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Journal of Chinese Integrative Medicine ›› 2011, Vol. 9 ›› Issue (6): 665-674.doi: 10.3736/jcim20110614

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Classification of 365 Chinese medicines in Shennong's Materia Medica Classic based on a semi-supervised incremental clustering method

Rui Jin1, Bing Zhang1(), Chun-miao Xue1, Sen-mao Liu2, Qian Zhao1, Kang Li2   

  1. 1. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China
    2. School of Mathematical Science, Peking University, Beijing 101871, China
  • Received:2011-03-18 Accepted:2011-04-13 Online:2011-06-20 Published:2011-06-15
  • Contact: Zhang Bing E-mail:zhangbing6@263.net

Evidence of the pharmacological activity of traditional Chinese medicine (TCM) provides the basis for clinical prescription. Study of the classification of Chinese medicines according to these activities is key to understanding the general active tendencies of medicinal prescriptions, exploring their material basis, investigating their properties and searching for their alternatives. Taking the herbal classic Shennong's Materia Medica Classic (Shennong Bencao Jing) for the data source, this paper studied the classification of Chinese medicines based on semi-supervised incremental clustering algorithm using "micro-cluster" concept in order to investigate the complex similarity among Chinese medicines. The results showed that 253 Chinese medicines were reasonably classified into 14 types, such as invigoration, clearing heat, diuresis, dredging blockages in the channels, treating gynecological conditions and treating strange diseases caused by ghosts. The results also showed that the other 112 Chinese medicines were classified into 112 individual types and the same high similarity to different known types was the main reason for this. The semi-supervised incremental clustering algorithm employed in the study had a high quality and a good development for clustering which is suitable for classification of Chinese medicines. This study illustrated the diversity of Chinese medicines and their complex similarities, thus aiming to provide innovative ideas and methods for related research.

Key words: drugs,Chinese herbal, semi-supervised incremental clustering, classification, cluster analysis, Bencaojing, data mining

