Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2007, Vol. 5 ›› Issue (1): 61-64.doi: 10.3736/jcim20070112

• Original Experimental Research • Previous Articles     Next Articles

Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1

ZHOU Yang,GU Jie,XU Lie-ming   

  1. Institute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Online:2007-01-31 Published:2018-10-21

Objective: To investigate the effects of salvianolic acid B (SA-B) on portal hypertension induced by endothelin-1 in rats. Methods: Twenty-eight Sprague-Dawley rats were randomly divided into four groups: ET-1 group, ET-1+SA-B group, ET-1+ETAR blocker (BQ-123) group and ET-1+ETBR blocker (BQ-788) group. The rats of ET-1+SA-B group underwent intragastrical administration of salvianolic acid B for five days before ET-1 injection, while in three other groups' drinking water was given. In BQ-123 group or BQ-788 group, an intravenous injection of BQ-123 or BQ-788 via femoral vein was administered 30 minutes prior to ET-1 injection. Then changes of portal pressure, cervical artery pressure and heart rate were monitored continuously. Results: After ET-1 injection, the portal pressure of all rats in the ET-1 group increased significantly, while slightly in groups that pretreated with SA-B, BQ-123 or BQ-788. Conclusion: SA-B can attenuate the elevated portal pressure induced by ET-1 with effect similar to ETR blocker.

Key words: hypertension, portal, Salvia miltiorrhiza, Chinese herbal drugs

CLC Number: 

  • R965

Table 1

Effects of SA-B and ETR blocker against elevated portal pressure induced by ET-1($\bar{x}±S$,mm Hg)"

Group n Initial value of portal pressure Maxium value of portal pressure Degree of elevation
ET-1 5 6.1±0.7 8.6±1.1** 2.5±0.4
ET-1+SA-B 5 6.2±0.7 7.8±1.6** 1.6±0.5△△
ET-1+BQ-123 5 5.9±1.1 7.1±1.0 1.2±0.2△△
ET-1+BQ-788 5 5.9±0.9 6.9±1.1 1.0±0.5△△

Figure 1

Effects of SA-B against elevated portal pressure induced by ET-1"

