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Journal of Chinese Integrative Medicine ›› 2007, Vol. 5 ›› Issue (1): 61-64.doi: 10.3736/jcim20070112

• Original Experimental Research • Previous Articles     Next Articles

Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1

ZHOU Yang,GU Jie,XU Lie-ming   

  1. Institute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Online:2007-01-31 Published:2018-10-21

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Objective: To investigate the effects of salvianolic acid B (SA-B) on portal hypertension induced by endothelin-1 in rats. Methods: Twenty-eight Sprague-Dawley rats were randomly divided into four groups: ET-1 group, ET-1+SA-B group, ET-1+ETAR blocker (BQ-123) group and ET-1+ETBR blocker (BQ-788) group. The rats of ET-1+SA-B group underwent intragastrical administration of salvianolic acid B for five days before ET-1 injection, while in three other groups' drinking water was given. In BQ-123 group or BQ-788 group, an intravenous injection of BQ-123 or BQ-788 via femoral vein was administered 30 minutes prior to ET-1 injection. Then changes of portal pressure, cervical artery pressure and heart rate were monitored continuously. Results: After ET-1 injection, the portal pressure of all rats in the ET-1 group increased significantly, while slightly in groups that pretreated with SA-B, BQ-123 or BQ-788. Conclusion: SA-B can attenuate the elevated portal pressure induced by ET-1 with effect similar to ETR blocker.

Key words: hypertension, portal, Salvia miltiorrhiza, Chinese herbal drugs

CLC Number: 

  • R965

Table 1

Effects of SA-B and ETR blocker against elevated portal pressure induced by ET-1（$\bar{x}±S$,mm Hg）"

Group n Initial value of portal pressure Maxium value of portal pressure Degree of elevation
ET-1 5 6.1±0.7 8.6±1.1** 2.5±0.4
ET-1+SA-B 5 6.2±0.7 7.8±1.6** 1.6±0.5△△
ET-1+BQ-123 5 5.9±1.1 7.1±1.0 1.2±0.2△△
ET-1+BQ-788 5 5.9±0.9 6.9±1.1 1.0±0.5△△

Figure 1

Effects of SA-B against elevated portal pressure induced by ET-1"

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