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统一名称 原名称 参考文献
轻身延年不老 轻身、延年、不老、神仙 《本经》P1,《药林外史》[4]P81
荡涤胃内积聚 荡胃中积聚、涤积聚饮食、逐六腑积聚 《本经》P18、144
虚劳羸瘦 虚劳、劳极、羸瘦、五劳七伤 《中医内科学》P855,《本经》P73、109
痈疽疮疡
痈、痈肿、疽、疡、伤热火烂、赤熛、浸淫疮
《中医外科学》P103,《本经》P178,《诸病源候论》P206、223
风头眩痛 风头脑动、头眩痛、风入脑户 《中医内科学》P294,《本经》P102
恶肉死肌 恶肉、死肌、息肉 《本经》P13、141
身面浮肿 肢体(满)浮肿、风水 《本经》P155、174
癥瘕积聚 癥瘕积聚、留固结癖、坚瘕、癥坚(痞)、血瘕(积) 《中医内科学》P867,《本经》P66
瘿瘤瘰疬 瘿瘤、瘰疬、颈下核、鼠瘘 《本经》P9、170
欬逆上气 欬(咳)逆上气、(胸胁)逆气 《本经》P15、96
带下赤白 漏下赤白、白沃、带下赤白 《中医妇产科学》[8]P424,《本经》P16
崩中漏下 下血、漏下、崩中 《中医妇产科学》P292,《本经》P183
养精神 (安)养(精)神、安心 《本经》P11、98
安魂魄 (定、强)安魂魄 《本经》P11、192
止惊悸 止(定)惊悸(气) 《本经》P31、86
和五脏 安(定、和)五脏 《本经》P53、101
辟恶气 辟(邪)恶气(不祥) 《本经》P68、210
填髓脑 (强、填)补骨髓(脑) 《本经》P36、109
增智慧 益(增)智(慧) 《本经》P53、63
益精气 益气(力)、益精气、益脾、肺、肾气,倍力 《本经》P52、64
益子精 多(有、增、益)子(阴)精 《本经》P15、137
和颜色 面生光、润泽、和颜色、媚好 《本经》P70、81
坚筋骨 坚骨齿(强骨节)、坚(强)筋骨 《本经》P17、57
利关节 通(利)百(关)节 《本经》P15、83
通血脉 通(保)血脉、逐血、通血气 《本经》P21、262
痫病 癫、痓 《中医内科学》P345,《本经》P46
痉病 痉、瘈疭、项背强急 《中医内科学》P567,《本经》P175
痹病
寒痹、风痹、湿痹、周痹、痹气,四肢拘挛、机关缓急、屈伸不利,胫重酸痛、骨节痛、膝痛 《中医内科学》P900,《诸病源候论》P41,《本经》P74、95
痿病 痿躄、四肢偏痿、四肢重弱 《中医内科学》P370
淋病 淋、气癃闭,溺不下、小便余沥,膀胱热 《中医内科学》P660,《本经》P47
虫病 杀三虫、去长虫、去白虫 《本经》P135、181
补中 补中、补五脏、补内 《本经》P73、94
除热 除热、主身(大或暴)热 《本经》P37、141
卒中 偏枯、中风 [依具体语境] 《中医内科学》P308,《本经》P196
泄泻 泄澼、肠(泄)澼、泄痢 《中医内科学》P495,《本经》P8
痢疾 下痢脓血、下痢赤白 《中医内科学》P434
疟疾 温疟、痎疟、疟 《中医内科学》P924,《本经》P116、124
臌胀 大腹水肿、腹中水气、大水 《中医内科学》P605,《本经》P8、271
便秘 胃胀闭、厌谷胃闭(痹) 《中医内科学》P510,《本经》P18、114
绝子 绝子、无子、不孕,令人有子 《本经》P135
阴蚀 阴蚀、阴疮、阴中肿痛 《本经》P16、137
瘀血 瘀(留、止)血、恶血 《本经》P71、74
恶疮 恶疮(不瘳)、久败疮 《本经》P72、138
消水 (除、逐、下)消水(气) 《本经》P41、143
消食 消(化)食(利水谷) 《本经》P96、239
解毒 解(诸)毒、鉤吻、鸩羽、蛇螫、蜂、猘狗、菜、肉毒 《本经》P120、211
烦满 烦热、烦满、大烦 《本经》P84、133
惊痫,[凡“惊”字] 《诸病源候论》P43,《本经》P9、170
[1] Jin R, Lin Q, Liu SM, Zhao Q, Zhang Q, Zhang B . Mathematical analysis of the relationship between yang-deficiency syndrome in traditional Chinese medicine and its objective indicators in clinical literature[J]. J Chin Integr Med, 2010,8(7):678-683
金锐, 林茜, 刘森茂, 赵茜, 张倩, 张冰 . 基于数学方法的中医“阳虚证”与临床文献中客观指标的关联分析[J]. 中西医结合学报, 2010,8(7):678-683
[2] Jin R, Zhang B, Liu SM, Ni L, Li M, Li LZ . Mathematical analysis of characteristics of glucocorticoid-induced yang deficiency or yin deficiency syndrome in animal models based on information entropy theory[J]. J Chin Integr Med, 2011,9(1):15-21
金锐, 张冰, 刘森茂, 倪莉, 李敏, 李连珍 . 基于数据信息熵探讨糖皮质激素诱导的阳虚或阴虚证候动物模型的状态特征[J]. 中西医结合学报, 2011,9(1):15-21
[3] Gu GG. Shennong’s materia medica classic. Annotated by Yang PJ[M]. Beijing: Academy Press,2007: Preface, 1-271
顾观光辑 , 杨鹏举校注.神农本草经[M]. 北京: 学苑出版社,2007:前言, 1-271
[4] Zheng JS. Related historical process of development of Chinese medicine[M]. Guiling: Guangxi Normal University Press, 2007: 35, 83-90
郑金生 . 药林外史[M]. 桂林: 广西师范大学出版社, 2007: 35, 83-90
[5] Chao YF. Treatise on the pathogenesis and manifestations of all diseases. One hundred classics of traditional Chinese medicine. Edited by China Association of Chinese Medicine[M]. Beijing: Huaxia Publishing House, 2008: 41-223
巢元方辑 , 中华中医药学会编.中医必读百部名著·诸病源候论[M]. 北京: 华夏出版社, 2008: 41-223
[6] Wang YY, Lu ZL. Internal medicine of traditional Chinese medicine[M]. Beijing: People’s Medical Publishing House, 1999: 294-900
王永炎, 鲁兆麟 . 中医内科学[M]. 北京: 人民卫生出版社, 1999: 294-900
[7] Tan XH, Lu DM. Surgery of traditional Chinese medicine[M]. Beijing: People’s Medical Publishing House, 1999: 103
谭新华, 陆德铭 . 中医外科学[M]. 北京: 人民卫生出版社, 1999: 103
[8] Liu MR, Tan WX. Obstetrics and gynecology of traditional Chinese medicine[M]. Beijing: People’s Medical Publishing House, 2001: 292-424
刘敏如, 谭万信 . 中医妇产科学[M]. 北京: 人民卫生出版社, 2001: 292-424
[9] Kantardizic M. Data mining: concepts, models, methods, and algorithms. Translated by Shan SQ, Chen Y, Cheng Y[M]. Beijing: Tsinghua University Press,2003:67- 70, 114-117
Kantardizic M著; 闪四清, 陈茵, 程雁译 . 数据挖掘: 概念、模型、方法和算法[M]. 北京: 清华大学出版社,2003:67- 70, 114-117
[10] Han JW, Kamber M. Data mining: concepts and techniques. Translated by Fan M, Meng XF [M]. Beijing: China Machine Press,2007,(2nd ed): 30, 256-293
Han JW, Kamber M著; 范明, 孟小峰译 .数据挖掘: 概念与技术 [M]. 北京: 机械工业出版社,2007,(第2版): 30, 256-293
[11] Li SZ. Compendium of materia medica[M]. Harbin: The North Arts Publishing House, 2007: 449-457
李时珍 . 本草纲目[M]. 哈尔滨: 北方文艺出版社, 2007: 449-457
[12] Liu Y. Xu Lingtai’s medical collection[M]. Beijing: China Press of Traditional Chinese Medicine, 1999: 264-266
刘洋 . 徐灵胎医学全书[M]. 北京: 中国中医药出版社, 1999: 264-266
[13] Gao XM. Chinese materia medica. Beijing: People’s Medical Publishing House. 2000: 313-320. Chinese.
高学敏 . 中药学[M]. 北京: 人民卫生出版社, 2000: 313-320
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