portal pressure of all rats in the ET-1 group increased significantly, while slightly in groups that pretreated with SA-B, BQ-123 or BQ-788. Conclusion: SA-B can attenuate the elevated portal pressure induced by ET-1 with effect similar to ETR blocker.

Key words: hypertension, portal, Salvia miltiorrhiza, Chinese herbal drugs

CLC Number: 

  • R965

Table 1

Effects of SA-B and ETR blocker against elevated portal pressure induced by ET-1（$\bar{x}±S$,mm Hg）"

Group n Initial value of portal pressure Maxium value of portal pressure Degree of elevation
ET-1 5 6.1±0.7 8.6±1.1** 2.5±0.4
ET-1+SA-B 5 6.2±0.7 7.8±1.6** 1.6±0.5△△
ET-1+BQ-123 5 5.9±1.1 7.1±1.0 1.2±0.2△△
ET-1+BQ-788 5 5.9±0.9 6.9±1.1 1.0±0.5△△

Figure 1

Effects of SA-B against elevated portal pressure induced by ET-1"

[1] 杨一林, 曹铁生, 段云友 , 等. 肝纤维化门静脉压力改变与血管活性物质关系的实验研究[J]. 中国医学影像技术, 2005,21(1):6-8
Yang YL, Cao TS, Duan YY , et al. Experimental study of portal vein pressure changes and serum ET-1, NO level on hepatic fibrosis[J]. Zhongguo Yi Yue Ying Xiang Ji Shu, 2005,21(1):6-8
[2] Chan CC, Wang SS, Lee FY , et al. Effects of endothelin-1 on portal-systemic collaterals of common bile duct-ligated cirrhotic rats[J]. Eur J Clin Invest, 2004,34(4):290-296
[3] Cho JJ, Hocher B, Herbst H , et al. An oral endothelin-A receptor antagonist blocks collagen synjournal and deposition in advanced rat liver fibrosis[J]. Gastroenterology, 2000,118(6):1169-1178
[4] De Gottardi A, Shaw S, Sagesser H , et al. Type A, but not type B, endothelin receptor antagonists significantly decrease portal pressure in portal hypertensive rats[J]. J Hepatol, 2000,33(5):733-737
[5] Kuntzen C, Gulberg V, Gerbes AL . Use of a mixed endothelin receptor antagonist in portopulmonary hypertension: a safe and effective therapy?[J]. Gastroenterology, 2005,128(1):164-168
[6] 张杰 . 丹参酚酸B盐对内皮素诱导的肝星状细胞收缩的抑制作用及机制研究. 上海: 上海中医药大学. 2004.
Zhangn J . Inhibitory action of salvianolic acid B on the contraction of hepatic stellate cells induced by endothelin and its mechanism. Shanghai: Shanghai University of Traditional Chinese Medicine. 2004. Chinese.
[7] 薛冬英, 洪嘉禾, 徐列明 . 丹参酚酸B对大鼠肝星状细胞中丝裂原激活的蛋白激酶通路的抑制作用[J]. 中华肝脏病杂志, 2004,12(8):471-474
Xue DY, Hong JH, Xu LM . Salianic-acid B inhibits MAPK signaling in activated rat hepatic stellate cells[J]. Zhonghua Gan Zang Bing Za Zhi, 2004,12(8):471-474
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