[1] 杨一林, 曹铁生, 段云友 , 等. 肝纤维化门静脉压力改变与血管活性物质关系的实验研究[J]. 中国医学影像技术, 2005,21(1):6-8
Yang YL, Cao TS, Duan YY , et al. Experimental study of portal vein pressure changes and serum ET-1, NO level on hepatic fibrosis[J]. Zhongguo Yi Yue Ying Xiang Ji Shu, 2005,21(1):6-8
[2] Chan CC, Wang SS, Lee FY , et al. Effects of endothelin-1 on portal-systemic collaterals of common bile duct-ligated cirrhotic rats[J]. Eur J Clin Invest, 2004,34(4):290-296
[3] Cho JJ, Hocher B, Herbst H , et al. An oral endothelin-A receptor antagonist blocks collagen synjournal and deposition in advanced rat liver fibrosis[J]. Gastroenterology, 2000,118(6):1169-1178
[4] De Gottardi A, Shaw S, Sagesser H , et al. Type A, but not type B, endothelin receptor antagonists significantly decrease portal pressure in portal hypertensive rats[J]. J Hepatol, 2000,33(5):733-737
[5] Kuntzen C, Gulberg V, Gerbes AL . Use of a mixed endothelin receptor antagonist in portopulmonary hypertension: a safe and effective therapy?[J]. Gastroenterology, 2005,128(1):164-168
[6] 张杰 . 丹参酚酸B盐对内皮素诱导的肝星状细胞收缩的抑制作用及机制研究. 上海: 上海中医药大学. 2004.
Zhangn J . Inhibitory action of salvianolic acid B on the contraction of hepatic stellate cells induced by endothelin and its mechanism. Shanghai: Shanghai University of Traditional Chinese Medicine. 2004. Chinese.
[7] 薛冬英, 洪嘉禾, 徐列明 . 丹参酚酸B对大鼠肝星状细胞中丝裂原激活的蛋白激酶通路的抑制作用[J]. 中华肝脏病杂志, 2004,12(8):471-474
Xue DY, Hong JH, Xu LM . Salianic-acid B inhibits MAPK signaling in activated rat hepatic stellate cells[J]. Zhonghua Gan Zang Bing Za Zhi, 2004,12(8):471-474
[1] Pranay Soni, Rajesh Choudhary, Surendra H. Bodakhe. Effects of a novel isoflavonoid from the stem bark of Alstonia scholaris against fructose-induced experimental cataract. Journal of Integrative Medicine, 2019, 17(5): 374-382.
[2] Sonia Chew Wen Phang, Uma Devi Palanisamy, Khalid Abdul Kadir. Effects of geraniin (rambutan rind extract) on blood pressure and metabolic parameters in rats fed high-fat diet. Journal of Integrative Medicine, 2019, 17(2): 100-106.
[3] Nathalia Gomes Ribeiro de Moura, Ivan Cordovil, Arthurde Sá Ferreira. Traditional Chinese medicine wrist pulse-taking is associated with pulse waveform analysis and hemodynamics in hypertension. Journal of Integrative Medicine, 2016, 14(2): 100-113.
[4] Nouran A. Aleyeidi, Khaled S. Aseri, Shadia M. Matbouli, Albaraa A. Sulaiamani, Sumayyah A. Kobeisy. Effects of wet-cupping on blood pressure in hypertensive patients: A randomized controlled trial. Journal of Integrative Medicine, 2015, 13(6): 391-399.
[5] Kylie Connolly, Douglas Jackson, Candice Pullen, Andrew Fenning. Alpha-adrenoceptor antagonism by Crassostrea gigas oyster extract inhibits noradrenaline-induced vascular contraction in Wistar rats. Journal of Integrative Medicine, 2015, 13(3): 194-200.
[6] Ya Yuwen, Yu-qi Liu, Yan-ping Wang, Jin-gang Dai, Da-sheng Liu, Yue-xi Wang, Xue-jie Han. The add-on effect of a Chinese herbal formula for patients with resistant hypertension: Study protocol for a pilot cohort study. Journal of Integrative Medicine, 2015, 13(2): 122-128.
[7] Vamsi Reddy, Arvind Sridhar, Roberto F. Machado, Jiwang Chen. High sodium causes hypertension: Evidence from clinical trials and animal experiments. Journal of Integrative Medicine, 2015, 13(1): 1-8.
[8] Yong-hong Lian, Mei-xia Fang, Li-guo Chen. Constructing protein-protein interaction network of hypertension with blood stasis syndrome via digital gene expression sequencing and database mining. Journal of Integrative Medicine, 2014, 12(6): 476-482.
[9] Yi Chen, De-yu Fu, Yu Chen, Yan-ming He, Xiao-dong Fu, Yan-qiu Xu, Yi Liu, Xiao-tao Feng, Teng Zhang, Wen-jian Wang. Effects of Chinese herbal medicine Yiqi Huaju Formula on hypertensive patients with metabolic syndrome: A randomized, placebo-controlled trial. Journal of Chinese Integrative Medicine, 2013, 11(3): 184-194.
[10] Chan Chen, Chang-xun Chen, Xi-min Wu, Rui Wang, Yi-ming Li. Effects of extracts of Radix Scrophulariae on blood pressure in spontaneously hypertensive rats and the underlying mechanisms. Journal of Chinese Integrative Medicine, 2012, 10(9): 1009-1017.
[11] Tao Li-li, Lei Yan. Effects of extracts from Panax ginseng, Panax notoginseng and Ligusticum chuanxiong on expression of β-galactosidase and signal pathway p16-cyclin D/CDK-Rb in vascular smooth muscle cells. Journal of Chinese Integrative Medicine, 2012, 10(1): 76-84.
[12] Rong Fan, Feng He, Yang Wang, Guang-wei Zhong, Yun-hui Li. Changes of protein expression profile in vascular tissues of spontaneously hypertensive rats treated by a compound Chinese herbal medicine. Journal of Chinese Integrative Medicine, 2011, 9(6): 643-650.
[13] Wan-li Gu , Zai-xiang Shi, Yun-xu Yu, Yu-wei Wu, Bao-wei Lu, Ka-kit Hui . Distribution characteristics of syndrome types in essential hypertension. Journal of Chinese Integrative Medicine, 2010, 8(9): 842-847.
[14] Hao Li , Long-tao Liu, Wen-ming Zhao, Jian-gang Liu, Ming-jiang Yao, Yong-xiang Han, Yan-peng Shen, Xing-dong Liu, Li Liu, Xue-mei Wang, Lin-lin Cai, Jie Guan. Traditional Chinese versus integrative treatment in elderly patients with isolated systolic hypertension: A multicenter, randomized, double-blind controlled trial. Journal of Chinese Integrative Medicine, 2010, 8(5): 410-416.
[15] Zhi-qiang Pan, Zhao-qin Fang, Wen-li Lu, Xiao-mei Liu, Dong-yuan Guan, Chao Liang. Differential gene expressions of steroid- and catecholamine-synthesizing enzymes in adrenal gland of rats with different diseases but the same syndromes. Journal of Chinese Integrative Medicine, 2010, 8(4): 352-357.
Full text



