丹参酚酸B盐抑制内皮素-1所致大鼠门静脉压力升高的药效及其作用机制

doi:10.3736/jcim20070112

Abstract

Objective: To investigate the effects of salvianolic acid B (SA-B) on portal hypertension induced by endothelin-1 in rats. Methods: Twenty-eight Sprague-Dawley rats were randomly divided into four groups: ET-1 group, ET-1+SA-B group, ET-1+ETAR blocker (BQ-123) group and ET-1+ETBR blocker (BQ-788) group. The rats of ET-1+SA-B group underwent intragastrical administration of salvianolic acid B for five days before ET-1 injection, while in three other groups' drinking water was given. In BQ-123 group or BQ-788 group, an intravenous injection of BQ-123 or BQ-788 via femoral vein was administered 30 minutes prior to ET-1 injection. Then changes of portal pressure, cervical artery pressure and heart rate were monitored continuously. Results: After ET-1 injection, the portal pressure of all rats in the ET-1 group increased significantly, while slightly in groups that pretreated with SA-B, BQ-123 or BQ-788. Conclusion: SA-B can attenuate the elevated portal pressure induced by ET-1 with effect similar to ETR blocker.

Key words: hypertension, portal, Salvia miltiorrhiza, Chinese herbal drugs

CLC Number:

R965

ZHOU Yang, GU Jie, XU Lie-ming. Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1. Journal of Chinese Integrative Medicine, 2007, 5(1): 61-64.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20070112

http://www.jcimjournal.com/EN/Y2007/V5/I1/61

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Group	n	Initial value of portal pressure	Maxium value of portal pressure	Degree of elevation
ET-1	5	6.1±0.7	8.6±1.1**	2.5±0.4
ET-1+SA-B	5	6.2±0.7	7.8±1.6**	1.6±0.5^△△
ET-1+BQ-123	5	5.9±1.1	7.1±1.0	1.2±0.2^△△
ET-1+BQ-788	5	5.9±0.9	6.9±1.1	1.0±0.5^△△

Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1

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