Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (1): 46-48.doi: 10.3736/jcim20040117

• Original Experimental Research • Previous Articles     Next Articles

Effect of reducing caloric intake on mice transplanted with S180 ascitic cancer

Xian-yong Liu1, Wei-guo Hua1, Wei-zhong Chu1, Dong-liang Jiang2, Hui-ju Chen1, Yu-ying Wang1, Xue-mei Liu3   

  1. 1. Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China
    2. Shanghai Tumor Research Institute,Shanghai 200032,China
    3. Xinyang Second People’s Hospital,Xinyang, Henan Province 464000,China;
  • Online:2004-01-20 Published:2018-10-25

Objective: To examine the effect of different reduced caloric intake on mice transplanted with S180 ascitic tumor. Methods: The institute for cancer research (ICR) mice were randomly divided into control group, 3.0 standard feed (SF) group, 2.0 SF group and 1.3 SF group. The mice in control group were fed enough (about 5 g/d) dietary intake, while the amounts of dietary intake in the latter three groups were scaled down in the proportion of 65%, which were 3.0 g, 2.0 g and 1.3 g standard feed respectively. Meanwhile the essential vitamins were added to the latter three groups to keep the amount of intake the same as that of the control's. Results: For most of the mice, the caloric intake obviously prolonged the mean survival days and improved the life quality was 7.14 kcal/d, and the fasting blood glucose level was 2-3 mmol/L.Conclusion: Properly reduced caloric intake and keeping lower blood glucose level is beneficial to prolonging the survival time of mice transplanted with S180 ascitic cancer.

Key words: food intake regulation, calorie, ascitic cancer, animals, laboratory

CLC Number: 

  • R37-36

Tab 1

Comparison of indexes tested at death in mice of 4 groups (ヌ±S)"

Group n Mean survival
Ascites weight in each
gram of body weight(g)
Volume of packed red and
black parts in ascites(ml)
Weight of
Ascites inhibiting
Control 10 17.5±1.1△△ 0.29±0.04△△ 1.32±0.42△△ 10.50±2.83△△ -
3.0 SF 20 19.2±2.1*△△ 0.26±0.091△△ 1.15±0.471△△ 9.75±3.991△△ 7.1
2.0 SF 20 27.8±6.4** 0.17±0.09** 0.55±0.55** 4.81±2.7** 54.2
1.3 SF 20 21.3±10.1 0.04±0.05**△△ 0.08±0.23**△△ 0.82±.12**△△ 92.2
[1] 蒋栋良, 储维忠 . 肿瘤的能量代谢与饮食调控的探讨[J]. 科学(中文版), 2000,283(2):41-42
[2] 郝光荣 . 实验动物学(第1版)[M]. 上海: 第二军医大学出版社, 1999,( 第1版):68-69
[3] 施新猷 . 实验动物学(第1版)[M]. 西安: 陕西科学技术出版社, 1989,( 第1版):485-486
[1] Cai Lin-lin, Li Hao, Liu Jian-gang, Liu Long-tao, Guan Jie, Liu Ming-fang, Hu Jia, Wei Yun. Effects of early intervention with Huannao Yicong formula effective components on behavior and cholinergic system of β-amyloid precursor protein transgenic mice. Journal of Chinese Integrative Medicine, 2011, 9(3): 292-298.
[2] Yong-jun Wang, Qi Shi, Jian-chun Jiang, Qian-qian Liang, Qin Bian, Chen-guang Li, Quan Zhou, Xue-jun Cui, Min Huang, Qing-gao Liu, Sheng Lu, Chong-jian Zhou. Establishment of a rat model of cervical syndrome with qi deficiency, blood stasis and kidney deficiency. Journal of Chinese Integrative Medicine, 2008, 6(11): 1152-1158.
[3] Qi Li​, Zhong-ze Fan​, Xian-qian Li​, Xiao-hua Liu​, Jue Sun​, Wei Gu​, Paul Heng​, Hong Gao​. Effects of interventional therapy with norcantharidin microsphere on hepatoma in rats and its mechanism. Journal of Chinese Integrative Medicine, 2006, 4(4): 378-383.
[4] Yue-lai Chen, Jue Cen, Wen-guang Hou, Zhi-qiang Gao, Xian-min Yu, Xue-mei Ma. Effects of electroacupuncture treatment on nitrergic neurotransmitter in bladder neck and detrusor of rats with unstable bladder. Journal of Chinese Integrative Medicine, 2006, 4(1): 73-75.
[5] Jun-xiang Li, Zhi-bin Wang, Ling-qun Zhu, Fu-ling Niu, Wei Cui. Apoptosis-promoting effect of Panax notoginseng extracts on MNNG-transformed GES-1 cells. Journal of Chinese Integrative Medicine, 2005, 3(2): 123-127.
[6] Jian-hong Zhou, Dong-feng Chen, Shao-hui Du, Hui Li, Yi-wei Li, Ru-dong Deng, Sai-xia Zhang. Effect of Niupo Zhibao Pellet on expression of neuronal nitric oxide synthase in brain of endotoxin-induced shock rats. Journal of Chinese Integrative Medicine, 2005, 3(2): 115-118.
[7] Bin Zhang, Mo-bin Wan, Ling-tai Wang. Therapeutic effect of Bushen Rougan Recipe on hepatic fibrosis in rats. Journal of Chinese Integrative Medicine, 2005, 3(2): 132-135.
[8] Li Liu, Hong-quan Zhang​. Effects of Danshen Decoction on experimental gastric ulcer in rats and mice. Journal of Chinese Integrative Medicine, 2005, 3(1): 35-38.
[9] Hong-li Xue, Wen-jian Wang, Jian-qiu Chen. Effects of Shenmai Huoxue Decoction on early diabetic peripheral neuropathy in rats. Journal of Chinese Integrative Medicine, 2005, 3(1): 31-34.
[10] Le-hong Jin, Chuan-fei Liu, Yu Zeng. Protective effects of puerarin on radiation injury of experimental rats. Journal of Chinese Integrative Medicine, 2005, 3(1): 43-45.
[11] Zhi-bin Wang, Jun-xiang Li, Ling-qun Zhu, Fu-ling Niu, Wei Cui. Inhibiting effects of Panax notoginseng extracts on proliferation of GES-1 cells and MNNG-transformed GES-1 cells. Journal of Chinese Integrative Medicine, 2004, 2(6): 445-449.
[12] Mu-rong Liu, Ting Han, Yao Chen, Lu-ping Qin, Han-chen Zheng, Yao-cheng Rui. Effect of madecassoside on depression behavior of mice and activities of MAO in different brain regions of rats. Journal of Chinese Integrative Medicine, 2004, 2(6): 440-444.
[13] Nan Li, He-ming Wang, Xu Lin, Liang-pu Zheng, Lin Shen, Yi-ping Lin, Lin-ying Zhou, Xiu-rong Zhong, Fang Lin. Effect of Bugu Mixture on all-trans retinoic acid-induced apoptosis of bone marrow stromal cells. Journal of Chinese Integrative Medicine, 2004, 2(5): 367-371.
[14] Zhe-hao Jiang, Hong-yan Cui, Cheng-hai Liu, Cheng Liu, Ping Liu, Lie-ming Xu, Yi-yang Hu, Ji-li Yuan, Feng-hua Li. Effects of Fuzheng Huayu Recipe on renal toxic interstitial fibrosis in rats. Journal of Chinese Integrative Medicine, 2004, 2(5): 358-360.
[15] Dong-feng Chen, Hui Li, Jian-hong Zhou, Yao Xie, Yi-wei Li, Shao-hui Du, Yi Zhang, Jie Huang, Min Xu. Osteogenesis characteristics of cultured rat mesenchymal stem cells under bone induction condition. Journal of Chinese Integrative Medicine, 2004, 2(5): 375-378.
Full text