[1] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[2] Pedro Saganha João, Doenitz Christoph, Greten Tobias, Efferth Thomas, J. Greten Henry. Qigong therapy for physiotherapists suffering from burnout: a preliminary study. Journal of Chinese Integrative Medicine, 2012, 10(11): 1233-1239
[3] Jia Guo, Li-na Wang, Dong Li. Exploring the effects of Chinese medicine in improving uterine endometrial blood flow for increasing the successful rate of in vitro fertilization and embryo transfer. Journal of Chinese Integrative Medicine, 2011, 9(12): 1301-1306
[4] Li Dong-tao, Li Fu-yu, Wang Jian, Liu Ji-hong, Yan Nan, Cheng Yong-mei, Hu Ai-hua, Jiang Hong-yang, Shi Feng-lei, Zhang Mei-zeng, Li Jie, Wei Ling-bo, Jiang Rong-qin. A study of diagnostic criteria for traditional Chinese medicine syndromes in osteoporosis. Journal of Chinese Integrative Medicine, 2011, 9(12): 1326-1332
[5] Wei Zhang, Hai-yu Liu. Variabilities of the impacts of cold pathogen and cold-dampness pathogen on fractalkine mRNA expression in lung tissues of rats. Journal of Chinese Integrative Medicine, 2008, 6(2): 171-174
[6] Huang-tong Li, Jian-hua Liu. Clinical observation on treatment of peripheral facial paralysis with acupuncture and pricking-cupping therapy. Journal of Chinese Integrative Medicine, 2005, 3(1): 18
[7] Vamsi Reddy, Arvind Sridhar, Roberto F. Machado, Jiwang Chen. High sodium causes hypertension: Evidence from clinical trials and animal experiments. Journal of Integrative Medicine, 2015, 13(1): 1-8
[8] May To, Caroline Alexander. The effects of Park sham needles: A pilot study. Journal of Integrative Medicine, 2015, 13(1): 20-24
[9] Ying-lu Feng, Chang-quan Ling, De-zeng Zhu, Chao-qin Yu, Zhe Chen, Bai Li. Ginsenosides combined with dexamethasone in preventing and treating postembolization syndrome following transcatheter arterial chemoembolization: A randomized, controlled and double-blinded prospective trial. Journal of Chinese Integrative Medicine, 2005, 3(2): 99-102
[10] Xuanbin Wang, Ning Wang, Fan Cheung, Lixing Lao, Charlie Li, Yibin Feng. Chinese medicines for prevention and treatment of human hepatocellular carcinoma: Current progress on pharmacological actions and mechanisms. Journal of Integrative Medicine, 2015, 13(3): 142-164