[1] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[2] Hai-feng Wei, Bai-liu Ya, Ling Zhao, Cui-fei Ye, Li Zhang, Lin Li. Evaluation of tongue manifestation of blood stasis syndrome and its relationship with blood rheological disorder in a rat model of transient brain ischemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 73-76
[3] Xi Lin, Jian-ping Liu. Herbal medicines for viral myocarditis. Journal of Chinese Integrative Medicine, 2008, 6(1): 76
[4] Xi Lin, Jian-ping Liu. Tai chi for treating rheumatoid arthritis. Journal of Chinese Integrative Medicine, 2008, 6(1): 82
[5] Liang-ping Hu, Hui Gao. Discrimination of errors in statistical analysis of medical papers published in the first issue of 2006 in Journal of Chinese Integrative Medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 98-106
[6] Yan-bo Zhu , Qi Wang, Cheng-yu Wu, Guo-ming Pang, Jian-xiong Zhao, Shi-lin Shen, Zhong-yuan Xia , Xue Yan . Logistic regression analysis on relationships between traditional Chinese medicine constitutional types and overweight or obesity. Journal of Chinese Integrative Medicine, 2010, 8(11): 1023-1035
[7] Wei Xu, Meng Shi, Jian-gang Liu, Cheng-long Wang . Collagen protein expressions in ischemic myocardium of rats with acute myocardial infarction and effects of qi-tonifying, yin-tonifying and blood-activating herbs and detoxifying and blood-activating herbs. Journal of Chinese Integrative Medicine, 2010, 8(11): 1041-1047
[8] Tao Wang , Feng Qin. Effects of Chinese herbal medicine Xiaoyao Powder on monoamine neurotransmitters in hippocampus of rats with postpartum depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1075-1079
[9] Ying Xu , Chang-chun Zeng , Xiu-yu Cai , Rong-ping Guo , Guang Nie , Ying Jin. Chromaticity and optical spectrum colorimetry of the tongue color in different syndromes of primary hepatic carcinoma. Journal of Chinese Integrative Medicine, 2012, 10(11): 1263-1271
[10] Xiang-ying Mao , Qin Bian , Zi-yin Shen. Analysis of the osteogenetic effects exerted on mesenchymal stem cell strain C3H10T1/2 by icariin via MAPK signaling pathway in vitro. Journal of Chinese Integrative Medicine, 2012, 10(11): 1272-1278